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| | Saci_0043 | Phosphoglycerate mutase. (208 aa) |
| | tpiA | Triosephosphate isomerase P; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (230 aa) |
| | Saci_0162 | Dihydrodipicolinate synthetase; Two copies in each of the Sulfolobus genomes. (285 aa) |
| | Saci_0180 | Thiamine diphosphate-binding domain transketolase. (271 aa) |
| | Saci_0181 | Pyridine-binding domain transketolase. (312 aa) |
| | Saci_0182 | Chorismate mutase/prephenate dehydrogenase. (341 aa) |
| | aroA | 2-dehydro-3-deoxyphosphooctonate aldolase. (330 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (353 aa) |
| | aroE | Shikimate/quinate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (263 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (391 aa) |
| | aroK | Shikimate kinase. (268 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase. (358 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (219 aa) |
| | cisY | Citrate synthase. (328 aa) |
| | Saci_0247 | D-isomer specific 2-hydroxyacid dehydrogenase; Catalytic domain and NAD binding domain; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (299 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (161 aa) |
| | leu2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (414 aa) |
| | Saci_0454 | Aminotransferase. (317 aa) |
| | glnA | Glutamine synthetase. (427 aa) |
| | leuB | 3-isopropylmalate dehydrogenase. (337 aa) |
| | fbp | Conserved Archaeal protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (385 aa) |
| | Saci_0712 | Prephenate dehydratase. (173 aa) |
| | Saci_0713 | Threonine dehydratase. (404 aa) |
| | Saci_0747 | Conserved Prokaryal protein. (222 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (350 aa) |
| | lysZ | Amino acid kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (261 aa) |
| | lysX | Conserved Archaeal protein; Catalyzes the ATP-dependent formation of a covalent bond between the amino group of alpha-aminoadipate (AAA) and the gamma- carboxyl group of the C-terminal glutamate residue in LysW. Belongs to the RimK family. LysX subfamily. (276 aa) |
| | argD | Acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (387 aa) |
| | lysK | Peptidase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (346 aa) |
| | matT | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (403 aa) |
| | Saci_0802 | Conserved protein; Similar to hexulose-6-phosphate synthase. (228 aa) |
| | Saci_0827 | Methionine synthase. (324 aa) |
| | metE | Methionine synthase II; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity). (339 aa) |
| | apgM | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (413 aa) |
| | Saci_0940 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Carries out the first step of the leucine biosynthesis pathway. Also displays a low citramalate synthase activity, using pyruvate as substrate, but is unable to use 2-oxoglutarate. (386 aa) |
| | Saci_0971 | Cystathionine beta-lyases/cystathionine gamma-synthase. (373 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (306 aa) |
| | Saci_1023 | Similar to sp:Q9S7B5 Threonine synthase, chloroplast precursor (EC4.2.3.1). (345 aa) |
| | Saci_1137 | Thiamine pyrophosphate enzyme; Belongs to the TPP enzyme family. (558 aa) |
| | acnA | Aconitate hydratase. (848 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (291 aa) |
| | rpiA | Phosphoriboisomerase, D-ribose-5-phosphate ketol-isomerase. (220 aa) |
| | Saci_1304 | Homocitrate synthase; Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. Does not display 2-isopropylmalate synthase and citramalate synthase activities since it cannot use 2-oxoisovalerate or pyruvate as substrate. (468 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (415 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase. (343 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (433 aa) |
| | Saci_1368 | D-isomer specific 2-hydroxyacid dehydrogenase. (310 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (416 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (306 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase. (350 aa) |
| | Saci_1412 | Aspartokinase; Belongs to the aspartokinase family. (447 aa) |
| | Saci_1413 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (392 aa) |
| | trpB1 | Tryptophan synthase beta chain 1; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (424 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (245 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa) |
| | trpF | N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (199 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (432 aa) |
| | trpGD | Anthranilate synthase component II. (189 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (248 aa) |
| | aspB | Aspartate aminotransferase; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (400 aa) |
| | cysM | Cysteine synthase B. (295 aa) |
| | glnA-2 | Glutamine synthetase; Probably involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (473 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | Saci_1561 | Acetolactate synthase large subunit. (572 aa) |
| | hisC | Histidinol-phosphate aminotransferase. (360 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. (226 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (193 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (249 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (393 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (95 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (199 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase. (124 aa) |
| | argG | Arginosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (391 aa) |
| | argH | Argininosuccinate lyase. (447 aa) |
| | argX | Conserved ribosomal protein S6; Catalyzes the ATP-dependent formation of a covalent bond between the amino group of glutamate and the gamma-carboxyl group of the C-terminal glutamate residue in LysW. Belongs to the RimK family. LysX subfamily. (282 aa) |
| | hdh | Homoserine dehydrogenase. (261 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase. (382 aa) |
| | Saci_1648 | Pyruvate kinase; Belongs to the pyruvate kinase family. (441 aa) |
| | ilvD | Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. (561 aa) |
| | argE | Acetylornithine deacetylase. (413 aa) |
| | glnA-3 | Glutamine synthetase. (431 aa) |
| | cimA | (R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. Makes part of a pathway for isoleucine biosynthesis, i.e. the citramalate-dependent pathway. Also displays a low alpha-isopropylmalate synthase activity, using 2-oxoisovalerate as substrate, but is unable to use 2-oxoglutarate. (523 aa) |
| | icd | Isocitrate dehydrogenase. (411 aa) |
