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| | AFUA_3G05575 | TBP interacting domain protein, putative. (186 aa) |
| | AFUA_5G12895 | SsDNA binding protein Ssb3, putative. (122 aa) |
| | AFUA_1G10355 | 26 proteasome complex subunit Sem1, putative. (83 aa) |
| | AFUA_1G14695 | DNA repair protein Dds20/Mei5, putative. (286 aa) |
| | AFUA_6G06530 | Uncharacterized protein. (249 aa) |
| | AFUA_6G06535 | Uncharacterized protein. (192 aa) |
| | AFUA_6G10965 | Apoptosis-inducing TAF9-like domain 1 family protein, putative. (110 aa) |
| | AFUA_1G03035 | HD superfamily hydrolase, putative. (243 aa) |
| | AFUA_1G03992 | CPSF_A domain-containing protein. (1285 aa) |
| | AFUA_1G13010 | SNF2 family helicase/ATPase PasG, putative. (867 aa) |
| | AFUA_7G00090 | Telomere-associated RecQ helicase, putative. (396 aa) |
| | AFUA_7G02200 | Meiotic recombination protein (Dmc1), putative; Belongs to the RecA family. (338 aa) |
| | AFUA_8G00430 | EthD domain-containing protein. (157 aa) |
| | AFUA_8G07400 | Telomere-associated RecQ helicase, putative. (360 aa) |
| | AFUA_8G05680 | Serine/threonine-protein kinase. (1119 aa) |
| | AFUA_6G02530 | DNA repair protein RAD1, putative. (975 aa) |
| | AFUA_6G02700 | Structural maintenance of chromosome complex subunit SmcA. (1187 aa) |
| | AFUA_6G03770 | Oxidoreductase (Msc7), putative; Belongs to the aldehyde dehydrogenase family. (636 aa) |
| | AFUA_6G03970 | Cell cycle checkpoint protein (Hus1), putative. (373 aa) |
| | kae1 | tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (352 aa) |
| | AFUA_5G02430 | ATP dependent DNA ligase domain protein. (912 aa) |
| | AFUA_5G02520 | DNA helicase; Belongs to the MCM family. (718 aa) |
| | slx1 | Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (423 aa) |
| | AFUA_5G04070 | Meiosis-specific topoisomerase Spo11, putative. (388 aa) |
| | AFUA_3G02390 | DNA repair protein Nse1, putative. (336 aa) |
| | AFUA_7G04270 | 3'-5' exonuclease/helicase (Wrn), putative. (419 aa) |
| | msh3 | DNA mismatch repair protein msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1123 aa) |
| | AFUA_7G05280 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (822 aa) |
| | AFUA_7G05890 | Uncharacterized protein. (252 aa) |
| | AFUA_2G06320 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (529 aa) |
| | AFUA_2G05850 | Double-strand-break repair protein rad21. (606 aa) |
| | AFUA_2G05470 | Sister chromatid cohesion protein. (1772 aa) |
| | AFUA_2G04960 | RecQ family helicase MusN. (1563 aa) |
| | cgi121 | EKC/KEOPS complex subunit cgi121; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Cgi121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transc [...] (189 aa) |
| | slx4 | Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (811 aa) |
| | AFUA_2G02660 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa) |
| | ku80 | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (725 aa) |
| | AFUA_2G00090 | Telomere-associated RecQ helicase, putative. (460 aa) |
| | AFUA_1G07195 | APH domain-containing protein. (379 aa) |
| | AFUA_1G06360 | MAGE domain-containing protein. (343 aa) |
| | AFUA_1G03920 | DNA helicase; Belongs to the MCM family. (892 aa) |
| | AFUA_1G02060 | Pachytene checkpoint component Pch2, putative; Belongs to the AAA ATPase family. (455 aa) |
| | AFUA_1G02000 | DNA mismatch repair protein Msh4, putative. (840 aa) |
| | AFUA_6G14720 | Telomere-associated RecQ helicase, putative. (1445 aa) |
| | AFUA_6G14690 | Telomere-associated RecQ helicase, putative. (352 aa) |
| | AFUA_6G14670 | C2H2-type domain-containing protein. (146 aa) |
| | ubc2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa) |
| | AFUA_6G13690 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1660 aa) |
| | AFUA_6G13080 | DEAD/DEAH box DNA helicase (Mer3), putative. (1439 aa) |
| | AFUA_6G12910 | DsDNA-dependent ATPase Rad54, putative. (807 aa) |
| | AFUA_6G11410 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa) |
| | AFUA_6G11130 | Possible replication factor-a protein. (289 aa) |
| | AFUA_6G10670 | Uncharacterized protein. (207 aa) |
| | AFUA_6G07700 | Chromosomal organization and DNA repair protein Mms21, putative. (497 aa) |
| | AFUA_4G06260 | Mating-type switch/DNA repair protein Swi10/Rad10, putative. (341 aa) |
| | AFUA_4G06970 | RAD52 DNA repair protein RADC. (564 aa) |
| | AFUA_4G07230 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (538 aa) |
| | AFUA_4G09640 | Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (189 aa) |
| | psf3 | DNA replication complex GINS protein psf3; The GINS complex plays an essential role in the initiation of DNA replication. (178 aa) |
| | AFUA_4G12430 | PSF1 domain protein. (253 aa) |
| | AFUA_4G12670 | DNA repair protein Rad1, putative. (491 aa) |
| | AFUA_4G12680 | DNA repair protein Rad50. (1312 aa) |
| | AFUA_1G15310 | DNA replication initiation factor Cdc45. (860 aa) |
| | AFUA_1G15120 | DsDNA-dependent ATPase (Rad54b), putative. (969 aa) |
| | AFUA_1G12520 | DNA repair protein (Rad57), putative. (647 aa) |
| | AFUA_1G11170 | DNA mismatch repair protein Msh5, putative. (830 aa) |
| | AFUA_1G10540 | SIR2 family histone deacetylase (Hst4), putative. (614 aa) |
| | AFUA_1G10410 | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa) |
| | AFUA_1G09530 | Uncharacterized protein. (724 aa) |
| | AFUA_1G08860 | Meiotic recombination protein Ski8/Rec14, putative. (209 aa) |
| | AFUA_5G06080 | DNA repair protein Swi5/Sae3, putative. (114 aa) |
| | ino80 | Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1708 aa) |
| | AFUA_5G07740 | DSB repair complex subunit Ku70, putative. (691 aa) |
| | AFUA_5G08660 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (447 aa) |
| | AFUA_5G10890 | DNA helicase; Belongs to the MCM family. (956 aa) |
| | AFUA_5G11700 | DNA mismatch repair protein Mlh1, putative. (709 aa) |
| | AFUA_5G11870 | WD repeat protein. (1051 aa) |
| | AFUA_5G12010 | Serine/threonine-protein phosphatase. (474 aa) |
| | lig4 | DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. (979 aa) |
| | AFUA_5G13220 | ERCC4 domain-containing protein. (649 aa) |
| | AFUA_5G13330 | Uncharacterized protein. (344 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (788 aa) |
| | AFUA_5G15150 | Telomere-associated RecQ helicase, putative. (395 aa) |
| | AFUA_3G05440 | DNA repair protein Rad18, putative. (1082 aa) |
| | AFUA_3G05540 | Cell cycle protein kinase, putative. (464 aa) |
| | AFUA_3G06780 | DNA polymerase. (1656 aa) |
| | AFUA_3G07280 | Uncharacterized protein. (335 aa) |
| | AFUA_3G08800 | DUF1767 domain-containing protein. (249 aa) |
| | AFUA_3G09050 | Exonuclease, putative. (658 aa) |
| | sld2 | DNA replication regulator sld2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (535 aa) |
| | AFUA_3G09850 | DNA mismatch repair protein Msh2, putative; Component of the post-replicative DNA mismatch repair system (MMR). (940 aa) |
| | AFUA_3G11140 | DNA ligase. (833 aa) |
| | mus81 | Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (596 aa) |
| | AFUA_3G13260 | Rad2-like endonuclease, putative. (869 aa) |
| | AFUA_3G14010 | DNA helicase; Belongs to the MCM family. (896 aa) |
| | AFUA_3G14460 | Rad51 family DNA repair protein, putative. (456 aa) |
| | AFUA_3G15395 | Telomere-associated RecQ helicase, putative. (714 aa) |
| | AFUA_2G18100 | Telomere-associated RecQ helicase, putative. (850 aa) |
| | AFUA_2G17190 | AAA domain-containing protein. (1129 aa) |
| | AFUA_2G12940 | Uncharacterized protein. (2275 aa) |
| | psf2 | DNA replication complex GINS protein psf2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (271 aa) |
| | AFUA_2G10640 | Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. (508 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (854 aa) |
| | AFUA_2G09560 | Mitochondrial genome maintenance protein Mgm101, putative. (306 aa) |
| | AFUA_2G09060 | DNA helicase; Belongs to the MCM family. (1023 aa) |
| | AFUA_2G09010 | DNA ligase. (909 aa) |
| | AFUA_2G08750 | Endonuclease. (340 aa) |
