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PIF1 PIF1 AFUA_8G04750 AFUA_8G04750 mmm1 mmm1 AFUA_7G05530 AFUA_7G05530 AFUA_7G08630 AFUA_7G08630 AFUA_2G04270 AFUA_2G04270 yme2 yme2 AFUA_1G00230 AFUA_1G00230 acoA acoA AFUA_6G10900 AFUA_6G10900 AFUA_6G09390 AFUA_6G09390 AFUA_6G08570 AFUA_6G08570 AFUA_4G07290 AFUA_4G07290 mdm34 mdm34 mdm12 mdm12 AFUA_1G11970 AFUA_1G11970 AFUA_1G11180 AFUA_1G11180 MEF2 MEF2 AFUA_5G07890 AFUA_5G07890 AFUA_5G10820 AFUA_5G10820 AFUA_5G12640 AFUA_5G12640 AFUA_5G13330 AFUA_5G13330 mdmB mdmB AFUA_3G06850 AFUA_3G06850 AFUA_3G06950 AFUA_3G06950 AFUA_3G11140 AFUA_3G11140 AFUA_3G14490 AFUA_3G14490 AFUA_2G11750 AFUA_2G11750 AFUA_2G09560 AFUA_2G09560
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (788 aa)
AFUA_8G04750DNA mismatch repair protein Msh1, putative. (1018 aa)
mmm1Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 su [...] (496 aa)
AFUA_7G05530DEAD/DEAH box helicase, putative. (690 aa)
AFUA_7G08630Uncharacterized protein. (459 aa)
AFUA_2G04270Mitochondrial inner membrane translocase subunit (TIM17), putative. (154 aa)
yme2Mitochondrial escape protein 2; Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity); Belongs to the YME2 family. (871 aa)
AFUA_1G00230Uncharacterized protein. (759 aa)
acoAAconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate, a step in the citric acid cycle. Also catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. Belongs to the aconitase/IPM isomerase family. (787 aa)
AFUA_6G10900UV-endonuclease UVE-1. (598 aa)
AFUA_6G09390Uncharacterized protein. (719 aa)
AFUA_6G08570DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1154 aa)
AFUA_4G07290SAP domain-containing protein. (396 aa)
mdm34Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (572 aa)
mdm12Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pat [...] (439 aa)
AFUA_1G11970Mitochondrial dynamin GTPase (Msp1), putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (918 aa)
AFUA_1G11180Heat shock protein/chaperonin HSP78, putative; Belongs to the ClpA/ClpB family. (797 aa)
MEF2Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (920 aa)
AFUA_5G07890SsDNA binding protein, putative. (149 aa)
AFUA_5G10820Mitochondrial ATP-dependent RNA helicase Suv3, putative. (765 aa)
AFUA_5G12640DNA polymerase gamma. (1135 aa)
AFUA_5G13330Uncharacterized protein. (344 aa)
mdmBMitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the recepto [...] (471 aa)
AFUA_3G06850Uncharacterized protein. (296 aa)
AFUA_3G06950Mitochondrial carrier protein (Rim2), putative; Belongs to the mitochondrial carrier (TC 2.A.29) family. (383 aa)
AFUA_3G11140DNA ligase. (833 aa)
AFUA_3G14490Ketol-acid reductoisomerase; Belongs to the ketol-acid reductoisomerase family. (508 aa)
AFUA_2G11750Mitochondrial DnaJ chaperone (Mdj1), putative. (543 aa)
AFUA_2G09560Mitochondrial genome maintenance protein Mgm101, putative. (306 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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