STRINGSTRING
AFUA_7G00530 AFUA_7G00530 AFUA_6G11410 AFUA_6G11410 AFUA_6G13050 AFUA_6G13050 AFUA_6G13160 AFUA_6G13160 ubc2 ubc2 AFUA_1G02060 AFUA_1G02060 AFUA_1G02940 AFUA_1G02940 AFUA_1G03710 AFUA_1G03710 AFUA_1G04950 AFUA_1G04950 AFUA_1G05610 AFUA_1G05610 AFUA_2G01910 AFUA_2G01910 AFUA_2G04140 AFUA_2G04140 AFUA_2G05070 AFUA_2G05070 AFUA_7G04310 AFUA_7G04310 AFUA_7G03750 AFUA_7G03750 AFUA_5G04020 AFUA_5G04020 AFUA_5G02560 AFUA_5G02560 AFUA_6G04110 AFUA_6G04110 AFUA_6G03970 AFUA_6G03970 AFUA_8G02820 AFUA_8G02820 AFUA_6G10620 AFUA_6G10620 tof1 tof1 AFUA_1G13580 AFUA_1G13580 csm3 csm3 AFUA_2G10710 AFUA_2G10710 AFUA_2G14920 AFUA_2G14920 AFUA_3G14340 AFUA_3G14340 mus81 mus81 AFUA_3G12250 AFUA_3G12250 AFUA_3G08100 AFUA_3G08100 AFUA_3G05540 AFUA_3G05540 AFUA_5G13570 AFUA_5G13570 AFUA_5G13560 AFUA_5G13560 AFUA_5G13380 AFUA_5G13380 AFUA_5G13220 AFUA_5G13220 tel1 tel1 dot1 dot1 AFUA_5G06750 AFUA_5G06750 ccr4 ccr4 AFUA_4G12670 AFUA_4G12670 AFUA_4G07620 AFUA_4G07620 AFUA_6G08120 AFUA_6G08120
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_7G00530NACHT and Ankyrin domain protein. (1334 aa)
AFUA_6G11410Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa)
AFUA_6G13050Meiosis specific protein Hop1, putative. (732 aa)
AFUA_6G13160Serine/threonine protein kinase, putative. (514 aa)
ubc2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
AFUA_1G02060Pachytene checkpoint component Pch2, putative; Belongs to the AAA ATPase family. (455 aa)
AFUA_1G02940Mitotic check point protein (Bub2), putative. (446 aa)
AFUA_1G03710C2H2 finger domain protein, putative. (433 aa)
AFUA_1G04950Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
AFUA_1G05610Protein phosphotase 2a 65kd regulatory sububit. (616 aa)
AFUA_2G01910MRC1 domain-containing protein. (1284 aa)
AFUA_2G04140Chromosome segregation protein Spc105, putative. (1559 aa)
AFUA_2G05070Uncharacterized protein. (506 aa)
AFUA_7G04310Cell division control protein; Belongs to the CDC6/cdc18 family. (647 aa)
AFUA_7G03750Cell-cycle checkpoint protein kinase, putative; Belongs to the protein kinase superfamily. (409 aa)
AFUA_5G04020DNA damage repair protein (Rad9), putative. (1338 aa)
AFUA_5G02560Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (675 aa)
AFUA_6G04110CLPTM1 domain protein. (638 aa)
AFUA_6G03970Cell cycle checkpoint protein (Hus1), putative. (373 aa)
AFUA_8G02820Cell cycle checkpoint protein Rad17, putative. (722 aa)
AFUA_6G10620Nuclear pore complex subunit, putative. (355 aa)
tof1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with csm3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1176 aa)
AFUA_1G13580M protein repeat protein. (731 aa)
csm3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with tof1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (270 aa)
AFUA_2G10710DNA repair protein rad9, putative. (376 aa)
AFUA_2G14920Protein kinase, putative. (1028 aa)
AFUA_3G14340Mitotic spindle checkpoint protein (Mad2), putative. (141 aa)
mus81Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (596 aa)
AFUA_3G12250Protein-tyrosine phosphatase, putative. (613 aa)
AFUA_3G08100Checkpoint protein kinase, putative. (841 aa)
AFUA_3G05540Cell cycle protein kinase, putative. (464 aa)
AFUA_5G13570Uncharacterized protein. (292 aa)
AFUA_5G13560FHA domain protein. (610 aa)
AFUA_5G13380BRCT domain protein. (786 aa)
AFUA_5G13220ERCC4 domain-containing protein. (649 aa)
tel1Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2796 aa)
dot1Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (502 aa)
AFUA_5G06750Protein kinase (Gcn2), putative. (1592 aa)
ccr4Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (696 aa)
AFUA_4G12670DNA repair protein Rad1, putative. (491 aa)
AFUA_4G07620Uncharacterized protein. (828 aa)
AFUA_6G08120Checkpoint protein kinase (SldA), putative. (1227 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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