9 items (Aspergillus fumigatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AFUA_6G03970	Cell cycle checkpoint protein (Hus1), putative. (373 aa)
	AFUA_2G01910	MRC1 domain-containing protein. (1284 aa)
	ubc2	Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	AFUA_6G13160	Serine/threonine protein kinase, putative. (514 aa)
	AFUA_6G11410	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa)
	AFUA_5G13220	ERCC4 domain-containing protein. (649 aa)
	AFUA_5G13380	BRCT domain protein. (786 aa)
	mus81	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (596 aa)
	AFUA_2G10710	DNA repair protein rad9, putative. (376 aa)

Your Current Organism:

Aspergillus fumigatus

NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFUA_2G01910	AFUA_2G10710	Q4WIG7	Q4X199	MRC1 domain-containing protein.	DNA repair protein rad9, putative.	0.654
AFUA_2G01910	AFUA_6G03970	Q4WIG7	Q4WD96	MRC1 domain-containing protein.	Cell cycle checkpoint protein (Hus1), putative.	0.545
AFUA_2G01910	AFUA_6G13160	Q4WIG7	Q4WLK9	MRC1 domain-containing protein.	Serine/threonine protein kinase, putative.	0.563
AFUA_2G10710	AFUA_2G01910	Q4X199	Q4WIG7	DNA repair protein rad9, putative.	MRC1 domain-containing protein.	0.654
AFUA_2G10710	AFUA_5G13380	Q4X199	Q4WVU8	DNA repair protein rad9, putative.	BRCT domain protein.	0.987
AFUA_2G10710	AFUA_6G03970	Q4X199	Q4WD96	DNA repair protein rad9, putative.	Cell cycle checkpoint protein (Hus1), putative.	0.999
AFUA_2G10710	AFUA_6G11410	Q4X199	Q4WM28	DNA repair protein rad9, putative.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.739
AFUA_2G10710	AFUA_6G13160	Q4X199	Q4WLK9	DNA repair protein rad9, putative.	Serine/threonine protein kinase, putative.	0.820
AFUA_2G10710	mus81	Q4X199	Q4WYE5	DNA repair protein rad9, putative.	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	0.496
AFUA_5G13220	mus81	Q4WVT2	Q4WYE5	ERCC4 domain-containing protein.	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	0.986
AFUA_5G13380	AFUA_2G10710	Q4WVU8	Q4X199	BRCT domain protein.	DNA repair protein rad9, putative.	0.987
AFUA_5G13380	AFUA_6G03970	Q4WVU8	Q4WD96	BRCT domain protein.	Cell cycle checkpoint protein (Hus1), putative.	0.832
AFUA_5G13380	AFUA_6G11410	Q4WVU8	Q4WM28	BRCT domain protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.689
AFUA_5G13380	AFUA_6G13160	Q4WVU8	Q4WLK9	BRCT domain protein.	Serine/threonine protein kinase, putative.	0.857
AFUA_5G13380	mus81	Q4WVU8	Q4WYE5	BRCT domain protein.	Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.	0.591
AFUA_6G03970	AFUA_2G01910	Q4WD96	Q4WIG7	Cell cycle checkpoint protein (Hus1), putative.	MRC1 domain-containing protein.	0.545
AFUA_6G03970	AFUA_2G10710	Q4WD96	Q4X199	Cell cycle checkpoint protein (Hus1), putative.	DNA repair protein rad9, putative.	0.999
AFUA_6G03970	AFUA_5G13380	Q4WD96	Q4WVU8	Cell cycle checkpoint protein (Hus1), putative.	BRCT domain protein.	0.832
AFUA_6G03970	AFUA_6G11410	Q4WD96	Q4WM28	Cell cycle checkpoint protein (Hus1), putative.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.802
AFUA_6G03970	AFUA_6G13160	Q4WD96	Q4WLK9	Cell cycle checkpoint protein (Hus1), putative.	Serine/threonine protein kinase, putative.	0.776