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AFUA_2G10980 AFUA_2G10980 AFUA_2G10610 AFUA_2G10610 AFUA_2G09040 AFUA_2G09040 AFUA_2G02610 AFUA_2G02610 hse1 hse1 vps27 vps27 mon1 mon1 AFUA_2G05440 AFUA_2G05440 AFUA_7G03640 AFUA_7G03640 AFUA_3G04060 AFUA_3G04060 AFUA_5G02900 AFUA_5G02900 AFUA_5G02510 AFUA_5G02510 AFUA_5G02360 AFUA_5G02360 AFUA_6G04780 AFUA_6G04780 AFUA_6G04770 AFUA_6G04770 AFUA_6G04760 AFUA_6G04760 AFUA_6G02510 AFUA_6G02510 AFUA_6G02420 AFUA_6G02420 AFUA_4G11000 AFUA_4G11000 AFUA_4G10710 AFUA_4G10710 AFUA_4G07070 AFUA_4G07070 AFUA_6G07560 AFUA_6G07560 AFUA_6G10410 AFUA_6G10410 AFUA_6G13020 AFUA_6G13020 AFUA_6G13430 AFUA_6G13430 AFUA_6G14250 AFUA_6G14250 AFUA_1G03460 AFUA_1G03460 AFUA_1G04080 AFUA_1G04080 AFUA_1G05730 AFUA_1G05730 AFUA_1G06030 AFUA_1G06030 AFUA_1G06420 AFUA_1G06420 AFUA_1G06680 AFUA_1G06680 AFUA_1G07250 AFUA_1G07250 AFUA_2G01570 AFUA_2G01570 AFUA_1G13960 AFUA_1G13960 AFUA_1G13260 AFUA_1G13260 AFUA_1G10950 AFUA_1G10950 vps10 vps10 AFUA_4G03870 AFUA_4G03870 AFUA_4G04100 AFUA_4G04100 AFUA_6G11190 AFUA_6G11190 AFUA_1G11450 AFUA_1G11450 AFUA_1G13330 AFUA_1G13330 AFUA_2G16692 AFUA_2G16692 AFUA_1G09540 AFUA_1G09540 hulA hulA AFUA_1G09220 AFUA_1G09220 AFUA_5G05670 AFUA_5G05670 AFUA_5G08230 AFUA_5G08230 AFUA_5G09660 AFUA_5G09660 AFUA_5G11360 AFUA_5G11360 AFUA_5G13410 AFUA_5G13410 AFUA_5G13600 AFUA_5G13600 AFUA_5G13890 AFUA_5G13890 AFUA_3G05820 AFUA_3G05820 AFUA_3G08730 AFUA_3G08730 AFUA_4G11560 AFUA_4G11560 AFUA_4G12070 AFUA_4G12070 AFUA_4G12080 AFUA_4G12080 AFUA_4G12290 AFUA_4G12290 AFUA_4G13740 AFUA_4G13740 AFUA_1G16320 AFUA_1G16320 AFUA_1G15570 AFUA_1G15570 ssh4 ssh4 AFUA_3G08790 AFUA_3G08790 AFUA_3G09360 AFUA_3G09360 AFUA_3G10060 AFUA_3G10060 AFUA_3G10650 AFUA_3G10650 AFUA_3G10740 AFUA_3G10740 AFUA_3G11200 AFUA_3G11200 AFUA_3G12360 AFUA_3G12360 AFUA_3G12370 AFUA_3G12370 AFUA_3G13390 AFUA_3G13390 AFUA_3G13770 AFUA_3G13770 AFUA_3G14380 AFUA_3G14380 mvp1 mvp1 AFUA_2G15820 AFUA_2G15820 bro1 bro1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AFUA_2G10980ADP-ribosylation factor, putative; Belongs to the small GTPase superfamily. Arf family. (182 aa)
AFUA_2G10610Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (855 aa)
AFUA_2G09040Vacuolar transporter chaperone (Vtc4), putative. (801 aa)
AFUA_2G02610SNARE complex subunit (Vam7), putative. (383 aa)
hse1Class E vacuolar protein-sorting machinery protein hse1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB). (584 aa)
vps27Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (729 aa)
mon1Vacuolar fusion protein mon1; Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis; Belongs to the MON1/SAND family. (621 aa)
AFUA_2G05440CTLH domain-containing protein. (229 aa)
AFUA_7G03640AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (953 aa)
AFUA_3G04060SNF7 family protein Fti1/Did2, putative. (209 aa)
AFUA_5G02900SNARE domain protein. (251 aa)
AFUA_5G02510GARP complex component (Vps54), putative. (1091 aa)
AFUA_5G02360Vacuolar dynamin-like GTPase VpsA, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (698 aa)
AFUA_6G04780Vacuolar protein sorting 55 superfamily. (128 aa)
AFUA_6G04770Sld7_C domain-containing protein. (223 aa)
AFUA_6G04760UPF0220 domain protein. (185 aa)
AFUA_6G02510Chitin biosynthesis protein (Chs5), putative. (457 aa)
AFUA_6G02420Ubiquitin conjugating enzyme (UbcM), putative; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
AFUA_4G11000SNF7 family protein (Cta1), putative. (216 aa)
AFUA_4G10710Vesicle transport v-snare protein, putative. (224 aa)
AFUA_4G07070Uncharacterized protein. (167 aa)
AFUA_6G07560Transcription factor Rap1, putative. (315 aa)
AFUA_6G10410E3 ubiquitin-protein ligase PEP5. (958 aa)
AFUA_6G13020AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (185 aa)
AFUA_6G13430Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (705 aa)
AFUA_6G14250Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (647 aa)
AFUA_1G03460Uncharacterized protein. (361 aa)
AFUA_1G04080GARP complex subunit (Sac2), putative. (678 aa)
AFUA_1G05730Vacuolar sorting receptor (Mrl1), putative. (351 aa)
AFUA_1G06030AP-1 complex subunit gamma. (803 aa)
AFUA_1G06420SNF7 family protein. (241 aa)
AFUA_1G06680VHS domain protein. (642 aa)
AFUA_1G07250SPX domain protein. (762 aa)
AFUA_2G01570AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (148 aa)
AFUA_1G13960DUF292 domian protein. (332 aa)
AFUA_1G13260Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family. (269 aa)
AFUA_1G10950Vesicle-mediated transport protein Vid24, putative. (330 aa)
vps10Vacuolar protein sorting/targeting protein 10; Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity); Belongs to the VPS10-related sortilin family. (1487 aa)
AFUA_4G03870Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (260 aa)
AFUA_4G04100Vacuolar protein sorting protein (Vps36), putative. (537 aa)
AFUA_6G11190Protein kinase (VPS15), putative. (1637 aa)
AFUA_1G11450Myosin class II heavy chain (MHC), putative. (2081 aa)
AFUA_1G13330Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
AFUA_2G16692Vacuolar sorting protein SNF7 family protein, putative. (480 aa)
AFUA_1G09540Vacuolar transporter chaperon Vtc1, putative. (123 aa)
hulAProbable E3 ubiquitin-protein ligase hulA; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization. (813 aa)
AFUA_1G09220SNF7 family protein. (217 aa)
AFUA_5G05670Transporter, putative. (425 aa)
AFUA_5G08230C3HC4 finger protein. (473 aa)
AFUA_5G09660AP-1 adaptor complex subunit mu, putative; Belongs to the adaptor complexes medium subunit family. (446 aa)
AFUA_5G11360AP-3 adaptor complex subunit beta, putative. (843 aa)
AFUA_5G13410SNF7 family protein. (224 aa)
AFUA_5G13600Probable vacuolar protein sorting-associated protein 16 homolog; Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. (828 aa)
AFUA_5G13890SNF7 family protein. (229 aa)
AFUA_3G05820ZZ type zinc finger domain protein. (838 aa)
AFUA_3G08730Endosome-associated ubiquitin isopeptidase (AmsH), putative. (532 aa)
AFUA_4G11560Vacuolar protein sorting-associated protein; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN; Belongs to the VPS13 family. (3187 aa)
AFUA_4G12070Endosomal peripheral membrane protein (Mon2), putative. (1688 aa)
AFUA_4G12080Ubiquitin conjugating enzyme (MmsB), putative. (139 aa)
AFUA_4G12290ESCRT-II complex component (Vps25), putative. (195 aa)
AFUA_4G13740Metal homeostatis protein bsd2. (446 aa)
AFUA_1G16320Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (244 aa)
AFUA_1G15570Ubiquitin-conjugating enzyme, putative. (287 aa)
ssh4Protein ssh4; Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity); Belongs to the SSH4 family. (507 aa)
AFUA_3G08790Uncharacterized protein. (294 aa)
AFUA_3G09360Vacuolar sorting ATPase Vps4, putative; Belongs to the AAA ATPase family. (435 aa)
AFUA_3G10060Dor1-like family protein. (478 aa)
AFUA_3G10650Glutamate carboxypeptidase Tre2, putative. (907 aa)
AFUA_3G10740RAB GTPase Vps21/Ypt51, putative. (262 aa)
AFUA_3G11200Vacuolar assembly protein, putative. (1298 aa)
AFUA_3G12360Uncharacterized protein. (514 aa)
AFUA_3G12370V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (161 aa)
AFUA_3G13390V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family. (363 aa)
AFUA_3G13770Vacuolar segregation protein (Pep7), putative. (672 aa)
AFUA_3G14380Endosomal sorting complex protein TSG101, putative. (579 aa)
mvp1Sorting nexin mvp1; Required for vacuolar protein sorting. (729 aa)
AFUA_2G15820SNARE complex subunit (Syn8), putative. (339 aa)
bro1Vacuolar protein-sorting protein bro1; Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles; Belongs to the BRO1 family. (976 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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