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AFUA_2G09060 AFUA_2G09060 ku80 ku80 AFUA_2G03750 AFUA_2G03750 AFUA_2G03900 AFUA_2G03900 AFUA_2G03910 AFUA_2G03910 AFUA_2G04960 AFUA_2G04960 AFUA_7G08480 AFUA_7G08480 AFUA_7G05890 AFUA_7G05890 msh3 msh3 AFUA_7G03830 AFUA_7G03830 AFUA_7G03820 AFUA_7G03820 AFUA_5G04070 AFUA_5G04070 AFUA_5G03320 AFUA_5G03320 AFUA_8G04750 AFUA_8G04750 AFUA_8G05820 AFUA_8G05820 AFUA_8G07400 AFUA_8G07400 AFUA_8G02820 AFUA_8G02820 swr1 swr1 AFUA_7G02200 AFUA_7G02200 AFUA_7G00090 AFUA_7G00090 AFUA_4G03840 AFUA_4G03840 AFUA_1G13010 AFUA_1G13010 AFUA_1G13060 AFUA_1G13060 AFUA_1G03035 AFUA_1G03035 AFUA_2G01090 AFUA_2G01090 AFUA_2G00090 AFUA_2G00090 AFUA_1G06670 AFUA_1G06670 AFUA_1G05830 AFUA_1G05830 mph1 mph1 rvb2 rvb2 AFUA_1G02000 AFUA_1G02000 AFUA_1G00630 AFUA_1G00630 AFUA_6G14720 AFUA_6G14720 AFUA_6G14690 AFUA_6G14690 AFUA_6G14670 AFUA_6G14670 ubc2 ubc2 AFUA_6G13690 AFUA_6G13690 AFUA_6G13290 AFUA_6G13290 AFUA_6G13080 AFUA_6G13080 AFUA_6G12910 AFUA_6G12910 AFUA_6G09220 AFUA_6G09220 AFUA_6G06550 AFUA_6G06550 AFUA_4G06490 AFUA_4G06490 AFUA_4G07230 AFUA_4G07230 AFUA_4G08300 AFUA_4G08300 rvb1 rvb1 AFUA_4G11180 AFUA_4G11180 AFUA_4G12210 AFUA_4G12210 AFUA_4G12680 AFUA_4G12680 AFUA_4G13440 AFUA_4G13440 AFUA_4G13460 AFUA_4G13460 AFUA_1G15120 AFUA_1G15120 AFUA_1G13910 AFUA_1G13910 AFUA_1G12520 AFUA_1G12520 AFUA_1G11170 AFUA_1G11170 AFUA_1G10410 AFUA_1G10410 AFUA_3G08400 AFUA_3G08400 AFUA_3G09850 AFUA_3G09850 AFUA_3G14460 AFUA_3G14460 AFUA_3G15395 AFUA_3G15395 AFUA_2G18100 AFUA_2G18100 AFUA_2G14080 AFUA_2G14080 dbp9 dbp9 AFUA_2G13410 AFUA_2G13410 AFUA_2G12220 AFUA_2G12220 AFUA_2G10820 AFUA_2G10820 MCM7 MCM7 AFUA_2G09120 AFUA_2G09120 AFUA_1G10290 AFUA_1G10290 AFUA_1G09610 AFUA_1G09610 ino80 ino80 AFUA_5G06330 AFUA_5G06330 AFUA_5G06600 AFUA_5G06600 AFUA_5G07740 AFUA_5G07740 AFUA_5G10880 AFUA_5G10880 AFUA_5G10890 AFUA_5G10890 AFUA_5G11170 AFUA_5G11170 AFUA_5G11700 AFUA_5G11700 rad5 rad5 PIF1 PIF1 AFUA_5G15150 AFUA_5G15150 AFUA_3G05440 AFUA_3G05440 chl1 chl1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_2G09060DNA helicase; Belongs to the MCM family. (1023 aa)
ku80ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (725 aa)
AFUA_2G03750DNA excision repair protein (Rad26L), putative. (1008 aa)
AFUA_2G03900Acetamidase/formamidase family protein. (320 aa)
AFUA_2G03910ATP-depentend DNA helicase, putative. (1001 aa)
AFUA_2G04960RecQ family helicase MusN. (1563 aa)
AFUA_7G08480SWI/SNF family DNA-dependent ATPase, putative. (707 aa)
AFUA_7G05890Uncharacterized protein. (252 aa)
msh3DNA mismatch repair protein msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1123 aa)
AFUA_7G03830DNA repair protein Rad7, protein. (642 aa)
AFUA_7G03820DNA excision repair protein Rad16, putative. (940 aa)
AFUA_5G04070Meiosis-specific topoisomerase Spo11, putative. (388 aa)
AFUA_5G03320TFIIH complex helicase Ssl2, putative. (830 aa)
AFUA_8G04750DNA mismatch repair protein Msh1, putative. (1018 aa)
AFUA_8G05820DNA mismatch repair protein, putative. (882 aa)
AFUA_8G07400Telomere-associated RecQ helicase, putative. (360 aa)
AFUA_8G02820Cell cycle checkpoint protein Rad17, putative. (722 aa)
swr1Helicase swr1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1695 aa)
AFUA_7G02200Meiotic recombination protein (Dmc1), putative; Belongs to the RecA family. (338 aa)
AFUA_7G00090Telomere-associated RecQ helicase, putative. (396 aa)
AFUA_4G03840DNA repair protein Rhp26/Rad26, putative. (1214 aa)
AFUA_1G13010SNF2 family helicase/ATPase PasG, putative. (867 aa)
AFUA_1G13060Regulator of nonsense transcripts, putative. (1079 aa)
AFUA_1G03035HD superfamily hydrolase, putative. (243 aa)
AFUA_2G01090DNA helicase, putative. (730 aa)
AFUA_2G00090Telomere-associated RecQ helicase, putative. (460 aa)
AFUA_1G06670Uncharacterized protein. (405 aa)
AFUA_1G05830TBP associated factor (Mot1), putative. (1891 aa)
mph1ATP-dependent DNA helicase mph1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1101 aa)
rvb2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (469 aa)
AFUA_1G02000DNA mismatch repair protein Msh4, putative. (840 aa)
AFUA_1G00630SWI/SNF family DNA-dependent ATPase, putative. (1005 aa)
AFUA_6G14720Telomere-associated RecQ helicase, putative. (1445 aa)
AFUA_6G14690Telomere-associated RecQ helicase, putative. (352 aa)
AFUA_6G14670C2H2-type domain-containing protein. (146 aa)
ubc2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
AFUA_6G13690DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1660 aa)
AFUA_6G13290SWI/SNF family DNA-dependent ATPase Ris1, putative. (1376 aa)
AFUA_6G13080DEAD/DEAH box DNA helicase (Mer3), putative. (1439 aa)
AFUA_6G12910DsDNA-dependent ATPase Rad54, putative. (807 aa)
AFUA_6G09220SNF2 family helicase/ATPase, putative. (1141 aa)
AFUA_6G06550SNF2 family helicase/ATPase, putative. (1461 aa)
AFUA_4G06490DNA mismatch repair protein (Mlh3), putative. (916 aa)
AFUA_4G07230ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (538 aa)
AFUA_4G08300DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1213 aa)
rvb1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
AFUA_4G11180AAA family ATPase, putative. (539 aa)
AFUA_4G12210DNA replication helicase Dna2, putative. (1657 aa)
AFUA_4G12680DNA repair protein Rad50. (1312 aa)
AFUA_4G13440Chromatin remodeling complex subunit (Chd3), putative. (1509 aa)
AFUA_4G13460SNF2 family helicase/ATPase, putative. (1111 aa)
AFUA_1G15120DsDNA-dependent ATPase (Rad54b), putative. (969 aa)
AFUA_1G13910TFIIH complex helicase Rad3, putative. (770 aa)
AFUA_1G12520DNA repair protein (Rad57), putative. (647 aa)
AFUA_1G11170DNA mismatch repair protein Msh5, putative. (830 aa)
AFUA_1G10410DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
AFUA_3G08400SNF2 family helicase/ATPase, putative. (1133 aa)
AFUA_3G09850DNA mismatch repair protein Msh2, putative; Component of the post-replicative DNA mismatch repair system (MMR). (940 aa)
AFUA_3G14460Rad51 family DNA repair protein, putative. (456 aa)
AFUA_3G15395Telomere-associated RecQ helicase, putative. (714 aa)
AFUA_2G18100Telomere-associated RecQ helicase, putative. (850 aa)
AFUA_2G14080Structural maintenance of chromosomes protein. (1199 aa)
dbp9ATP-dependent RNA helicase dbp9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (649 aa)
AFUA_2G13410DNA mismatch repair protein (Pms1), putative. (1044 aa)
AFUA_2G12220Replication factor C subunit 1. (1085 aa)
AFUA_2G10820DEAD/DEAH box helicase, putative. (1206 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (854 aa)
AFUA_2G09120SNF2 family helicase, putative. (2115 aa)
AFUA_1G10290Chromodomain helicase (Chd1), putative. (1523 aa)
AFUA_1G09610Uncharacterized protein. (708 aa)
ino80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1708 aa)
AFUA_5G06330RSC complex subunit (Sth1), putative. (1406 aa)
AFUA_5G06600SNF2 family helicase/ATPase, putative. (1827 aa)
AFUA_5G07740DSB repair complex subunit Ku70, putative. (691 aa)
AFUA_5G10880SNF2 family helicase, putative. (1167 aa)
AFUA_5G10890DNA helicase; Belongs to the MCM family. (956 aa)
AFUA_5G11170Nucleosome remodeling complex ATPase subunit (Snf2h), putative. (986 aa)
AFUA_5G11700DNA mismatch repair protein Mlh1, putative. (709 aa)
rad5DNA repair protein rad5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1245 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (788 aa)
AFUA_5G15150Telomere-associated RecQ helicase, putative. (395 aa)
AFUA_3G05440DNA repair protein Rad18, putative. (1082 aa)
chl1ATP-dependent DNA helicase chl1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (782 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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