(28 nodes) Cell septum network (Aspergillus fumigatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AFUA_2G13440	Chitin synthase ChsE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1848 aa)
	AFUA_3G12250	Protein-tyrosine phosphatase, putative. (613 aa)
	AFUA_3G09900	GTPase activating protein Sar1, putative. (779 aa)
	AFUA_3G07530	pH signal transduction protein PalI, putative. (677 aa)
	AFUA_3G05580	Chitin synthase activator (Chs3), putative. (726 aa)
	AFUA_5G14060	Rho GTPase Rho4, putative. (286 aa)
	AFUA_5G12150	PH domain protein. (408 aa)
	AFUA_5G11970	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1106 aa)
	AFUA_5G11810	Dynein heavy chain. (4368 aa)
	AFUA_4G12800	Puatative oxidoreductase. (280 aa)
	AFUA_4G11450	Rho guanyl nucleotide exchange factor, putative. (907 aa)
	AFUA_6G07890	Telomere silencing protein Zds1, putative. (857 aa)
	AFUA_2G09500	Universal stress protein family domain protein. (453 aa)
	exgA	Probable glucan 1,3-beta-glucosidase A; Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity). (416 aa)
	AFUA_1G04950	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
	AFUA_2G01870	Chitin synthase; Plays a major role in cell wall biogenesis. (933 aa)
	AFUA_2G13430	Chitin synthase, putative. (1756 aa)
	AFUA_7G04300	RhoGAP and Fes/CIP4 domain protein. (790 aa)
	AFUA_5G01140	Plasma membrane ammonium transporter (Ato3), putative. (269 aa)
	AFUA_8G05630	Chitin synthase F. (1182 aa)
	chsD	Chitin synthase D; Plays a major role in cell wall biogenesis. (745 aa)
	alcS	Protein alcS. (272 aa)
	AFUA_4G04180	Chitin synthase B. (1084 aa)
	hsp90	Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). (706 aa)
	AFUA_1G12760	Adenylyl cyclase-associated protein; Belongs to the CAP family. (526 aa)
	AFUA_6G10550	Arrestin domain protein. (401 aa)
	chsC	Chitin synthase C; Plays a major role in cell wall biogenesis. (893 aa)
	chsG	Chitin synthase G; Plays a major role in cell wall biogenesis and required for normal hyphal growth and development. (911 aa)

Your Current Organism:

Aspergillus fumigatus

NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFUA_1G04950	AFUA_5G11970	Q4WJS6	Q4WVG0	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.404
AFUA_1G04950	AFUA_5G14060	Q4WJS6	Q4WW13	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	Rho GTPase Rho4, putative.	0.481
AFUA_3G09900	AFUA_5G14060	Q4WXL2	Q4WW13	GTPase activating protein Sar1, putative.	Rho GTPase Rho4, putative.	0.503
AFUA_4G11450	AFUA_5G14060	Q4WQ37	Q4WW13	Rho guanyl nucleotide exchange factor, putative.	Rho GTPase Rho4, putative.	0.610
AFUA_4G12800	AFUA_5G11810	Q4WQH0	Q4WVE4	Puatative oxidoreductase.	Dynein heavy chain.	0.595
AFUA_4G12800	AFUA_5G14060	Q4WQH0	Q4WW13	Puatative oxidoreductase.	Rho GTPase Rho4, putative.	0.412
AFUA_5G11810	AFUA_4G12800	Q4WVE4	Q4WQH0	Dynein heavy chain.	Puatative oxidoreductase.	0.595
AFUA_5G11810	hsp90	Q4WVE4	P40292	Dynein heavy chain.	Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).	0.595
AFUA_5G11970	AFUA_1G04950	Q4WVG0	Q4WJS6	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.404
AFUA_5G11970	AFUA_5G14060	Q4WVG0	Q4WW13	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	Rho GTPase Rho4, putative.	0.800
AFUA_5G14060	AFUA_1G04950	Q4WW13	Q4WJS6	Rho GTPase Rho4, putative.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.481
AFUA_5G14060	AFUA_3G09900	Q4WW13	Q4WXL2	Rho GTPase Rho4, putative.	GTPase activating protein Sar1, putative.	0.503
AFUA_5G14060	AFUA_4G11450	Q4WW13	Q4WQ37	Rho GTPase Rho4, putative.	Rho guanyl nucleotide exchange factor, putative.	0.610
AFUA_5G14060	AFUA_4G12800	Q4WW13	Q4WQH0	Rho GTPase Rho4, putative.	Puatative oxidoreductase.	0.412
AFUA_5G14060	AFUA_5G11970	Q4WW13	Q4WVG0	Rho GTPase Rho4, putative.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.800
AFUA_5G14060	hsp90	Q4WW13	P40292	Rho GTPase Rho4, putative.	Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).	0.412
chsC	chsD	Q92197	P78746	Chitin synthase C; Plays a major role in cell wall biogenesis.	Chitin synthase D; Plays a major role in cell wall biogenesis.	0.653
chsD	chsC	P78746	Q92197	Chitin synthase D; Plays a major role in cell wall biogenesis.	Chitin synthase C; Plays a major role in cell wall biogenesis.	0.653
hsp90	AFUA_5G11810	P40292	Q4WVE4	Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).	Dynein heavy chain.	0.595
hsp90	AFUA_5G14060	P40292	Q4WW13	Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).	Rho GTPase Rho4, putative.	0.412