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AKO51026.1 AKO51026.1 AKO54181.1 AKO54181.1 AKO51595.1 AKO51595.1 AKO51600.1 AKO51600.1 AKO51606.1 AKO51606.1 AKO51607.1 AKO51607.1 bamD bamD AKO51685.1 AKO51685.1 AKO51686.1 AKO51686.1 AKO51687.1 AKO51687.1 lpxC lpxC dapE dapE dapD dapD AKO54224.1 AKO54224.1 AKO52033.1 AKO52033.1 glnD glnD pyrH pyrH frr frr uppS uppS AKO52041.1 AKO52041.1 AKO52043.1 AKO52043.1 bamA bamA AKO52045.1 AKO52045.1 lpxD lpxD fabZ fabZ lpxA lpxA lpxB lpxB rnhB rnhB kdsA kdsA AKO52190.1 AKO52190.1 AKO52191.1 AKO52191.1 AKO52382.1 AKO52382.1 bamB bamB AKO52569.1 AKO52569.1 AKO52570.1 AKO52570.1 AKO52571.1 AKO52571.1 AKO52572.1 AKO52572.1 AKO52830.1 AKO52830.1 cpoB cpoB pal pal tolB tolB AKO54328.1 AKO54328.1 tolR tolR tolQ tolQ AKO52869.1 AKO52869.1 kdsB kdsB AKO52871.1 AKO52871.1 lpxK lpxK msbA msbA AKO52873.1 AKO52873.1 AKO52874.1 AKO52874.1 AKO52876.1 AKO52876.1 AKO52951.1 AKO52951.1 lpxH lpxH AKO53167.1 AKO53167.1 AKO53168.1 AKO53168.1 lptC lptC lptA lptA AKO53170.1 AKO53170.1 lptE lptE AKO53223.1 AKO53223.1 orn orn cca cca bamE bamE AKO53730.1 AKO53730.1 AKO53731.1 AKO53731.1 AKO53732.1 AKO53732.1 AKO54422.1 AKO54422.1 AKO53839.1 AKO53839.1 rsmA rsmA pdxA pdxA surA surA lptD lptD AKO53843.1 AKO53843.1 AKO53844.1 AKO53844.1 AKO53845.1 AKO53845.1 AKO53929.1 AKO53929.1 AKO53938.1 AKO53938.1 AKO53939.1 AKO53939.1 AKO53965.1 AKO53965.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKO51026.1Histidinol phosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
AKO54181.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
AKO51595.13-deoxy-manno-octulosonate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
AKO51600.1Lipid A biosynthesis acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
AKO51606.1Lipid A biosynthesis acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
AKO51607.13-deoxy-D-manno-octulosonic acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (417 aa)
bamDTransporter; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (276 aa)
AKO51685.1Stringent starvation protein A; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
AKO51686.1Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
AKO51687.1Phosphoheptose isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
lpxCUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (304 aa)
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (382 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (342 aa)
AKO54224.1ArsC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (114 aa)
AKO52033.1Catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
glnDprotein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (881 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (242 aa)
frrRibosome-recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa)
uppSFarnesyl-diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (255 aa)
AKO52041.1Phosphatidate cytidylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDS family. (280 aa)
AKO52043.1Zinc metallopeptidase RseP; Catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
bamAMembrane protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (773 aa)
AKO52045.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (346 aa)
fabZ3-hydroxyacyl-ACP dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (145 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (263 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (395 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (219 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the KdsA family. (281 aa)
AKO52190.1Permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
AKO52191.1Permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
AKO52382.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
bamBPyrrolo-quinoline quinone; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (373 aa)
AKO52569.1Flagellar motor protein MotA; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
AKO52570.1Ferric siderophore transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
AKO52571.1Biopolymer transporter ExbD; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
AKO52572.1Energy transducer TonB; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
AKO52830.1Lipoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
cpoBHypothetical protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (255 aa)
palPeptidoglycan-binding protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (189 aa)
tolBTranslocation protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (442 aa)
AKO54328.1Energy transducer TonB; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
tolRBiopolymer transporter TolR; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (148 aa)
tolQProtein tolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (229 aa)
AKO52869.1Phosphotyrosine protein phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (159 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (269 aa)
AKO52871.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0434 family. (62 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (361 aa)
msbALipid transporter ATP-binding/permease; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (591 aa)
AKO52873.1Biopolymer transporter ExbD; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
AKO52874.1Biopolymer transporter ExbB; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
AKO52876.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
AKO52951.1Peptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (169 aa)
lpxHUDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (241 aa)
AKO53167.1D-arabinose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
AKO53168.1HAD family hydrolase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (202 aa)
lptCHypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. (182 aa)
lptAOrganic solvent tolerance protein OstA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (195 aa)
AKO53170.1Sugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
lptELipoprotein; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (212 aa)
AKO53223.1N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
ornOligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (180 aa)
ccatRNA nucleotidyl transferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 2 subfamily. (382 aa)
bamEMembrane protein SmpA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (108 aa)
AKO53730.1Protein RnfH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0125 (RnfH) family. (93 aa)
AKO53731.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
AKO53732.1Sodium:calcium symporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (494 aa)
AKO54422.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
AKO53839.1Diadenosine tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (266 aa)
rsmARibosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (277 aa)
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (337 aa)
surAMolecular chaperone SurA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (449 aa)
lptDLPS biosynthesis protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (800 aa)
AKO53843.1Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
AKO53844.1Mannose-1-phosphate guanylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
AKO53845.1Fis family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
AKO53929.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
AKO53938.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (479 aa)
AKO53939.1Flagellar motor protein MotB; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
AKO53965.1Energy transducer TonB; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
Your Current Organism:
Marinobacter psychrophilus
NCBI taxonomy Id: 330734
Other names: CGMCC 1.6499, JCM 14643, M. psychrophilus, Marinobacter psychrophilus Zhang et al. 2008, Marinobacter sp. BSi20041, strain 20041
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