STRINGSTRING
SB4_05995 SB4_05995 SB4_07830 SB4_07830 purD purD SB4_17460 SB4_17460 SB4_17560 SB4_17560 cysD cysD purH purH SB4_18685 SB4_18685 SB4_18705 SB4_18705 SB4_18715 SB4_18715 gmk gmk SB4_07985 SB4_07985 SB4_08255 SB4_08255 prs prs SB4_09730 SB4_09730 SB4_09805 SB4_09805 adk adk purC purC purS purS purQ purQ guaA guaA tilS tilS SB4_11685 SB4_11685 nrdR nrdR SB4_12080 SB4_12080 surE surE SB4_12815 SB4_12815 SB4_12895 SB4_12895 SB4_12900 SB4_12900 SB4_12905 SB4_12905 SB4_13690 SB4_13690 SB4_13850 SB4_13850 SB4_14045 SB4_14045 SB4_14575 SB4_14575 SB4_14595 SB4_14595 SB4_14670 SB4_14670 SB4_15090 SB4_15090 apt apt SB4_15220 SB4_15220 purE purE purK purK SB4_16505 SB4_16505 ychF ychF SB4_17110 SB4_17110 SB4_17295 SB4_17295 truA truA guaB guaB ndk ndk purN purN purM purM SB4_00425 SB4_00425 mazG mazG tadA tadA SB4_01135 SB4_01135 SB4_01140 SB4_01140 SB4_01460 SB4_01460 purF purF SB4_01785 SB4_01785 SB4_01865 SB4_01865 SB4_02290 SB4_02290 SB4_02385 SB4_02385 SB4_02680 SB4_02680 SB4_03045 SB4_03045 amn amn SB4_03090 SB4_03090 SB4_03470 SB4_03470 SB4_03630 SB4_03630 ihfA ihfA purA purA SB4_04085 SB4_04085 SB4_04160 SB4_04160 SB4_04765 SB4_04765 SB4_05355 SB4_05355 SB4_05725 SB4_05725 SB4_05990 SB4_05990 SB4_06000 SB4_06000 SB4_06445 SB4_06445 SB4_06935 SB4_06935 SB4_07115 SB4_07115 SB4_07250 SB4_07250 rph rph
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SB4_05995Molybdopterin dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
SB4_07830Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (208 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (425 aa)
SB4_17460Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
SB4_17560Phosphoglucomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (541 aa)
cysDSulfate adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (539 aa)
SB4_18685Polysaccharide deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)
SB4_18705Sulfate adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (59 aa)
SB4_18715GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (699 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (202 aa)
SB4_07985Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
SB4_08255Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
prsPhosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (311 aa)
SB4_09730Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
SB4_09805Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (259 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (76 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (222 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (517 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (330 aa)
SB4_11685Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
nrdRNrdR family transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (155 aa)
SB4_12080Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
surEStationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (254 aa)
SB4_12815Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (489 aa)
SB4_12895Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
SB4_12900Xanthine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
SB4_12905Xanthine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (745 aa)
SB4_13690Phosphoribosylformylglycinamidine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (741 aa)
SB4_13850Transcriptional regulator HU subunit alpha; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
SB4_14045Polysaccharide deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
SB4_14575Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (638 aa)
SB4_14595Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (351 aa)
SB4_14670BolA family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the BolA/IbaG family. (94 aa)
SB4_15090Endonuclease/exonuclease/phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (178 aa)
SB4_15220Magnesium transporter; Acts as a magnesium transporter. (470 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (351 aa)
SB4_16505Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
ychFGTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (366 aa)
SB4_17110Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
SB4_17295Polysaccharide deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
truAPseudouridine synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (249 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa)
ndkPhosphodiesterase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (192 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
SB4_00425Exopolyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (490 aa)
mazGNucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
tadACMP deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (142 aa)
SB4_01135DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
SB4_01140Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)
SB4_01460Permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (499 aa)
SB4_01785Magnesium transporter; Acts as a magnesium transporter. (452 aa)
SB4_01865Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (368 aa)
SB4_02290ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the BolA/IbaG family. (78 aa)
SB4_02385Integration host factor subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial histone-like protein family. (95 aa)
SB4_02680Permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
SB4_03045Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (478 aa)
SB4_03090Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (187 aa)
SB4_03470Electron transfer flavoprotein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
SB4_03630Serine/threonine protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
ihfAIntegration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (99 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
SB4_04085Lysine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (295 aa)
SB4_04160Cobalt transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
SB4_04765Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
SB4_05355Cytosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
SB4_05725Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
SB4_05990Xanthine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (736 aa)
SB4_06000Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
SB4_06445NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
SB4_06935Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
SB4_07115Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (428 aa)
SB4_07250Decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (193 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa)
Your Current Organism:
Sphingomonas sanguinis
NCBI taxonomy Id: 33051
Other names: 13937T, ATCC 51382, CIP 104197, DSM 13885, GIFU 2397, GIFU:2397, HAMBI 2010, IFO 13937, JCM 7514, LMG 17325, LMG:17325, NBRC 13937, S. sanguinis, Sphingomonas sanguis, strain 13937
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