STRINGSTRING
AFUA_3G12250 AFUA_3G12250 AFUA_5G13392 AFUA_5G13392 AFUA_5G08965 AFUA_5G08965 AFUA_1G09757 AFUA_1G09757 AFUA_1G13195 AFUA_1G13195 atg12 atg12 AFUA_6G05174 AFUA_6G05174 MZM1 MZM1 AFUA_1G11870 AFUA_1G11870 AFUA_1G13330 AFUA_1G13330 AFUA_1G13470 AFUA_1G13470 AFUA_4G01260 AFUA_4G01260 AFUA_4G01460 AFUA_4G01460 AFUA_4G04620 AFUA_4G04620 AFUA_4G04060 AFUA_4G04060 AFUA_4G03990 AFUA_4G03990 AFUA_7G01860 AFUA_7G01860 AFUA_7G02030 AFUA_7G02030 AFUA_7G02240 AFUA_7G02240 AFUA_7G02360 AFUA_7G02360 AFUA_7G02470 AFUA_7G02470 AFUA_7G02490 AFUA_7G02490 AFUA_8G00160 AFUA_8G00160 AFUA_8G02840 AFUA_8G02840 AFUA_8G04750 AFUA_8G04750 AFUA_6G02930 AFUA_6G02930 AFUA_6G02960 AFUA_6G02960 AFUA_6G04030 AFUA_6G04030 AFUA_6G04310 AFUA_6G04310 mmm1 mmm1 AFUA_6G04900 AFUA_6G04900 AFUA_6G04980 AFUA_6G04980 AFUA_6G05110 AFUA_6G05110 AFUA_5G02200 AFUA_5G02200 AFUA_5G03040 AFUA_5G03040 AFUA_5G03630 AFUA_5G03630 AFUA_5G03640 AFUA_5G03640 AFUA_5G03910 AFUA_5G03910 AFUA_7G04150 AFUA_7G04150 AFUA_7G04670 AFUA_7G04670 mia40 mia40 AFUA_7G05530 AFUA_7G05530 AFUA_7G05920 AFUA_7G05920 AFUA_7G06040 AFUA_7G06040 AFUA_7G08630 AFUA_7G08630 AFUA_2G06250 AFUA_2G06250 AFUA_2G05090 AFUA_2G05090 atg13 atg13 AFUA_2G04430 AFUA_2G04430 AFUA_2G04270 AFUA_2G04270 AFUA_2G03840 AFUA_2G03840 tim50 tim50 AFUA_2G03400 AFUA_2G03400 AFUA_2G03220 AFUA_2G03220 AFUA_2G03100 AFUA_2G03100 AFUA_2G03010 AFUA_2G03010 pam18 pam18 AFUA_2G02500 AFUA_2G02500 AFUA_2G02430 AFUA_2G02430 AFUA_2G01660 AFUA_2G01660 tim9 tim9 AFUA_1G07360 AFUA_1G07360 yme2 yme2 AFUA_1G06880 AFUA_1G06880 AFUA_1G06610 AFUA_1G06610 AFUA_1G05180 AFUA_1G05180 sar1 sar1 AFUA_1G04930 AFUA_1G04930 tim10 tim10 AFUA_1G02620 AFUA_1G02620 AFUA_1G02170 AFUA_1G02170 pam17 pam17 AFUA_1G00230 AFUA_1G00230 atg2 atg2 acoA acoA AFUA_6G12860 AFUA_6G12860 atg9 atg9 AFUA_6G12280 AFUA_6G12280 AFUA_6G11380 AFUA_6G11380 AFUA_6G10900 AFUA_6G10900 AFUA_6G10700 AFUA_6G10700 AFUA_6G09810 AFUA_6G09810 AFUA_6G09390 AFUA_6G09390 oct1 oct1 AFUA_6G08630 AFUA_6G08630 AFUA_6G08570 AFUA_6G08570 AFUA_6G08230 AFUA_6G08230 gem1 gem1 atg5 atg5 AFUA_6G06570 AFUA_6G06570 AFUA_6G06420 AFUA_6G06420 AFUA_6G06360 AFUA_6G06360 AFUA_4G05860 AFUA_4G05860 AFUA_4G05920 AFUA_4G05920 AFUA_4G05990 AFUA_4G05990 AFUA_4G06760 AFUA_4G06760 AFUA_4G06790 AFUA_4G06790 AFUA_4G07290 AFUA_4G07290 mic60 mic60 rcf1 rcf1 atg1 atg1 mdm34 mdm34 AFUA_4G11530 AFUA_4G11530 AFUA_4G11560 AFUA_4G11560 tim54 tim54 AFUA_4G11940 AFUA_4G11940 snx4 snx4 AFUA_4G13240 AFUA_4G13240 AFUA_1G16280 AFUA_1G16280 dml1 dml1 mdm12 mdm12 AFUA_1G14590 AFUA_1G14590 AFUA_1G14200 AFUA_1G14200 AFUA_1G13180 AFUA_1G13180 AFUA_1G12250 AFUA_1G12250 AFUA_1G11970 AFUA_1G11970 AFUA_1G11860 AFUA_1G11860 AFUA_1G11180 AFUA_1G11180 AFUA_1G10490 AFUA_1G10490 AFUA_1G09840 AFUA_1G09840 AFUA_1G09780 AFUA_1G09780 AFUA_1G09420 AFUA_1G09420 AFUA_5G06380 AFUA_5G06380 AFUA_5G06540 AFUA_5G06540 MEF2 MEF2 AFUA_5G07380 AFUA_5G07380 AFUA_5G07890 AFUA_5G07890 atg3 atg3 AFUA_5G08530 AFUA_5G08530 she9 she9 AFUA_5G10820 AFUA_5G10820 atg18 atg18 AFUA_5G12610 AFUA_5G12610 AFUA_5G12640 AFUA_5G12640 AFUA_5G12820 AFUA_5G12820 mdv1 mdv1 AFUA_5G13330 AFUA_5G13330 AFUA_5G13340 AFUA_5G13340 PIF1 PIF1 mdmB mdmB AFUA_3G06190 AFUA_3G06190 AFUA_3G06340 AFUA_3G06340 AFUA_3G06370 AFUA_3G06370 AFUA_3G06850 AFUA_3G06850 AFUA_3G06950 AFUA_3G06950 AFUA_3G07360 AFUA_3G07360 AFUA_3G07630 AFUA_3G07630 AFUA_3G07690 AFUA_3G07690 AFUA_3G08230 AFUA_3G08230 AFUA_3G08590 AFUA_3G08590 AFUA_3G08770 AFUA_3G08770 AFUA_3G08850 AFUA_3G08850 AFUA_3G09570 AFUA_3G09570 AFUA_3G09780 AFUA_3G09780 AFUA_3G10700 AFUA_3G10700 AFUA_3G10710 AFUA_3G10710 clu1 clu1 AFUA_3G11100 AFUA_3G11100 AFUA_3G11140 AFUA_3G11140 atg11 atg11 AFUA_3G13000 AFUA_3G13000 AFUA_3G13840 AFUA_3G13840 AFUA_3G13910 AFUA_3G13910 AFUA_3G14490 AFUA_3G14490 atp25 atp25 AFUA_2G14760 AFUA_2G14760 AFUA_2G14190 AFUA_2G14190 atg17 atg17 AFUA_2G13970 AFUA_2G13970 AFUA_2G13960 AFUA_2G13960 fis1 fis1 AFUA_2G13040 AFUA_2G13040 AFUA_2G13010 AFUA_2G13010 AFUA_2G12460 AFUA_2G12460 tim13 tim13 AFUA_2G11750 AFUA_2G11750 pim1 pim1 tim21 tim21 AFUA_2G09740 AFUA_2G09740 AFUA_2G09560 AFUA_2G09560 AFUA_2G09290 AFUA_2G09290 AFUA_2G09090 AFUA_2G09090 atp23 atp23 AFUA_2G07530 AFUA_2G07530
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AFUA_3G12250Protein-tyrosine phosphatase, putative. (613 aa)
AFUA_5G13392Transmembrane GTPase Fzo1, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (932 aa)
AFUA_5G08965Cytochrome c oxidase assembly protein (Pet191), putative. (117 aa)
AFUA_1G09757Cytochrome c oxidase assembly protein Cox19, putative. (98 aa)
AFUA_1G13195MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (91 aa)
atg12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity). (174 aa)
AFUA_6G05174TOM complex component Tom7, putative. (53 aa)
MZM1Mitochondrial zinc maintenance protein 1, mitochondrial; Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool (By similarity). (115 aa)
AFUA_1G11870Mitochondrial processing peptidase alpha subunit, putative; Belongs to the peptidase M16 family. (581 aa)
AFUA_1G13330Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
AFUA_1G13470Prohibitin. (280 aa)
AFUA_4G01260Mitochondrial chaperone ATPase (Bcs1), putative; Belongs to the AAA ATPase family. (520 aa)
AFUA_4G01460Uncharacterized protein. (722 aa)
AFUA_4G04620Mitochondrial outer membrane protein (Sam50), putative. (544 aa)
AFUA_4G04060Uncharacterized protein. (401 aa)
AFUA_4G03990Membrane-spanning ATPase, putative; Belongs to the AAA ATPase family. (419 aa)
AFUA_7G01860Heat shock protein (Sti1), putative. (585 aa)
AFUA_7G02030Cytochrome c oxidase assembly protein (Pet117), putative. (82 aa)
AFUA_7G02240Uncharacterized protein. (514 aa)
AFUA_7G02360Uncharacterized protein. (154 aa)
AFUA_7G02470mRNA processing protein (Mss51), putative. (529 aa)
AFUA_7G02490Mitochondrial molecular chaperone (Atp12), putative. (375 aa)
AFUA_8G00160Uncharacterized protein. (219 aa)
AFUA_8G02840Dynamin-like GTPase Dnm1, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (800 aa)
AFUA_8G04750DNA mismatch repair protein Msh1, putative. (1018 aa)
AFUA_6G02930Uncharacterized protein. (122 aa)
AFUA_6G02960NADH-ubiquinone oxidoreductase 105 kDa subunit. (94 aa)
AFUA_6G04030Uncharacterized protein. (83 aa)
AFUA_6G04310mRNA binding protein Pumilio 2, putative. (908 aa)
mmm1Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 su [...] (496 aa)
AFUA_6G04900Sucrase/ferredoxin-like family protein Fmi1, putative. (354 aa)
AFUA_6G04980Cytochrome c mitochondrial import factor (Cyc2), putative. (381 aa)
AFUA_6G05110Mitochondrial import receptor subunit (Tom40), putative. (355 aa)
AFUA_5G02200Mitochondrial import inner membrane translocase subunit (TIM22), putative. (175 aa)
AFUA_5G03040DnaJ domain protein. (798 aa)
AFUA_5G03630Uncharacterized protein. (130 aa)
AFUA_5G03640Mitochondrial export translocase Oxa1, putative. (436 aa)
AFUA_5G03910Mitochondrial fusion protein (Ugo1), putative. (512 aa)
AFUA_7G04150Cochaperone Pam16. (173 aa)
AFUA_7G04670F1F0 ATP synthase assembly protein Atp11, putative. (347 aa)
mia40Mitochondrial intermembrane space import and assembly protein 40; Required for the import and folding of small cysteine- containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond [...] (297 aa)
AFUA_7G05530DEAD/DEAH box helicase, putative. (690 aa)
AFUA_7G05920Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (456 aa)
AFUA_7G06040Uncharacterized membrane protein. (184 aa)
AFUA_7G08630Uncharacterized protein. (459 aa)
AFUA_2G06250Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (723 aa)
AFUA_2G05090Succinate dehydrogenase assembly factor 3, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. (129 aa)
atg13Autophagy-related protein 13; Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, atg13 is also required for glycogen storage during stationary phase (By similarity). (958 aa)
AFUA_2G04430DUF21 and CBS domain protein (Mam3), putative. (729 aa)
AFUA_2G04270Mitochondrial inner membrane translocase subunit (TIM17), putative. (154 aa)
AFUA_2G03840Mitochondrial import receptor subunit (Tom37), putative. (442 aa)
tim50Mitochondrial import inner membrane translocase subunit tim50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity). (501 aa)
AFUA_2G03400Proteasome regulatory particle subunit (RpnK), putative. (335 aa)
AFUA_2G03220Bax Inhibitor family protein; Belongs to the BI1 family. (337 aa)
AFUA_2G03100Uncharacterized protein. (234 aa)
AFUA_2G03010Cytochrome c subunit Vb, putative. (191 aa)
pam18Mitochondrial import inner membrane translocase subunit tim14; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1/sscA) (By similarity); Belongs to the TIM14 family. (105 aa)
AFUA_2G02500DUF2263 domain-containing protein. (271 aa)
AFUA_2G02430Mitochondrial genome maintenance protein Mgr2, putative. (108 aa)
AFUA_2G01660Mitochondrial outer membrane translocase receptor (TOM70), putative. (630 aa)
tim9Mitochondrial import inner membrane translocase subunit tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta- barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family. (90 aa)
AFUA_1G07360Uncharacterized protein. (227 aa)
yme2Mitochondrial escape protein 2; Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity); Belongs to the YME2 family. (871 aa)
AFUA_1G06880Mitochondrial export translocase Oxa2, putative. (342 aa)
AFUA_1G06610NADH-quinone oxidoreductase, 23 kDa subunit, putative. (228 aa)
AFUA_1G05180N-acetyltransferase (Nat5), putative. (190 aa)
sar1Small COPII coat GTPase sar1; Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. Sar1 controls the coat assembly in a stepwise manner. Activated Sar1-GTP binds to membranes first and recruits the sec23/24 complex. These sec23/24-sar1 prebudding intermediates are then collected by the Sec13/31 complex as subunits polymerize to form coated trans [...] (189 aa)
AFUA_1G04930Uncharacterized protein. (711 aa)
tim10Mitochondrial import inner membrane translocase subunit tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta- barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family. (93 aa)
AFUA_1G02620COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family. (155 aa)
AFUA_1G02170ATP-dependent Clp protease, putative. (638 aa)
pam17Presequence translocated-associated motor subunit pam17, mitochondrial; Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. (247 aa)
AFUA_1G00230Uncharacterized protein. (759 aa)
atg2Autophagy-related protein 2; Required for cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes completion and peroxisome degradation. Belongs to the ATG2 family. (2160 aa)
acoAAconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate, a step in the citric acid cycle. Also catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. Belongs to the aconitase/IPM isomerase family. (787 aa)
AFUA_6G12860Altered inheritance of mitochondria protein 24, mitochondrial. (412 aa)
atg9Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] (951 aa)
AFUA_6G12280NADH-ubiquinone oxidoreductase 213 kDa subunit. (197 aa)
AFUA_6G11380Mitochondrial import receptor subunit (Tom20), putative. (169 aa)
AFUA_6G10900UV-endonuclease UVE-1. (598 aa)
AFUA_6G10700Chaperonin, putative; Belongs to the GroES chaperonin family. (122 aa)
AFUA_6G09810Nucleotide binding protein, putative. (344 aa)
AFUA_6G09390Uncharacterized protein. (719 aa)
oct1Mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity). (801 aa)
AFUA_6G08630MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (247 aa)
AFUA_6G08570DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1154 aa)
AFUA_6G08230Mitochondrial import protein Zim17, putative. (195 aa)
gem1Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. (632 aa)
atg5Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1- like activating enzyme and atg10 as an E2- [...] (326 aa)
AFUA_6G06570Uncharacterized protein. (312 aa)
AFUA_6G06420Mitochondrion biogenesis protein (Mdm31), putative. (716 aa)
AFUA_6G06360Mating alpha-pheromone PpgA. (102 aa)
AFUA_4G05860NADH-ubiquinone oxidoreductase subunit B, putative; Belongs to the complex I 20 kDa subunit family. (223 aa)
AFUA_4G05920Mitochondrial protein sorting (Msf1), putative. (190 aa)
AFUA_4G05990Uncharacterized protein. (186 aa)
AFUA_4G06760Ubiquinone biosynthesis protein, putative. (624 aa)
AFUA_4G06790Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family. (93 aa)
AFUA_4G07290SAP domain-containing protein. (396 aa)
mic60MICOS complex subunit mic60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity). (624 aa)
rcf1Respiratory supercomplex factor 1, mitochondrial; Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes. (181 aa)
atg1Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] (973 aa)
mdm34Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (572 aa)
AFUA_4G11530Intermembrane space AAA protease IAP-1. (799 aa)
AFUA_4G11560Vacuolar protein sorting-associated protein; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN; Belongs to the VPS13 family. (3187 aa)
tim54Mitochondrial import inner membrane translocase subunit tim54; Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as external driving force (By similarity). (439 aa)
AFUA_4G11940DUF2263 domain-containing protein. (335 aa)
snx4Sorting nexin-4; Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans- Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity). (497 aa)
AFUA_4G13240NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (184 aa)
AFUA_1G16280Mitochondrial F1F0-ATP synthase g subunit, putative. (196 aa)
dml1Protein dml1; Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance; Belongs to the misato family. (505 aa)
mdm12Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pat [...] (439 aa)
AFUA_1G14590COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family. (148 aa)
AFUA_1G14200Mitochondrial processing peptidase beta subunit, putative; Belongs to the peptidase M16 family. (479 aa)
AFUA_1G13180Mitochondrial outer membrane protein (Sam35), putative. (296 aa)
AFUA_1G12250Mitochondrial hypoxia responsive domain protein. (268 aa)
AFUA_1G11970Mitochondrial dynamin GTPase (Msp1), putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (918 aa)
AFUA_1G11860Mitochondrial import receptor subunit tom22. (143 aa)
AFUA_1G11180Heat shock protein/chaperonin HSP78, putative; Belongs to the ClpA/ClpB family. (797 aa)
AFUA_1G10490F1F0 ATP synthase assembly protein Atp10, putative. (360 aa)
AFUA_1G09840Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. (523 aa)
AFUA_1G09780Stomatin family protein. (439 aa)
AFUA_1G09420MICOS complex subunit MIC12; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (121 aa)
AFUA_5G06380Uncharacterized protein. (219 aa)
AFUA_5G06540NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. (138 aa)
MEF2Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (920 aa)
AFUA_5G07380NADH-ubiquinone oxidoreductase B12 subunit, putative. (82 aa)
AFUA_5G07890SsDNA binding protein, putative. (149 aa)
atg3Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8. The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of [...] (353 aa)
AFUA_5G08530Phosphatidylinositol 3,5-bisphosphate-binding protein, putative. (258 aa)
she9Sensitive to high expression protein 9 homolog, mitochondrial; Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity). (502 aa)
AFUA_5G10820Mitochondrial ATP-dependent RNA helicase Suv3, putative. (765 aa)
atg18Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct atg9 trafficking to the pre- autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (436 aa)
AFUA_5G12610Uncharacterized protein. (393 aa)
AFUA_5G12640DNA polymerase gamma. (1135 aa)
AFUA_5G12820Mitochondrial inner membrane protease subunit 1, putative. (179 aa)
mdv1Mitochondrial division protein 1; Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity); Belongs to the WD repeat MDV1/CAF4 family. (658 aa)
AFUA_5G13330Uncharacterized protein. (344 aa)
AFUA_5G13340Protein phosphatase 2C, putative. (557 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (788 aa)
mdmBMitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the recepto [...] (471 aa)
AFUA_3G06190Cytochrome c oxidase subunit VIa, putative; Belongs to the cytochrome c oxidase subunit 6A family. (136 aa)
AFUA_3G06340SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family. (289 aa)
AFUA_3G06370CHCH domain protein. (260 aa)
AFUA_3G06850Uncharacterized protein. (296 aa)
AFUA_3G06950Mitochondrial carrier protein (Rim2), putative; Belongs to the mitochondrial carrier (TC 2.A.29) family. (383 aa)
AFUA_3G07360Mitochondrial metallochaperone Sco1, putative. (303 aa)
AFUA_3G07630Metallo-beta-lactamase superfamily protein. (179 aa)
AFUA_3G07690Cytochrome c oxidase copper chaperone Cox17, putative. (76 aa)
AFUA_3G08230MRS7 family protein. (614 aa)
AFUA_3G08590Uncharacterized protein. (125 aa)
AFUA_3G08770NADH-ubiquinone oxidoreductase subunit GRIM-19, putative. (127 aa)
AFUA_3G08850Sulfhydryl oxidase. (220 aa)
AFUA_3G09570Cytochrome c oxidase assembly protein COX20, mitochondrial; Involved in the assembly of the cytochrome c oxidase complex. Belongs to the COX20 family. (205 aa)
AFUA_3G09780Uncharacterized protein. (115 aa)
AFUA_3G10700Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (193 aa)
AFUA_3G10710Methyltransf_11 domain-containing protein. (357 aa)
clu1Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. (1310 aa)
AFUA_3G11100Mitochondrial protein Fmp25, putative. (580 aa)
AFUA_3G11140DNA ligase. (833 aa)
atg11Autophagy-related protein 11; Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity). (1264 aa)
AFUA_3G13000Mitochondrial chaperone BCS1, putative; Belongs to the AAA ATPase family. (499 aa)
AFUA_3G13840Mitochondrial inner membrane protease subunit Imp2, putative. (297 aa)
AFUA_3G13910NADH-ubiquinone oxidoreductase B18 subunit, putative. (93 aa)
AFUA_3G14490Ketol-acid reductoisomerase; Belongs to the ketol-acid reductoisomerase family. (508 aa)
atp25ATPase synthesis protein 25, mitochondrial; Probable mitochondrial mRNA stabilization factor. Belongs to the ATP25 family. (704 aa)
AFUA_2G14760BCS1-like ATPase, putative; Belongs to the AAA ATPase family. (574 aa)
AFUA_2G14190Mitochondrial import inner membrane translocase subunit TIM23, putative. (212 aa)
atg17Autophagy-related protein 17; Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity); Belongs to the ATG17 family. (551 aa)
AFUA_2G13970Uncharacterized protein. (585 aa)
AFUA_2G13960Tafazzin family protein; Belongs to the taffazin family. (433 aa)
fis1Mitochondrial fission 1 protein; Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). (151 aa)
AFUA_2G13040GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family. (250 aa)
AFUA_2G13010Cytochrome c oxidase subunit; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. (91 aa)
AFUA_2G12460Uncharacterized protein. (150 aa)
tim13Mitochondrial import inner membrane translocase subunit tim13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8- TIM13 complex is non essential and only mediates [...] (113 aa)
AFUA_2G11750Mitochondrial DnaJ chaperone (Mdj1), putative. (543 aa)
pim1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1108 aa)
tim21Mitochondrial import inner membrane translocase subunit tim21; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity). (237 aa)
AFUA_2G09740Protein arginine methyltransferase NDUFAF7; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). (502 aa)
AFUA_2G09560Mitochondrial genome maintenance protein Mgm101, putative. (306 aa)
AFUA_2G09290Antigenic mitochondrial protein HSP60, putative; Belongs to the chaperonin (HSP60) family. (587 aa)
AFUA_2G09090Prohibitin. (311 aa)
atp23Mitochondrial inner membrane protease atp23; Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring (By similarity); Belongs to the peptidase M76 family. (237 aa)
AFUA_2G07530Uncharacterized protein. (144 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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