7 items (Aspergillus fumigatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	AFUA_6G10965	Apoptosis-inducing TAF9-like domain 1 family protein, putative. (110 aa)
	AFUA_8G05680	Serine/threonine-protein kinase. (1119 aa)
	AFUA_6G02530	DNA repair protein RAD1, putative. (975 aa)
	AFUA_6G13690	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1660 aa)
	AFUA_5G13220	ERCC4 domain-containing protein. (649 aa)
	AFUA_3G08800	DUF1767 domain-containing protein. (249 aa)
	mus81	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (596 aa)

Your Current Organism:

Aspergillus fumigatus

NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFUA_3G08800	AFUA_6G02530	Q4WXA5	Q4WCV1	DUF1767 domain-containing protein.	DNA repair protein RAD1, putative.	0.862
AFUA_3G08800	mus81	Q4WXA5	Q4WYE5	DUF1767 domain-containing protein.	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	0.923
AFUA_5G13220	AFUA_6G02530	Q4WVT2	Q4WCV1	ERCC4 domain-containing protein.	DNA repair protein RAD1, putative.	0.414
AFUA_5G13220	AFUA_8G05680	Q4WVT2	Q4WC53	ERCC4 domain-containing protein.	Serine/threonine-protein kinase.	0.628
AFUA_5G13220	mus81	Q4WVT2	Q4WYE5	ERCC4 domain-containing protein.	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	0.986
AFUA_6G02530	AFUA_3G08800	Q4WCV1	Q4WXA5	DNA repair protein RAD1, putative.	DUF1767 domain-containing protein.	0.862
AFUA_6G02530	AFUA_5G13220	Q4WCV1	Q4WVT2	DNA repair protein RAD1, putative.	ERCC4 domain-containing protein.	0.414
AFUA_6G02530	AFUA_8G05680	Q4WCV1	Q4WC53	DNA repair protein RAD1, putative.	Serine/threonine-protein kinase.	0.506
AFUA_6G02530	mus81	Q4WCV1	Q4WYE5	DNA repair protein RAD1, putative.	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	0.906
AFUA_6G13690	AFUA_8G05680	Q4WLF7	Q4WC53	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Serine/threonine-protein kinase.	0.547
AFUA_6G13690	mus81	Q4WLF7	Q4WYE5	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	0.492
AFUA_8G05680	AFUA_5G13220	Q4WC53	Q4WVT2	Serine/threonine-protein kinase.	ERCC4 domain-containing protein.	0.628
AFUA_8G05680	AFUA_6G02530	Q4WC53	Q4WCV1	Serine/threonine-protein kinase.	DNA repair protein RAD1, putative.	0.506
AFUA_8G05680	AFUA_6G13690	Q4WC53	Q4WLF7	Serine/threonine-protein kinase.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.547
AFUA_8G05680	mus81	Q4WC53	Q4WYE5	Serine/threonine-protein kinase.	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	0.680
mus81	AFUA_3G08800	Q4WYE5	Q4WXA5	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	DUF1767 domain-containing protein.	0.923
mus81	AFUA_5G13220	Q4WYE5	Q4WVT2	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	ERCC4 domain-containing protein.	0.986
mus81	AFUA_6G02530	Q4WYE5	Q4WCV1	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	DNA repair protein RAD1, putative.	0.906
mus81	AFUA_6G13690	Q4WYE5	Q4WLF7	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.	0.492
mus81	AFUA_8G05680	Q4WYE5	Q4WC53	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	Serine/threonine-protein kinase.	0.680