(29 nodes) Endoplasmic reticulum organization network (Aspergillus fumigatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AFUA_2G16430	Uncharacterized protein. (200 aa)
	AFUA_7G05940	Uncharacterized protein. (242 aa)
	AFUA_1G06510	Uncharacterized protein. (280 aa)
	AFUA_6G13670	Reticulon-like protein. (270 aa)
	get1	Protein get1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble get3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. (200 aa)
	AFUA_4G06950	Integral ER membrane protein Scs2, putative. (328 aa)
	AFUA_4G11110	C2 domain protein. (1242 aa)
	AFUA_1G09040	Intermediate filament protein (Mdm1), putative. (1274 aa)
	AFUA_1G08970	Uncharacterized protein. (441 aa)
	yop1	Protein yop1; Involved in membrane/vesicle trafficking; Belongs to the DP1 family. (169 aa)
	AFUA_5G08440	Uncharacterized protein. (286 aa)
	AFUA_3G10170	Uncharacterized protein. (1022 aa)
	get3	ATPase get3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] (340 aa)
	AFUA_2G16800	Lectin family integral membrane protein, putative. (328 aa)
	AFUA_5G04280	DUF2012 domain-containing protein. (245 aa)
	sec31	Protein transport protein sec31; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1263 aa)
	AFUA_2G12180	Lectin family integral membrane protein, putative. (327 aa)
	AFUA_2G09470	Protein YOP1. (328 aa)
	sey1	Protein sey1; Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily. (864 aa)
	AFUA_8G01830	Zn(2)-C6 fungal-type domain-containing protein. (497 aa)
	AFUA_1G12790	Exocyst complex component SEC5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (1035 aa)
	AFUA_4G03330	Plasma membrane stress response protein (Ist2), putative. (729 aa)
	AFUA_4G02970	Plasma membrane channel protein (Aqy1), putative. (735 aa)
	AFUA_4G02920	Zinc_ribbon_10 domain-containing protein. (402 aa)
	AFUA_7G01840	Membrane bound C2 domain protein (Vp115), putative. (1538 aa)
	AFUA_8G02170	C6 finger domain protein, putative. (462 aa)
	AFUA_8G05350	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family. (268 aa)
	AFUA_6G05050	DUF410 domain protein. (346 aa)
	AFUA_5G01460	C6 finger domain protein, putative. (480 aa)

Your Current Organism:

Aspergillus fumigatus

NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFUA_1G06510	get1	Q4WJC0	Q4WNN2	Uncharacterized protein.	Protein get1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble get3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	0.437
AFUA_1G08970	AFUA_4G06950	Q4WTK6	Q4WNU1	Uncharacterized protein.	Integral ER membrane protein Scs2, putative.	0.447
AFUA_1G08970	AFUA_7G01840	Q4WTK6	Q4WAM6	Uncharacterized protein.	Membrane bound C2 domain protein (Vp115), putative.	0.457
AFUA_2G09470	AFUA_4G02920	Q4X1M2	Q4WA23	Protein YOP1.	Zinc_ribbon_10 domain-containing protein.	0.476
AFUA_2G16430	get1	Q4WZM4	Q4WNN2	Uncharacterized protein.	Protein get1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble get3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	0.437
AFUA_2G16800	sec31	Q4WZI6	Q4X0M4	Lectin family integral membrane protein, putative.	Protein transport protein sec31; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).	0.441
AFUA_4G02920	AFUA_2G09470	Q4WA23	Q4X1M2	Zinc_ribbon_10 domain-containing protein.	Protein YOP1.	0.476
AFUA_4G02920	AFUA_6G13670	Q4WA23	Q4WLF9	Zinc_ribbon_10 domain-containing protein.	Reticulon-like protein.	0.637
AFUA_4G02920	sey1	Q4WA23	Q8TGG5	Zinc_ribbon_10 domain-containing protein.	Protein sey1; Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily.	0.594
AFUA_4G02920	yop1	Q4WA23	Q4WTW3	Zinc_ribbon_10 domain-containing protein.	Protein yop1; Involved in membrane/vesicle trafficking; Belongs to the DP1 family.	0.475
AFUA_4G06950	AFUA_1G08970	Q4WNU1	Q4WTK6	Integral ER membrane protein Scs2, putative.	Uncharacterized protein.	0.447
AFUA_4G06950	AFUA_6G13670	Q4WNU1	Q4WLF9	Integral ER membrane protein Scs2, putative.	Reticulon-like protein.	0.568
AFUA_4G06950	AFUA_7G01840	Q4WNU1	Q4WAM6	Integral ER membrane protein Scs2, putative.	Membrane bound C2 domain protein (Vp115), putative.	0.571
AFUA_5G01460	get1	Q4WE19	Q4WNN2	C6 finger domain protein, putative.	Protein get1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble get3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	0.437
AFUA_5G04280	AFUA_8G05350	Q4WEV0	Q4WC85	DUF2012 domain-containing protein.	ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family.	0.984
AFUA_5G08440	get1	Q4WUH1	Q4WNN2	Uncharacterized protein.	Protein get1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble get3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	0.825
AFUA_5G08440	get3	Q4WUH1	Q4WY07	Uncharacterized protein.	ATPase get3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.849
AFUA_6G05050	get1	Q4WDK4	Q4WNN2	DUF410 domain protein.	Protein get1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble get3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.	0.640
AFUA_6G05050	get3	Q4WDK4	Q4WY07	DUF410 domain protein.	ATPase get3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.994
AFUA_6G13670	AFUA_4G02920	Q4WLF9	Q4WA23	Reticulon-like protein.	Zinc_ribbon_10 domain-containing protein.	0.637