STRINGSTRING
AFUA_4G04760 AFUA_4G04760 AFUA_7G00090 AFUA_7G00090 AFUA_7G02200 AFUA_7G02200 AFUA_8G02820 AFUA_8G02820 AFUA_8G07400 AFUA_8G07400 AFUA_6G03970 AFUA_6G03970 AFUA_5G02610 AFUA_5G02610 AFUA_5G04020 AFUA_5G04020 AFUA_5G04070 AFUA_5G04070 AFUA_7G04270 AFUA_7G04270 AFUA_7G05890 AFUA_7G05890 AFUA_2G06320 AFUA_2G06320 AFUA_2G04960 AFUA_2G04960 AFUA_2G03910 AFUA_2G03910 AFUA_2G02660 AFUA_2G02660 AFUA_2G00090 AFUA_2G00090 AFUA_1G07620 AFUA_1G07620 AFUA_1G02060 AFUA_1G02060 AFUA_6G14720 AFUA_6G14720 AFUA_6G13160 AFUA_6G13160 AFUA_6G12910 AFUA_6G12910 AFUA_6G11410 AFUA_6G11410 AFUA_6G11130 AFUA_6G11130 AFUA_4G06970 AFUA_4G06970 AFUA_4G08730 AFUA_4G08730 AFUA_4G11180 AFUA_4G11180 AFUA_4G12210 AFUA_4G12210 AFUA_4G12310 AFUA_4G12310 AFUA_4G12670 AFUA_4G12670 AFUA_4G12680 AFUA_4G12680 AFUA_1G15120 AFUA_1G15120 AFUA_1G12520 AFUA_1G12520 AFUA_1G10410 AFUA_1G10410 rad5 rad5 tel1 tel1 AFUA_5G13220 AFUA_5G13220 AFUA_5G13380 AFUA_5G13380 AFUA_5G15150 AFUA_5G15150 fen1 fen1 AFUA_3G08800 AFUA_3G08800 mus81 mus81 AFUA_3G13260 AFUA_3G13260 AFUA_3G14460 AFUA_3G14460 AFUA_3G15395 AFUA_3G15395 AFUA_2G18100 AFUA_2G18100 rad18 rad18 AFUA_2G10710 AFUA_2G10710
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_4G04760Inositol kinase kinase (UvsB), putative; Belongs to the PI3/PI4-kinase family. (2449 aa)
AFUA_7G00090Telomere-associated RecQ helicase, putative. (396 aa)
AFUA_7G02200Meiotic recombination protein (Dmc1), putative; Belongs to the RecA family. (338 aa)
AFUA_8G02820Cell cycle checkpoint protein Rad17, putative. (722 aa)
AFUA_8G07400Telomere-associated RecQ helicase, putative. (360 aa)
AFUA_6G03970Cell cycle checkpoint protein (Hus1), putative. (373 aa)
AFUA_5G02610Cytochrome P450, putative; Belongs to the cytochrome P450 family. (466 aa)
AFUA_5G04020DNA damage repair protein (Rad9), putative. (1338 aa)
AFUA_5G04070Meiosis-specific topoisomerase Spo11, putative. (388 aa)
AFUA_7G042703'-5' exonuclease/helicase (Wrn), putative. (419 aa)
AFUA_7G05890Uncharacterized protein. (252 aa)
AFUA_2G06320Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (529 aa)
AFUA_2G04960RecQ family helicase MusN. (1563 aa)
AFUA_2G03910ATP-depentend DNA helicase, putative. (1001 aa)
AFUA_2G02660DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
AFUA_2G00090Telomere-associated RecQ helicase, putative. (460 aa)
AFUA_1G07620SAE2 domain-containing protein. (747 aa)
AFUA_1G02060Pachytene checkpoint component Pch2, putative; Belongs to the AAA ATPase family. (455 aa)
AFUA_6G14720Telomere-associated RecQ helicase, putative. (1445 aa)
AFUA_6G13160Serine/threonine protein kinase, putative. (514 aa)
AFUA_6G12910DsDNA-dependent ATPase Rad54, putative. (807 aa)
AFUA_6G11410Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa)
AFUA_6G11130Possible replication factor-a protein. (289 aa)
AFUA_4G06970RAD52 DNA repair protein RADC. (564 aa)
AFUA_4G08730BRCT domain-containing protein. (1507 aa)
AFUA_4G11180AAA family ATPase, putative. (539 aa)
AFUA_4G12210DNA replication helicase Dna2, putative. (1657 aa)
AFUA_4G12310DNA repair protein Rtt107, putative. (856 aa)
AFUA_4G12670DNA repair protein Rad1, putative. (491 aa)
AFUA_4G12680DNA repair protein Rad50. (1312 aa)
AFUA_1G15120DsDNA-dependent ATPase (Rad54b), putative. (969 aa)
AFUA_1G12520DNA repair protein (Rad57), putative. (647 aa)
AFUA_1G10410DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
rad5DNA repair protein rad5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1245 aa)
tel1Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2796 aa)
AFUA_5G13220ERCC4 domain-containing protein. (649 aa)
AFUA_5G13380BRCT domain protein. (786 aa)
AFUA_5G15150Telomere-associated RecQ helicase, putative. (395 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
AFUA_3G08800DUF1767 domain-containing protein. (249 aa)
mus81Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (596 aa)
AFUA_3G13260Rad2-like endonuclease, putative. (869 aa)
AFUA_3G14460Rad51 family DNA repair protein, putative. (456 aa)
AFUA_3G15395Telomere-associated RecQ helicase, putative. (714 aa)
AFUA_2G18100Telomere-associated RecQ helicase, putative. (850 aa)
rad18Postreplication repair E3 ubiquitin-protein ligase rad18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. (418 aa)
AFUA_2G10710DNA repair protein rad9, putative. (376 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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