(37 nodes) Cytoskeleton-dependent cytokinesis network (Aspergillus fumigatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	AFUA_5G04180	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (739 aa)
	AFUA_3G14230	BAR adaptor protein RVS167, putative. (406 aa)
	AFUA_3G12250	Protein-tyrosine phosphatase, putative. (613 aa)
	AFUA_3G10250	Cell division control protein (Cdc15), putative. (944 aa)
	AFUA_3G08540	Calcium binding modulator protein (Alg2), putative. (323 aa)
	AFUA_3G07015	Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (553 aa)
	AFUA_3G05580	Chitin synthase activator (Chs3), putative. (726 aa)
	AFUA_4G04180	Chitin synthase B. (1084 aa)
	AFUA_1G13390	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (455 aa)
	AFUA_7G04210	Tropomyosin, putative. (154 aa)
	AFUA_7G05340	Cellular morphogenesis protein (Rax2), putative. (1203 aa)
	AFUA_7G05370	Septin AspB; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (527 aa)
	AFUA_7G05950	Cytokinesis EF-hand protein Cdc4, putative. (167 aa)
	ste20	Serine/threonine-protein kinase ste20; MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (815 aa)
	AFUA_2G01790	Conserved serine proline-rich protein. (871 aa)
	cap2	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (322 aa)
	AFUA_1G02930	Calmodulin, putative. (216 aa)
	AFUA_6G12340	GTPase activating protein (BUD2/CLA2), putative. (1266 aa)
	AFUA_4G12270	LIM domain protein. (806 aa)
	AFUA_1G09640	Actin-interacting protein (Bud6/Aip3), putative. (1055 aa)
	AFUA_1G09270	Transmembrane glycoprotein, putative. (890 aa)
	AFUA_1G08850	Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (346 aa)
	AFUA_5G05860	CRIB domain-containing protein. (815 aa)
	AFUA_5G05900	Non-specific serine/threonine protein kinase. (836 aa)
	AFUA_5G08300	Alpha-actinin, sarcomeric (F-actin cross linking protein). (645 aa)
	AFUA_5G08540	Septin AspA, putative; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (354 aa)
	AFUA_5G08700	Myosin type II heavy chain, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2405 aa)
	AFUA_5G11560	Arp2/3 complex subunit (Arp3), putative; Belongs to the actin family. (439 aa)
	AFUA_5G11970	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1106 aa)
	AFUA_5G12150	PH domain protein. (408 aa)
	AFUA_5G14060	Rho GTPase Rho4, putative. (286 aa)
	AFUA_5G03400	SH3 domain protein (Cyk3), putative. (1234 aa)
	AFUA_5G03080	Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (384 aa)
	AFUA_6G05045	Uncharacterized protein. (128 aa)
	AFUA_6G04940	Cytokinesis protein SepA/Bni1. (1800 aa)
	AFUA_6G04740	Actin Act1. (393 aa)
	AFUA_4G03050	Profilin; Belongs to the profilin family. (136 aa)

Your Current Organism:

Aspergillus fumigatus

NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFUA_1G02930	AFUA_3G10250	Q4WKC7	Q4WXP7	Calmodulin, putative.	Cell division control protein (Cdc15), putative.	0.445
AFUA_1G02930	AFUA_4G03050	Q4WKC7	Q4WA10	Calmodulin, putative.	Profilin; Belongs to the profilin family.	0.503
AFUA_1G02930	AFUA_4G12270	Q4WKC7	Q4WQB8	Calmodulin, putative.	LIM domain protein.	0.794
AFUA_1G02930	AFUA_5G05860	Q4WKC7	Q4WTR8	Calmodulin, putative.	CRIB domain-containing protein.	0.640
AFUA_1G02930	AFUA_5G05900	Q4WKC7	Q4WTS2	Calmodulin, putative.	Non-specific serine/threonine protein kinase.	0.672
AFUA_1G02930	AFUA_5G08300	Q4WKC7	Q4WUF8	Calmodulin, putative.	Alpha-actinin, sarcomeric (F-actin cross linking protein).	0.640
AFUA_1G02930	AFUA_5G08700	Q4WKC7	Q4WUJ7	Calmodulin, putative.	Myosin type II heavy chain, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.999
AFUA_1G02930	AFUA_5G11560	Q4WKC7	Q4WVC0	Calmodulin, putative.	Arp2/3 complex subunit (Arp3), putative; Belongs to the actin family.	0.442
AFUA_1G02930	AFUA_5G14060	Q4WKC7	Q4WW13	Calmodulin, putative.	Rho GTPase Rho4, putative.	0.492
AFUA_1G02930	AFUA_6G04740	Q4WKC7	Q4WDH2	Calmodulin, putative.	Actin Act1.	0.791
AFUA_1G02930	AFUA_6G04940	Q4WKC7	Q4WDJ2	Calmodulin, putative.	Cytokinesis protein SepA/Bni1.	0.404
AFUA_1G02930	AFUA_7G04210	Q4WKC7	Q4WG92	Calmodulin, putative.	Tropomyosin, putative.	0.905
AFUA_1G02930	AFUA_7G05950	Q4WKC7	Q4WGR4	Calmodulin, putative.	Cytokinesis EF-hand protein Cdc4, putative.	0.860
AFUA_1G02930	ste20	Q4WKC7	Q4WHP3	Calmodulin, putative.	Serine/threonine-protein kinase ste20; MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.	0.672
AFUA_1G08850	AFUA_3G07015	Q4WTL8	Q4WWT7	Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	0.540
AFUA_1G08850	AFUA_5G03080	Q4WTL8	Q4WEI0	Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	0.960
AFUA_1G08850	AFUA_5G04180	Q4WTL8	Q4WEU0	Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	0.768
AFUA_1G08850	AFUA_5G08540	Q4WTL8	Q4WUI1	Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	Septin AspA, putative; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	0.948
AFUA_1G08850	AFUA_7G05370	Q4WTL8	Q4WGK7	Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	Septin AspB; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	0.966
AFUA_1G09270	AFUA_7G05340	Q4WTH6	Q4WGK4	Transmembrane glycoprotein, putative.	Cellular morphogenesis protein (Rax2), putative.	0.463