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| | Saci_2289 | Conserved Archaeal protein. (136 aa) |
| | Saci_0030 | Conserved protein. (296 aa) |
| | Saci_0032 | Conserved protein. (87 aa) |
| | rnp4 | Conserved protein; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (118 aa) |
| | nep1 | Conserved protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (219 aa) |
| | lysS | lysyl-tRNA synthetase type II; Belongs to the class-II aminoacyl-tRNA synthetase family. (500 aa) |
| | Saci_0073 | Acetyltransferase. (154 aa) |
| | tys1 | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (361 aa) |
| | rps13 | 30S ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (170 aa) |
| | rps4 | 30S ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (176 aa) |
| | rps11 | 30S ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (132 aa) |
| | rpoD | DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (264 aa) |
| | rpl18e | 50S ribosomal protein L18E; HL29e; Belongs to the eukaryotic ribosomal protein eL18 family. (110 aa) |
| | rpl13 | 50S ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (148 aa) |
| | rps9 | 30S ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (138 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (66 aa) |
| | rps2 | 30S ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (225 aa) |
| | tmcA | Conserved protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (738 aa) |
| | Saci_0138 | Conserved protein. (284 aa) |
| | cysRS | cysteinyl-tRNA synthetase. (469 aa) |
| | rpoM | DNA-directed RNA polymerase subunit M; Induces RNA cleavage activity in the RNA polymerase. In its presence, the cleavage activity of the RNA polymerase truncates the RNA back to position +15 in a stepwise manner by releasing mainly dinucleotides from the 3'-end of the nascent RNA. The truncated RNAs are able to continue elongation. Involved in transcriptional proofreading and fidelity. Misincorporation of nucleotides during elongation of transcription leads to arrested elongation complexes which are rescued by TFS-promoted removal of a dinucleotide from the 3'-end. TFS is able to indu [...] (100 aa) |
| | rpoL | DNA-directed RNA polymerase subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (90 aa) |
| | csl4 | Conserved Archaeal protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (180 aa) |
| | rpl10e | 50S ribosomal protein L10E; Belongs to the universal ribosomal protein uL16 family. (176 aa) |
| | Saci_0194 | Conserved protein. (75 aa) |
| | Saci_0271 | Conserved protein. (231 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (286 aa) |
| | Saci_0313 | Conserved Archaeal protein. (134 aa) |
| | Saci_0330 | Conserved protein. (77 aa) |
| | Saci_0335 | Conserved protein. (80 aa) |
| | Saci_0351 | Biotin/lipoate A/B protein ligase. (365 aa) |
| | gatA | glutamyl-tRNA(Gln) amidotransferase subunit A. (467 aa) |
| | leuS1 | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (942 aa) |
| | Saci_0378 | Predicted ATPase of the PP-loop superfamily implicated in cell cycle control. (315 aa) |
| | Saci_0390 | Conserved protein. (313 aa) |
| | tmcA-2 | Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (772 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (381 aa) |
| | Saci_0459 | N-acetyltransferase; Displays alpha (N-terminal) acetyltransferase activity. Catalyzes the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein. Belongs to the acetyltransferase family. ARD1 subfamily. (168 aa) |
| | Saci_0546 | Conserved protein. (261 aa) |
| | rtcA | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (335 aa) |
| | Saci_0559 | Conserved Archaeal protein. (258 aa) |
| | Saci_0565 | Conserved Archaeal protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). (139 aa) |
| | rpl34e | 50S ribosomal protein L34E; Belongs to the eukaryotic ribosomal protein eL34 family. (87 aa) |
| | rpl15 | 50S ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (144 aa) |
| | rpl30 | 50S ribosomal protein L30P. (156 aa) |
| | rps5 | 30S ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (214 aa) |
| | rpl18 | 50S ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (197 aa) |
| | rpl19e | 50S ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa) |
| | rpl32e | 50S ribosomal protein L32E; Belongs to the eukaryotic ribosomal protein eL32 family. (131 aa) |
| | rpl6 | 50S ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (186 aa) |
| | rps8 | 30S ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (133 aa) |
| | rps14 | 30S ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (63 aa) |
| | rpl5 | 50S ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (178 aa) |
| | rps4e | 30S ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (244 aa) |
| | rpl24 | 50S ribosomal protein L24AB; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (134 aa) |
| | rpl14 | 50S ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (138 aa) |
| | rps17 | 30S ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (114 aa) |
| | Saci_0589 | Conserved protein; Identification based on homology with Sulfolobus solfataricus and Sulfolobus tokodaii; upstream SD sequence was found. (69 aa) |
| | rpl29 | 50S ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (69 aa) |
| | rps3 | 30S ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (231 aa) |
| | rpl22 | 50S ribosomal protein L22P; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (156 aa) |
| | rps19 | 30S ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (140 aa) |
| | rpl2 | 50S ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (238 aa) |
| | rpl23 | 50S ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (82 aa) |
| | rpl4 | 50S ribosomal protein L4E; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (266 aa) |
| | rpl3 | 50S ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (342 aa) |
| | ileS | isoleucine-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1050 aa) |
| | fusA | Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (724 aa) |
| | Saci_0606 | Conserved protein; TATA box upstream. (77 aa) |
| | Saci_0607 | Conserved brix domain protein; Probably involved in the biogenesis of the ribosome. (199 aa) |
| | rpl37ae | 50S ribosomal protein L37AE; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily. (70 aa) |
| | rnp2 | Conserved protein; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (140 aa) |
| | Saci_0615 | Conserved RNase_P_p30-like protein. (183 aa) |
| | rpl15e | 50S ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (217 aa) |
| | rps3ae | 30S ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (197 aa) |
| | trmJ | SpoU rRNA methylase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) at position 32 in tRNA. Is specific for cytidine. Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (235 aa) |
| | Saci_0623 | Ribosomal RNA adenine dimethylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (222 aa) |
| | rpl21e | 50S ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (103 aa) |
| | rpl37e | 50S ribosomal protein L37E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (61 aa) |
| | tfe | Conserved Archaeal protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Se [...] (168 aa) |
| | Saci_0653 | Conserved Archaeal protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (132 aa) |
| | Saci_0657 | Conserved Archaeal PUA domain protein; PUA domain: The PUA domain named after Pseudouridine synthase and Archaeosine transglycosylase. (168 aa) |
| | tgtA | Queuine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. (498 aa) |
| | Saci_0660 | Conserved Archaeal protein. (144 aa) |
| | hisS | Histidyl tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (428 aa) |
| | Saci_0664 | Conserved Archaeal protein. (91 aa) |
| | Saci_0665 | Conserved protein. (195 aa) |
| | Saci_0669 | Conserved Archaeal protein. (84 aa) |
| | rps17e | 30S ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (82 aa) |
| | Saci_0672 | RNase L inhibitor-like protein; Similar to sp:Q96B10 ATP-binding cassette sub-family E member 1 (RNase L-inhibitor)(Ribonuclease 4 inhibitor). (604 aa) |
| | rps10 | 30S ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa) |
| | tuf | Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (435 aa) |
| | rps7 | 30S ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (195 aa) |
| | rps12 | 30S ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa) |
| | nusA | NusA; Participates in transcription termination. Belongs to the NusA family. (130 aa) |
| | rpl30e | 50S ribosomal protein L30E; Belongs to the eukaryotic ribosomal protein eL30 family. (104 aa) |
| | rpoA2 | DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (393 aa) |
| | rpoA1 | DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (880 aa) |
| | rpoB | DNA directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1126 aa) |
| | rpoH | DNA-directed RNA polymerase, subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (84 aa) |
| | infB | Translation initiation factor 2-like protein; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). (602 aa) |
| | thiI | Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (369 aa) |
| | rpl24e | 50S ribosomal protein L24E; Binds to the 23S rRNA. (62 aa) |
| | rps28e | 30S ribosomal protein S28E; Belongs to the eukaryotic ribosomal protein eS28 family. (84 aa) |
| | gatB | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (472 aa) |
| | Saci_0727 | Conserved Crenarchaeal protein; Contains a putative zinc binding domain. (99 aa) |
| | Saci_0730 | Conserved Archaeal protein; Probable pre-rRNA processing protein involved in ribosome biogenesis; Belongs to the TSR3 family. (165 aa) |
| | Saci_0732 | Conserved Archaeal protein. (393 aa) |
| | rps8e | 30S ribosomal protein S8E. (128 aa) |
| | Saci_0766 | 50S ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (56 aa) |
| | Saci_0767 | Conserved Archaeal protein. (133 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (428 aa) |
| | Saci_0769 | Conserved Archaeal protein. (373 aa) |
| | pth | Conserved Archaeal protein; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. (118 aa) |
| | ef1b | Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (106 aa) |
| | Saci_0795 | Conserved Prokaryal protein; Similar to gi:15920412 and gi:15897146. (594 aa) |
| | Saci_0799 | Sm-like protein. (87 aa) |
| | tru | tRNA pseudouridine synthase; Two fragments in Sulfolobus, interrupted by an intron. (319 aa) |
| | rpl14e | 50S ribosomal protein L14E; Belongs to the eukaryotic ribosomal protein eL14 family. (96 aa) |
| | rps15 | 30S ribosomal protein S15P. (153 aa) |
| | rps6e | 30S ribosomal protein S6E; Full length match to SSO0411 but only N-terminal match to the sequences in COG2125; Belongs to the eukaryotic ribosomal protein eS6 family. (213 aa) |
| | Saci_0832 | Translation initiation factor 2 gamma subunit; eIF-2-gamma. (416 aa) |
| | rpoE | DNA-directed RNA polymerase subunit E; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (183 aa) |
| | Saci_0841 | 30S ribosomal protein S25E; Only found in Crenarchaea and Eukarya. (109 aa) |
| | Saci_0844 | Conserved Archaeal protein. (255 aa) |
| | Saci_0850 | Serine/threonine protein kinase. (219 aa) |
| | kae1 | O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37; Belongs to the KAE1 / TsaD family. (332 aa) |
| | rbsS27AE | 30S ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family. (67 aa) |
| | rps24e | 30S ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (118 aa) |
| | endA | tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (181 aa) |
| | glyRS | glycyl-tRNA synthetase class II. (574 aa) |
| | rpoP | DNA directed RNA polymerase subunit P-like protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (48 aa) |
| | Saci_0865 | Protein translation factor SUI1; Belongs to the SUI1 family. (99 aa) |
| | tifB | Transcription initiation factor B; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (311 aa) |
| | Saci_0892 | Conserved Crenarchaeal protein. (119 aa) |
| | Saci_0894 | Conserved protein. (363 aa) |
| | Saci_0902 | Conserved protein. (169 aa) |
| | Saci_0910 | glutamyl-tRNA(Gln) amidotransferase subunit A. (395 aa) |
| | Saci_0920 | GTP-binding protein 1. (526 aa) |
| | Saci_0957 | GTPase-like protein. (360 aa) |
| | eif2b | Translation initiation factor 2 beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (141 aa) |
| | Saci_0962 | Universally conserved protein. (421 aa) |
| | eif1a | Translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (108 aa) |
| | Saci_0966 | Conserved Archaeal protein; Similar to gi:15920728. (178 aa) |
| | prf1 | Peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (336 aa) |
| | Saci_1010 | Conserved Archaeal protein; PF01472: Pseudouridine synthase and Archaeosinetransglycosylase. (162 aa) |
| | Saci_1044 | Conserved Archaeal protein. (456 aa) |
| | fau-1 | Conserved Archaeal protein; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. (418 aa) |
| | Saci_1224 | Similar to snRNP Sm-like protein. (79 aa) |
| | Saci_1241 | Thioesterase superfamily protein. (140 aa) |
| | thrS-cat | threonine-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also activates L-serine and transfers it to tRNA(Thr) but cannot deacylate incorrectly charged amino acid; unlike most archaea the editing function is found in a freestanding protein. (552 aa) |
| | Saci_1275 | Translation initiation factor eIF2 alpha. (263 aa) |
| | rps27e | SSU ribosomal protein S27E. (66 aa) |
| | rpl44e | 50S ribosomal protein L44E; Binds to the 23S rRNA. (95 aa) |
| | Saci_1283 | RNA methylase. (301 aa) |
| | rnz | Metallo-beta-lactamase superfamily protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (292 aa) |
| | cca | tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. (416 aa) |
| | Saci_1309 | Conserved Archaeal protein. (358 aa) |
| | eif5a | Translation initiation factor 5A; Functions by promoting the formation of the first peptide bond. (131 aa) |
| | dys | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (311 aa) |
| | rtcB | Universally conserved protein; Uncharacterized protein family UPF002; Belongs to the RtcB family. (482 aa) |
| | gatC | glutamyl-tRNA(Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (97 aa) |
| | gatA-2 | glutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (476 aa) |
| | taw1 | Conserved protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (358 aa) |
| | tbp | TATA-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). (166 aa) |
| | tfb2 | Transcription initiation factor B; TFIIB homolog. (291 aa) |
| | trm1 | N(2),N(2)-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (382 aa) |
| | flpA | Fribrillarin-like pre-rRNA processing protein; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (231 aa) |
| | Saci_1348 | 30S ribosomal protein S30E. (54 aa) |
| | gatD | glutamyl-tRNA(Gln) amidotransferase subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (446 aa) |
| | gatE | glutamyl-tRNA(Gln) amidotransferase subunit E; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (642 aa) |
| | rpoK | DNA-directed RNA polymerase subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (89 aa) |
| | Saci_1380 | Conserved Archaeal protein. (137 aa) |
| | argS | arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (618 aa) |
| | Saci_1407 | Conserved Archaeal protein. (206 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (831 aa) |
| | alaRS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (907 aa) |
| | rpl12 | 50S ribosomal protein L12P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (105 aa) |
| | rpl10 | 50S ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. (335 aa) |
| | rpl1 | 50S ribosomal protein L1P; Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA. (178 aa) |
| | rpl11 | 50S ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (170 aa) |
| | nusG | NusG; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (152 aa) |
| | rpl18a | 50S ribosomal protein LX. (86 aa) |
| | eif6 | Translation initiation factor 6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (223 aa) |
| | rpl31e | 50S ribosomal protein L31E; Belongs to the eukaryotic ribosomal protein eL31 family. (129 aa) |
| | rpl39e | Conserved 50S ribosomal protein L39e; Binds specifically to a region in 26S rRNA near the subunit interface. (53 aa) |
| | rps19e | 30S ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (154 aa) |
| | Saci_1474 | Conserved protein; Identification based on homology with Sulfolobus solfataricus and Sulfolobus tokodaii; upstream SD sequence was found. (73 aa) |
| | Saci_1487 | Conserved Archaeal SUN family protein. (349 aa) |
| | pheT | phenylalanyl-tRNA synthetase beta chain. (542 aa) |
| | pheS | phenylalanyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (465 aa) |
| | map | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (299 aa) |
| | gltX | Glutamyl- and glutaminyl-tRNA synthetases; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (567 aa) |
| | rpl7ae | 50S ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (126 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. (571 aa) |
| | proS | Bifunctional aminoacyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (483 aa) |
| | Saci_1554 | 30S ribosomal protein S26E. (95 aa) |
| | Saci_1570 | ATP binding protein. (320 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (893 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (458 aa) |
| | Saci_2363 | threonyl-tRNA synthetase; Insert not found in other Archaea. (387 aa) |
| | Saci_1587 | Conserved Archaeal protein, similar to rpoM. (99 aa) |
| | taw3 | Conserved Archaeal protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (210 aa) |
| | Saci_1606 | tRNA binding domain protein. (113 aa) |
| | Saci_1637 | Conserved Archaeal protein. (222 aa) |
| | Saci_1642 | Universally conserved protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (352 aa) |
| | Saci_1651 | Conserved Archaeal protein. (193 aa) |
| | Saci_1656 | Conserved Archaeal protein. (478 aa) |
| | Saci_1676 | Conserved protein. (214 aa) |
| | Saci_1677 | Conserved Archaeal protein; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 9 (m1A9) in tRNA. (292 aa) |
| | Saci_1678 | Conserved protein. (211 aa) |
| | paaX | Phenylacetic acid degradation operon negative regulatory protein. (262 aa) |
| | Saci_1795 | Membrane protein. (368 aa) |
| | Saci_1902 | Conserved protein. (140 aa) |
| | Saci_2072 | Conserved protein. (217 aa) |
| | gatA-3 | glutamyl-tRNA(Gln) amidotransferase subunit A. (461 aa) |
| | Saci_2206 | Universally conserved protein. (374 aa) |
| | Saci_2267 | Conserved protein. (141 aa) |
| | Saci_2276 | AIR synthase-related protein. (341 aa) |
