(51 nodes) Mixed, incl. Nicotinate and nicotinamide metabolism, and Purine nucleoside metabolic process network (Aspergillus fumigatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AFUA_1G13240	Adenosine deaminase, putative. (352 aa)
	AFUA_6G00160	Ser/Thr protein phosphatase family protein. (666 aa)
	isn1	IMP-specific 5'-nucleotidase 1; IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation; Belongs to the ISN1 family. (450 aa)
	AFUA_4G04550	Xanthine-guanine phosphoribosyl transferase Xpt1, putative. (173 aa)
	AFUA_4G02960	UDP-sugar hydrolase, putative; Belongs to the 5'-nucleotidase family. (396 aa)
	AFUA_4G02950	Nucleotidase, putative. (143 aa)
	AFUA_7G01880	Nicotinate phosphoribosyltransferase. (490 aa)
	AFUA_7G02310	Adenine phosphoribosyltransferase 1. (217 aa)
	AFUA_8G01700	Haloalkane dehalogenase family protein. (463 aa)
	AFUA_8G07300	Alpha/beta hydrolase, putative. (300 aa)
	AFUA_6G05320	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (320 aa)
	AFUA_5G02780	Nicotinamide nucleotide transhydrogenase, putative. (1086 aa)
	AFUA_5G03350	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (674 aa)
	AFUA_5G03360	NADH pyrophosphatase, putative. (412 aa)
	AFUA_5G04120	SIR2 family histone deacetylase, putative. (381 aa)
	AFUA_3G04160	Ser/Thr protein phosphatase family. (626 aa)
	AFUA_3G02790	Amidohydrolase family protein. (512 aa)
	AFUA_3G01280	Alpha/beta hydrolase, putative. (308 aa)
	AFUA_3G00520	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (403 aa)
	AFUA_2G05900	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (425 aa)
	AFUA_2G02580	HAD superfamily hydrolase, putative. (401 aa)
	AFUA_2G01350	NAD+ kinase Utr1, putative. (657 aa)
	AFUA_1G06780	CBS and PB1 domain protein. (661 aa)
	AFUA_1G02390	Alpha/beta hydrolase, putative. (520 aa)
	AFUA_1G01160	5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family. (586 aa)
	AFUA_6G13180	CECR1 family adenosine deaminase, putative. (574 aa)
	AFUA_6G10960	Uncharacterized protein. (79 aa)
	AFUA_6G09210	SIR2 family histone deacetylase, putative. (318 aa)
	AFUA_6G08870	Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family. (288 aa)
	AFUA_6G08720	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (342 aa)
	AFUA_4G07310	Cytidylyltransferase family protein. (289 aa)
	AFUA_4G10840	Uncharacterized protein. (339 aa)
	AFUA_4G11720	Phosphatidyl synthase. (613 aa)
	AFUA_4G12120	Histone deacetylase SIR2, putative. (493 aa)
	AFUA_4G12720	Phosphoesterase, putative. (551 aa)
	tvp38	Golgi apparatus membrane protein tvp38; Golgi membrane protein involved in vesicular trafficking and spindle migration. (418 aa)
	AFUA_4G13290	HAD superfamily hydrolase, putative. (262 aa)
	AFUA_1G11790	Nucleoside hydrolase, putative. (522 aa)
	AFUA_1G10540	SIR2 family histone deacetylase (Hst4), putative. (614 aa)
	AFUA_5G05890	Mitochondrial NADH kinase POS5, putative. (302 aa)
	AFUA_5G06390	Adenosine kinase, putative. (338 aa)
	AFUA_5G12870	NAD+ kinase, putative. (433 aa)
	AFUA_3G05730	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (313 aa)
	AFUA_3G09450	Alpha/beta fold family hydrolase, putative. (292 aa)
	AFUA_3G12330	Phosphatidyl synthase. (445 aa)
	AFUA_3G15090	Adenosine deaminase family protein. (587 aa)
	AFUA_2G16900	Epoxide hydrolase, putative. (284 aa)
	atp25	ATPase synthesis protein 25, mitochondrial; Probable mitochondrial mRNA stabilization factor. Belongs to the ATP25 family. (704 aa)
	AFUA_2G14860	Epoxide hydrolase, putative. (255 aa)
	AFUA_2G13470	Pyrimidine 5'-nucleotidase, putative. (284 aa)
	aah1	Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily. (354 aa)

Your Current Organism:

Aspergillus fumigatus

NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFUA_1G01160	AFUA_4G13290	Q4WKV5	Q4WQM0	5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family.	HAD superfamily hydrolase, putative.	0.415
AFUA_1G01160	AFUA_5G03350	Q4WKV5	Q4WEK7	5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.412
AFUA_1G01160	AFUA_5G03360	Q4WKV5	Q4WEK8	5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family.	NADH pyrophosphatase, putative.	0.446
AFUA_1G01160	AFUA_6G05320	Q4WKV5	Q4WDN1	5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.444
AFUA_1G01160	AFUA_6G08720	Q4WKV5	Q4WMU1	5'-nucleotidase, putative; Belongs to the 5'-nucleotidase family.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.432
AFUA_1G02390	AFUA_2G02580	Q4WKI1	Q4WIA0	Alpha/beta hydrolase, putative.	HAD superfamily hydrolase, putative.	0.496
AFUA_1G02390	AFUA_3G12330	Q4WKI1	Q4WYA3	Alpha/beta hydrolase, putative.	Phosphatidyl synthase.	0.496
AFUA_1G02390	AFUA_4G11720	Q4WKI1	Q4WQ64	Alpha/beta hydrolase, putative.	Phosphatidyl synthase.	0.496
AFUA_1G06780	AFUA_2G14860	Q4WJ93	Q4X035	CBS and PB1 domain protein.	Epoxide hydrolase, putative.	0.703
AFUA_1G06780	AFUA_2G16900	Q4WJ93	Q4WZH6	CBS and PB1 domain protein.	Epoxide hydrolase, putative.	0.703
AFUA_1G06780	AFUA_3G09450	Q4WJ93	Q4WXG7	CBS and PB1 domain protein.	Alpha/beta fold family hydrolase, putative.	0.703
AFUA_1G06780	AFUA_4G13290	Q4WJ93	Q4WQM0	CBS and PB1 domain protein.	HAD superfamily hydrolase, putative.	0.485
AFUA_1G06780	AFUA_8G01700	Q4WJ93	Q4WBB4	CBS and PB1 domain protein.	Haloalkane dehalogenase family protein.	0.703
AFUA_1G10540	AFUA_2G01350	Q4WT50	Q4WIM2	SIR2 family histone deacetylase (Hst4), putative.	NAD+ kinase Utr1, putative.	0.913
AFUA_1G10540	AFUA_2G05900	Q4WT50	Q4WHC4	SIR2 family histone deacetylase (Hst4), putative.	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	0.427
AFUA_1G10540	AFUA_3G00520	Q4WT50	Q4WFZ3	SIR2 family histone deacetylase (Hst4), putative.	NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily.	0.424
AFUA_1G10540	AFUA_4G07310	Q4WT50	Q4WNX7	SIR2 family histone deacetylase (Hst4), putative.	Cytidylyltransferase family protein.	0.900
AFUA_1G10540	AFUA_5G02780	Q4WT50	Q4WEF1	SIR2 family histone deacetylase (Hst4), putative.	Nicotinamide nucleotide transhydrogenase, putative.	0.900
AFUA_1G10540	AFUA_5G03350	Q4WT50	Q4WEK7	SIR2 family histone deacetylase (Hst4), putative.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.929
AFUA_1G10540	AFUA_5G03360	Q4WT50	Q4WEK8	SIR2 family histone deacetylase (Hst4), putative.	NADH pyrophosphatase, putative.	0.902