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| | Saci_0025 | Acetyl-coenzyme A synthetase. (568 aa) |
| | Saci_0061 | Conserved Archaeal protein. (319 aa) |
| | Saci_0062 | methylmalonyl-CoA mutase C-terminal domain/subunit. (140 aa) |
| | fumC | Fumarate hydratase class II. (438 aa) |
| | korB | 2-oxoglutarate synthase subunit B. (304 aa) |
| | korA | 2-oxoacid-ferredoxin oxidoreductase, alfa domain; N-terminal domain of unknown function (seen in all archaea). (622 aa) |
| | cisY | Citrate synthase. (328 aa) |
| | Saci_0244 | Carboxyvinyl-carboxyphosphonate phosphorylmutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (280 aa) |
| | Saci_0245 | MmgE family protein; Family includes 2-methylcitrate dehydratase EC :4.2.1.79 (PrpD) that is required for propionate catabolism; it catalyses the third step of the2-methylcitric acid cycle. (431 aa) |
| | mdh | Lactate/malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (306 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) |
| | leu2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa) |
| | pycA | Pyruvate carboxylase subunit A. (510 aa) |
| | Saci_0261 | Conserved protein. (167 aa) |
| | pccB | propionyl-CoA carboxylase beta chain. (511 aa) |
| | etfB | Electron transfer flavoprotein; Could be both subunits. (243 aa) |
| | etfA | Electron transfer flavoprotein. (281 aa) |
| | Saci_0292 | Dehydrogenase; Function of the other proteins in this operon makes this conclusion tempting. (407 aa) |
| | Saci_0293 | Ferredoxin-like protein. (89 aa) |
| | dld | D-lactate dehydrogenase. (440 aa) |
| | Saci_0306 | Acetyl-coenzyme A synthetase. (665 aa) |
| | citE | citryl-CoA lyase beta subunit-like protein. (270 aa) |
| | Saci_0315 | Electron transfer flavoprotein; Looks like a hybrid protein, since it contains both the alpha and the beta domain. (609 aa) |
| | Saci_0316 | FixC. (394 aa) |
| | Saci_0317 | Ferredoxin-like protein. (96 aa) |
| | Saci_0385 | 3-hydroxyisobutyrate dehydrogenase. (287 aa) |
| | leuB | 3-isopropylmalate dehydrogenase. (337 aa) |
| | adh-2 | Alcohol dehydrogenase. (334 aa) |
| | Saci_0923 | Conserved protein. (141 aa) |
| | Saci_0924 | methylmalonyl-CoA mutase. (559 aa) |
| | Saci_0940 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Carries out the first step of the leucine biosynthesis pathway. Also displays a low citramalate synthase activity, using pyruvate as substrate, but is unable to use 2-oxoglutarate. (386 aa) |
| | Saci_0963 | acetyl-CoA acetyltransferase. (392 aa) |
| | sdhD | Succinate dehydrogenase subunit D. (122 aa) |
| | sdhC | Succinate dehydrogenase subunit C. (290 aa) |
| | sdhB | Succinate dehydrogenase subunit B; Similar to gi:15920714. (317 aa) |
| | sdhA | Succinate dehydrogenase subunit A. (566 aa) |
| | Saci_1033 | acyl-CoA dehydrogenase. (399 aa) |
| | ivd | isovaleryl-CoA dehydrogenase. (362 aa) |
| | Saci_1070 | Conserved Prokaryal protein. (145 aa) |
| | Saci_1071 | Conserved protein; acyl-CoA dehydrogenase, C-terminal domain. (267 aa) |
| | Saci_1078 | 3-hydroxybutyryl-CoA dehydrogenase; Contains an archaeal insert (ca 281 to 300 AA); similar to sp:P52041. (396 aa) |
| | acs | acyl-CoA synthetase. (505 aa) |
| | Saci_1085 | Conserved Prokaryal protein. (167 aa) |
| | Saci_1086 | CoA-transferase family III; Similar to sp:P70473; O09176 Alpha-methylacyl-CoA racemase (EC 5.1.99.4). (382 aa) |
| | Saci_1088 | Conserved Archaeal protein. (107 aa) |
| | gdh | Glucose 1-dehydrogenase. (252 aa) |
| | acd | acyl-CoA dehydrogenase. (373 aa) |
| | Saci_1109 | 3-hydroxybutyryl-CoA dehydrogenase; Looks like fusion protein; sp:P52046, sp:P520 41; Belongs to the enoyl-CoA hydratase/isomerase family. (663 aa) |
| | Saci_1113 | Matching Pfam: acyl-CoA dehydrogenase, C-terminal domaim. (302 aa) |
| | Saci_1114 | Thiolase. (395 aa) |
| | Saci_1120 | Conserved Archaeal protein. (175 aa) |
| | Saci_1121 | acetyl-CoA thiolase. (395 aa) |
| | Saci_1134 | Hypothetical protein; Similar to 3-hydroxybutyryl-CoA dehydrogenase (N-term) and 3-hydroxybutyryl-CoA dehydratase (C-term); Belongs to the enoyl-CoA hydratase/isomerase family. (662 aa) |
| | Saci_1137 | Thiamine pyrophosphate enzyme; Belongs to the TPP enzyme family. (558 aa) |
| | Saci_1184 | Acetyl-coenzyme A synthetase; acetate-CoA ligase, acyl-activating enzyme. (654 aa) |
| | acnA | Aconitate hydratase. (848 aa) |
| | sucC | succinyl-CoA synthetase beta chain. (337 aa) |
| | Saci_1266 | succinyl-CoA ligase, alfa chain; Matches PF02629:CoA binding domain and PF00549: CoA-ligase: family includes the CoA ligases succinyl-Co A synthetase alpha and beta chains, malateCoA ligase and ATP-citrate lyase Some members of the family utilise ATP others use GTP. (256 aa) |
| | Saci_1304 | Homocitrate synthase; Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. Does not display 2-isopropylmalate synthase and citramalate synthase activities since it cannot use 2-oxoisovalerate or pyruvate as substrate. (468 aa) |
| | Saci_1359 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (411 aa) |
| | Saci_1360 | Conserved Archaeal protein. (137 aa) |
| | acaB1 | acetyl-CoA acetyltransferases. (364 aa) |
| | Saci_1362 | DNA/RNA binding protein Alba; Belongs to the thiolase-like superfamily. UPF0219 family. (348 aa) |
| | Saci_1417 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | acyP | Acylphosphatase. (92 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | Saci_1561 | Acetolactate synthase large subunit. (572 aa) |
| | Saci_1623 | 3-hydroxybutyryl-CoA dehydrogenase. (320 aa) |
| | paaF | 3-hydroxybutyryl-CoA dehydratase; Several copies; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa) |
| | birA | Biotin operon repressor/acetyl-CoA carboxylase ligase. (230 aa) |
| | Saci_1648 | Pyruvate kinase; Belongs to the pyruvate kinase family. (441 aa) |
| | acd-2 | Multicopy acyl-CoA dehydrogenase. (390 aa) |
| | ilvD | Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (561 aa) |
| | Saci_1728 | Nonspecific lipid-transfer protein. (376 aa) |
| | Saci_1729 | Hypothetical protein. (89 aa) |
| | Saci_1738 | Aldehyde dehydrogenase. (468 aa) |
| | Saci_1758 | Conserved Archaeal protein. (115 aa) |
| | Saci_1759 | acetyl-CoA acetyltransferase. (382 aa) |
| | crt | 3-hydroxybutyryl-CoA dehydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (267 aa) |
| | Saci_1774 | Acetyl-coenzyme A synthetase. (526 aa) |
| | Saci_1778 | acyl-CoA dehydrogenase; Similar to fragment of transposase ISC1225 from Sulfolobus solfataricus. (557 aa) |
| | alkK | medium-chain-fatty-acid-CoA ligase. (513 aa) |
| | Saci_1857 | Aldehyde dehydrogenase. (481 aa) |
| | pox | Pyruvate oxidase; Belongs to the TPP enzyme family. (549 aa) |
| | Saci_1965 | Short chain dehydrogenase. (244 aa) |
| | fadD | long-chain-fatty-acid-CoA ligase. (511 aa) |
| | Saci_1967 | Mandelate racemase/muconate lactonizing enzyme. (372 aa) |
| | Saci_1968 | Conserved acetyl-CoA acetyltransferase. (386 aa) |
| | Saci_1969 | Conserved protein. (114 aa) |
| | Saci_1970 | Conserved protein; Identification based on homology with Sulfolobus solfataricus and Sulfolobus tokodaii; upstream TATA box was found. (80 aa) |
| | acs-2 | Acetyl-coenzyme A synthetase. (561 aa) |
| | Saci_2063 | enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (254 aa) |
| | adh-7 | Conserved alcohol dehydrogenase; The first 32 aa are archaea specific. (363 aa) |
| | Saci_2147 | Aspartate-semialdehyde dehydrogenase. (352 aa) |
| | Saci_2154 | NAD-dependent malic enzyme. (427 aa) |
| | mas | Malate synthase. (824 aa) |
| | aceA | Isocitrate lyase; Isocitrase; isocitratase. (437 aa) |
| | Saci_2207 | 4-coumarate-CoA ligase 1. (495 aa) |
| | Saci_2208 | 3-hydroxybutyryl-CoA dehydrogenase; Split in two in many organisms. (657 aa) |
| | Saci_2209 | acetyl-CoA thiolase. (395 aa) |
| | Saci_2210 | Conserved Archaeal protein. (180 aa) |
| | Saci_2217 | acyl-CoA dehydrogenase. (399 aa) |
| | Saci_2218 | Conserved 3-hydroxybutyryl-CoA. (639 aa) |
| | iorB | Indolepyruvate ferredoxin oxidoreductase beta. (188 aa) |
| | iorA | Indolepyruvate ferredoxin oxidoreductase alpha; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (611 aa) |
| | Saci_2230 | Conserved protein. (144 aa) |
| | Saci_2231 | Conserved Archaeal protein. (165 aa) |
| | Saci_2232 | Conserved Archaeal acetyl-CoA acetyltransferase. (392 aa) |
| | Saci_2233 | acetyl-CoA C-acetyltransferase. (382 aa) |
| | acd-3 | isovaleryl-CoA dehydrogenase. (374 aa) |
| | Saci_2235 | acyl-CoA synthetase. (619 aa) |
| | porC | Pyruvate/ketoisovalerate oxidoreductases common gamma subunit. (187 aa) |
| | porD | Pyruvate synthase delta chain. (88 aa) |
| | porA | Pyruvate synthase alpha chain. (397 aa) |
| | porB | Pyruvate synthase beta chain. (296 aa) |
| | paaF-2 | enoyl-CoA hydratase/isomerase. (247 aa) |
| | paaF-3 | enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family. (256 aa) |
| | Saci_2287 | Pyridine nucleotide-disulphide oxidoreductase. (423 aa) |
| | Saci_2288 | Nonspecific lipid-transfer protein. (386 aa) |
| | acsA | Acetyl-coenzyme A synthetase. (606 aa) |
| | Saci_2306 | Pyruvate flavodoxin/ferredoxin oxidoreductase. (621 aa) |
| | korB-2 | 2-oxoglutarate synthase subunit B. (303 aa) |
| | cimA | (R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. Makes part of a pathway for isoleucine biosynthesis, i.e. the citramalate-dependent pathway. Also displays a low alpha-isopropylmalate synthase activity, using 2-oxoisovalerate as substrate, but is unable to use 2-oxoglutarate. (523 aa) |
| | Saci_2359 | Conserved Archaeal HTH-domain protein. (232 aa) |
| | Saci_2370 | Aspartate-semialdehyde dehydrogenase. (354 aa) |
| | icd | Isocitrate dehydrogenase. (411 aa) |
