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| | AFUA_4G06260 | Mating-type switch/DNA repair protein Swi10/Rad10, putative. (341 aa) |
| | AFUA_4G07010 | Hydrolase, TatD family protein, putative. (299 aa) |
| | AFUA_4G07290 | SAP domain-containing protein. (396 aa) |
| | AFUA_4G12200 | Uncharacterized protein. (367 aa) |
| | AFUA_4G12210 | DNA replication helicase Dna2, putative. (1657 aa) |
| | AFUA_4G12250 | Exosome complex exonuclease exoribonuclease (Rrp44), putative; Belongs to the RNR ribonuclease family. (1034 aa) |
| | AFUA_4G12670 | DNA repair protein Rad1, putative. (491 aa) |
| | ysh1 | Endoribonuclease ysh1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. (872 aa) |
| | AFUA_1G16600 | Ribonuclease T2, putative; Belongs to the RNase T2 family. (262 aa) |
| | AFUA_1G16470 | tRNA processing endoribonuclease Trz1, putative. (1081 aa) |
| | AFUA_1G13850 | Uncharacterized protein. (624 aa) |
| | AFUA_1G12730 | 60S ribosomal protein L3. (363 aa) |
| | AFUA_1G11420 | Cell wall biogenesis protein phosphatase Ssd1, putative. (1378 aa) |
| | AFUA_1G10020 | Ribonuclease H1, putative. (221 aa) |
| | AFUA_5G06150 | Uncharacterized protein. (159 aa) |
| | AFUA_5G06830 | DsRNA-specific ribonuclease III, putative. (142 aa) |
| | AFUA_5G07370 | CCR4-NOT core complex subunit Caf1, putative. (500 aa) |
| | AFUA_5G09250 | Transcription factor (Snd1/p100), putative. (980 aa) |
| | AFUA_5G11140 | tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] (310 aa) |
| | dcl1 | ATP-dependent helicase dcl1; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity); Belongs to the helicase family. Dicer subfamily. (1537 aa) |
| | AFUA_5G12250 | Posttranscriptional regulation nuclease (Mkt1), putative. (731 aa) |
| | AFUA_5G12640 | DNA polymerase gamma. (1135 aa) |
| | AFUA_5G12860 | Uncharacterized protein. (392 aa) |
| | AFUA_5G13220 | ERCC4 domain-containing protein. (649 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa) |
| | AFUA_3G06160 | Mating locus protein, putative. (250 aa) |
| | AFUA_3G06180 | DNA lyase Apn2. (648 aa) |
| | AFUA_3G09050 | Exonuclease, putative. (658 aa) |
| | pol2 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication. (2230 aa) |
| | AFUA_7G04220 | Protein required for cell viability Rrp17, putative. (251 aa) |
| | AFUA_3G02450 | Uncharacterized protein. (1178 aa) |
| | AFUA_3G03050 | RNAse III, putative. (150 aa) |
| | AFUA_5G04440 | Nucleolar RNAse III, putative. (373 aa) |
| | AFUA_5G04010 | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (484 aa) |
| | AFUA_5G04000 | 20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (435 aa) |
| | slx1 | Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (423 aa) |
| | AFUA_5G03120 | 5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1418 aa) |
| | AFUA_5G02610 | Cytochrome P450, putative; Belongs to the cytochrome P450 family. (466 aa) |
| | AFUA_5G01600 | PHP domain protein. (486 aa) |
| | rai1 | Decapping nuclease rai1; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). Belongs to the DXO/Dom3Z family. (365 aa) |
| | AFUA_3G09880 | Exosome complex exonuclease Rrp6, putative. (764 aa) |
| | AFUA_3G10290 | Uncharacterized protein. (423 aa) |
| | AFUA_3G11010 | Eukaryotic translation initiation factor eIF-2C4, putative. (917 aa) |
| | ccr4 | Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (696 aa) |
| | AFUA_3G14160 | Uncharacterized protein. (170 aa) |
| | AFUA_6G06530 | Uncharacterized protein. (249 aa) |
| | AFUA_6G06535 | Uncharacterized protein. (192 aa) |
| | AFUA_m0430 | Intron-encoded LAGLIDADG endonuclease family protein. (291 aa) |
| | mitF | Ribonuclease mitogillin; This purine-specific ribonuclease cleaves 28S RNA in eukaryotic ribosomes, inhibits protein synthesis, and shows antitumor activity. (176 aa) |
| | AFUA_4G03230 | Extracellular guanyl-specific ribonuclease RntA. (131 aa) |
| | dcl2 | ATP-dependent helicase dcl2; Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity); Belongs to the helicase family. Dicer subfamily. (1388 aa) |
| | AFUA_7G00870 | RNA exonuclease, putative. (423 aa) |
| | AFUA_7G01330 | Translin-associated factor TraX, putative. (289 aa) |
| | AFUA_7G01550 | Mitochondrial exoribonuclease Cyt-4, putative. (1043 aa) |
| | AFUA_8G01900 | Uncharacterized protein. (278 aa) |
| | AFUA_8G05280 | RNA interference and gene silencing protein (Qde2), putative. (1047 aa) |
| | USB1 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (306 aa) |
| | AFUA_8G04820 | Ribonuclease P complex subunit Pop2, putative. (318 aa) |
| | AFUA_8G04640 | RNA-3'-phosphate cyclase family protein. (403 aa) |
| | AFUA_6G02270 | Ribonuclease P complex subunit Pop1, putative. (913 aa) |
| | AFUA_6G02530 | DNA repair protein RAD1, putative. (975 aa) |
| | AFUA_6G04350 | Uncharacterized protein. (277 aa) |
| | AFUA_7G05280 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (822 aa) |
| | AFUA_7G08520 | Uncharacterized protein. (476 aa) |
| | rex4 | RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family. (310 aa) |
| | pan2n2 | PAN2-PAN3 deadenylation complex catalytic subunit pan2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1155 aa) |
| | AFUA_2G03340 | DUF652 domain protein. (192 aa) |
| | slx4 | Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (811 aa) |
| | AFUA_2G02400 | Uncharacterized protein. (240 aa) |
| | AFUA_1G07620 | SAE2 domain-containing protein. (747 aa) |
| | AFUA_1G07600 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (363 aa) |
| | AFUA_1G07180 | Ribonuclease H, putative. (410 aa) |
| | AFUA_1G04570 | DNA repair protein, putative. (760 aa) |
| | lcl3 | Probable endonuclease lcl3. (296 aa) |
| | AFUA_1G01720 | Protein kinase and ribonuclease Ire1, putative. (1165 aa) |
| | AFUA_6G12140 | Uncharacterized protein. (288 aa) |
| | AFUA_6G11410 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa) |
| | AFUA_6G10900 | UV-endonuclease UVE-1. (598 aa) |
| | AFUA_6G10540 | tRNA splicing endonuclease subunit (Sen54), putative. (460 aa) |
| | AFUA_6G10370 | RNA lariat debranching enzyme, putative. (785 aa) |
| | AFUA_6G07850 | Smr domain protein. (569 aa) |
| | AFUA_6G07500 | DNA excision repair protein Rad2. (1130 aa) |
| | AFUA_7G04270 | 3'-5' exonuclease/helicase (Wrn), putative. (419 aa) |
| | AFUA_2G16820 | Curved DNA-binding protein (42 kDa protein). (426 aa) |
| | AFUA_2G16600 | DNA polymerase. (1105 aa) |
| | AFUA_2G16130 | zf-C2HE domain-containing protein. (280 aa) |
| | AFUA_2G15220 | DNA repair protein Pso2/Snm1, putative. (850 aa) |
| | AFUA_2G14950 | Exonuclease, putative. (750 aa) |
| | AFUA_2G13650 | Endonuclease/exonuclease/phosphatase family protein. (362 aa) |
| | AFUA_2G13340 | Uncharacterized protein. (313 aa) |
| | AFUA_2G11070 | Tyrosyl-DNA phosphodiesterase, putative. (564 aa) |
| | AFUA_2G08750 | Endonuclease. (340 aa) |
| | rat1 | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (1058 aa) |
| | rex3 | RNA exonuclease 3; 3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA; Belongs to the REXO1/REXO3 family. (645 aa) |
| | mus81 | Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (596 aa) |
| | AFUA_3G13260 | Rad2-like endonuclease, putative. (869 aa) |
| | AFUA_2G17230 | NACHT domain protein. (1785 aa) |
| | AFUA_2G16960 | CAF1 family ribonuclease, putative. (573 aa) |
| | AFUA_2G16830 | Endonuclease/exonuclease/phosphatase family protein. (300 aa) |
| | AFUA_3G11820 | RNA exonuclease Rex2, putative. (250 aa) |
| | rny1 | Ribonuclease T2-like; Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration (By similarity). (408 aa) |
