(10 nodes) Cytoplasmic dynein complex, and Vesicle transport along microtubule network (Aspergillus fumigatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AFUA_8G04460	Dynein intermediate chain, putative. (711 aa)
	AFUA_6G02040	Robl_LC7 domain-containing protein. (207 aa)
	AFUA_1G04860	Rhodopsin family protein. (135 aa)
	AFUA_1G04850	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. (94 aa)
	nudF	Nuclear distribution protein nudF; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family. (467 aa)
	AFUA_6G07120	Nuclear movement protein NudC. (200 aa)
	AFUA_1G09550	Dynein light chain (Tctex1), putative. (143 aa)
	AFUA_5G08510	Dynein family protein. (307 aa)
	AFUA_5G11810	Dynein heavy chain. (4368 aa)
	nde1	Nuclear distribution protein nudE homolog 1; Required for nuclear migration within hyphae during vegetative growth. (621 aa)

Your Current Organism:

Aspergillus fumigatus

NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFUA_1G04850	AFUA_1G04860	Q4WJT6	Q4WJT5	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	Rhodopsin family protein.	0.653
AFUA_1G04850	AFUA_1G09550	Q4WJT6	Q4WTE8	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	Dynein light chain (Tctex1), putative.	0.898
AFUA_1G04850	AFUA_5G08510	Q4WJT6	Q4WUH8	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	Dynein family protein.	0.915
AFUA_1G04850	AFUA_5G11810	Q4WJT6	Q4WVE4	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	Dynein heavy chain.	0.974
AFUA_1G04850	AFUA_6G02040	Q4WJT6	Q4WCQ3	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	Robl_LC7 domain-containing protein.	0.955
AFUA_1G04850	AFUA_6G07120	Q4WJT6	Q4WN97	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	Nuclear movement protein NudC.	0.874
AFUA_1G04850	AFUA_8G04460	Q4WJT6	Q4WCG9	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	Dynein intermediate chain, putative.	0.998
AFUA_1G04850	nde1	Q4WJT6	Q4X1V0	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	Nuclear distribution protein nudE homolog 1; Required for nuclear migration within hyphae during vegetative growth.	0.511
AFUA_1G04850	nudF	Q4WJT6	Q4WLM7	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	Nuclear distribution protein nudF; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family.	0.924
AFUA_1G04860	AFUA_1G04850	Q4WJT5	Q4WJT6	Rhodopsin family protein.	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	0.653
AFUA_1G04860	AFUA_1G09550	Q4WJT5	Q4WTE8	Rhodopsin family protein.	Dynein light chain (Tctex1), putative.	0.711
AFUA_1G04860	AFUA_5G08510	Q4WJT5	Q4WUH8	Rhodopsin family protein.	Dynein family protein.	0.572
AFUA_1G04860	AFUA_5G11810	Q4WJT5	Q4WVE4	Rhodopsin family protein.	Dynein heavy chain.	0.841
AFUA_1G04860	AFUA_6G02040	Q4WJT5	Q4WCQ3	Rhodopsin family protein.	Robl_LC7 domain-containing protein.	0.776
AFUA_1G04860	AFUA_6G07120	Q4WJT5	Q4WN97	Rhodopsin family protein.	Nuclear movement protein NudC.	0.418
AFUA_1G04860	AFUA_8G04460	Q4WJT5	Q4WCG9	Rhodopsin family protein.	Dynein intermediate chain, putative.	0.848
AFUA_1G04860	nudF	Q4WJT5	Q4WLM7	Rhodopsin family protein.	Nuclear distribution protein nudF; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family.	0.600
AFUA_1G09550	AFUA_1G04850	Q4WTE8	Q4WJT6	Dynein light chain (Tctex1), putative.	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.	0.898
AFUA_1G09550	AFUA_1G04860	Q4WTE8	Q4WJT5	Dynein light chain (Tctex1), putative.	Rhodopsin family protein.	0.711
AFUA_1G09550	AFUA_5G08510	Q4WTE8	Q4WUH8	Dynein light chain (Tctex1), putative.	Dynein family protein.	0.874