STRINGSTRING
AFUA_4G12250 AFUA_4G12250 AFUA_7G00870 AFUA_7G00870 AFUA_7G01550 AFUA_7G01550 USB1 USB1 AFUA_5G01600 AFUA_5G01600 AFUA_5G03120 AFUA_5G03120 AFUA_7G04220 AFUA_7G04220 AFUA_7G04270 AFUA_7G04270 AFUA_7G05280 AFUA_7G05280 rex4 rex4 pan2n2 pan2n2 AFUA_1G04570 AFUA_1G04570 AFUA_6G11410 AFUA_6G11410 AFUA_4G07010 AFUA_4G07010 ysh1 ysh1 AFUA_1G13850 AFUA_1G13850 AFUA_1G11420 AFUA_1G11420 AFUA_5G07370 AFUA_5G07370 AFUA_5G12640 AFUA_5G12640 fen1 fen1 AFUA_3G06160 AFUA_3G06160 AFUA_3G06180 AFUA_3G06180 AFUA_3G09050 AFUA_3G09050 pol2 pol2 AFUA_3G09880 AFUA_3G09880 AFUA_3G11820 AFUA_3G11820 rex3 rex3 AFUA_2G17230 AFUA_2G17230 AFUA_2G16960 AFUA_2G16960 AFUA_2G16830 AFUA_2G16830 AFUA_2G16600 AFUA_2G16600 AFUA_2G16130 AFUA_2G16130 AFUA_2G15220 AFUA_2G15220 AFUA_2G14950 AFUA_2G14950 AFUA_2G11070 AFUA_2G11070 rat1 rat1 ccr4 ccr4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_4G12250Exosome complex exonuclease exoribonuclease (Rrp44), putative; Belongs to the RNR ribonuclease family. (1034 aa)
AFUA_7G00870RNA exonuclease, putative. (423 aa)
AFUA_7G01550Mitochondrial exoribonuclease Cyt-4, putative. (1043 aa)
USB1U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (306 aa)
AFUA_5G01600PHP domain protein. (486 aa)
AFUA_5G031205'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1418 aa)
AFUA_7G04220Protein required for cell viability Rrp17, putative. (251 aa)
AFUA_7G042703'-5' exonuclease/helicase (Wrn), putative. (419 aa)
AFUA_7G05280Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (822 aa)
rex4RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family. (310 aa)
pan2n2PAN2-PAN3 deadenylation complex catalytic subunit pan2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1155 aa)
AFUA_1G04570DNA repair protein, putative. (760 aa)
AFUA_6G11410Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa)
AFUA_4G07010Hydrolase, TatD family protein, putative. (299 aa)
ysh1Endoribonuclease ysh1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. (872 aa)
AFUA_1G13850Uncharacterized protein. (624 aa)
AFUA_1G11420Cell wall biogenesis protein phosphatase Ssd1, putative. (1378 aa)
AFUA_5G07370CCR4-NOT core complex subunit Caf1, putative. (500 aa)
AFUA_5G12640DNA polymerase gamma. (1135 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
AFUA_3G06160Mating locus protein, putative. (250 aa)
AFUA_3G06180DNA lyase Apn2. (648 aa)
AFUA_3G09050Exonuclease, putative. (658 aa)
pol2DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication. (2230 aa)
AFUA_3G09880Exosome complex exonuclease Rrp6, putative. (764 aa)
AFUA_3G11820RNA exonuclease Rex2, putative. (250 aa)
rex3RNA exonuclease 3; 3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA; Belongs to the REXO1/REXO3 family. (645 aa)
AFUA_2G17230NACHT domain protein. (1785 aa)
AFUA_2G16960CAF1 family ribonuclease, putative. (573 aa)
AFUA_2G16830Endonuclease/exonuclease/phosphatase family protein. (300 aa)
AFUA_2G16600DNA polymerase. (1105 aa)
AFUA_2G16130zf-C2HE domain-containing protein. (280 aa)
AFUA_2G15220DNA repair protein Pso2/Snm1, putative. (850 aa)
AFUA_2G14950Exonuclease, putative. (750 aa)
AFUA_2G11070Tyrosyl-DNA phosphodiesterase, putative. (564 aa)
rat15'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (1058 aa)
ccr4Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (696 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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