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AFUA_3G09210 AFUA_3G09210 AFUA_7G03680 AFUA_7G03680 AFUA_5G03120 AFUA_5G03120 AFUA_7G00870 AFUA_7G00870 AFUA_7G04270 AFUA_7G04270 rat1 rat1 AFUA_2G13650 AFUA_2G13650 AFUA_2G14950 AFUA_2G14950 AFUA_2G16830 AFUA_2G16830 rex3 rex3 AFUA_3G11820 AFUA_3G11820 AFUA_3G09880 AFUA_3G09880 AFUA_3G09050 AFUA_3G09050 fen1 fen1 AFUA_3G05860 AFUA_3G05860 ccr4 ccr4 AFUA_4G12250 AFUA_4G12250 AFUA_6G11410 AFUA_6G11410 AFUA_1G01540 AFUA_1G01540 AFUA_2G02340 AFUA_2G02340 pan2n2 pan2n2 rex4 rex4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_3G09210Endonuclease/exonuclease/phosphatase family protein. (606 aa)
AFUA_7G03680SacI domain and endonuclease/exonuclease/phosphatase family protein. (1160 aa)
AFUA_5G031205'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. (1418 aa)
AFUA_7G00870RNA exonuclease, putative. (423 aa)
AFUA_7G042703'-5' exonuclease/helicase (Wrn), putative. (419 aa)
rat15'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (1058 aa)
AFUA_2G13650Endonuclease/exonuclease/phosphatase family protein. (362 aa)
AFUA_2G14950Exonuclease, putative. (750 aa)
AFUA_2G16830Endonuclease/exonuclease/phosphatase family protein. (300 aa)
rex3RNA exonuclease 3; 3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA; Belongs to the REXO1/REXO3 family. (645 aa)
AFUA_3G11820RNA exonuclease Rex2, putative. (250 aa)
AFUA_3G09880Exosome complex exonuclease Rrp6, putative. (764 aa)
AFUA_3G09050Exonuclease, putative. (658 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
AFUA_3G05860Exosome complex exonuclease Rrp4, putative. (390 aa)
ccr4Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (696 aa)
AFUA_4G12250Exosome complex exonuclease exoribonuclease (Rrp44), putative; Belongs to the RNR ribonuclease family. (1034 aa)
AFUA_6G11410Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa)
AFUA_1G01540Endonuclease/exonuclease/phosphatase family protein. (439 aa)
AFUA_2G02340Exosome complex exonuclease Rrp40, putative. (274 aa)
pan2n2PAN2-PAN3 deadenylation complex catalytic subunit pan2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1155 aa)
rex4RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family. (310 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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