(62 nodes) Supramolecular fiber organization network (Aspergillus fumigatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AFUA_6G12570	EH domain binding protein epsin 2. (561 aa)
	AFUA_6G12980	Spindle pole body component, putative. (911 aa)
	AFUA_1G01140	Uncharacterized protein. (252 aa)
	AFUA_1G01640	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (457 aa)
	AFUA_1G02440	Indole-diterpene biosynthesis protein PaxU, putative. (286 aa)
	AFUA_1G02550	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
	AFUA_1G09640	Actin-interacting protein (Bud6/Aip3), putative. (1055 aa)
	AFUA_1G02670	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (320 aa)
	AFUA_1G07580	Cell polarity protein (Alp11), putative. (274 aa)
	AFUA_2G01200	Actin polymerization protein Bzz1, putative. (743 aa)
	AFUA_2G03150	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1009 aa)
	AFUA_2G03180	C6 finger domain protein, putative. (621 aa)
	AFUA_2G06040	Actin cortical patch component, putative. (577 aa)
	AFUA_7G04210	Tropomyosin, putative. (154 aa)
	AFUA_7G03710	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (955 aa)
	AFUA_5G02730	Spindle pole body component. (888 aa)
	AFUA_5G02460	Uncharacterized protein. (621 aa)
	AFUA_5G01860	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (188 aa)
	AFUA_6G04940	Cytokinesis protein SepA/Bni1. (1800 aa)
	AFUA_6G02540	Actin associated protein Wsp1, putative. (643 aa)
	AFUA_6G02370	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
	AFUA_6G02360	Uncharacterized protein. (624 aa)
	AFUA_8G04140	Uncharacterized protein. (772 aa)
	AFUA_8G04660	Noc1p protein, putative. (679 aa)
	myoA	Myosin-1; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation (By similarity). (1249 aa)
	AFUA_4G02760	DUF829 domain protein (PaxU), putative. (324 aa)
	AFUA_3G06690	Rho GTPase Rho3. (197 aa)
	AFUA_1G13390	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (455 aa)
	AFUA_1G13030	Uncharacterized protein. (672 aa)
	AFUA_1G11450	Myosin class II heavy chain (MHC), putative. (2081 aa)
	AFUA_1G13330	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
	AFUA_1G12760	Adenylyl cyclase-associated protein; Belongs to the CAP family. (526 aa)
	AFUA_6G06900	Rho GTPase Rho1. (200 aa)
	AFUA_2G16980	Uncharacterized protein. (129 aa)
	AFUA_5G05860	CRIB domain-containing protein. (815 aa)
	AFUA_5G08300	Alpha-actinin, sarcomeric (F-actin cross linking protein). (645 aa)
	AFUA_5G10360	Actin-binding protein Fragmin, putative. (399 aa)
	AFUA_5G10570	Cofilin; Belongs to the actin-binding proteins ADF family. (154 aa)
	AFUA_5G11380	Rho-gdp dissociation inhibitor. (197 aa)
	AFUA_5G11560	Arp2/3 complex subunit (Arp3), putative; Belongs to the actin family. (439 aa)
	AFUA_5G11810	Dynein heavy chain. (4368 aa)
	AFUA_5G14060	Rho GTPase Rho4, putative. (286 aa)
	AFUA_3G06140	Cytoskeleton assembly control protein Sla2, putative. (1043 aa)
	AFUA_3G10340	Rho GTPase Rho 2, putative. (207 aa)
	AFUA_3G10700	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (193 aa)
	AFUA_3G11320	Spindle pole body component. (1035 aa)
	AFUA_2G07420	Actin-bundling protein Sac6, putative. (646 aa)
	AFUA_3G13340	Rho-like small GTPase, putative. (192 aa)
	AFUA_2G16920	Actin monomer binding protein, putative. (311 aa)
	AFUA_2G15750	Spindle pole body component. (826 aa)
	AFUA_2G14280	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (769 aa)
	AFUA_2G14270	Coronin; Belongs to the WD repeat coronin family. (615 aa)
	AFUA_2G13450	Dynactin, putative. (1378 aa)
	AFUA_2G11430	Spindle pole body component. (891 aa)
	nde1	Nuclear distribution protein nudE homolog 1; Required for nuclear migration within hyphae during vegetative growth. (621 aa)
	AFUA_6G09080	VHS domain protein. (436 aa)
	AFUA_6G07880	DUF500 and SH3 domain protein. (402 aa)
	AFUA_6G06500	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family. (363 aa)
	AFUA_4G07000	Tyrosine phosphatase family protein. (241 aa)
	AFUA_1G14960	Gelsolin repeat protein, putative. (1637 aa)
	end3	Actin cytoskeleton-regulatory complex protein end3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (404 aa)
	stu1	Protein stu1; Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity). (1344 aa)

Your Current Organism:

Aspergillus fumigatus

NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFUA_1G01140	AFUA_1G01640	Q4WKV6	Q4WKQ6	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.432
AFUA_1G01140	AFUA_1G02550	Q4WKV6	Q4WKG5	Uncharacterized protein.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.434
AFUA_1G01140	AFUA_1G13390	Q4WKV6	E9R808	Uncharacterized protein.	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	0.502
AFUA_1G01140	AFUA_2G03150	Q4WKV6	Q4WI43	Uncharacterized protein.	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.644
AFUA_1G01140	AFUA_5G11810	Q4WKV6	Q4WVE4	Uncharacterized protein.	Dynein heavy chain.	0.671
AFUA_1G01140	AFUA_6G12980	Q4WKV6	Q4WLM6	Uncharacterized protein.	Spindle pole body component, putative.	0.573
AFUA_1G01140	AFUA_7G03710	Q4WKV6	Q4WG42	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.570
AFUA_1G01640	AFUA_1G01140	Q4WKQ6	Q4WKV6	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.432
AFUA_1G01640	AFUA_2G03150	Q4WKQ6	Q4WI43	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.569
AFUA_1G01640	AFUA_2G13450	Q4WKQ6	Q4X0H5	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Dynactin, putative.	0.484
AFUA_1G01640	AFUA_2G14280	Q4WKQ6	Q4X092	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.432
AFUA_1G01640	AFUA_6G12980	Q4WKQ6	Q4WLM6	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Spindle pole body component, putative.	0.472
AFUA_1G01640	AFUA_7G03710	Q4WKQ6	Q4WG42	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.569
AFUA_1G02550	AFUA_1G01140	Q4WKG5	Q4WKV6	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Uncharacterized protein.	0.434
AFUA_1G02550	AFUA_1G07580	Q4WKG5	Q4WJ16	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Cell polarity protein (Alp11), putative.	0.428
AFUA_1G02550	AFUA_1G13330	Q4WKG5	E9R082	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.510
AFUA_1G02550	AFUA_2G03150	Q4WKG5	Q4WI43	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.680
AFUA_1G02550	AFUA_2G14280	Q4WKG5	Q4X092	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.434
AFUA_1G02550	AFUA_5G11560	Q4WKG5	Q4WVC0	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Arp2/3 complex subunit (Arp3), putative; Belongs to the actin family.	0.452
AFUA_1G02550	AFUA_5G11810	Q4WKG5	Q4WVE4	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Dynein heavy chain.	0.984