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AFUA_6G05174 AFUA_6G05174 AFUA_7G01620 AFUA_7G01620 AFUA_1G13470 AFUA_1G13470 AFUA_4G01260 AFUA_4G01260 AFUA_4G04620 AFUA_4G04620 AFUA_7G01900 AFUA_7G01900 mmm1 mmm1 AFUA_6G05110 AFUA_6G05110 AFUA_5G02200 AFUA_5G02200 AFUA_7G04150 AFUA_7G04150 AFUA_2G04270 AFUA_2G04270 AFUA_2G03840 AFUA_2G03840 tim50 tim50 pam18 pam18 AFUA_2G02680 AFUA_2G02680 AFUA_2G02500 AFUA_2G02500 AFUA_2G02430 AFUA_2G02430 AFUA_2G01660 AFUA_2G01660 tim9 tim9 tim10 tim10 pam17 pam17 AFUA_6G12280 AFUA_6G12280 AFUA_6G11380 AFUA_6G11380 gem1 gem1 mdm34 mdm34 AFUA_4G10310 AFUA_4G10310 AFUA_4G11530 AFUA_4G11530 tim54 tim54 AFUA_4G11940 AFUA_4G11940 mdm12 mdm12 AFUA_1G13180 AFUA_1G13180 AFUA_1G11860 AFUA_1G11860 AFUA_1G09840 AFUA_1G09840 AFUA_1G09780 AFUA_1G09780 AFUA_1G09150 AFUA_1G09150 AFUA_5G09310 AFUA_5G09310 mdmB mdmB AFUA_3G13000 AFUA_3G13000 AFUA_3G13440 AFUA_3G13440 AFUA_2G16490 AFUA_2G16490 AFUA_2G14760 AFUA_2G14760 AFUA_2G14190 AFUA_2G14190 AFUA_2G13040 AFUA_2G13040 tim13 tim13 AFUA_2G09960 AFUA_2G09960 tim21 tim21 AFUA_2G09090 AFUA_2G09090 AFUA_2G08180 AFUA_2G08180 AFUA_2G07530 AFUA_2G07530
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_6G05174TOM complex component Tom7, putative. (53 aa)
AFUA_7G01620Uncharacterized protein. (566 aa)
AFUA_1G13470Prohibitin. (280 aa)
AFUA_4G01260Mitochondrial chaperone ATPase (Bcs1), putative; Belongs to the AAA ATPase family. (520 aa)
AFUA_4G04620Mitochondrial outer membrane protein (Sam50), putative. (544 aa)
AFUA_7G01900TOM core complex subunit Tom6, putative. (75 aa)
mmm1Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 su [...] (496 aa)
AFUA_6G05110Mitochondrial import receptor subunit (Tom40), putative. (355 aa)
AFUA_5G02200Mitochondrial import inner membrane translocase subunit (TIM22), putative. (175 aa)
AFUA_7G04150Cochaperone Pam16. (173 aa)
AFUA_2G04270Mitochondrial inner membrane translocase subunit (TIM17), putative. (154 aa)
AFUA_2G03840Mitochondrial import receptor subunit (Tom37), putative. (442 aa)
tim50Mitochondrial import inner membrane translocase subunit tim50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity). (501 aa)
pam18Mitochondrial import inner membrane translocase subunit tim14; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1/sscA) (By similarity); Belongs to the TIM14 family. (105 aa)
AFUA_2G02680Mitochondrial inner membrane AAA protease Yta12, putative. (885 aa)
AFUA_2G02500DUF2263 domain-containing protein. (271 aa)
AFUA_2G02430Mitochondrial genome maintenance protein Mgr2, putative. (108 aa)
AFUA_2G01660Mitochondrial outer membrane translocase receptor (TOM70), putative. (630 aa)
tim9Mitochondrial import inner membrane translocase subunit tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta- barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family. (90 aa)
tim10Mitochondrial import inner membrane translocase subunit tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta- barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family. (93 aa)
pam17Presequence translocated-associated motor subunit pam17, mitochondrial; Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. (247 aa)
AFUA_6G12280NADH-ubiquinone oxidoreductase 213 kDa subunit. (197 aa)
AFUA_6G11380Mitochondrial import receptor subunit (Tom20), putative. (169 aa)
gem1Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. (632 aa)
mdm34Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (572 aa)
AFUA_4G10310MCU domain-containing protein. (496 aa)
AFUA_4G11530Intermembrane space AAA protease IAP-1. (799 aa)
tim54Mitochondrial import inner membrane translocase subunit tim54; Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as external driving force (By similarity). (439 aa)
AFUA_4G11940DUF2263 domain-containing protein. (335 aa)
mdm12Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pat [...] (439 aa)
AFUA_1G13180Mitochondrial outer membrane protein (Sam35), putative. (296 aa)
AFUA_1G11860Mitochondrial import receptor subunit tom22. (143 aa)
AFUA_1G09840Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. (523 aa)
AFUA_1G09780Stomatin family protein. (439 aa)
AFUA_1G09150Rhomboid family protein, putative. (568 aa)
AFUA_5G09310Bax Inhibitor family protein; Belongs to the BI1 family. (270 aa)
mdmBMitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the recepto [...] (471 aa)
AFUA_3G13000Mitochondrial chaperone BCS1, putative; Belongs to the AAA ATPase family. (499 aa)
AFUA_3G13440Stomatin family protein. (347 aa)
AFUA_2G16490RHOMBOID-like protein. (524 aa)
AFUA_2G14760BCS1-like ATPase, putative; Belongs to the AAA ATPase family. (574 aa)
AFUA_2G14190Mitochondrial import inner membrane translocase subunit TIM23, putative. (212 aa)
AFUA_2G13040GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (250 aa)
tim13Mitochondrial import inner membrane translocase subunit tim13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8- TIM13 complex is non essential and only mediates [...] (113 aa)
AFUA_2G09960Mitochondrial Hsp70 chaperone (Ssc70), putative; Belongs to the heat shock protein 70 family. (685 aa)
tim21Mitochondrial import inner membrane translocase subunit tim21; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity). (237 aa)
AFUA_2G09090Prohibitin. (311 aa)
AFUA_2G08180Flotillin domain protein; Belongs to the band 7/mec-2 family. Flotillin subfamily. (455 aa)
AFUA_2G07530Uncharacterized protein. (144 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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