STRINGSTRING
AFUA_2G10730 AFUA_2G10730 AFUA_3G13950 AFUA_3G13950 AFUA_3G09935 AFUA_3G09935 AFUA_3G09930 AFUA_3G09930 AFUA_3G05575 AFUA_3G05575 AFUA_1G14695 AFUA_1G14695 AFUA_6G10965 AFUA_6G10965 AFUA_1G13330 AFUA_1G13330 AFUA_1G13390 AFUA_1G13390 AFUA_4G04760 AFUA_4G04760 AFUA_4G03980 AFUA_4G03980 AFUA_7G02200 AFUA_7G02200 AFUA_8G05820 AFUA_8G05820 AFUA_8G05680 AFUA_8G05680 AFUA_8G05630 AFUA_8G05630 AFUA_8G04140 AFUA_8G04140 AFUA_6G02530 AFUA_6G02530 AFUA_6G02900 AFUA_6G02900 AFUA_6G03770 AFUA_6G03770 AFUA_6G03970 AFUA_6G03970 AFUA_5G02560 AFUA_5G02560 AFUA_5G04070 AFUA_5G04070 AFUA_3G03060 AFUA_3G03060 AFUA_3G02880 AFUA_3G02880 msh3 msh3 AFUA_7G05580 AFUA_7G05580 AFUA_7G05890 AFUA_7G05890 AFUA_2G06320 AFUA_2G06320 AFUA_2G04010 AFUA_2G04010 AFUA_2G02660 AFUA_2G02660 AFUA_2G02530 AFUA_2G02530 AFUA_2G02480 AFUA_2G02480 AFUA_2G01900 AFUA_2G01900 AFUA_1G07590 AFUA_1G07590 AFUA_1G07195 AFUA_1G07195 AFUA_1G05970 AFUA_1G05970 AFUA_1G04950 AFUA_1G04950 AFUA_1G04920 AFUA_1G04920 AFUA_1G04850 AFUA_1G04850 AFUA_1G02060 AFUA_1G02060 AFUA_1G02000 AFUA_1G02000 AFUA_1G01140 AFUA_1G01140 ubc2 ubc2 AFUA_6G13690 AFUA_6G13690 AFUA_6G13080 AFUA_6G13080 AFUA_6G13050 AFUA_6G13050 AFUA_6G12950 AFUA_6G12950 AFUA_6G12910 AFUA_6G12910 AFUA_6G11410 AFUA_6G11410 AFUA_6G11030 AFUA_6G11030 AFUA_6G10670 AFUA_6G10670 AFUA_6G10440 AFUA_6G10440 AFUA_6G10380 AFUA_6G10380 AFUA_6G10240 AFUA_6G10240 AFUA_6G09930 AFUA_6G09930 AFUA_6G08320 AFUA_6G08320 AFUA_4G06260 AFUA_4G06260 AFUA_4G06490 AFUA_4G06490 AFUA_4G08300 AFUA_4G08300 AFUA_4G09640 AFUA_4G09640 AFUA_4G12670 AFUA_4G12670 AFUA_4G12680 AFUA_4G12680 AFUA_1G15120 AFUA_1G15120 AFUA_1G12520 AFUA_1G12520 AFUA_1G11170 AFUA_1G11170 AFUA_1G10410 AFUA_1G10410 AFUA_1G08860 AFUA_1G08860 AFUA_5G07710 AFUA_5G07710 AFUA_5G09000 AFUA_5G09000 AFUA_5G09710 AFUA_5G09710 nuf2 nuf2 AFUA_5G11390 AFUA_5G11390 AFUA_5G11700 AFUA_5G11700 AFUA_5G13150 AFUA_5G13150 AFUA_5G13220 AFUA_5G13220 AFUA_5G13640 AFUA_5G13640 AFUA_3G05530 AFUA_3G05530 AFUA_3G05540 AFUA_3G05540 AFUA_3G05630 AFUA_3G05630 AFUA_3G06080 AFUA_3G06080 AFUA_3G06980 AFUA_3G06980 AFUA_3G07280 AFUA_3G07280 AFUA_3G08800 AFUA_3G08800 AFUA_3G09910 AFUA_3G09910 AFUA_3G12250 AFUA_3G12250 mus81 mus81 AFUA_2G16850 AFUA_2G16850 AFUA_2G16520 AFUA_2G16520 AFUA_2G14990 AFUA_2G14990 AFUA_2G14280 AFUA_2G14280 AFUA_2G14040 AFUA_2G14040 AFUA_2G13540 AFUA_2G13540 AFUA_2G13410 AFUA_2G13410 AFUA_2G12560 AFUA_2G12560
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_2G10730DNA polymerase. (1462 aa)
AFUA_3G13950Mis12-Mtw1 family protein. (589 aa)
AFUA_3G09935Uncharacterized protein. (832 aa)
AFUA_3G09930Peroxin/Ferlin domain-containing protein. (480 aa)
AFUA_3G05575TBP interacting domain protein, putative. (186 aa)
AFUA_1G14695DNA repair protein Dds20/Mei5, putative. (286 aa)
AFUA_6G10965Apoptosis-inducing TAF9-like domain 1 family protein, putative. (110 aa)
AFUA_1G13330Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa)
AFUA_1G13390Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (455 aa)
AFUA_4G04760Inositol kinase kinase (UvsB), putative; Belongs to the PI3/PI4-kinase family. (2449 aa)
AFUA_4G03980Chromosome segregation protein (Pcs1), putative. (529 aa)
AFUA_7G02200Meiotic recombination protein (Dmc1), putative; Belongs to the RecA family. (338 aa)
AFUA_8G05820DNA mismatch repair protein, putative. (882 aa)
AFUA_8G05680Serine/threonine-protein kinase. (1119 aa)
AFUA_8G05630Chitin synthase F. (1182 aa)
AFUA_8G04140Uncharacterized protein. (772 aa)
AFUA_6G02530DNA repair protein RAD1, putative. (975 aa)
AFUA_6G02900Rad21/Rec8 N terminal domain protein. (741 aa)
AFUA_6G03770Oxidoreductase (Msc7), putative; Belongs to the aldehyde dehydrogenase family. (636 aa)
AFUA_6G03970Cell cycle checkpoint protein (Hus1), putative. (373 aa)
AFUA_5G02560Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (675 aa)
AFUA_5G04070Meiosis-specific topoisomerase Spo11, putative. (388 aa)
AFUA_3G03060Cell wall protein PhiA. (185 aa)
AFUA_3G02880Alpha-L-rhamnosidase C, putative. (813 aa)
msh3DNA mismatch repair protein msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1123 aa)
AFUA_7G05580Phospholipase. (879 aa)
AFUA_7G05890Uncharacterized protein. (252 aa)
AFUA_2G06320Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (529 aa)
AFUA_2G04010Trehalose-6-phosphate synthase. (479 aa)
AFUA_2G02660DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
AFUA_2G02530Casein kinase I, putative; Belongs to the protein kinase superfamily. (383 aa)
AFUA_2G02480Uncharacterized protein. (264 aa)
AFUA_2G01900RNA polymerase II transcription elongation factor Rtf1p, putative. (607 aa)
AFUA_1G07590Cupin domain protein. (634 aa)
AFUA_1G07195APH domain-containing protein. (379 aa)
AFUA_1G05970Ubiquitin ligase complex F-box protein GRR1, putative. (586 aa)
AFUA_1G04950Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
AFUA_1G04920Calmodulin-binding protein Sha1, putative. (1015 aa)
AFUA_1G04850Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. (94 aa)
AFUA_1G02060Pachytene checkpoint component Pch2, putative; Belongs to the AAA ATPase family. (455 aa)
AFUA_1G02000DNA mismatch repair protein Msh4, putative. (840 aa)
AFUA_1G01140Uncharacterized protein. (252 aa)
ubc2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
AFUA_6G13690DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1660 aa)
AFUA_6G13080DEAD/DEAH box DNA helicase (Mer3), putative. (1439 aa)
AFUA_6G13050Meiosis specific protein Hop1, putative. (732 aa)
AFUA_6G12950Trehalose-6-phosphate synthase. (515 aa)
AFUA_6G12910DsDNA-dependent ATPase Rad54, putative. (807 aa)
AFUA_6G11410Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa)
AFUA_6G11030RNA binding protein MSSP-2, putative. (624 aa)
AFUA_6G10670Uncharacterized protein. (207 aa)
AFUA_6G10440Uncharacterized protein. (214 aa)
AFUA_6G10380Cullin binding protein CanA, putative. (1240 aa)
AFUA_6G10240Sensor histidine kinase/response regulator Fos-1/TcsA. (708 aa)
AFUA_6G09930BZIP transcription factor AP-1/Yap1, putative. (615 aa)
AFUA_6G08320Uncharacterized protein. (470 aa)
AFUA_4G06260Mating-type switch/DNA repair protein Swi10/Rad10, putative. (341 aa)
AFUA_4G06490DNA mismatch repair protein (Mlh3), putative. (916 aa)
AFUA_4G08300DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1213 aa)
AFUA_4G09640Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (189 aa)
AFUA_4G12670DNA repair protein Rad1, putative. (491 aa)
AFUA_4G12680DNA repair protein Rad50. (1312 aa)
AFUA_1G15120DsDNA-dependent ATPase (Rad54b), putative. (969 aa)
AFUA_1G12520DNA repair protein (Rad57), putative. (647 aa)
AFUA_1G11170DNA mismatch repair protein Msh5, putative. (830 aa)
AFUA_1G10410DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
AFUA_1G08860Meiotic recombination protein Ski8/Rec14, putative. (209 aa)
AFUA_5G07710Nuclear migration protein (ApsA), putative. (1639 aa)
AFUA_5G09000Sister chromatid cohesion protein (Eso1), putative. (672 aa)
AFUA_5G09710Separin, putative. (2120 aa)
nuf2Probable kinetochore protein nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (463 aa)
AFUA_5G11390APSES transcription factor, putative. (427 aa)
AFUA_5G11700DNA mismatch repair protein Mlh1, putative. (709 aa)
AFUA_5G13150SUN domain-containing protein. (732 aa)
AFUA_5G13220ERCC4 domain-containing protein. (649 aa)
AFUA_5G13640Thioredoxin, putative. (565 aa)
AFUA_3G05530Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1118 aa)
AFUA_3G05540Cell cycle protein kinase, putative. (464 aa)
AFUA_3G05630Phospholipase. (1807 aa)
AFUA_3G06080Multicopy suppressor of stt4 mutation. (905 aa)
AFUA_3G06980Uncharacterized protein. (304 aa)
AFUA_3G07280Uncharacterized protein. (335 aa)
AFUA_3G08800DUF1767 domain-containing protein. (249 aa)
AFUA_3G09910Phosphatidylinositol transporter, putative. (331 aa)
AFUA_3G12250Protein-tyrosine phosphatase, putative. (613 aa)
mus81Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (596 aa)
AFUA_2G16850Sister chromatid cohesion and DNA repair protein (BimD), putative. (1492 aa)
AFUA_2G16520Phospholipase. (1101 aa)
AFUA_2G14990Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
AFUA_2G14280Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (769 aa)
AFUA_2G14040PIPK domain-containing protein. (341 aa)
AFUA_2G13540CCCH zinc finger and RRM domain protein. (744 aa)
AFUA_2G13410DNA mismatch repair protein (Pms1), putative. (1044 aa)
AFUA_2G12560Pterin-4-alpha-carbinolamine dehydratase family protein. (268 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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