STRINGSTRING
AFUA_1G13010 AFUA_1G13010 AFUA_7G00090 AFUA_7G00090 AFUA_7G02200 AFUA_7G02200 AFUA_8G00430 AFUA_8G00430 AFUA_8G07400 AFUA_8G07400 AFUA_6G02530 AFUA_6G02530 kae1 kae1 msh3 msh3 AFUA_7G05890 AFUA_7G05890 AFUA_2G06320 AFUA_2G06320 AFUA_2G04960 AFUA_2G04960 cgi121 cgi121 AFUA_2G00090 AFUA_2G00090 ubc2 ubc2 AFUA_4G06260 AFUA_4G06260 AFUA_4G06970 AFUA_4G06970 AFUA_4G12680 AFUA_4G12680 AFUA_1G12520 AFUA_1G12520 AFUA_1G10410 AFUA_1G10410 ino80 ino80 AFUA_5G15150 AFUA_5G15150 AFUA_3G09850 AFUA_3G09850 AFUA_3G13260 AFUA_3G13260 AFUA_3G15395 AFUA_3G15395 AFUA_2G18100 AFUA_2G18100
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_1G13010SNF2 family helicase/ATPase PasG, putative. (867 aa)
AFUA_7G00090Telomere-associated RecQ helicase, putative. (396 aa)
AFUA_7G02200Meiotic recombination protein (Dmc1), putative; Belongs to the RecA family. (338 aa)
AFUA_8G00430EthD domain-containing protein. (157 aa)
AFUA_8G07400Telomere-associated RecQ helicase, putative. (360 aa)
AFUA_6G02530DNA repair protein RAD1, putative. (975 aa)
kae1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (352 aa)
msh3DNA mismatch repair protein msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1123 aa)
AFUA_7G05890Uncharacterized protein. (252 aa)
AFUA_2G06320Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (529 aa)
AFUA_2G04960RecQ family helicase MusN. (1563 aa)
cgi121EKC/KEOPS complex subunit cgi121; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Cgi121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transc [...] (189 aa)
AFUA_2G00090Telomere-associated RecQ helicase, putative. (460 aa)
ubc2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
AFUA_4G06260Mating-type switch/DNA repair protein Swi10/Rad10, putative. (341 aa)
AFUA_4G06970RAD52 DNA repair protein RADC. (564 aa)
AFUA_4G12680DNA repair protein Rad50. (1312 aa)
AFUA_1G12520DNA repair protein (Rad57), putative. (647 aa)
AFUA_1G10410DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
ino80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1708 aa)
AFUA_5G15150Telomere-associated RecQ helicase, putative. (395 aa)
AFUA_3G09850DNA mismatch repair protein Msh2, putative; Component of the post-replicative DNA mismatch repair system (MMR). (940 aa)
AFUA_3G13260Rad2-like endonuclease, putative. (869 aa)
AFUA_3G15395Telomere-associated RecQ helicase, putative. (714 aa)
AFUA_2G18100Telomere-associated RecQ helicase, putative. (850 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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