(25 nodes) Pyridoxal phosphate-dependent transferase network (Ruminococcus torques)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Your Input:
	nifS	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (396 aa)
	metB	Cystathionine gamma-synthase. (243 aa)
	mdeA_2	Methionine gamma-lyase. (435 aa)
	speA_2	Arginine decarboxylase. (478 aa)
	patB	Cystathionine beta-lyase PatB. (397 aa)
	gabR_2	HTH-type transcriptional regulatory protein gabR. (467 aa)
	CUQ89314.1	Aspartate aminotransferase. (498 aa)
	cobD_2	Threonine-phosphate decarboxylase. (363 aa)
	serC	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (360 aa)
	CUQ88136.1	Cystathionine beta-lyase family protein involved in aluminum resistance. (437 aa)
	mdeA_1	Methionine gamma-lyase. (425 aa)
	csd	Probable cysteine desulfurase. (375 aa)
	ltaE	Low specificity L-threonine aldolase. (341 aa)
	argD	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa)
	bioF	8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily. (644 aa)
	bioA	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (401 aa)
	cobD_1	Threonine-phosphate decarboxylase. (349 aa)
	gabR_1	HTH-type transcriptional regulatory protein gabR. (472 aa)
	glyA	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa)
	hisC	Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (355 aa)
	aspC	Aspartate aminotransferase. (395 aa)
	iscS	Cysteine desulfurase. (385 aa)
	arnB_1	UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase; Belongs to the DegT/DnrJ/EryC1 family. (402 aa)
	CUQ80765.1	Putative aminotransferase MSMEG_6286. (428 aa)
	speA_1	Arginine decarboxylase. (488 aa)

Your Current Organism:

Ruminococcus torques

NCBI taxonomy Id: 33039
Other names: ATCC 27756, [. torques, [Ruminococcus] torques

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUQ88136.1	speA_1	ERS852502_01710	ERS852502_00025	Cystathionine beta-lyase family protein involved in aluminum resistance.	Arginine decarboxylase.	0.418
CUQ88136.1	speA_2	ERS852502_01710	ERS852502_02803	Cystathionine beta-lyase family protein involved in aluminum resistance.	Arginine decarboxylase.	0.731
CUQ89314.1	aspC	ERS852502_01946	ERS852502_00330	Aspartate aminotransferase.	Aspartate aminotransferase.	0.900
argD	bioF	ERS852502_00519	ERS852502_00462	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.	0.513
argD	serC	ERS852502_00519	ERS852502_01816	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.	0.485
aspC	CUQ89314.1	ERS852502_00330	ERS852502_01946	Aspartate aminotransferase.	Aspartate aminotransferase.	0.900
aspC	glyA	ERS852502_00330	ERS852502_00336	Aspartate aminotransferase.	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.540
aspC	hisC	ERS852502_00330	ERS852502_00331	Aspartate aminotransferase.	Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.982
aspC	patB	ERS852502_00330	ERS852502_02526	Aspartate aminotransferase.	Cystathionine beta-lyase PatB.	0.900
bioA	bioF	ERS852502_00461	ERS852502_00462	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.	0.996
bioF	argD	ERS852502_00462	ERS852502_00519	8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	0.513
bioF	bioA	ERS852502_00462	ERS852502_00461	8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.996
cobD_1	cobD_2	ERS852502_00440	ERS852502_01860	Threonine-phosphate decarboxylase.	Threonine-phosphate decarboxylase.	0.919
cobD_2	cobD_1	ERS852502_01860	ERS852502_00440	Threonine-phosphate decarboxylase.	Threonine-phosphate decarboxylase.	0.919
csd	iscS	ERS852502_01505	ERS852502_00081	Probable cysteine desulfurase.	Cysteine desulfurase.	0.607
csd	nifS	ERS852502_01505	ERS852502_00278	Probable cysteine desulfurase.	Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.	0.588
glyA	aspC	ERS852502_00336	ERS852502_00330	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Aspartate aminotransferase.	0.540
glyA	hisC	ERS852502_00336	ERS852502_00331	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.536
glyA	ltaE	ERS852502_00336	ERS852502_00562	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Low specificity L-threonine aldolase.	0.931
glyA	serC	ERS852502_00336	ERS852502_01816	Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.	0.790