STRINGSTRING
AFUA_4G12210 AFUA_4G12210 AFUA_6G06530 AFUA_6G06530 AFUA_6G06535 AFUA_6G06535 AFUA_6G02530 AFUA_6G02530 slx1 slx1 AFUA_7G05280 AFUA_7G05280 slx4 slx4 AFUA_6G11410 AFUA_6G11410 AFUA_6G07500 AFUA_6G07500 AFUA_4G07290 AFUA_4G07290 AFUA_3G09050 AFUA_3G09050 AFUA_5G12250 AFUA_5G12250 fen1 fen1 AFUA_2G08750 AFUA_2G08750 AFUA_3G13260 AFUA_3G13260 mus81 mus81
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_4G12210DNA replication helicase Dna2, putative. (1657 aa)
AFUA_6G06530Uncharacterized protein. (249 aa)
AFUA_6G06535Uncharacterized protein. (192 aa)
AFUA_6G02530DNA repair protein RAD1, putative. (975 aa)
slx1Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (423 aa)
AFUA_7G05280Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (822 aa)
slx4Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (811 aa)
AFUA_6G11410Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa)
AFUA_6G07500DNA excision repair protein Rad2. (1130 aa)
AFUA_4G07290SAP domain-containing protein. (396 aa)
AFUA_3G09050Exonuclease, putative. (658 aa)
AFUA_5G12250Posttranscriptional regulation nuclease (Mkt1), putative. (731 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
AFUA_2G08750Endonuclease. (340 aa)
AFUA_3G13260Rad2-like endonuclease, putative. (869 aa)
mus81Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (596 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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