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| | Saci_0025 | Acetyl-coenzyme A synthetase. (568 aa) |
| | Saci_0043 | Phosphoglycerate mutase. (208 aa) |
| | fni | Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (303 aa) |
| | gds | Geranylgeranyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylgeranyl diphosphate (GGPP) which is a precursor of the ether-linked lipids. It is able to use dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), and (all- E)-geranyl diphosphate (E-FPP) as an allylic substrate. (330 aa) |
| | Saci_0113 | MOFRL family protein; MOFRL (multi-organism fragment with rich Leucine) family exists in bacteria and eukaryotes. (393 aa) |
| | tpiA | Triosephosphate isomerase P; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (230 aa) |
| | fumC | Fumarate hydratase class II. (438 aa) |
| | lpdV | Dihydrolipoamide dehydrogenase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (414 aa) |
| | Saci_0151 | Bifunctional phosphoglucose isomerase/phosphomannose isomerase; Involved in the synthesis of UDP-N-acetylgalactosamine (UDP- GalNAc). Catalyzes the conversion of glucosamine-6-phosphate (GlcN-6-P) to galactosamine-6-phosphate (GalN-6-P). Belongs to the PGI/PMI family. (306 aa) |
| | Saci_0158 | Short chain dehydrogenase. (262 aa) |
| | Saci_0162 | Dihydrodipicolinate synthetase; Two copies in each of the Sulfolobus genomes. (285 aa) |
| | Saci_0180 | Thiamine diphosphate-binding domain transketolase. (271 aa) |
| | Saci_0181 | Pyridine-binding domain transketolase. (312 aa) |
| | Saci_0182 | Chorismate mutase/prephenate dehydrogenase. (341 aa) |
| | aroA | 2-dehydro-3-deoxyphosphooctonate aldolase. (330 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (353 aa) |
| | aroE | Shikimate/quinate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (263 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (391 aa) |
| | aroK | Shikimate kinase. (268 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase. (358 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (219 aa) |
| | mpg1 | Mannose-1-phosphate guanyltransferase. (359 aa) |
| | glcD | Glycolate oxidase subunit. (458 aa) |
| | korB | 2-oxoglutarate synthase subunit B. (304 aa) |
| | korA | 2-oxoacid-ferredoxin oxidoreductase, alfa domain; N-terminal domain of unknown function (seen in all archaea). (622 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (398 aa) |
| | Saci_0238 | Short chain dehydrogenase. (251 aa) |
| | cisY | Citrate synthase. (328 aa) |
| | mdh | Lactate/malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. (306 aa) |
| | Saci_0247 | D-isomer specific 2-hydroxyacid dehydrogenase; Catalytic domain and NAD binding domain; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (299 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) |
| | leu2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa) |
| | pycA | Pyruvate carboxylase subunit A. (510 aa) |
| | Saci_0261 | Conserved protein. (167 aa) |
| | pccB | propionyl-CoA carboxylase beta chain. (511 aa) |
| | Saci_0294 | Glycosyl transferase. (493 aa) |
| | dld | D-lactate dehydrogenase. (440 aa) |
| | Saci_0306 | Acetyl-coenzyme A synthetase. (665 aa) |
| | pdhD | Dihydrolipoamide dehydrogenase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (444 aa) |
| | gcs2 | Glycine cleavage H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (149 aa) |
| | Saci_0402 | Asparaginase. (284 aa) |
| | Saci_0443 | Conserved protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (189 aa) |
| | Saci_0454 | Aminotransferase. (317 aa) |
| | adk | Adenylate kinase. (194 aa) |
| | leuB | 3-isopropylmalate dehydrogenase. (337 aa) |
| | Saci_0619 | Nucleotidyl transferase; Matching sp:P17114; Bifunctional glmU protein UDP-N-acetylglucosaminepyrophosphorylase (EC 2.7.7.23) & glucosamine-1-phosphate N-acetyltransferase (EC2.3.1.57). (405 aa) |
| | fbp | Conserved Archaeal protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (385 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (145 aa) |
| | als | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (452 aa) |
| | purP | Conserved Archaeal protein; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. (333 aa) |
| | Saci_0708 | Conserved Archaeal protein. (349 aa) |
| | Saci_0712 | Prephenate dehydratase. (173 aa) |
| | Saci_0713 | Threonine dehydratase. (404 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (350 aa) |
| | lysZ | Amino acid kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (261 aa) |
| | argD | Acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (387 aa) |
| | Saci_0776 | Conserved Archaeal protein. (218 aa) |
| | gluTR | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (414 aa) |
| | alaD | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (336 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (420 aa) |
| | pbg | Porphobilinogen deaminase. (296 aa) |
| | Saci_0781 | Conserved protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (189 aa) |
| | matT | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (403 aa) |
| | Saci_0806 | Phosphoglucomutase/phosphomannomutase; Belongs to the phosphohexose mutase family. (454 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (158 aa) |
| | Saci_0821 | Conserved Archaeal riboflavin synthase. (156 aa) |
| | Saci_0822 | 3,4-dihydroxy-2-butanone 4-phosphate synthase. (220 aa) |
| | Saci_0827 | Methionine synthase. (324 aa) |
| | metE | Methionine synthase II; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity). (339 aa) |
| | apgM | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (413 aa) |
| | pad | Phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (220 aa) |
| | Saci_0914 | uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (238 aa) |
| | Saci_0930 | Inositol-1-monophosphatase. (267 aa) |
| | Saci_0940 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Carries out the first step of the leucine biosynthesis pathway. Also displays a low citramalate synthase activity, using pyruvate as substrate, but is unable to use 2-oxoglutarate. (386 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (268 aa) |
| | Saci_0963 | acetyl-CoA acetyltransferase. (392 aa) |
| | Saci_0971 | Cystathionine beta-lyases/cystathionine gamma-synthase. (373 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (306 aa) |
| | sdhD | Succinate dehydrogenase subunit D. (122 aa) |
| | sdhC | Succinate dehydrogenase subunit C. (290 aa) |
| | sdhB | Succinate dehydrogenase subunit B; Similar to gi:15920714. (317 aa) |
| | sdhA | Succinate dehydrogenase subunit A. (566 aa) |
| | Saci_0995 | Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (283 aa) |
| | Saci_1023 | Similar to sp:Q9S7B5 Threonine synthase, chloroplast precursor (EC4.2.3.1). (345 aa) |
| | gdh-2 | Glucose 1-dehydrogenase; Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. (364 aa) |
| | Saci_1088 | Conserved Archaeal protein. (107 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (604 aa) |
| | gdh | Glucose 1-dehydrogenase. (252 aa) |
| | Saci_1114 | Thiolase. (395 aa) |
| | adh-3 | Alcohol dehydrogenase. (335 aa) |
| | Saci_1118 | Glycerol-3-phosphate dehydrogenase. (428 aa) |
| | Saci_1121 | acetyl-CoA thiolase. (395 aa) |
| | Saci_1137 | Thiamine pyrophosphate enzyme; Belongs to the TPP enzyme family. (558 aa) |
| | malA | Alpha-glucosidase; Sso3051 maltase (MalA) ortholog; Belongs to the glycosyl hydrolase 31 family. (627 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (157 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (364 aa) |
| | Saci_1200 | Sso0988 alpha-amylase ortholog Sto0817 alpha-amylase orthologue. (444 aa) |
| | Saci_1201 | Glycosyl transferase; Similar to gi:1592105. (566 aa) |
| | acnA | Aconitate hydratase. (848 aa) |
| | Saci_1244 | GHMP kinase; Neighboring protein in same putative functional group. (322 aa) |
| | mvd | Diphosphomevalonate decarboxylase. (325 aa) |
| | sucC | succinyl-CoA synthetase beta chain. (337 aa) |
| | Saci_1266 | succinyl-CoA ligase, alfa chain; Matches PF02629:CoA binding domain and PF00549: CoA-ligase: family includes the CoA ligases succinyl-Co A synthetase alpha and beta chains, malateCoA ligase and ATP-citrate lyase Some members of the family utilise ATP others use GTP. (256 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (291 aa) |
| | rpiA | Phosphoriboisomerase, D-ribose-5-phosphate ketol-isomerase. (220 aa) |
| | Saci_1304 | Homocitrate synthase; Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. Does not display 2-isopropylmalate synthase and citramalate synthase activities since it cannot use 2-oxoisovalerate or pyruvate as substrate. (468 aa) |
| | Saci_1308 | Short chain dehydrogenase; Similar to sp:P25529 7-alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159). (265 aa) |
| | Saci_1333 | Conserved Archaeal protein. (228 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (415 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase. (343 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa) |
| | Saci_1359 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (411 aa) |
| | acaB1 | acetyl-CoA acetyltransferases. (364 aa) |
| | Saci_1362 | DNA/RNA binding protein Alba; Belongs to the thiolase-like superfamily. UPF0219 family. (348 aa) |
| | Saci_1368 | D-isomer specific 2-hydroxyacid dehydrogenase. (310 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (416 aa) |
| | gcvP | Glycine dehydrogenase. (505 aa) |
| | gcvPA | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (447 aa) |
| | gcsT | Aminomethyltransferase. (351 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (138 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (306 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase. (350 aa) |
| | Saci_1412 | Aspartokinase; Belongs to the aspartokinase family. (447 aa) |
| | Saci_1413 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (392 aa) |
| | ubiD | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Polyprenylp-hydroxybenzoate decarboxylase. (483 aa) |
| | Saci_1417 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa) |
| | Saci_1419 | Inositol-1-phosphate synthase. (358 aa) |
| | trpB1 | Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (424 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (245 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa) |
| | trpF | N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (199 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (432 aa) |
| | trpGD | Anthranilate synthase component II. (189 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (248 aa) |
| | aspB | Aspartate aminotransferase; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (400 aa) |
| | Saci_1439 | Amylase. (713 aa) |
| | treZ | Maltooligosyl trehalose trehalohydrolase. (556 aa) |
| | cysM | Cysteine synthase B. (295 aa) |
| | Saci_1507 | Aminotransferase. (399 aa) |
| | Saci_1518 | Conserved Archaeal protein; Catalyzes the dephosphorylation of 2-phosphoglycolate. (227 aa) |
| | gltX | Glutamyl- and glutaminyl-tRNA synthetases; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (567 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | Saci_1561 | Acetolactate synthase large subunit. (572 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (360 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. (226 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (193 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (249 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (393 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (95 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (199 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase. (124 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; SAICAR synthetase. (235 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (92 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (710 aa) |
| | purF-1 | Glutamine amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (444 aa) |
| | purF-2 | Glutamine phosphoribosylpyrophosphate amidotransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (404 aa) |
| | purD | Phosphoribosylglycinamide synthetase. (478 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (320 aa) |
| | argG | Arginosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (391 aa) |
| | argH | Argininosuccinate lyase. (447 aa) |
| | ctaB | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (285 aa) |
| | hdh | Homoserine dehydrogenase. (261 aa) |
| | Saci_1648 | Pyruvate kinase; Belongs to the pyruvate kinase family. (441 aa) |
| | Saci_1703 | Nucleotidyl transferase. (364 aa) |
| | Saci_1704 | NAD-dependent epimerase/dehydratase protein. (309 aa) |
| | Saci_1705 | dTDP-4-dehydrorhamnose reductase. (282 aa) |
| | Saci_1706 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (184 aa) |
| | ilvD | Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (561 aa) |
| | Saci_1728 | Nonspecific lipid-transfer protein. (376 aa) |
| | Saci_1732 | Phytoene dehydrogenase. (412 aa) |
| | crtZ | Beta-carotene hydroxylase. (154 aa) |
| | Saci_1734 | Phytoene synthase. (275 aa) |
| | Saci_1774 | Acetyl-coenzyme A synthetase. (526 aa) |
| | Saci_1785 | Conserved Prokaryal protein. (533 aa) |
| | Saci_1857 | Aldehyde dehydrogenase. (481 aa) |
| | Saci_1900 | Conserved protein. (236 aa) |
| | Saci_1965 | Short chain dehydrogenase. (244 aa) |
| | Saci_2032 | Glycerol-3-phosphate dehydrogenase. (431 aa) |
| | adh-9 | Alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. (344 aa) |
| | acs-2 | Acetyl-coenzyme A synthetase. (561 aa) |
| | adh-6 | Conserved NAD-dependent alcohol dehydrogenase. (341 aa) |
| | tynA | Copper amine oxidase; Belongs to the copper/topaquinone oxidase family. (664 aa) |
| | Saci_2185 | Conserved Archaeal protein. (262 aa) |
| | mas | Malate synthase. (824 aa) |
| | aceA | Isocitrate lyase; Isocitrase; isocitratase. (437 aa) |
| | uroM | uroporphyrin-III C-methyltransferase; Similar to sp:P36150. (231 aa) |
| | sat | Sulfate adenylyltransferase. (411 aa) |
| | Saci_2205 | NAD-dependent alcohol dehydrogenase. (311 aa) |
| | Saci_2209 | acetyl-CoA thiolase. (395 aa) |
| | adh-8 | Alcohol dehydrogenase. (352 aa) |
| | Saci_2232 | Conserved Archaeal acetyl-CoA acetyltransferase. (392 aa) |
| | Saci_2233 | acetyl-CoA C-acetyltransferase. (382 aa) |
| | Saci_2235 | acyl-CoA synthetase. (619 aa) |
| | porC | Pyruvate/ketoisovalerate oxidoreductases common gamma subunit. (187 aa) |
| | porD | Pyruvate synthase delta chain. (88 aa) |
| | porA | Pyruvate synthase alpha chain. (397 aa) |
| | porB | Pyruvate synthase beta chain. (296 aa) |
| | Saci_2273 | Conserved cysteine-rich domain protein. (397 aa) |
| | Saci_2288 | Nonspecific lipid-transfer protein. (386 aa) |
| | acsA | Acetyl-coenzyme A synthetase. (606 aa) |
| | Saci_2306 | Pyruvate flavodoxin/ferredoxin oxidoreductase. (621 aa) |
| | korB-2 | 2-oxoglutarate synthase subunit B. (303 aa) |
| | Saci_2310 | Conserved Prokaryal protein. (236 aa) |
| | cimA | (R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. Makes part of a pathway for isoleucine biosynthesis, i.e. the citramalate-dependent pathway. Also displays a low alpha-isopropylmalate synthase activity, using 2-oxoisovalerate as substrate, but is unable to use 2-oxoglutarate. (523 aa) |
| | ubiA | 4-hydroxybenzoate octaprenyltransferase. (296 aa) |
| | mipS | Myo-inositol-1-phosphate synthase. (345 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (314 aa) |
| | Saci_2366 | Conserved protein. (356 aa) |
| | icd | Isocitrate dehydrogenase. (411 aa) |
