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AFUA_4G04180 AFUA_4G04180 AFUA_3G09935 AFUA_3G09935 AFUA_3G09930 AFUA_3G09930 AFUA_4G03615 AFUA_4G03615 AFUA_1G13140 AFUA_1G13140 AFUA_5G11230 AFUA_5G11230 AFUA_1G13330 AFUA_1G13330 AFUA_1G11450 AFUA_1G11450 abaA abaA arp1 arp1 rodA rodA chsG chsG chsD chsD AFUA_4G04320 AFUA_4G04320 AFUA_4G02760 AFUA_4G02760 AFUA_7G01030 AFUA_7G01030 AFUA_8G07060 AFUA_8G07060 AFUA_8G05630 AFUA_8G05630 AFUA_6G03210 AFUA_6G03210 AFUA_6G05150 AFUA_6G05150 AFUA_6G05160 AFUA_6G05160 AFUA_3G03060 AFUA_3G03060 AFUA_7G05560 AFUA_7G05560 AFUA_7G05570 AFUA_7G05570 AFUA_7G05580 AFUA_7G05580 AFUA_2G05020 AFUA_2G05020 AFUA_2G04010 AFUA_2G04010 AFUA_2G02480 AFUA_2G02480 AFUA_2G01870 AFUA_2G01870 AFUA_2G00360 AFUA_2G00360 crzA crzA AFUA_1G05970 AFUA_1G05970 AFUA_1G04950 AFUA_1G04950 AFUA_1G04850 AFUA_1G04850 AFUA_1G04700 AFUA_1G04700 AFUA_1G02440 AFUA_1G02440 AFUA_6G12950 AFUA_6G12950 AFUA_6G11030 AFUA_6G11030 AFUA_6G10670 AFUA_6G10670 AFUA_6G10240 AFUA_6G10240 AFUA_6G09050 AFUA_6G09050 AFUA_6G08320 AFUA_6G08320 AFUA_4G10860 AFUA_4G10860 wetA wetA AFUA_4G14380 AFUA_4G14380 brlA brlA AFUA_1G10880 AFUA_1G10880 AFUA_1G10690 AFUA_1G10690 AFUA_1G10580 AFUA_1G10580 AFUA_1G09230 AFUA_1G09230 AFUA_5G06600 AFUA_5G06600 AFUA_5G07710 AFUA_5G07710 AFUA_5G11520 AFUA_5G11520 AFUA_5G11810 AFUA_5G11810 AFUA_3G05630 AFUA_3G05630 AFUA_3G06080 AFUA_3G06080 AFUA_3G07140 AFUA_3G07140 AFUA_3G07210 AFUA_3G07210 AFUA_3G09910 AFUA_3G09910 AFUA_3G10690 AFUA_3G10690 AFUA_3G11090 AFUA_3G11090 AFUA_3G12480 AFUA_3G12480 AFUA_2G16520 AFUA_2G16520 AFUA_2G16470 AFUA_2G16470 AFUA_2G15390 AFUA_2G15390 AFUA_2G14990 AFUA_2G14990 AFUA_2G14040 AFUA_2G14040 AFUA_2G12560 AFUA_2G12560 AFUA_2G11180 AFUA_2G11180 AFUA_2G09410 AFUA_2G09410 stuA stuA AFUA_2G07800 AFUA_2G07800 chsC chsC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_4G04180Chitin synthase B. (1084 aa)
AFUA_3G09935Uncharacterized protein. (832 aa)
AFUA_3G09930Peroxin/Ferlin domain-containing protein. (480 aa)
AFUA_4G03615Conidiation protein Con-6, putative. (103 aa)
AFUA_1G13140G-protein complex alpha subunit GpaA/FadA. (353 aa)
AFUA_5G11230RAS small monomeric GTPase RasA. (213 aa)
AFUA_1G13330Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
AFUA_1G11450Myosin class II heavy chain (MHC), putative. (2081 aa)
abaAConidiophore development regulator abaA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (By similarity). Essential for differentiation and functionality of phialides as conidiogenous cells. Regulates autolysis and cell death. Positively regulates expression of the gliotoxin biosynt [...] (797 aa)
arp1Scytalone dehydratase arp1; Scytalone dehydratase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall. The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA. The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayg1 though chain-length shortening. 1,3,6,8-THN is substrate of the h [...] (168 aa)
rodAHydrophobin; Cell wall protein regularly arranged in interwoven fascicules of clustered proteinaceous microfibrils, or rodlets, to form the outer spore coat protein. It is involved in resistance to environmental stress and may well be associated with conidial hydrophobicity. It is important in the morphogenesis of the dispersible conidia. (159 aa)
chsGChitin synthase G; Plays a major role in cell wall biogenesis and required for normal hyphal growth and development. (911 aa)
chsDChitin synthase D; Plays a major role in cell wall biogenesis. (745 aa)
AFUA_4G04320Homeobox transcription factor, putative. (575 aa)
AFUA_4G02760DUF829 domain protein (PaxU), putative. (324 aa)
AFUA_7G01030Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1077 aa)
AFUA_8G07060Hydrophobin. (155 aa)
AFUA_8G05630Chitin synthase F. (1182 aa)
AFUA_6G03210Conidiation-specific protein (Con-10), putative. (83 aa)
AFUA_6G05150Transcriptional repressor TupA/RocA, putative. (702 aa)
AFUA_6G05160C2H2 transcription factor (Azf1), putative. (444 aa)
AFUA_3G03060Cell wall protein PhiA. (185 aa)
AFUA_7G05560Thioredoxin-like_fold domain-containing protein. (122 aa)
AFUA_7G05570Uncharacterized protein. (106 aa)
AFUA_7G05580Phospholipase. (879 aa)
AFUA_2G05020Cellular morphogenesis regulator DopA. (1675 aa)
AFUA_2G04010Trehalose-6-phosphate synthase. (479 aa)
AFUA_2G02480Uncharacterized protein. (264 aa)
AFUA_2G01870Chitin synthase; Plays a major role in cell wall biogenesis. (933 aa)
AFUA_2G00360Homeobox and C2H2 transcription factor, putative. (593 aa)
crzAC2H2 finger domain transcription factor crzA; Transcription factor involved in the regulation of calcium ion homeostasis. Regulates genes encoding calcium transporters, transcription factors and genes that could be directly or indirectly involved in calcium metabolism. Supports especially pmcA, pmcB and pmcC expression encoding for calcium- translocating P-type ATPases. Binds target promoters at motif A[GT][CG]CA[AC][AG]. Plays an essential role germination, radial growth, and asexual development. Plays also a major role in proper chitin and glucan incorporation into the cell wall. Inv [...] (754 aa)
AFUA_1G05970Ubiquitin ligase complex F-box protein GRR1, putative. (586 aa)
AFUA_1G04950Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
AFUA_1G04850Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. (94 aa)
AFUA_1G04700Ras guanyl-nucleotide exchange factor RasGEF, putative. (882 aa)
AFUA_1G02440Indole-diterpene biosynthesis protein PaxU, putative. (286 aa)
AFUA_6G12950Trehalose-6-phosphate synthase. (515 aa)
AFUA_6G11030RNA binding protein MSSP-2, putative. (624 aa)
AFUA_6G10670Uncharacterized protein. (207 aa)
AFUA_6G10240Sensor histidine kinase/response regulator Fos-1/TcsA. (708 aa)
AFUA_6G09050Nuclear membrane fusion protein Kar5, putative. (506 aa)
AFUA_6G08320Uncharacterized protein. (470 aa)
AFUA_4G10860Velvet domain-containing protein. (445 aa)
wetADevelopmental regulatory protein wetA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Plays an essential role in the completion of conidial maturation and is essential for trehalose biogenesis in conidia. Negatively regulates expression of the melanin biosynthetic gene cluster. Plays also an a role in the early phase of fungal growth including proper hyphal branching. (566 aa)
AFUA_4G14380Glutathione S-transferase, putative. (266 aa)
brlAC2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (By similarity). Positively regulates expression of the gliotoxin biosynthetic gene cluster in actively growing vegetative cells, and likely bridges morphological and chem [...] (426 aa)
AFUA_1G10880Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1432 aa)
AFUA_1G10690M protein repeat protein. (878 aa)
AFUA_1G10580Homeobox transcription factor, putative. (697 aa)
AFUA_1G09230DUF1000 domain protein. (181 aa)
AFUA_5G06600SNF2 family helicase/ATPase, putative. (1827 aa)
AFUA_5G07710Nuclear migration protein (ApsA), putative. (1639 aa)
AFUA_5G11520Serine/threonine protein kinase (Nrc-2), putative. (817 aa)
AFUA_5G11810Dynein heavy chain. (4368 aa)
AFUA_3G05630Phospholipase. (1807 aa)
AFUA_3G06080Multicopy suppressor of stt4 mutation. (905 aa)
AFUA_3G07140Extracellular developmental signal biosynthesis protein FluG; Belongs to the glutamine synthetase family. (860 aa)
AFUA_3G07210Polysaccharide deacetylase, putative. (452 aa)
AFUA_3G09910Phosphatidylinositol transporter, putative. (331 aa)
AFUA_3G10690Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1202 aa)
AFUA_3G11090Golgi complex component Cog3, putative. (756 aa)
AFUA_3G12480Conidiophore development protein HymA. (396 aa)
AFUA_2G16520Phospholipase. (1101 aa)
AFUA_2G16470Ubiquitin conjugating enzyme (UbcF), putative. (312 aa)
AFUA_2G15390FluG family protein; Belongs to the glutamine synthetase family. (447 aa)
AFUA_2G14990Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
AFUA_2G14040PIPK domain-containing protein. (341 aa)
AFUA_2G12560Pterin-4-alpha-carbinolamine dehydratase family protein. (268 aa)
AFUA_2G11180Developmental regulator FlbA. (712 aa)
AFUA_2G09410Alpha-N-acetylglucosaminidase, putative. (756 aa)
stuACell pattern formation-associated protein stuA; Transcription factor that regulates asexual reproduction. Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (By similarity). Controls the expression of 6 secondary metabolite biosynthetic clusters including 2 involved in the synthesis of alkaloids (fumigaclavine and fumitremorgen), 2 clusters of the ETP class (gliotoxin and an unknown ETP-like toxin), a cluster predicted to produce pseurotin A, and the product of the last cluster is unknown. Controls the product [...] (635 aa)
AFUA_2G07800GPI anchored protein, putative. (156 aa)
chsCChitin synthase C; Plays a major role in cell wall biogenesis. (893 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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