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| | AFUA_1G07730 | Extracellular metalloprotease AFUA_1G07730; Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Plays a pivotal role as a pathogenicity determinant during infections and contributes to the ability of the pathogen to persist within the mammalian host (By similarity). Belongs to the peptidase M43B family. (322 aa) |
| | pelB | Probable pectin lyase B; Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins (By similarity). (378 aa) |
| | gpi11 | Glycosylphosphatidylinositol anchor biosynthesis protein 11; Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein. (297 aa) |
| | crf2 | Probable glycosidase crf2; Belongs to the glycosyl hydrolase 16 family. (443 aa) |
| | mirC | MFS siderochrome iron transporter C; Major facilitator transporter that contributes to the maintenance of intracellular siderophore ferricrocin (FC) levels. Plays a role in conidiation and confers protection against oxidative stress. Contributes also to fungal virulence in the Galleria mellonella animal model system. Does not appear to play a role in either siderophore export or uptake. (611 aa) |
| | atg22-1 | Autophagy-related protein 22-1; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity); Belongs to the ATG22 family. (609 aa) |
| | plyD | Probable pectate lyase D; Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester (By similarity); Belongs to the polysaccharide lyase 3 family. (242 aa) |
| | sed5 | Tripeptidyl-peptidase sed5; Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence. (580 aa) |
| | bglL | Probable beta-glucosidase L; Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity). Belongs to the glycosyl hydrolase 3 family. (739 aa) |
| | sit1 | Siderophore iron transporter 1; Major facilitator transporter involved in ferrichrome (FC) and ferrioxamine B (FOB) uptake. (577 aa) |
| | bst1 | GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. (1156 aa) |
| | sun1 | Secreted beta-glucosidase sun1; Cell surface beta-glucosidase involved in cell wall biosynthesis and septation, and thus required for normal growth and correct hyphal morphogenesis. Has hydrolytic activity on linear (1->3)- beta-D-glucans such as laminaribiose and other laminarioligosaccharides. Has also a minor transferase activity. Belongs to the SUN family. (414 aa) |
| | sit2 | Siderochrome iron transporter 2; Major facilitator transporter involved in ferrichrome (FC) uptake. (607 aa) |
| | eglC | Probable glucan endo-1,3-beta-glucosidase eglC; Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase (By similarity). Belongs to the glycosyl hydrolase 17 family. (446 aa) |
| | xlnA | Endo-1,4-beta-xylanase xynf11a; Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. (228 aa) |
| | lacE | Probable beta-galactosidase E; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. (1011 aa) |
| | lap2 | Probable leucine aminopeptidase 2; Extracellular aminopeptidase that releases a wide variety of amino acids from natural peptides and contributes to pathogenicity. Belongs to the peptidase M28 family. M28A subfamily. (501 aa) |
| | AFUA_3G00880 | UPF0619 GPI-anchored membrane protein AFUA_3G00880; Belongs to the UPF0619 family. (219 aa) |
| | AFUA_3G01220 | Probable aspartic-type endopeptidase AFUA_3G01220; Probable aspartic-type endopeptidase which contributes to virulence; Belongs to the peptidase A1 family. (439 aa) |
| | cbhC | Probable 1,4-beta-D-glucan cellobiohydrolase C; The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose. Belongs to the glycosyl hydrolase 6 (cellulase B) family. (454 aa) |
| | bxlB | Probable exo-1,4-beta-xylosidase bxlB; Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose; Belongs to the glycosyl hydrolase 3 family. (771 aa) |
| | mdr3 | Major facilitator superfamily multidrug transporter mdr3; Major facilitator superfamily transporter that confers resistance to azoles such as itraconazole. (528 aa) |
| | chiA1 | Endochitinase A1; GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation (By similarity); Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily. (888 aa) |
| | xanG | Cytochrome P450 monooxygenase xanG; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the isocyanide xanthocillin and its derivatives. The first step of the pathway consists in the conversion of tyrosine into a vinyl-isonitrile intermediate by the isocyanide synthase xanB. Subsequent oxidative dimerization of this intermediate to form xanthocillin may involve the cytochrome P450 monooxygenase xanG, whose expression is coregulated with that of XanB. Xanthocillin can be further modified by the isonitrile hydratase-like protein xanA which introduces [...] (538 aa) |
| | aglB | Probable alpha-galactosidase B; Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides. (447 aa) |
| | opsB | Probable aspartic-type endopeptidase opsB; Probable GPI-anchored aspartic-type endopeptidase which contributes to virulence; Belongs to the peptidase A1 family. (485 aa) |
| | las21 | GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity). (767 aa) |
| | atrF | ABC multidrug transporter atrF; Pleiotropic ABC efflux transporter involved in the basal level of azole susceptibility. Confers resistance to fluconazole and voriconazole. (1547 aa) |
| | bglE | Probable beta-glucosidase E; Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity). Belongs to the glycosyl hydrolase 3 family. (1033 aa) |
| | fmpD | ABC transporter fmpD; ABC transporter; part of the gene cluster that mediates the biosynthesis of fumipyrrole, a brown pigment that is involved in growth and conidiation. (1285 aa) |
| | fmpB | N-methyltransferase fmpB; Methyltransferase; part of the gene cluster that mediates the biosynthesis of fumipyrrole, a brown pigment that is involved in growth and conidiation. (366 aa) |
| | fmpA | Amino acid oxidase fmpA; Amino acid oxidase; part of the gene cluster that mediates the biosynthesis of fumipyrrole, a brown pigment that is involved in growth and conidiation. (497 aa) |
| | pgaX | Probable exopolygalacturonase X; Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates. (432 aa) |
| | AFUA_6G02800 | Uncharacterized protein AFUA_6G02800. (242 aa) |
| | plyE | Probable pectate lyase E; Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester (By similarity); Belongs to the polysaccharide lyase 3 family. (254 aa) |
| | axeA | Probable acetylxylan esterase A; Acetylxylan esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Degrades acetylated xylans by cleaving acetyl side groups from the hetero-xylan backbone (By similarity); Belongs to the carbohydrate esterase 1 (CE1) family. AxeA subfamily. (371 aa) |
| | eglD | Probable endo-beta-1,4-glucanase D; Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates (By similarity). Belongs to the glycosyl hydrolase 61 family. (349 aa) |
| | pmeA | Probable pectinesterase A; Involved in maceration and soft-rotting of plant tissue. Belongs to the pectinesterase family. (324 aa) |
| | xghA | Probable endo-xylogalacturonan hydrolase A; Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin. Activity requires a galacturonic acid backbone substituted with xylose (By similarity); Belongs to the glycosyl hydrolase 28 family. (406 aa) |
| | manF | Mannan endo-1,4-beta-mannosidase F; Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans. (438 aa) |
| | neg1 | Endo-1,6-beta-D-glucanase neg1; Endoglucanase that has highest activity on the linear beta- 1,6-glucan pustulan and lower activity against laminarin (beta-1,3- glucans with beta-1,6-branches). Is active on C.albicans cell walls allowing the release of a previously described cell wall proteins. Belongs to the glycosyl hydrolase 30 family. (488 aa) |
| | vps10 | Vacuolar protein sorting/targeting protein 10; Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity); Belongs to the VPS10-related sortilin family. (1487 aa) |
| | gnt1 | Glucose N-acetyltransferase 1; N-acetylglucosaminyltransferase involved in the Golgi- specific modification of N-linked glycans; Belongs to the GNT1 family. (384 aa) |
| | pgxB | Probable exopolygalacturonase B; Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates. (453 aa) |
| | AFUA_8G02130 | 1,3-beta-glucanosyltransferase; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall; Belongs to the glycosyl hydrolase 72 family. (537 aa) |
| | pgaB | Probable endopolygalacturonase B; Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall (By similarity). (364 aa) |
| | csn | Endo-chitosanase; Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall. Chitoolisaccharides produced by the hydrolysis of partially N- acetylated chitosan are known to have many biological activities, including antibacterial activity, immune-enhancing effects, and ellicitor activity. The chitosans with higher degrees of deacetylation were shown to be the better substrates. Chitodimer, chitotrimer, and chitotetramer are the major products but m [...] (242 aa) |
| | af510 | Multifunctional cytochrome P450 monooxygenase af510; Multifunctional cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid that has numerous biological activities including irreversible inhibition of human type 2 methionine aminopeptidase (METAP2). The pathway begins with the conversion of farnesyl pyrophosphate (FPP) to beta-trans- bergamotene by the membrane-bound beta-trans-bergamotene synthase af520. The initial oxidation of beta-trans-bergamotene by the multifunctional cytochrome P450 monooxygenase af510 involves C-H [...] (536 aa) |
| | celB | Probable endo-beta-1,4-glucanase celB; Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates (By similarity). (407 aa) |
| | mndB | Beta-mannosidase B; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Prefers mannobiose over mannotriose and has no activity against polymeric mannan. Is also severely restricted by galactosyl substitutions at the +1 subsite (By similarity); Belongs to the glycosyl hydrolase 2 family. Beta- mannosidase B subfamily. (845 aa) |
| | abcE | ABC multidrug transporter E; Pleiotropic ABC efflux transporter that may be involved in A.fumigatus adaptation to azoles such as vorizonazole. (1274 aa) |
| | bglK | Probable beta-glucosidase K; Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity). Belongs to the glycosyl hydrolase 3 family. (767 aa) |
| | nscC | FAD-dependent monooxygenase nscC; FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of neosartoricin, a prenylated anthracenone that exhibits T-cell antiproliferative activity, suggestive of a physiological role as an immunosuppressive agent. The non-reducing polyketide synthase nscA probably synthesizes and cyclizes the decaketide backbone. The hydrolase nscB then mediates the product release through hydrolysis followed by spontaneous decarboxylation. The prenyltransferase nscD catalyzes the addition of the dimethylallyl group to the aromatic C5. The [...] (408 aa) |
| | AFUA_4G02770 | Manganese lipoxygenase; Lipoxygenase that metabolizes linoleic acid to 9- and 13- hydroperoxy fatty acids. Specific towards 13-HPODE yielding 89% of the total HPODE. (608 aa) |
| | rglA | Probable rhamnogalacturonate lyase A; Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Degrades the rhamnogalacturonan I (RG-I) backbone of pectin (By similarity). (528 aa) |
| | mcd4 | GPI ethanolamine phosphate transferase 1; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). (1032 aa) |
| | lap1 | Leucine aminopeptidase 1; Extracellular aminopeptidase that allows assimilation of proteinaceous substrates and which contributes to pathogenicity. Belongs to the peptidase M28 family. M28E subfamily. (388 aa) |
| | abnC | Probable arabinan endo-1,5-alpha-L-arabinosidase C; Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan (By similarity); Belongs to the glycosyl hydrolase 43 family. (321 aa) |
| | faeB-1 | Probable feruloyl esterase B-1; Involved in degradation of plant cell walls. Hydrolyzes of the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin (By similarity); Belongs to the tannase family. (528 aa) |
| | alp2 | Alkaline protease 2; Alkaline protease that allows assimilation of proteinaceous substrates. Acts as a significant virulence factor in invasive aspergillosis. Required for regular sporulation. (495 aa) |
| | AFUA_4G09580 | Major allergen Asp f 2; Belongs to the ZPS1 family. (310 aa) |
| | mep | Extracellular metalloproteinase mep; Secreted metalloproteinase that allows assimilation of proteinaceous substrates and probably acts as a virulence factor (By similarity). Catalyzes the hydrolysis of elastin; Belongs to the peptidase M36 family. (634 aa) |
| | alp1 | Alkaline protease 1; Secreted alkaline protease that allows assimilation of proteinaceous substrates. Acts as a significant virulence factor in invasive aspergillosis. Involved in immune evasion from the human and mice complement systems during infection. Efficiently cleaves important components of the complement cascade such as such as C3, C4, C5, and C1q, as well as IgG, which leads to down-regulation of complement activation at the hyphal surface; Belongs to the peptidase S8 family. (403 aa) |
| | AFUA_2G09030 | Dipeptidyl-peptidase 5; May be involved in metabolism of dipeptides or may affect host defense mechanisms. Has a substrate specificity limited to the hydrolysis of X-Ala, His-Ser, and Ser-Tyr dipeptides at a neutral pH optimum (By similarity); Belongs to the peptidase S9C family. (721 aa) |
| | plb3 | Lysophospholipase 3; Catalyzes the release of fatty acids from lysophospholipids. (630 aa) |
| | plb1 | Lysophospholipase 1; Catalyzes the release of fatty acids from lysophospholipids. (633 aa) |
| | gel4 | 1,3-beta-glucanosyltransferase gel4; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis (By similarity). (548 aa) |
| | gel3 | 1,3-beta-glucanosyltransferase gel3; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis (By similarity). (544 aa) |
| | gel2 | 1,3-beta-glucanosyltransferase gel2; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis (By similarity). (475 aa) |
| | gel1 | 1,3-beta-glucanosyltransferase gel1; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis (By similarity). (452 aa) |
| | pep2 | Vacuolar protease A; Vacuolar aspartic endopeptidase which is probably also secreted and contributes to virulence. (398 aa) |
| | phyA | 3-phytase A; Catalyzes the hydrolysis of inorganic orthophosphate from phytate; Belongs to the histidine acid phosphatase family. (465 aa) |
| | gliC | Cytochrome P450 monooxygenase gliC; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide. The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP. GliP is also able to produce the DKP cyclo-L- tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is suffi [...] (512 aa) |
| | abr2 | Laccase abr2; Laccase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall. The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA. The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayg1 though chain-length shortening. 1,3,6,8-THN is substrate of the hydroxynaphthalene reductase [...] (587 aa) |
| | abcC | ABC multidrug transporter C; Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as itraconazole, posaconazole, and voriconazole (Probable). Also required for normal pathogenesis in a Galleria mellonella (greater wax moth) infection model. Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1497 aa) |
| | gliA | MFS gliotoxin efflux transporter gliA; Efflux pump that provides the dual role of gliotoxin export and self-protection by allowing the fungus to evade the harmful effect of its own gliotoxin production. Moreover, it contributes also to the virulence through gliotoxin secretion. Belongs to the major facilitator superfamily. (542 aa) |
| | fetC | Iron transport multicopper oxidase fetC; Cell surface ferroxidase; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism. Required to oxidize Fe(2+) and release it from the transporter (By similarity). (592 aa) |
| | chiB1 | Endochitinase B1; Major secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Plays a role in the morphogenesis and autolysis (By similarity); Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily. (433 aa) |
| | aglD | Probable alpha-galactosidase D; Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides. (648 aa) |
| | xanD | Xanthocillin biosynthesis cluster protein D; Part of the gene cluster that mediates the biosynthesis of the isocyanide xanthocillin and its derivatives. The first step of the pathway consists in the conversion of tyrosine into a vinyl-isonitrile intermediate by the isocyanide synthase xanB. Subsequent oxidative dimerization of this intermediate to form xanthocillin may involve the cytochrome P450 monooxygenase xanG, whose expression is coregulated with that of XanB. Xanthocillin can be further modified by the isonitrile hydratase-like protein xanA which introduces N-formyl groups and t [...] (156 aa) |
| | pyr9 | Cytochrome P450 monooxygenase pyr9; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of pyripyropene A, a specific human acyl- coenzyme A:cholesterol acyltransferase 2 inhibitor. The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase pyr1. Nicotinyl-CoA is then a substrate of polyketide synthase pyr2 to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase pyr6 to yield farnesyl-HPPO. The next steps consist of an epoxidation of [...] (502 aa) |
| | mdr4 | ABC multidrug transporter mdr4; Pleiotropic ABC efflux transporter that confers resistance to azoles such as itraconazole and voriconazole. (1330 aa) |
| | abcB | ABC multidrug transporter B; Pleiotropic ABC efflux transporter that may be involved in A.fumigatus adaptation to azoles such as vorizonazole. (1458 aa) |
| | abfC | Probable alpha-L-arabinofuranosidase C; Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides (By similarity); Belongs to the glycosyl hydrolase 51 family. (505 aa) |
| | kex1 | Pheromone-processing carboxypeptidase kex1; Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). (632 aa) |
| | smp3 | GPI mannosyltransferase 4; Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity). (547 aa) |
| | mdr1 | ABC multidrug transporter mdr1; Pleiotropic ABC efflux transporter that may be involved in A.fumigatus adaptation to azoles such as vorizonazole. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1349 aa) |
| | pbn1 | Protein pbn1; Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase gpi14 (By similarity). (489 aa) |
| | bglI | Probable beta-glucosidase I; Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity). Belongs to the glycosyl hydrolase 3 family. (838 aa) |
| | sho1 | High osmolarity signaling protein sho1; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Regulates radial hyphal growth and germination. Involved in virulence and mediates resistance to oxidative stress. (288 aa) |
| | btgC | Probable glucan endo-1,3-beta-glucosidase btgC; Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan (By similarity). (688 aa) |
| | pelA | Probable pectin lyase A; Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins (By similarity). (380 aa) |
| | rhgB | Probable rhamnogalacturonase B; Pectinolytic enzymes consist of four classes of enzymes: pectine lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Hydrolyzes alpha-D-galacturonopyranosyl-(1,2)- alpha-L-rhamnopyranosyl linkages in the backbone of the hairy regions of pectins (By similarity). (521 aa) |
| | aglA | Probable alpha-galactosidase A; Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides. (532 aa) |
| | aguA | Probable alpha-glucuronidase A; Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan (By similarity). (840 aa) |
| | atrI | ABC multidrug transporter atrI; Pleiotropic ABC efflux transporter involved in the basal level of azole susceptibility. Confers resistance to fluconazole, itraconazole and voriconazole. (1472 aa) |
| | dapB | Probable dipeptidyl-aminopeptidase B; Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N- termini provided that the penultimate residue is proline. (919 aa) |
| | pgxC | Probable exopolygalacturonase C; Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates. (440 aa) |
| | freB | Ferric/cupric reductase transmembrane component B; Ferric reductase involved in adaptation to iron starvation and which is most likely part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism. (743 aa) |
| | tvp18 | Golgi apparatus membrane protein tvp18; Golgi membrane protein involved in vesicular trafficking. Belongs to the TVP18 family. (151 aa) |
| | rny1 | Ribonuclease T2-like; Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration (By similarity). (408 aa) |
| | pns1 | Protein pns1; Probably involved in transport through the plasma membrane. Belongs to the CTL (choline transporter-like) family. (537 aa) |
| | AFUA_3G13200 | 1,3-beta-glucanosyltransferase; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall; Belongs to the glycosyl hydrolase 72 family. (460 aa) |
| | crmC | Major facilitator copper-regulated transporter crmC; Major facilitator copper-regulated transporter; part of the crm gene cluster that mediates the biosynthesis of a yet unidentified copper-responsive metabolite. (585 aa) |
| | easE | FAD-linked oxidoreductase easE; FAD binding oxidoreductase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid. DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan. The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity). The catalase easC and the FAD-dependent oxidoreduc [...] (628 aa) |
| | easM | Cytochrome P450 monooxygenase easM; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid. DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan. The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity). The catalase easC and the FAD-dependent oxi [...] (519 aa) |
| | easK | Cytochrome P450 monooxygenase easK; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid. DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan. The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity). The catalase easC and the FAD-dependent oxi [...] (338 aa) |
| | abr1 | Multicopper oxidase abr1; Multicopper oxidase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment and a structural component of the conidial wall. The first step of the pathway is the production of the heptaketide naphtopyrone YWA1 by the polyketide synthase alb1 though condensation of acetyl-CoA with malonyl-CoA. The naphtopyrone YWA1 is then converted to the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN) by the heptaketide hydrolyase ayg1 though chain-length shortening. 1,3,6,8-THN is substrate of the hydro [...] (664 aa) |
| | AFUA_2G15950 | Putative aspergillopepsin A-like aspartic endopeptidase AFUA_2G15950. (428 aa) |
| | atg22-2 | Autophagy-related protein 22-2; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity); Belongs to the ATG22 family. (613 aa) |
| | abcA-2 | ABC multidrug transporter A-2; Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as itraconazole, posaconazole, and voriconazole. (1499 aa) |
| | AFUA_2G14360 | Probable endo-1,3(4)-beta-glucanase AFUA_2G14360; Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates. (652 aa) |
| | abnB | Probable arabinan endo-1,5-alpha-L-arabinosidase B; Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan (By similarity); Belongs to the glycosyl hydrolase 43 family. (372 aa) |
| | alg10 | Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol; Belongs to the ALG10 glucosyltransferase family. (614 aa) |
| | atg15 | Putative lipase atg15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by atg15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (650 aa) |
| | exgB | Probable glucan endo-1,6-beta-glucosidase B; Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides (By similarity). (396 aa) |
| | ecm14 | Putative metallocarboxypeptidase ecm14; Probable carboxypeptidase that may be involved in cell wall organization and biogenesis. (586 aa) |
| | cpyA | Carboxypeptidase Y homolog A; Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity). (543 aa) |
| | AFUA_4G12850 | Calnexin homolog; Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity). Belongs to the calreticulin family. (563 aa) |
| | sed1 | Tripeptidyl-peptidase sed1; Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence. (644 aa) |
| | sed3 | Tripeptidyl-peptidase sed3; Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence. (596 aa) |
| | sed2 | Tripeptidyl-peptidase sed2; Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence. (602 aa) |
| | gwt1 | GPI-anchored wall transfer protein 1; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. (501 aa) |
| | crf1 | Probable glycosidase crf1. (395 aa) |
| | gda1 | Probable guanosine-diphosphatase; After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol; Belongs to the GDA1/CD39 NTPase family. (503 aa) |
| | phoA | Acid phosphatase; Has both phosphomonoesterase and phosphodiesterase activity. Cleaves a broad range of phosphate esters. (447 aa) |
| | catB | Catalase B; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide; Belongs to the catalase family. (728 aa) |
| | plb2 | Lysophospholipase 2; Catalyzes the release of fatty acids from lysophospholipids; Belongs to the lysophospholipase family. (588 aa) |
| | rglB | Probable rhamnogalacturonate lyase B; Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Degrades the rhamnogalacturonan I (RG-I) backbone of pectin (By similarity). (658 aa) |
| | AFUA_1G17220 | Probable endopolygalacturonase AFUA_1G17220; Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall (By similarity). (378 aa) |
| | xlnD | Probable exo-1,4-beta-xylosidase xlnD; Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose; Belongs to the glycosyl hydrolase 3 family. (792 aa) |
| | lacB | Probable beta-galactosidase B; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. (1015 aa) |
| | agdC | Probable alpha/beta-glucosidase agdC; Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity (By similarity). Belongs to the glycosyl hydrolase 31 family. (881 aa) |
| | ssh4 | Protein ssh4; Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity); Belongs to the SSH4 family. (507 aa) |
| | mns1B | Probable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B; Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) (By similarity). (493 aa) |
| | lacA | Probable beta-galactosidase A; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. (1006 aa) |
| | bglM | Probable beta-glucosidase M; Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity). Belongs to the glycosyl hydrolase 3 family. (769 aa) |
| | abcA | ABC multidrug transporter A-1; ABC transporter that seems not to be involved in the efflux of toxic substances, at least not the classical compounds such as itraconazole, amphotericin B, voriconazole, posaconazole, ravuconazole, or echinocandins. (1452 aa) |
| | helB3 | Cytochrome P450 monooxygenase helB3; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid. Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)- protosta-17(20),24-dien-3-beta-ol (protostadienol). The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid. Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at [...] (507 aa) |
| | helC | Short chain dehydrogenase helC; Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid. Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)- protosta-17(20),24-dien-3-beta-ol (protostadienol). The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid. Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at C-4 and C [...] (257 aa) |
| | helB1 | Cytochrome P450 monooxygenase helB1; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of helvolic acid, an antibacterial nortriterpenoid. Protostadienol synthase helA cyclizes (3S)-oxidosqualene to (17Z)- protosta-17(20),24-dien-3-beta-ol (protostadienol). The synthesis of protostadienol is followed by several steps of monooxygenation, dehydrogenation, and acyl transfer to yield the final helvolic acid. Following the cyclization to the tetracyclic protostadienol by helA, cytochrome P450 monooxygenases helB1-mediated and helB2-mediated oxidation at [...] (580 aa) |
| | tpcJ | Oxidoreductase tpcJ; Oxidoreductase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC. The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC. The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone. The next step is performed by the [...] (609 aa) |
| | tpcL | Anthrone oxygenase tpcL; Methyltransferase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process. The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC. The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC. The decarboxylase tpcK converts atrochrysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone. The next step is performed [...] (161 aa) |
| | sed4 | Tripeptidyl-peptidase sed4; Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence. (594 aa) |
| | pgaA | Probable endopolygalacturonase A; Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall (By similarity). (368 aa) |
| | AFUA_4G13800 | Exo-alpha-sialidase; Sialidase is able to release sialic acid from a wide variety of natural substrates including bovine salivary mucin, colominic acid, bovine fetuin, a serum glycoprotein containing both alpha-2-6 and alpha-2-3-linkages in a ratio of about 3:2, and glycoproteins and glycolipids from thermally denatured human lung epithelial cells. Does not show any trans-sialidase activity since it is able to remove terminal sialic acid residues but is unable to catalyze their transfer to the acceptor substrate. 2-keto-3-deoxynononic acid (KDN) is the preferred substrate and A.fumigat [...] (406 aa) |
| | prm1 | Plasma membrane fusion protein prm1; Involved in cell fusion during mating by stabilizing the plasma membrane fusion event; Belongs to the PRM1 family. (740 aa) |
| | ADM-B | Disintegrin and metalloproteinase domain-containing protein B; Probable zinc protease. (785 aa) |
| | mdr2 | ABC multidrug transporter mdr2; Pleiotropic ABC efflux transporter that may be involved in A.fumigatus adaptation to azoles. (791 aa) |
| | dpp4 | Probable dipeptidyl peptidase 4; Extracellular dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N- termini provided that the penultimate residue is proline. Contributes to pathogenicity (By similarity). (765 aa) |
| | cpr2 | Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. (209 aa) |
| | ctsD | Aspartic-type endopeptidase ctsD; Secreted aspartic-type endopeptidase which is secreted and contributes to virulence; Belongs to the peptidase A1 family. (474 aa) |
| | cyp51A | Sterol 14-alpha demethylase; Cytochrome P450 monooxygenase involved in the biosynthesis of ergosterol. The existence of several duplicated sterol 14-alpha demethylase genes could be a good strategy to modulate the composition and fluidity of the cell membrane (Probable). Catalyzes C14- demethylation of erburicol to produce 4,4,24-trimethyl cholesta- 8,24(28)-dien-3-beta-ol. As a target of azole drugs, plays a crucial role in azole susceptibility. (515 aa) |
| | ecm33 | Protein ecm33; Involved in conidial and mycelial cell wall biogenesis. (398 aa) |
| | lacC | Probable beta-galactosidase C; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. (983 aa) |
| | cfmC | GPI anchored CFEM domain protein C; GPI-anchored cell wall protein involved in stabilizing the cell wall. Not implicated in virulence, heme uptake, and biofilm formation. (198 aa) |
| | AFUA_6G06800 | Probable carboxypeptidase AFUA_6G06800; Belongs to the peptidase M20A family. (440 aa) |
| | cbhA | Probable 1,4-beta-D-glucan cellobiohydrolase A; The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose. (452 aa) |
| | bglF | Probable beta-glucosidase F; Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity). Belongs to the glycosyl hydrolase 3 family. (869 aa) |
| | mndA | Beta-mannosidase A; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of beta-mannosidic oligosaccharides of various complexity and length. Involved in the degradation of polymeric mannan and galactomannan (By similarity). (926 aa) |
| | faeB-2 | Probable feruloyl esterase B-2; Involved in degradation of plant cell walls. Hydrolyzes of the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin (By similarity); Belongs to the tannase family. (526 aa) |
| | exgD | Probable glucan 1,3-beta-glucosidase D; Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan (By similarity). (833 aa) |
| | gliF | Cytochrome P450 monooxygenase gliF; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide. The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP. GliP is also able to produce the DKP cyclo-L- tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is suffi [...] (504 aa) |
| | cfmB | GPI-anchored CFEM domain protein B; GPI-anchored cell wall protein involved in stabilizing the cell wall. Not implicated in virulence, heme uptake and biofilm formation. (202 aa) |
| | cbhB | Probable 1,4-beta-D-glucan cellobiohydrolase B; The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose. Belongs to the glycosyl hydrolase 7 (cellulase C) family. (532 aa) |
| | bglJ | Probable beta-glucosidase J; Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity). Belongs to the glycosyl hydrolase 3 family. (865 aa) |
| | fmqD | FAD-linked oxidoreductase fmqD; Secreted FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the antitumor cytotoxic peptidyl alkaloids fumiquinazolines. The simplest member is fumiquinazoline F (FQF) with a 6-6-6 tricyclic core derived from anthranilic acid (Ant), tryptophan (Trp), and alanine (Ala). The trimodular NRPS fmqA is responsible for FQF formation. Modules 1, 2 and 3 of fmqA are predicted to activate and load Ant, Trp and Ala, respectively, providing for the assembly of an Ant-Trp-Ala-S-enzyme intermediate that would undergo double cyclizati [...] (497 aa) |
| | atg9 | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] (951 aa) |
| | AFUA_6G12410 | 1,3-beta-glucanosyltransferase; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall; Belongs to the glycosyl hydrolase 72 family. (541 aa) |
| | pyr6 | Polyprenyl transferase pyr6; Polyprenyl transferase; part of the gene cluster that mediates the biosynthesis of pyripyropene A, a specific human acyl- coenzyme A:cholesterol acyltransferase 2 inhibitor. The first step of the pathway is the synthesis of nicotinyl-CoA from nicotinic acid by the nicotinic acid-CoA ligase pyr1. Nicotinyl-CoA is then a substrate of polyketide synthase pyr2 to produce 4-hydroxy-6-(3-pyridinyl)-2H-pyran-2-one (HPPO) which is further prenylated by the polyprenyl transferase pyr6 to yield farnesyl-HPPO. The next steps consist of an epoxidation of farnesyl-HPPO [...] (320 aa) |
| | cfmA | GPI-anchored CFEM domain protein A; GPI-anchored cell wall protein involved in stabilizing the cell wall. Not implicated in virulence, heme uptake and biofilm formation; Belongs to the RBT5 family. (305 aa) |
| | plyC | Probable pectate lyase C; Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester (By similarity); Belongs to the polysaccharide lyase 1 family. (420 aa) |
| | bglH | Probable beta-glucosidase H; Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity). Belongs to the glycosyl hydrolase 3 family. (829 aa) |
| | abfB | Probable alpha-L-arabinofuranosidase B; Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Able to hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L- arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan (By similarity). (506 aa) |
| | mfsC | Major facilitator superfamily multidrug transporter mfsC; Major facilitator superfamily transporter that may be involved in A.fumigatus adaptation to azoles such as vorizonazole. (518 aa) |
| | exgA | Probable glucan 1,3-beta-glucosidase A; Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase (By similarity). (416 aa) |
| | xgeA | Probable xyloglucan-specific endo-beta-1,4-glucanase A; Catalyzes endohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan with retention of the beta-configuration of the glycosyl residues. Specific for xyloglucan and does not hydrolyze other cell wall components (By similarity). (238 aa) |
| | hut1 | UDP-galactose transporter homolog 1; May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity); Belongs to the nucleotide-sugar transporter family. SLC35B subfamily. (415 aa) |
| | bglA | Probable beta-glucosidase A; Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity). Belongs to the glycosyl hydrolase 3 family. (873 aa) |
| | AFUA_1G05960 | Vacuolar membrane protease; May be involved in vacuolar sorting and osmoregulation. (965 aa) |
| | galA | Probable arabinogalactan endo-beta-1,4-galactanase A; Endogalactanase involved in the degradation of plant cell wall polysaccharides, and more particularly of hairy regions of pectin. (356 aa) |
| | plyA | Probable pectate lyase A; Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester (By similarity); Belongs to the polysaccharide lyase 1 family. (321 aa) |
