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AFUA_4G12210 AFUA_4G12210 AFUA_4G11180 AFUA_4G11180 rvb1 rvb1 prp28 prp28 AFUA_3G06922 AFUA_3G06922 AFUA_1G03035 AFUA_1G03035 AFUA_1G13060 AFUA_1G13060 AFUA_4G01270 AFUA_4G01270 AFUA_4G03840 AFUA_4G03840 AFUA_4G03070 AFUA_4G03070 dcl2 dcl2 AFUA_7G00090 AFUA_7G00090 AFUA_7G02120 AFUA_7G02120 swr1 swr1 AFUA_7G02440 AFUA_7G02440 AFUA_8G07400 AFUA_8G07400 AFUA_8G04740 AFUA_8G04740 AFUA_6G02060 AFUA_6G02060 sub2 sub2 AFUA_6G04330 AFUA_6G04330 fal1 fal1 AFUA_5G02520 AFUA_5G02520 AFUA_5G03320 AFUA_5G03320 AFUA_7G03820 AFUA_7G03820 AFUA_7G05530 AFUA_7G05530 AFUA_7G08480 AFUA_7G08480 dbp3 dbp3 AFUA_2G05180 AFUA_2G05180 AFUA_2G04960 AFUA_2G04960 rrp3 rrp3 AFUA_1G05830 AFUA_1G05830 AFUA_1G03920 AFUA_1G03920 AFUA_1G03820 AFUA_1G03820 rvb2 rvb2 AFUA_1G00630 AFUA_1G00630 AFUA_6G14720 AFUA_6G14720 AFUA_6G14690 AFUA_6G14690 AFUA_6G14670 AFUA_6G14670 ubc2 ubc2 AFUA_6G13290 AFUA_6G13290 AFUA_6G13080 AFUA_6G13080 AFUA_6G12910 AFUA_6G12910 dbp4 dbp4 AFUA_6G09220 AFUA_6G09220 mak5 mak5 AFUA_6G06550 AFUA_6G06550 mph1 mph1 dbp10 dbp10 AFUA_2G07710 AFUA_2G07710 AFUA_2G07950 AFUA_2G07950 mrh4 mrh4 AFUA_2G09060 AFUA_2G09060 AFUA_2G09230 AFUA_2G09230 AFUA_2G10000 AFUA_2G10000 MCM7 MCM7 AFUA_4G07160 AFUA_4G07160 dbp2 dbp2 AFUA_2G10820 AFUA_2G10820 dbp9 dbp9 AFUA_2G16140 AFUA_2G16140 AFUA_2G17520 AFUA_2G17520 AFUA_2G18100 AFUA_2G18100 AFUA_3G15395 AFUA_3G15395 AFUA_3G14010 AFUA_3G14010 spb4 spb4 dbp8 dbp8 AFUA_3G08400 AFUA_3G08400 tif1 tif1 AFUA_3G07200 AFUA_3G07200 chl1 chl1 dhh1 dhh1 AFUA_5G15150 AFUA_5G15150 PIF1 PIF1 rad5 rad5 dcl1 dcl1 AFUA_5G11620 AFUA_5G11620 AFUA_5G11170 AFUA_5G11170 dbp7 dbp7 AFUA_5G10890 AFUA_5G10890 AFUA_5G10830 AFUA_5G10830 AFUA_5G10820 AFUA_5G10820 AFUA_5G09090 AFUA_5G09090 AFUA_5G07740 AFUA_5G07740 AFUA_5G07680 AFUA_5G07680 AFUA_5G06600 AFUA_5G06600 AFUA_5G06330 AFUA_5G06330 ino80 ino80 AFUA_1G09240 AFUA_1G09240 prp5 prp5 AFUA_1G10290 AFUA_1G10290 AFUA_1G13910 AFUA_1G13910 drs1 drs1 AFUA_1G15120 AFUA_1G15120 mss116 mss116 rok1 rok1 AFUA_4G07230 AFUA_4G07230 ded1 ded1 AFUA_2G03910 AFUA_2G03910 AFUA_2G03750 AFUA_2G03750 ku80 ku80 dbp5 dbp5 AFUA_2G01090 AFUA_2G01090 AFUA_2G00090 AFUA_2G00090 AFUA_1G16940 AFUA_1G16940 AFUA_1G17050 AFUA_1G17050 AFUA_4G13460 AFUA_4G13460 AFUA_4G13440 AFUA_4G13440 has1 has1 AFUA_4G13060 AFUA_4G13060
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AFUA_4G12210DNA replication helicase Dna2, putative. (1657 aa)
AFUA_4G11180AAA family ATPase, putative. (539 aa)
rvb1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
prp28Pre-mRNA-splicing ATP-dependent RNA helicase prp28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (796 aa)
AFUA_3G06922DEAD/DEAH box helicase, putative. (1796 aa)
AFUA_1G03035HD superfamily hydrolase, putative. (243 aa)
AFUA_1G13060Regulator of nonsense transcripts, putative. (1079 aa)
AFUA_4G01270Integral membrane protein. (400 aa)
AFUA_4G03840DNA repair protein Rhp26/Rad26, putative. (1214 aa)
AFUA_4G03070DEAD/DEAH box helicase, putative. (2043 aa)
dcl2ATP-dependent helicase dcl2; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity); Belongs to the helicase family. Dicer subfamily. (1388 aa)
AFUA_7G00090Telomere-associated RecQ helicase, putative. (396 aa)
AFUA_7G02120Uncharacterized protein. (741 aa)
swr1Helicase swr1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1695 aa)
AFUA_7G02440Conserved glycine-rich protein. (256 aa)
AFUA_8G07400Telomere-associated RecQ helicase, putative. (360 aa)
AFUA_8G04740Pre-mRNA splicing helicase, putative. (2209 aa)
AFUA_6G02060tRNA-splicing endonuclease, putative. (2076 aa)
sub2ATP-dependent RNA helicase sub2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (448 aa)
AFUA_6G04330DEAH-box RNA helicase (Dhr1), putative. (1211 aa)
fal1ATP-dependent RNA helicase fal1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. (398 aa)
AFUA_5G02520DNA helicase; Belongs to the MCM family. (718 aa)
AFUA_5G03320TFIIH complex helicase Ssl2, putative. (830 aa)
AFUA_7G03820DNA excision repair protein Rad16, putative. (940 aa)
AFUA_7G05530DEAD/DEAH box helicase, putative. (690 aa)
AFUA_7G08480SWI/SNF family DNA-dependent ATPase, putative. (707 aa)
dbp3ATP-dependent RNA helicase dbp3; ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity); Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. (503 aa)
AFUA_2G05180NF-X1 finger and helicase domain protein, putative. (1914 aa)
AFUA_2G04960RecQ family helicase MusN. (1563 aa)
rrp3ATP-dependent rRNA helicase rrp3; ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA. (472 aa)
AFUA_1G05830TBP associated factor (Mot1), putative. (1891 aa)
AFUA_1G03920DNA helicase; Belongs to the MCM family. (892 aa)
AFUA_1G03820mRNA splicing factor RNA helicase (Prp16), putative. (915 aa)
rvb2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (469 aa)
AFUA_1G00630SWI/SNF family DNA-dependent ATPase, putative. (1005 aa)
AFUA_6G14720Telomere-associated RecQ helicase, putative. (1445 aa)
AFUA_6G14690Telomere-associated RecQ helicase, putative. (352 aa)
AFUA_6G14670C2H2-type domain-containing protein. (146 aa)
ubc2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
AFUA_6G13290SWI/SNF family DNA-dependent ATPase Ris1, putative. (1376 aa)
AFUA_6G13080DEAD/DEAH box DNA helicase (Mer3), putative. (1439 aa)
AFUA_6G12910DsDNA-dependent ATPase Rad54, putative. (807 aa)
dbp4ATP-dependent RNA helicase dbp4; ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity). (787 aa)
AFUA_6G09220SNF2 family helicase/ATPase, putative. (1141 aa)
mak5ATP-dependent RNA helicase mak5; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily. (777 aa)
AFUA_6G06550SNF2 family helicase/ATPase, putative. (1461 aa)
mph1ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1101 aa)
dbp10ATP-dependent RNA helicase dbp10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (869 aa)
AFUA_2G07710mRNA splicing factor RNA helicase (Cdc28), putative. (1120 aa)
AFUA_2G07950ATP dependent RNA helicase, putative. (1455 aa)
mrh4ATP-dependent RNA helicase mrh4, mitochondrial; ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity); Belongs to the DEAD box helicase family. MRH4 subfamily. (631 aa)
AFUA_2G09060DNA helicase; Belongs to the MCM family. (1023 aa)
AFUA_2G09230ATP-dependent RNA helicase (Hrh1), putative. (821 aa)
AFUA_2G10000DEAD/DEAH box RNA helicase (Ski2), putative. (1293 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (854 aa)
AFUA_4G07160ATP dependent RNA helicase (Dob1), putative. (1082 aa)
dbp2ATP-dependent RNA helicase dbp2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing. (547 aa)
AFUA_2G10820DEAD/DEAH box helicase, putative. (1206 aa)
dbp9ATP-dependent RNA helicase dbp9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (649 aa)
AFUA_2G16140DEAD/DEAH box helicase, putative. (1344 aa)
AFUA_2G17520GNAT family N-acetyltransferase, putative. (220 aa)
AFUA_2G18100Telomere-associated RecQ helicase, putative. (850 aa)
AFUA_3G15395Telomere-associated RecQ helicase, putative. (714 aa)
AFUA_3G14010DNA helicase; Belongs to the MCM family. (896 aa)
spb4ATP-dependent rRNA helicase spb4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (640 aa)
dbp8ATP-dependent RNA helicase dbp8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (526 aa)
AFUA_3G08400SNF2 family helicase/ATPase, putative. (1133 aa)
tif1ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (406 aa)
AFUA_3G07200DEAD/DEAH box RNA helicase, putative; Belongs to the DEAD box helicase family. (587 aa)
chl1ATP-dependent DNA helicase chl1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (782 aa)
dhh1ATP-dependent RNA helicase dhh1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (507 aa)
AFUA_5G15150Telomere-associated RecQ helicase, putative. (395 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (788 aa)
rad5DNA repair protein rad5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1245 aa)
dcl1ATP-dependent helicase dcl1; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity); Belongs to the helicase family. Dicer subfamily. (1537 aa)
AFUA_5G11620Pre-mRNA splicing factor RNA helicase (Prp43), putative. (767 aa)
AFUA_5G11170Nucleosome remodeling complex ATPase subunit (Snf2h), putative. (986 aa)
dbp7ATP-dependent RNA helicase dbp7; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (758 aa)
AFUA_5G10890DNA helicase; Belongs to the MCM family. (956 aa)
AFUA_5G10830RNA helicase-like splicing factor (HRH1), putative. (1230 aa)
AFUA_5G10820Mitochondrial ATP-dependent RNA helicase Suv3, putative. (765 aa)
AFUA_5G09090DEAD box helicase involved in nonsense mediated decay, putative. (1007 aa)
AFUA_5G07740DSB repair complex subunit Ku70, putative. (691 aa)
AFUA_5G07680DUF2439 domain-containing protein. (510 aa)
AFUA_5G06600SNF2 family helicase/ATPase, putative. (1827 aa)
AFUA_5G06330RSC complex subunit (Sth1), putative. (1406 aa)
ino80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1708 aa)
AFUA_1G09240ATP dependent RNA helicase, putative. (639 aa)
prp5Pre-mRNA-processing ATP-dependent RNA helicase prp5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1211 aa)
AFUA_1G10290Chromodomain helicase (Chd1), putative. (1523 aa)
AFUA_1G13910TFIIH complex helicase Rad3, putative. (770 aa)
drs1ATP-dependent RNA helicase drs1; ATP-binding RNA helicase involved in ribosome assembly. (830 aa)
AFUA_1G15120DsDNA-dependent ATPase (Rad54b), putative. (969 aa)
mss116ATP-dependent RNA helicase mss116, mitochondrial; ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Also required for efficient mitochondrial translation (By similarity); Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. (655 aa)
rok1ATP-dependent RNA helicase rok1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (739 aa)
AFUA_4G07230ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (538 aa)
ded1ATP-dependent RNA helicase ded1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (674 aa)
AFUA_2G03910ATP-depentend DNA helicase, putative. (1001 aa)
AFUA_2G03750DNA excision repair protein (Rad26L), putative. (1008 aa)
ku80ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (725 aa)
dbp5ATP-dependent RNA helicase dbp5; ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity). (489 aa)
AFUA_2G01090DNA helicase, putative. (730 aa)
AFUA_2G00090Telomere-associated RecQ helicase, putative. (460 aa)
AFUA_1G16940DEAD/DEAH box helicase, putative. (856 aa)
AFUA_1G17050Uncharacterized protein. (198 aa)
AFUA_4G13460SNF2 family helicase/ATPase, putative. (1111 aa)
AFUA_4G13440Chromatin remodeling complex subunit (Chd3), putative. (1509 aa)
has1ATP-dependent RNA helicase has1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (622 aa)
AFUA_4G13060Zinc knuckle transcription factor (CnjB), putative. (509 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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