STRINGSTRING
AFUA_5G07740 AFUA_5G07740 AFUA_1G03035 AFUA_1G03035 AFUA_4G04760 AFUA_4G04760 AFUA_7G00090 AFUA_7G00090 AFUA_8G00430 AFUA_8G00430 AFUA_8G07400 AFUA_8G07400 AFUA_6G03970 AFUA_6G03970 kae1 kae1 AFUA_7G04590 AFUA_7G04590 AFUA_2G06320 AFUA_2G06320 AFUA_2G04960 AFUA_2G04960 cgi121 cgi121 AFUA_2G02660 AFUA_2G02660 ku80 ku80 AFUA_2G00090 AFUA_2G00090 AFUA_1G04950 AFUA_1G04950 AFUA_1G04570 AFUA_1G04570 ubc2 ubc2 AFUA_6G11410 AFUA_6G11410 AFUA_4G08830 AFUA_4G08830 AFUA_4G12210 AFUA_4G12210 AFUA_4G12680 AFUA_4G12680 AFUA_1G10410 AFUA_1G10410 ino80 ino80 AFUA_5G07120 AFUA_5G07120 AFUA_5G11390 AFUA_5G11390 AFUA_5G11470 AFUA_5G11470 tel1 tel1 PIF1 PIF1 AFUA_5G15150 AFUA_5G15150 AFUA_3G07070 AFUA_3G07070 AFUA_3G11740 AFUA_3G11740 AFUA_3G15395 AFUA_3G15395 AFUA_2G18100 AFUA_2G18100 AFUA_2G17230 AFUA_2G17230 AFUA_2G16100 AFUA_2G16100 AFUA_2G15220 AFUA_2G15220 AFUA_2G13740 AFUA_2G13740 AFUA_2G09160 AFUA_2G09160
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_5G07740DSB repair complex subunit Ku70, putative. (691 aa)
AFUA_1G03035HD superfamily hydrolase, putative. (243 aa)
AFUA_4G04760Inositol kinase kinase (UvsB), putative; Belongs to the PI3/PI4-kinase family. (2449 aa)
AFUA_7G00090Telomere-associated RecQ helicase, putative. (396 aa)
AFUA_8G00430EthD domain-containing protein. (157 aa)
AFUA_8G07400Telomere-associated RecQ helicase, putative. (360 aa)
AFUA_6G03970Cell cycle checkpoint protein (Hus1), putative. (373 aa)
kae1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (352 aa)
AFUA_7G04590Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1248 aa)
AFUA_2G06320Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (529 aa)
AFUA_2G04960RecQ family helicase MusN. (1563 aa)
cgi121EKC/KEOPS complex subunit cgi121; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Cgi121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transc [...] (189 aa)
AFUA_2G02660DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
ku80ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (725 aa)
AFUA_2G00090Telomere-associated RecQ helicase, putative. (460 aa)
AFUA_1G04950Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
AFUA_1G04570DNA repair protein, putative. (760 aa)
ubc2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
AFUA_6G11410Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa)
AFUA_4G08830Telomere length regulator protein (Rif1), putative. (1703 aa)
AFUA_4G12210DNA replication helicase Dna2, putative. (1657 aa)
AFUA_4G12680DNA repair protein Rad50. (1312 aa)
AFUA_1G10410DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
ino80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1708 aa)
AFUA_5G07120RNP domain protein. (352 aa)
AFUA_5G11390APSES transcription factor, putative. (427 aa)
AFUA_5G11470MYB DNA binding protein (Tbf1), putative. (846 aa)
tel1Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2796 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (788 aa)
AFUA_5G15150Telomere-associated RecQ helicase, putative. (395 aa)
AFUA_3G07070MYB DNA-binding domain protein. (911 aa)
AFUA_3G11740RNAPII degradation factor Def1, putative. (905 aa)
AFUA_3G15395Telomere-associated RecQ helicase, putative. (714 aa)
AFUA_2G18100Telomere-associated RecQ helicase, putative. (850 aa)
AFUA_2G17230NACHT domain protein. (1785 aa)
AFUA_2G16100Telomere-binding alpha subunit central domain protein. (635 aa)
AFUA_2G15220DNA repair protein Pso2/Snm1, putative. (850 aa)
AFUA_2G13740Telomere_reg-2 domain-containing protein. (1002 aa)
AFUA_2G09160Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (433 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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