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mon1 mon1 vps27 vps27 hse1 hse1 AFUA_1G06420 AFUA_1G06420 AFUA_1G05100 AFUA_1G05100 AFUA_1G03460 AFUA_1G03460 AFUA_1G03450 AFUA_1G03450 AFUA_1G02540 AFUA_1G02540 AFUA_1G02320 AFUA_1G02320 AFUA_1G02310 AFUA_1G02310 AFUA_6G12890 AFUA_6G12890 AFUA_6G08290 AFUA_6G08290 AFUA_6G07930 AFUA_6G07930 AFUA_6G07560 AFUA_6G07560 AFUA_6G07440 AFUA_6G07440 AFUA_6G06910 AFUA_6G06910 AFUA_4G06400 AFUA_4G06400 AFUA_4G08040 AFUA_4G08040 AFUA_4G10040 AFUA_4G10040 AFUA_4G10710 AFUA_4G10710 AFUA_4G12290 AFUA_4G12290 snx4 snx4 AFUA_1G16930 AFUA_1G16930 AFUA_1G16320 AFUA_1G16320 ssh4 ssh4 end3 end3 AFUA_1G09560 AFUA_1G09560 AFUA_1G09220 AFUA_1G09220 AFUA_5G06520 AFUA_5G06520 AFUA_5G07860 AFUA_5G07860 atg18 atg18 AFUA_5G13410 AFUA_5G13410 AFUA_5G13890 AFUA_5G13890 snx3 snx3 AFUA_3G09360 AFUA_3G09360 AFUA_3G13770 AFUA_3G13770 PSD2 PSD2 AFUA_2G14900 AFUA_2G14900 AFUA_2G14160 AFUA_2G14160 atg15 atg15 akr1 akr1 AFUA_2G16692 AFUA_2G16692 AFUA_7G01620 AFUA_7G01620 AFUA_1G13030 AFUA_1G13030 AFUA_4G04100 AFUA_4G04100 AFUA_4G03870 AFUA_4G03870 AFUA_8G05170 AFUA_8G05170 AFUA_8G04900 AFUA_8G04900 AFUA_8G04520 AFUA_8G04520 AFUA_6G04760 AFUA_6G04760 AFUA_6G04770 AFUA_6G04770 AFUA_6G04780 AFUA_6G04780 AFUA_5G03510 AFUA_5G03510 AFUA_3G04060 AFUA_3G04060 AFUA_3G02050 AFUA_3G02050 AFUA_7G03640 AFUA_7G03640 pan1 pan1 AFUA_7G04950 AFUA_7G04950
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mon1Vacuolar fusion protein mon1; Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis; Belongs to the MON1/SAND family. (621 aa)
vps27Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (729 aa)
hse1Class E vacuolar protein-sorting machinery protein hse1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB). (584 aa)
AFUA_1G06420SNF7 family protein. (241 aa)
AFUA_1G05100GARP complex subunit Vps53, putative. (854 aa)
AFUA_1G03460Uncharacterized protein. (361 aa)
AFUA_1G03450Calpain-like protease PalBory; Belongs to the peptidase C2 family. (805 aa)
AFUA_1G02540EF hand domain protein. (1258 aa)
AFUA_1G02320Uncharacterized protein. (229 aa)
AFUA_1G02310Uncharacterized protein. (225 aa)
AFUA_6G12890Vacuole-associated enzyme activator complex component (Vac14), putative. (927 aa)
AFUA_6G08290ADP-ribosylation factor family protein. (175 aa)
AFUA_6G07930Uncharacterized protein. (406 aa)
AFUA_6G07560Transcription factor Rap1, putative. (315 aa)
AFUA_6G074401-phosphatidylinositol-3-phosphate 5-kinase (Fab1), putative. (2475 aa)
AFUA_6G06910Uncharacterized protein. (786 aa)
AFUA_4G06400pH signal transduction protein PalA, putative. (834 aa)
AFUA_4G08040RAB GTPase Ypt5, putative. (218 aa)
AFUA_4G10040SNARE complex subunit (Tlg2), putative; Belongs to the syntaxin family. (390 aa)
AFUA_4G10710Vesicle transport v-snare protein, putative. (224 aa)
AFUA_4G12290ESCRT-II complex component (Vps25), putative. (195 aa)
snx4Sorting nexin-4; Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans- Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity). (497 aa)
AFUA_1G16930Phosphatidylserine decarboxylase, putative. (346 aa)
AFUA_1G16320Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (244 aa)
ssh4Protein ssh4; Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity); Belongs to the SSH4 family. (507 aa)
end3Actin cytoskeleton-regulatory complex protein end3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (404 aa)
AFUA_1G09560Protein transport protein (LST8), putative. (415 aa)
AFUA_1G09220SNF7 family protein. (217 aa)
AFUA_5G06520Low-temperature viability protein ltv1. (490 aa)
AFUA_5G07860Phosphatase family protein. (1061 aa)
atg18Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct atg9 trafficking to the pre- autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (436 aa)
AFUA_5G13410SNF7 family protein. (224 aa)
AFUA_5G13890SNF7 family protein. (229 aa)
snx3Sorting nexin-3; Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity). (142 aa)
AFUA_3G09360Vacuolar sorting ATPase Vps4, putative; Belongs to the AAA ATPase family. (435 aa)
AFUA_3G13770Vacuolar segregation protein (Pep7), putative. (672 aa)
PSD2Phosphatidylserine decarboxylase 2 alpha chain; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily. (1077 aa)
AFUA_2G14900pH-signalling protein PalC. (509 aa)
AFUA_2G14160Autophagy protein Atg20, putative. (636 aa)
atg15Putative lipase atg15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by atg15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (650 aa)
akr1Palmitoyltransferase akr1; Palmitoyltransferase specific for casein kinase 1. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. (738 aa)
AFUA_2G16692Vacuolar sorting protein SNF7 family protein, putative. (480 aa)
AFUA_7G01620Uncharacterized protein. (566 aa)
AFUA_1G13030Uncharacterized protein. (672 aa)
AFUA_4G04100Vacuolar protein sorting protein (Vps36), putative. (537 aa)
AFUA_4G03870Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (260 aa)
AFUA_8G05170Autophagy protein Apg6, putative. (446 aa)
AFUA_8G04900Uncharacterized protein. (197 aa)
AFUA_8G04520Cytoskeleton assembly control protein Sla1, putative. (1168 aa)
AFUA_6G04760UPF0220 domain protein. (185 aa)
AFUA_6G04770Sld7_C domain-containing protein. (223 aa)
AFUA_6G04780Vacuolar protein sorting 55 superfamily. (128 aa)
AFUA_5G03510PQ loop repeat protein. (194 aa)
AFUA_3G04060SNF7 family protein Fti1/Did2, putative. (209 aa)
AFUA_3G02050Uncharacterized protein. (171 aa)
AFUA_7G03640AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (953 aa)
pan1Actin cytoskeleton-regulatory complex protein pan1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (1467 aa)
AFUA_7G04950Lipase, putative. (281 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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