STRINGSTRING
AFUA_4G04760 AFUA_4G04760 AFUA_8G02820 AFUA_8G02820 AFUA_6G03970 AFUA_6G03970 AFUA_5G04020 AFUA_5G04020 AFUA_7G04270 AFUA_7G04270 AFUA_7G05890 AFUA_7G05890 AFUA_2G06320 AFUA_2G06320 AFUA_2G02660 AFUA_2G02660 AFUA_6G13160 AFUA_6G13160 AFUA_6G11410 AFUA_6G11410 AFUA_6G11130 AFUA_6G11130 AFUA_4G06970 AFUA_4G06970 AFUA_4G08730 AFUA_4G08730 AFUA_4G12210 AFUA_4G12210 AFUA_4G12670 AFUA_4G12670 AFUA_4G12680 AFUA_4G12680 AFUA_1G12520 AFUA_1G12520 AFUA_1G10410 AFUA_1G10410 tel1 tel1 AFUA_5G13380 AFUA_5G13380 fen1 fen1 AFUA_3G08800 AFUA_3G08800 AFUA_3G14460 AFUA_3G14460 AFUA_2G10710 AFUA_2G10710
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_4G04760Inositol kinase kinase (UvsB), putative; Belongs to the PI3/PI4-kinase family. (2449 aa)
AFUA_8G02820Cell cycle checkpoint protein Rad17, putative. (722 aa)
AFUA_6G03970Cell cycle checkpoint protein (Hus1), putative. (373 aa)
AFUA_5G04020DNA damage repair protein (Rad9), putative. (1338 aa)
AFUA_7G042703'-5' exonuclease/helicase (Wrn), putative. (419 aa)
AFUA_7G05890Uncharacterized protein. (252 aa)
AFUA_2G06320Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (529 aa)
AFUA_2G02660DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
AFUA_6G13160Serine/threonine protein kinase, putative. (514 aa)
AFUA_6G11410Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa)
AFUA_6G11130Possible replication factor-a protein. (289 aa)
AFUA_4G06970RAD52 DNA repair protein RADC. (564 aa)
AFUA_4G08730BRCT domain-containing protein. (1507 aa)
AFUA_4G12210DNA replication helicase Dna2, putative. (1657 aa)
AFUA_4G12670DNA repair protein Rad1, putative. (491 aa)
AFUA_4G12680DNA repair protein Rad50. (1312 aa)
AFUA_1G12520DNA repair protein (Rad57), putative. (647 aa)
AFUA_1G10410DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
tel1Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2796 aa)
AFUA_5G13380BRCT domain protein. (786 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
AFUA_3G08800DUF1767 domain-containing protein. (249 aa)
AFUA_3G14460Rad51 family DNA repair protein, putative. (456 aa)
AFUA_2G10710DNA repair protein rad9, putative. (376 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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