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| | AFUA_4G12670 | DNA repair protein Rad1, putative. (491 aa) |
| | AFUA_4G12310 | DNA repair protein Rtt107, putative. (856 aa) |
| | AFUA_4G12210 | DNA replication helicase Dna2, putative. (1657 aa) |
| | AFUA_4G12080 | Ubiquitin conjugating enzyme (MmsB), putative. (139 aa) |
| | AFUA_4G11930 | Formamidopyrimidine-DNA glycosylase, putative. (367 aa) |
| | AFUA_4G11690 | RNA polymerase II transcription factor related protein. (642 aa) |
| | psf3 | DNA replication complex GINS protein psf3; The GINS complex plays an essential role in the initiation of DNA replication. (178 aa) |
| | AFUA_4G11290 | Proteasome activator subunit 4, putative. (1965 aa) |
| | AFUA_4G11180 | AAA family ATPase, putative. (539 aa) |
| | AFUA_4G11140 | DNA polymerase iota, putative. (596 aa) |
| | rvb1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa) |
| | eaf3 | Chromatin modification-related protein eaf3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (330 aa) |
| | AFUA_4G10540 | Transcription regulator BDF1, putative. (832 aa) |
| | yaf9 | Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (252 aa) |
| | AFUA_4G09620 | WD repeat protein. (485 aa) |
| | AFUA_4G08900 | CDK-activating kinase assembly factor MAT1. (379 aa) |
| | AFUA_4G08300 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1213 aa) |
| | eaf1 | Chromatin modification-related protein eaf1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (1467 aa) |
| | swc4 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (588 aa) |
| | AFUA_4G07230 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (538 aa) |
| | AFUA_4G06970 | RAD52 DNA repair protein RADC. (564 aa) |
| | AFUA_4G06800 | DNA-3-methyladenine glycosylase, putative. (382 aa) |
| | AFUA_4G06490 | DNA mismatch repair protein (Mlh3), putative. (916 aa) |
| | AFUA_4G06260 | Mating-type switch/DNA repair protein Swi10/Rad10, putative. (341 aa) |
| | AFUA_4G06180 | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (364 aa) |
| | AFUA_4G06120 | RSC complex subunit Sfh1, putative. (566 aa) |
| | AFUA_6G06550 | SNF2 family helicase/ATPase, putative. (1461 aa) |
| | AFUA_6G06780 | Proteasome regulatory particle subunit Rpt4, putative; Belongs to the AAA ATPase family. (393 aa) |
| | AFUA_6G06820 | DNA 3'-phosphatase Tpp1, putative. (472 aa) |
| | AFUA_6G07500 | DNA excision repair protein Rad2. (1130 aa) |
| | AFUA_6G07700 | Chromosomal organization and DNA repair protein Mms21, putative. (497 aa) |
| | AFUA_6G07990 | Oxidoreductase, 2OG-Fe(II) oxygenase family family. (359 aa) |
| | AFUA_6G08110 | DNA (Apurinic or apyrimidinic site) lyase, endon uclease. (561 aa) |
| | AFUA_6G08330 | Uncharacterized protein. (664 aa) |
| | AFUA_6G08570 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1154 aa) |
| | AFUA_6G09220 | SNF2 family helicase/ATPase, putative. (1141 aa) |
| | AFUA_6G10560 | DNA polymerase delta subunit 4, putative. (193 aa) |
| | AFUA_6G10900 | UV-endonuclease UVE-1. (598 aa) |
| | AFUA_6G10980 | UV-damaged DNA binding protein, putative. (1140 aa) |
| | AFUA_6G11130 | Possible replication factor-a protein. (289 aa) |
| | AFUA_6G11410 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa) |
| | AFUA_6G12330 | DNA damage-binding protein cmr1; DNA-binding protein that binds to both single- and double- stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes. (527 aa) |
| | AFUA_6G12420 | SprT family metallopeptidase, putative. (707 aa) |
| | AFUA_6G12910 | DsDNA-dependent ATPase Rad54, putative. (807 aa) |
| | AFUA_6G13160 | Serine/threonine protein kinase, putative. (514 aa) |
| | AFUA_6G13290 | SWI/SNF family DNA-dependent ATPase Ris1, putative. (1376 aa) |
| | ubc2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa) |
| | AFUA_6G14670 | C2H2-type domain-containing protein. (146 aa) |
| | AFUA_6G14690 | Telomere-associated RecQ helicase, putative. (352 aa) |
| | AFUA_6G14720 | Telomere-associated RecQ helicase, putative. (1445 aa) |
| | AFUA_1G00630 | SWI/SNF family DNA-dependent ATPase, putative. (1005 aa) |
| | AFUA_1G01600 | Deoxyribodipyrimidine photo-lyase Phr1, putative. (586 aa) |
| | rvb2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (469 aa) |
| | mph1 | ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1101 aa) |
| | AFUA_1G03410 | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (500 aa) |
| | AFUA_1G03920 | DNA helicase; Belongs to the MCM family. (892 aa) |
| | AFUA_1G04570 | DNA repair protein, putative. (760 aa) |
| | AFUA_1G04900 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (219 aa) |
| | AFUA_1G04910 | Vezatin domain-containing protein. (629 aa) |
| | AFUA_1G04950 | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa) |
| | AFUA_1G05260 | DNA-directed DNA polymerase theta, putative. (940 aa) |
| | AFUA_1G06360 | MAGE domain-containing protein. (343 aa) |
| | AFUA_1G07320 | Chromosome segregation protein (SepB), putative. (841 aa) |
| | AFUA_1G07600 | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (363 aa) |
| | spt16 | FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1019 aa) |
| | AFUA_2G00870 | Uncharacterized protein. (430 aa) |
| | AFUA_2G01110 | Uncharacterized protein. (491 aa) |
| | NTH1 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (432 aa) |
| | AFUA_2G01900 | RNA polymerase II transcription elongation factor Rtf1p, putative. (607 aa) |
| | AFUA_2G01910 | MRC1 domain-containing protein. (1284 aa) |
| | AFUA_2G02090 | Methylated-DNA-protein-cysteine methyltransferase. (150 aa) |
| | AFUA_2G02530 | Casein kinase I, putative; Belongs to the protein kinase superfamily. (383 aa) |
| | ku80 | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (725 aa) |
| | AFUA_2G02660 | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa) |
| | slx4 | Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (811 aa) |
| | AFUA_2G03460 | C6 transcription factor (Leu3), putative. (920 aa) |
| | AFUA_2G03750 | DNA excision repair protein (Rad26L), putative. (1008 aa) |
| | AFUA_2G03900 | Acetamidase/formamidase family protein. (320 aa) |
| | AFUA_2G03910 | ATP-depentend DNA helicase, putative. (1001 aa) |
| | AFUA_2G04860 | DNA repair protein Rad4, putative. (916 aa) |
| | AFUA_2G05470 | Sister chromatid cohesion protein. (1772 aa) |
| | esa1 | Histone acetyltransferase esa1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (483 aa) |
| | AFUA_2G05850 | Double-strand-break repair protein rad21. (606 aa) |
| | arp4 | Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (466 aa) |
| | AFUA_2G06130 | Fungal specific transcription factor, putative. (651 aa) |
| | UNG1 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (376 aa) |
| | AFUA_2G06190 | DNA polymerase epsilon subunit B, putative. (762 aa) |
| | AFUA_2G06320 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (529 aa) |
| | AFUA_7G08480 | SWI/SNF family DNA-dependent ATPase, putative. (707 aa) |
| | AFUA_7G06280 | Uncharacterized protein. (401 aa) |
| | AFUA_7G05890 | Uncharacterized protein. (252 aa) |
| | AFUA_7G05440 | Transcription factor Tos4, putative. (514 aa) |
| | pob3 | FACT complex subunit pob3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (573 aa) |
| | AFUA_7G05320 | DNA N-glycosylase, putative. (349 aa) |
| | AFUA_7G05280 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (822 aa) |
| | msh3 | DNA mismatch repair protein msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1123 aa) |
| | AFUA_7G03830 | DNA repair protein Rad7, protein. (642 aa) |
| | AFUA_7G03820 | DNA excision repair protein Rad16, putative. (940 aa) |
| | AFUA_7G03750 | Cell-cycle checkpoint protein kinase, putative; Belongs to the protein kinase superfamily. (409 aa) |
| | AFUA_3G01310 | Uncharacterized protein. (101 aa) |
| | AFUA_3G02390 | DNA repair protein Nse1, putative. (336 aa) |
| | AFUA_5G04070 | Meiosis-specific topoisomerase Spo11, putative. (388 aa) |
| | AFUA_5G04020 | DNA damage repair protein (Rad9), putative. (1338 aa) |
| | slx1 | Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (423 aa) |
| | AFUA_5G03320 | TFIIH complex helicase Ssl2, putative. (830 aa) |
| | AFUA_5G02570 | Histone acetylase complex subunit Paf400, putative; Belongs to the PI3/PI4-kinase family. (3896 aa) |
| | AFUA_5G02520 | DNA helicase; Belongs to the MCM family. (718 aa) |
| | AFUA_5G02430 | ATP dependent DNA ligase domain protein. (912 aa) |
| | AFUA_5G01870 | DNA replication factor C subunit Rfc3, putative. (396 aa) |
| | AFUA_5G01800 | DNA repair protein Rad14, putative. (301 aa) |
| | AFUA_6G05040 | DNA replication factor C subunit Rfc4, putative. (348 aa) |
| | epl1 | Enhancer of polycomb-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity). (582 aa) |
| | AFUA_6G04350 | Uncharacterized protein. (277 aa) |
| | AFUA_6G03970 | Cell cycle checkpoint protein (Hus1), putative. (373 aa) |
| | AFUA_6G02900 | Rad21/Rec8 N terminal domain protein. (741 aa) |
| | AFUA_6G02700 | Structural maintenance of chromosome complex subunit SmcA. (1187 aa) |
| | sub2 | ATP-dependent RNA helicase sub2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (448 aa) |
| | AFUA_6G02530 | DNA repair protein RAD1, putative. (975 aa) |
| | AFUA_6G02470 | Fumarate hydratase, putative. (582 aa) |
| | AFUA_6G02420 | Ubiquitin conjugating enzyme (UbcM), putative; Belongs to the ubiquitin-conjugating enzyme family. (149 aa) |
| | AFUA_8G04750 | DNA mismatch repair protein Msh1, putative. (1018 aa) |
| | AFUA_8G04810 | Casein kinase, putative; Belongs to the protein kinase superfamily. (336 aa) |
| | AFUA_8G05370 | DNA repair/transcription protein, putative. (1063 aa) |
| | AFUA_8G05820 | DNA mismatch repair protein, putative. (882 aa) |
| | AFUA_8G02820 | Cell cycle checkpoint protein Rad17, putative. (722 aa) |
| | AFUA_7G02200 | Meiotic recombination protein (Dmc1), putative; Belongs to the RecA family. (338 aa) |
| | AFUA_7G02100 | Uncharacterized protein. (262 aa) |
| | AFUA_7G01870 | Chromatin modification-related protein. (417 aa) |
| | AFUA_7G01270 | DNA-directed polymerase kappa, putative. (614 aa) |
| | AFUA_7G00530 | NACHT and Ankyrin domain protein. (1334 aa) |
| | AFUA_4G03150 | MGMT family protein. (152 aa) |
| | AFUA_4G03840 | DNA repair protein Rhp26/Rad26, putative. (1214 aa) |
| | AFUA_4G04360 | RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (479 aa) |
| | tof1 | Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with csm3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1176 aa) |
| | AFUA_4G04660 | Proteasome regulatory particle subunit Rpt6, putative; Belongs to the AAA ATPase family. (389 aa) |
| | AFUA_4G04760 | Inositol kinase kinase (UvsB), putative; Belongs to the PI3/PI4-kinase family. (2449 aa) |
| | AFUA_1G14080 | Integral membrane protein Pth11-like, putative. (535 aa) |
| | AFUA_1G12640 | Zinc metalloproteinase, putative. (341 aa) |
| | csm3 | Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with tof1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (270 aa) |
| | AFUA_5G04333 | General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (456 aa) |
| | AFUA_7G04783 | Pre-mRNA splicing factor, putative. (889 aa) |
| | AFUA_1G03992 | CPSF_A domain-containing protein. (1285 aa) |
| | AFUA_1G03035 | HD superfamily hydrolase, putative. (243 aa) |
| | AFUA_6G13340 | Mismatch-specific thymine-DNA glycosylase, putative. (364 aa) |
| | AFUA_6G10965 | Apoptosis-inducing TAF9-like domain 1 family protein, putative. (110 aa) |
| | AFUA_6G06535 | Uncharacterized protein. (192 aa) |
| | AFUA_6G06530 | Uncharacterized protein. (249 aa) |
| | AFUA_1G14695 | DNA repair protein Dds20/Mei5, putative. (286 aa) |
| | AFUA_1G10355 | 26 proteasome complex subunit Sem1, putative. (83 aa) |
| | AFUA_5G12895 | SsDNA binding protein Ssb3, putative. (122 aa) |
| | AFUA_3G05540 | Cell cycle protein kinase, putative. (464 aa) |
| | AFUA_3G05440 | DNA repair protein Rad18, putative. (1082 aa) |
| | hta1 | Histone H2A; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (133 aa) |
| | AFUA_5G14820 | Replication factor C subunit. (389 aa) |
| | AFUA_5G13870 | mRNA export factor Mlo3, putative. (85 aa) |
| | AFUA_5G13860 | RNA annealing protein Yra1, putative. (170 aa) |
| | AFUA_5G13790 | C6 transcription factor (Acr-2), putative. (456 aa) |
| | AFUA_5G13510 | Cell cycle control protein (Cwf8), putative. (476 aa) |
| | AFUA_5G13380 | BRCT domain protein. (786 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (788 aa) |
| | AFUA_5G13220 | ERCC4 domain-containing protein. (649 aa) |
| | AFUA_5G12680 | Ubiquitin ligase subunit CulD, putative; Belongs to the cullin family. (911 aa) |
| | tel1 | Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2796 aa) |
| | rad5 | DNA repair protein rad5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1245 aa) |
| | AFUA_5G12250 | Posttranscriptional regulation nuclease (Mkt1), putative. (731 aa) |
| | dot1 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (502 aa) |
| | lig4 | DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. (979 aa) |
| | AFUA_5G12010 | Serine/threonine-protein phosphatase. (474 aa) |
| | AFUA_5G11870 | WD repeat protein. (1051 aa) |
| | AFUA_5G11700 | DNA mismatch repair protein Mlh1, putative. (709 aa) |
| | AFUA_5G11580 | Transcription factor TFIIH subunit Tfb4, putative. (387 aa) |
| | AFUA_5G10890 | DNA helicase; Belongs to the MCM family. (956 aa) |
| | AFUA_5G09540 | Histone acetyltransferase. (543 aa) |
| | AFUA_5G09000 | Sister chromatid cohesion protein (Eso1), putative. (672 aa) |
| | AFUA_5G08660 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (447 aa) |
| | AFUA_5G08370 | Polyubiquitin binding protein (Doa1/Ufd3), putative. (790 aa) |
| | AFUA_5G08260 | Uncharacterized protein. (215 aa) |
| | AFUA_5G07830 | DUF625 domain protein, putative. (885 aa) |
| | AFUA_5G07740 | DSB repair complex subunit Ku70, putative. (691 aa) |
| | AFUA_5G07320 | Poly [ADP-ribose] polymerase. (688 aa) |
| | AFUA_5G06750 | Protein kinase (Gcn2), putative. (1592 aa) |
| | AFUA_5G06600 | SNF2 family helicase/ATPase, putative. (1827 aa) |
| | AFUA_5G06350 | DNA repair and transcription factor Ada, putative. (228 aa) |
| | AFUA_5G06330 | RSC complex subunit (Sth1), putative. (1406 aa) |
| | ino80 | Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1708 aa) |
| | AFUA_5G06080 | DNA repair protein Swi5/Sae3, putative. (114 aa) |
| | AFUA_5G06040 | UV excision repair protein (RadW), putative. (376 aa) |
| | AFUA_1G09530 | Uncharacterized protein. (724 aa) |
| | AFUA_1G10040 | HMG box protein, putative. (399 aa) |
| | AFUA_1G10410 | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa) |
| | AFUA_1G10480 | DNA polymerase POL4, putative. (702 aa) |
| | AFUA_1G10540 | SIR2 family histone deacetylase (Hst4), putative. (614 aa) |
| | AFUA_1G10550 | CBF/NF-Y family transcription factor, putative. (282 aa) |
| | AFUA_1G11170 | DNA mismatch repair protein Msh5, putative. (830 aa) |
| | AFUA_1G12520 | DNA repair protein (Rad57), putative. (647 aa) |
| | AFUA_1G13080 | BRCT domain protein. (368 aa) |
| | AFUA_1G13910 | TFIIH complex helicase Rad3, putative. (770 aa) |
| | AFUA_1G15120 | DsDNA-dependent ATPase (Rad54b), putative. (969 aa) |
| | AFUA_1G15310 | DNA replication initiation factor Cdc45. (860 aa) |
| | AFUA_1G15410 | CUE domain protein, putative. (493 aa) |
| | AFUA_4G13150 | DUF159 domain protein. (415 aa) |
| | AFUA_4G12680 | DNA repair protein Rad50. (1312 aa) |
| | AFUA_4G12430 | PSF1 domain protein. (253 aa) |
| | AFUA_2G07890 | BRCT domain-containing protein. (307 aa) |
| | AFUA_2G08540 | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (128 aa) |
| | AFUA_2G08840 | Terminal deoxynucleotidyl transferase, putative. (704 aa) |
| | AFUA_2G09010 | DNA ligase. (909 aa) |
| | AFUA_2G09060 | DNA helicase; Belongs to the MCM family. (1023 aa) |
| | AFUA_2G09120 | SNF2 family helicase, putative. (2115 aa) |
| | AFUA_2G09560 | Mitochondrial genome maintenance protein Mgm101, putative. (306 aa) |
| | AFUA_2G09730 | Uncharacterized protein. (319 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (854 aa) |
| | AFUA_2G10710 | DNA repair protein rad9, putative. (376 aa) |
| | AFUA_2G10730 | DNA polymerase. (1462 aa) |
| | AFUA_2G10820 | DEAD/DEAH box helicase, putative. (1206 aa) |
| | AFUA_2G10990 | Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (720 aa) |
| | AFUA_2G11070 | Tyrosyl-DNA phosphodiesterase, putative. (564 aa) |
| | psf2 | DNA replication complex GINS protein psf2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (271 aa) |
| | AFUA_2G11660 | Rad4 family protein. (917 aa) |
| | hat1 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (570 aa) |
| | AFUA_2G12100 | Uncharacterized protein. (248 aa) |
| | AFUA_2G12220 | Replication factor C subunit 1. (1085 aa) |
| | AFUA_2G12250 | DNA replication factor C subunit Rfc5, putative. (294 aa) |
| | AFUA_2G12940 | Uncharacterized protein. (2275 aa) |
| | AFUA_2G12960 | PAPA-1-like conserved region protein. (381 aa) |
| | AFUA_2G13340 | Uncharacterized protein. (313 aa) |
| | AFUA_2G13410 | DNA mismatch repair protein (Pms1), putative. (1044 aa) |
| | AFUA_2G13650 | Endonuclease/exonuclease/phosphatase family protein. (362 aa) |
| | AFUA_2G14920 | Protein kinase, putative. (1028 aa) |
| | AFUA_2G15220 | DNA repair protein Pso2/Snm1, putative. (850 aa) |
| | AFUA_2G15760 | Poly(A)+ RNA transport protein (UbaA), putative; Belongs to the ubiquitin-activating E1 family. (1028 aa) |
| | AFUA_2G15880 | Mitotic spindle checkpoint protein (Mad2B), putative. (290 aa) |
| | AFUA_2G16130 | zf-C2HE domain-containing protein. (280 aa) |
| | AFUA_2G16600 | DNA polymerase. (1105 aa) |
| | rad18 | Postreplication repair E3 ubiquitin-protein ligase rad18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. (418 aa) |
| | AFUA_2G16710 | Uncharacterized protein. (438 aa) |
| | AFUA_2G16850 | Sister chromatid cohesion and DNA repair protein (BimD), putative. (1492 aa) |
| | AFUA_2G17190 | AAA domain-containing protein. (1129 aa) |
| | AFUA_2G17230 | NACHT domain protein. (1785 aa) |
| | tfb5 | General transcription and DNA repair factor IIH subunit tfb5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (72 aa) |
| | AFUA_3G14460 | Rad51 family DNA repair protein, putative. (456 aa) |
| | AFUA_3G14010 | DNA helicase; Belongs to the MCM family. (896 aa) |
| | AFUA_3G13260 | Rad2-like endonuclease, putative. (869 aa) |
| | mus81 | Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (596 aa) |
| | AFUA_3G12660 | C6 finger domain protein Acr-2, putative. (624 aa) |
| | AFUA_3G12250 | Protein-tyrosine phosphatase, putative. (613 aa) |
| | AFUA_3G11740 | RNAPII degradation factor Def1, putative. (905 aa) |
| | nhp6 | Non-histone chromosomal protein 6; DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity). (104 aa) |
| | AFUA_3G11140 | DNA ligase. (833 aa) |
| | AFUA_3G10960 | Cell wall protein, putative. (267 aa) |
| | AFUA_3G09850 | DNA mismatch repair protein Msh2, putative; Component of the post-replicative DNA mismatch repair system (MMR). (940 aa) |
| | pol2 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication. (2230 aa) |
| | sld2 | DNA replication regulator sld2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (535 aa) |
| | AFUA_3G09050 | Exonuclease, putative. (658 aa) |
| | AFUA_3G08800 | DUF1767 domain-containing protein. (249 aa) |
| | AFUA_3G08300 | DNA replication factor C subunit Rfc2, putative. (394 aa) |
| | AFUA_3G08220 | NUDIX domain protein. (398 aa) |
| | AFUA_3G08190 | Uncharacterized protein. (257 aa) |
| | AFUA_3G06780 | DNA polymerase. (1656 aa) |
| | AFUA_3G06700 | COP9 signalosome subunit 2 (CsnB), putative. (504 aa) |
| | AFUA_3G06290 | C6 transcription factor, putative. (379 aa) |
| | AFUA_3G06180 | DNA lyase Apn2. (648 aa) |
| | AFUA_3G06160 | Mating locus protein, putative. (250 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa) |
| | chl1 | ATP-dependent DNA helicase chl1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (782 aa) |
