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AFUA_1G10850 AFUA_1G10850 AFUA_2G09060 AFUA_2G09060 AFUA_2G09890 AFUA_2G09890 MCM7 MCM7 AFUA_2G10710 AFUA_2G10710 AFUA_2G10730 AFUA_2G10730 AFUA_2G10990 AFUA_2G10990 psf2 psf2 AFUA_2G11170 AFUA_2G11170 AFUA_2G11210 AFUA_2G11210 AFUA_2G12520 AFUA_2G12520 AFUA_2G12960 AFUA_2G12960 AFUA_2G14080 AFUA_2G14080 AFUA_2G16600 AFUA_2G16600 AFUA_2G16710 AFUA_2G16710 AFUA_4G03020 AFUA_4G03020 AFUA_4G03030 AFUA_4G03030 tof1 tof1 arp6 arp6 csm3 csm3 AFUA_6G06535 AFUA_6G06535 AFUA_6G06530 AFUA_6G06530 AFUA_4G11602 AFUA_4G11602 AFUA_1G14695 AFUA_1G14695 AFUA_3G05575 AFUA_3G05575 AFUA_6G02900 AFUA_6G02900 AFUA_6G03970 AFUA_6G03970 AFUA_6G05280 AFUA_6G05280 htz1 htz1 AFUA_5G02520 AFUA_5G02520 slx1 slx1 AFUA_5G04070 AFUA_5G04070 AFUA_3G03940 AFUA_3G03940 pob3 pob3 AFUA_2G06320 AFUA_2G06320 AFUA_2G06190 AFUA_2G06190 arp4 arp4 AFUA_2G05850 AFUA_2G05850 AFUA_2G05620 AFUA_2G05620 AFUA_2G05030 AFUA_2G05030 AFUA_2G04030 AFUA_2G04030 AFUA_2G03390 AFUA_2G03390 slx4 slx4 AFUA_2G01910 AFUA_2G01910 AFUA_2G01090 AFUA_2G01090 AFUA_1G07320 AFUA_1G07320 AFUA_1G05830 AFUA_1G05830 AFUA_1G04910 AFUA_1G04910 AFUA_1G04900 AFUA_1G04900 AFUA_1G04480 AFUA_1G04480 AFUA_1G03920 AFUA_1G03920 AFUA_1G03410 AFUA_1G03410 AFUA_1G02500 AFUA_1G02500 rvb2 rvb2 AFUA_1G02000 AFUA_1G02000 AFUA_1G00580 AFUA_1G00580 AFUA_6G13050 AFUA_6G13050 AFUA_6G11130 AFUA_6G11130 AFUA_6G10670 AFUA_6G10670 AFUA_6G10490 AFUA_6G10490 AFUA_4G06120 AFUA_4G06120 swc4 swc4 eaf1 eaf1 AFUA_4G07670 AFUA_4G07670 AFUA_4G07970 AFUA_4G07970 yaf9 yaf9 eaf3 eaf3 rvb1 rvb1 psf3 psf3 AFUA_4G11660 AFUA_4G11660 AFUA_4G12430 AFUA_4G12430 AFUA_4G12670 AFUA_4G12670 AFUA_4G12680 AFUA_4G12680 AFUA_1G15310 AFUA_1G15310 AFUA_1G10550 AFUA_1G10550 AFUA_1G10410 AFUA_1G10410 AFUA_1G09060 AFUA_1G09060 AFUA_1G08860 AFUA_1G08860 AFUA_5G06080 AFUA_5G06080 ino80 ino80 AFUA_5G08110 AFUA_5G08110 AFUA_5G08840 AFUA_5G08840 AFUA_5G09000 AFUA_5G09000 AFUA_5G10890 AFUA_5G10890 AFUA_5G12190 AFUA_5G12190 AFUA_5G13020 AFUA_5G13020 AFUA_3G06070 AFUA_3G06070 AFUA_3G07280 AFUA_3G07280 AFUA_3G09020 AFUA_3G09020 pol2 pol2 AFUA_3G10280 AFUA_3G10280 AFUA_3G11010 AFUA_3G11010 AFUA_3G11940 AFUA_3G11940 AFUA_3G13150 AFUA_3G13150 AFUA_3G14010 AFUA_3G14010 AFUA_2G16850 AFUA_2G16850 AFUA_2G16840 AFUA_2G16840 AFUA_2G16810 AFUA_2G16810 AFUA_8G04050 AFUA_8G04050 AFUA_8G04240 AFUA_8G04240 AFUA_8G05280 AFUA_8G05280 swr1 swr1 AFUA_7G02200 AFUA_7G02200 AFUA_7G02100 AFUA_7G02100
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_1G10850Ubiquitin-like modifier SUMO, putative. (93 aa)
AFUA_2G09060DNA helicase; Belongs to the MCM family. (1023 aa)
AFUA_2G09890NDT80 / PhoG like DNA-binding family protein. (605 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (854 aa)
AFUA_2G10710DNA repair protein rad9, putative. (376 aa)
AFUA_2G10730DNA polymerase. (1462 aa)
AFUA_2G10990Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (720 aa)
psf2DNA replication complex GINS protein psf2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (271 aa)
AFUA_2G11170Origin recognition complex subunit Orc4, putative. (704 aa)
AFUA_2G11210PHD finger and SET domain protein, putative. (924 aa)
AFUA_2G12520Uncharacterized protein. (1045 aa)
AFUA_2G12960PAPA-1-like conserved region protein. (381 aa)
AFUA_2G14080Structural maintenance of chromosomes protein. (1199 aa)
AFUA_2G16600DNA polymerase. (1105 aa)
AFUA_2G16710Uncharacterized protein. (438 aa)
AFUA_4G03020Chromatin remodeling complex subunit (Arp5), putative; Belongs to the actin family. (757 aa)
AFUA_4G03030YL1_C domain-containing protein. (185 aa)
tof1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with csm3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1176 aa)
arp6Actin-like protein arp6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (468 aa)
csm3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with tof1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (270 aa)
AFUA_6G06535Uncharacterized protein. (192 aa)
AFUA_6G06530Uncharacterized protein. (249 aa)
AFUA_4G11602Cnn_1N domain-containing protein. (987 aa)
AFUA_1G14695DNA repair protein Dds20/Mei5, putative. (286 aa)
AFUA_3G05575TBP interacting domain protein, putative. (186 aa)
AFUA_6G02900Rad21/Rec8 N terminal domain protein. (741 aa)
AFUA_6G03970Cell cycle checkpoint protein (Hus1), putative. (373 aa)
AFUA_6G05280Meiosis protein MEI2, putative. (692 aa)
htz1Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (138 aa)
AFUA_5G02520DNA helicase; Belongs to the MCM family. (718 aa)
slx1Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (423 aa)
AFUA_5G04070Meiosis-specific topoisomerase Spo11, putative. (388 aa)
AFUA_3G039402,3-diketo-5-methylthio-1-phosphopentane phosphatase, putative. (294 aa)
pob3FACT complex subunit pob3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (573 aa)
AFUA_2G06320Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (529 aa)
AFUA_2G06190DNA polymerase epsilon subunit B, putative. (762 aa)
arp4Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (466 aa)
AFUA_2G05850Double-strand-break repair protein rad21. (606 aa)
AFUA_2G05620Signal transducer, putative. (746 aa)
AFUA_2G05030HIT finger domain protein, putative. (286 aa)
AFUA_2G04030Chromatin assembly factor 1 subunit B, putative. (644 aa)
AFUA_2G03390Histone deacetylase RpdA/Rpd3. (688 aa)
slx4Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (811 aa)
AFUA_2G01910MRC1 domain-containing protein. (1284 aa)
AFUA_2G01090DNA helicase, putative. (730 aa)
AFUA_1G07320Chromosome segregation protein (SepB), putative. (841 aa)
AFUA_1G05830TBP associated factor (Mot1), putative. (1891 aa)
AFUA_1G04910Vezatin domain-containing protein. (629 aa)
AFUA_1G04900Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (219 aa)
AFUA_1G04480Sin3 complex subunit (Stb2), putative. (851 aa)
AFUA_1G03920DNA helicase; Belongs to the MCM family. (892 aa)
AFUA_1G03410DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (500 aa)
AFUA_1G02500Origin recognition complex subunit Orc5, putative. (541 aa)
rvb2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (469 aa)
AFUA_1G02000DNA mismatch repair protein Msh4, putative. (840 aa)
AFUA_1G00580Transcriptional regulator PacG/VIB-1. (529 aa)
AFUA_6G13050Meiosis specific protein Hop1, putative. (732 aa)
AFUA_6G11130Possible replication factor-a protein. (289 aa)
AFUA_6G10670Uncharacterized protein. (207 aa)
AFUA_6G10490Uncharacterized protein. (441 aa)
AFUA_4G06120RSC complex subunit Sfh1, putative. (566 aa)
swc4SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (588 aa)
eaf1Chromatin modification-related protein eaf1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (1467 aa)
AFUA_4G07670INO80 chromatin remodeling complex (Ies1), putative. (862 aa)
AFUA_4G07970DNA polymerase delta subunit 2, putative. (554 aa)
yaf9Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (252 aa)
eaf3Chromatin modification-related protein eaf3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (330 aa)
rvb1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
psf3DNA replication complex GINS protein psf3; The GINS complex plays an essential role in the initiation of DNA replication. (178 aa)
AFUA_4G11660Chromatin modification-related protein. (647 aa)
AFUA_4G12430PSF1 domain protein. (253 aa)
AFUA_4G12670DNA repair protein Rad1, putative. (491 aa)
AFUA_4G12680DNA repair protein Rad50. (1312 aa)
AFUA_1G15310DNA replication initiation factor Cdc45. (860 aa)
AFUA_1G10550CBF/NF-Y family transcription factor, putative. (282 aa)
AFUA_1G10410DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
AFUA_1G09060RXT2_N domain-containing protein. (512 aa)
AFUA_1G08860Meiotic recombination protein Ski8/Rec14, putative. (209 aa)
AFUA_5G06080DNA repair protein Swi5/Sae3, putative. (114 aa)
ino80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1708 aa)
AFUA_5G08110Origin recognition complex subunit 2, putative. (559 aa)
AFUA_5G08840Transcriptional regulator (Cti6), putative. (628 aa)
AFUA_5G09000Sister chromatid cohesion protein (Eso1), putative. (672 aa)
AFUA_5G10890DNA helicase; Belongs to the MCM family. (956 aa)
AFUA_5G12190Transcription initiation factor subunit (TAF30), putative. (229 aa)
AFUA_5G13020DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (617 aa)
AFUA_3G06070Histone H1. (206 aa)
AFUA_3G07280Uncharacterized protein. (335 aa)
AFUA_3G09020DNA primase; Belongs to the eukaryotic-type primase small subunit family. (522 aa)
pol2DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication. (2230 aa)
AFUA_3G10280DNA replication protein, putative. (792 aa)
AFUA_3G11010Eukaryotic translation initiation factor eIF-2C4, putative. (917 aa)
AFUA_3G11940Chromatin modification-related protein. (707 aa)
AFUA_3G13150Deacetylase complex subunit Sds3, putative. (506 aa)
AFUA_3G14010DNA helicase; Belongs to the MCM family. (896 aa)
AFUA_2G16850Sister chromatid cohesion and DNA repair protein (BimD), putative. (1492 aa)
AFUA_2G16840SWI-SNF complex subunit (Snf5), putative. (803 aa)
AFUA_2G16810PHD finger domain protein, putative. (939 aa)
AFUA_8G04050Transcriptional regulator PacG/VIB-1. (583 aa)
AFUA_8G04240Origin recognition complex subunit 3, putative. (698 aa)
AFUA_8G05280RNA interference and gene silencing protein (Qde2), putative. (1047 aa)
swr1Helicase swr1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1695 aa)
AFUA_7G02200Meiotic recombination protein (Dmc1), putative; Belongs to the RecA family. (338 aa)
AFUA_7G02100Uncharacterized protein. (262 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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