STRINGSTRING
AFUA_2G10990 AFUA_2G10990 sin4 sin4 AFUA_5G01272 AFUA_5G01272 xanC xanC AFUA_5G02690 AFUA_5G02690 AFUA_5G04333 AFUA_5G04333 AFUA_7G00652 AFUA_7G00652 AcuM AcuM AFUA_1G13510 AFUA_1G13510 AFUA_6G11230 AFUA_6G11230 veA veA abaA abaA AFUA_6G00120 AFUA_6G00120 AFUA_6G00200 AFUA_6G00200 srb4 srb4 AFUA_4G01105 AFUA_4G01105 AFUA_4G01510 AFUA_4G01510 arp6 arp6 atrR atrR AFUA_2G01550 AFUA_2G01550 spt16 spt16 crzA crzA nut2 nut2 AFUA_1G05740 AFUA_1G05740 amdR amdR AFUA_1G03800 AFUA_1G03800 AFUA_1G03210 AFUA_1G03210 rvb2 rvb2 AFUA_1G01590 AFUA_1G01590 AFUA_1G01240 AFUA_1G01240 ubc2 ubc2 MED4 MED4 AFUA_6G13130 AFUA_6G13130 AFUA_6G12160 AFUA_6G12160 AFUA_6G12130 AFUA_6G12130 AFUA_6G11750 AFUA_6G11750 AFUA_6G11640 AFUA_6G11640 AFUA_6G11450 AFUA_6G11450 AFUA_6G10140 AFUA_6G10140 med7 med7 AFUA_6G10010 AFUA_6G10010 AFUA_6G09870 AFUA_6G09870 gliZ gliZ AFUA_6G09335 AFUA_6G09335 AFUA_6G08790 AFUA_6G08790 AFUA_6G08550 AFUA_6G08550 creC creC AFUA_6G07230 AFUA_6G07230 rtt106 rtt106 srb5 srb5 nut1 nut1 AFUA_4G07140 AFUA_4G07140 swc4 swc4 eaf1 eaf1 med8 med8 sebA sebA nosA nosA yaf9 yaf9 AFUA_4G09860 AFUA_4G09860 MED20 MED20 prtT prtT AFUA_4G10160 AFUA_4G10160 eaf3 eaf3 rvb1 rvb1 AFUA_4G12180 AFUA_4G12180 MED19 MED19 AFUA_4G12560 AFUA_4G12560 AFUA_4G12570 AFUA_4G12570 ccr4 ccr4 AFUA_4G13130 AFUA_4G13130 wetA wetA tpcE tpcE tpcD tpcD AFUA_4G14590 AFUA_4G14590 AFUA_1G17640 AFUA_1G17640 AFUA_1G17150 AFUA_1G17150 swc5 swc5 brlA brlA AFUA_1G15470 AFUA_1G15470 AFUA_1G15370 AFUA_1G15370 laeA laeA AFUA_1G14360 AFUA_1G14360 hog1 hog1 iws1 iws1 AFUA_1G11620 AFUA_1G11620 AFUA_1G11000 AFUA_1G11000 hir1 hir1 AFUA_5G05570 AFUA_5G05570 set2 set2 AFUA_5G06140 AFUA_5G06140 AFUA_5G06800 AFUA_5G06800 AFUA_5G10040 AFUA_5G10040 sreA sreA AFUA_5G11460 AFUA_5G11460 AFUA_5G12060 AFUA_5G12060 dot1 dot1 atfB atfB AFUA_5G14290 AFUA_5G14290 AFUA_5G14390 AFUA_5G14390 AFUA_5G14530 AFUA_5G14530 spt6 spt6 AFUA_3G06050 AFUA_3G06050 srb8 srb8 AFUA_3G06740 AFUA_3G06740 AFUA_3G08050 AFUA_3G08050 AFUA_3G08520 AFUA_3G08520 mbf1 mbf1 AFUA_3G09130 AFUA_3G09130 MED9 MED9 dvrA dvrA AFUA_3G10160 AFUA_3G10160 asf1 asf1 AFUA_3G11380 AFUA_3G11380 nhp6 nhp6 pacC pacC AFUA_3G11990 AFUA_3G11990 AFUA_3G12180 AFUA_3G12180 AFUA_3G12780 AFUA_3G12780 AFUA_3G12940 AFUA_3G12940 AFUA_3G13600 AFUA_3G13600 ssn3 ssn3 soh1 soh1 bud32 bud32 tfb5 tfb5 AFUA_3G14840 AFUA_3G14840 AFUA_2G17860 AFUA_2G17860 AFUA_2G16310 AFUA_2G16310 ssn8 ssn8 AFUA_2G15680 AFUA_2G15680 xlnR xlnR sconB sconB srb7 srb7 ptaB ptaB creA creA AFUA_2G10640 AFUA_2G10640 AFUA_2G10400 AFUA_2G10400 AFUA_2G08240 AFUA_2G08240 stuA stuA rat1 rat1 AFUA_4G03430 AFUA_4G03430 AFUA_4G04360 AFUA_4G04360 kapC kapC nscR nscR AFUA_7G01310 AFUA_7G01310 AFUA_7G01810 AFUA_7G01810 somA somA swr1 swr1 fumR fumR AFUA_8G00750 AFUA_8G00750 AFUA_8G01140 AFUA_8G01140 AFUA_8G01240 AFUA_8G01240 AFUA_8G01990 AFUA_8G01990 AFUA_8G02640 AFUA_8G02640 AFUA_8G02710 AFUA_8G02710 AFUA_8G07360 AFUA_8G07360 AFUA_8G07180 AFUA_8G07180 AFUA_8G07000 AFUA_8G07000 AFUA_8G06460 AFUA_8G06460 AFUA_8G06010 AFUA_8G06010 AFUA_8G04540 AFUA_8G04540 AFUA_8G04130 AFUA_8G04130 AFUA_8G03970 AFUA_8G03970 AFUA_6G01840 AFUA_6G01840 AFUA_6G02110 AFUA_6G02110 egd1 egd1 AFUA_6G03110 AFUA_6G03110 fmpR fmpR kae1 kae1 epl1 epl1 med6 med6 rai1 rai1 AFUA_5G01550 AFUA_5G01550 AFUA_5G01700 AFUA_5G01700 htz1 htz1 AFUA_5G02270 AFUA_5G02270 AFUA_5G03030 AFUA_5G03030 hapX hapX AFUA_3G04230 AFUA_3G04230 AFUA_3G02750 AFUA_3G02750 AFUA_3G02210 AFUA_3G02210 AFUA_3G02160 AFUA_3G02160 AFUA_3G01880 AFUA_3G01880 AFUA_3G01510 AFUA_3G01510 AFUA_3G00690 AFUA_3G00690 AFUA_3G00210 AFUA_3G00210 AFUA_7G04340 AFUA_7G04340 AFUA_7G04820 AFUA_7G04820 AFUA_7G04890 AFUA_7G04890 AFUA_7G05080 AFUA_7G05080 pob3 pob3 AFUA_7G06320 AFUA_7G06320 rgr1 rgr1 arp4 arp4 jhd1 jhd1 acuK acuK esa1 esa1 AFUA_2G05380 AFUA_2G05380 AFUA_2G05310 AFUA_2G05310 AFUA_2G04790 AFUA_2G04790 AFUA_2G03810 AFUA_2G03810 AFUA_2G03460 AFUA_2G03460 AFUA_2G03430 AFUA_2G03430 cgi121 cgi121
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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AFUA_2G10990Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (720 aa)
sin4Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (955 aa)
AFUA_5G01272C6 transcription factor, putative. (589 aa)
xanCXanthocillin biosynthesis cluster transcription factor xanC; Transcription regulator that specifically up-regulates the gene cluster that mediates the biosynthesis of the isocyanide xanthocillin and its derivatives; Belongs to the bZIP family. (318 aa)
AFUA_5G02690C6 transcription factor, putative. (807 aa)
AFUA_5G04333General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (456 aa)
AFUA_7G00652C6 and C2H2 transcription factor RegA-like, putative. (874 aa)
AcuMZinc cluster transcription factor acuM; Transcription factor that governs genes involved in reductive and siderophore-mediated iron acquisition, and carbon metabolism. Suppresses the expression of sreA and induces hapX to stimulate expression of genes involved in both reductive iron assimilation and siderophore-mediated iron uptake which is essential for the maximal virulence. Regulates also genes involved in gluconeogenesis. (627 aa)
AFUA_1G13510C6 transcription factor FacB/Cat8. (862 aa)
AFUA_6G11230C6 transcription factor, putative. (625 aa)
veADevelopmental and secondary metabolism regulator veA; Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex hat acts as a global regulator for secondary metabolite gene expression (By similarity). Controls the expression of hundreds of genes, including those comprising more than a dozen known secondary metabolite gene clusters. Controls the expression of the gliotoxin gene cluster. [...] (570 aa)
abaAConidiophore development regulator abaA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (By similarity). Essential for differentiation and functionality of phialides as conidiogenous cells. Regulates autolysis and cell death. Positively regulates expression of the gliotoxin biosynt [...] (797 aa)
AFUA_6G00120C6 transcription factor, putative. (708 aa)
AFUA_6G00200C6 transcription factor, putative. (799 aa)
srb4Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (639 aa)
AFUA_4G01105C6 and C2H2 transcription factor, putative. (384 aa)
AFUA_4G01510C6 transcription factor, putative. (690 aa)
arp6Actin-like protein arp6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (468 aa)
atrRABC-transporter-regulating transcription factor; Transcription factor that regulates expression of the genes related to ergosterol biosynthesis, including erg3B, erg24A, erg25A, as well as cyp51A that encodes a target protein of azoles. Responsible for the expression of the ABC transporter abcC/cdr1B/abcG1 related to azole resistance. Directly binds both the cyp51A and abcC/cdr1B/abcG1 promoters at a conserved 34 bp region called the atrR response element (ATRE). AtrR also binds to the promoter regions of both the sterol response transcription factor srbA and atrR genes themselves, the [...] (895 aa)
AFUA_2G01550Repressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (335 aa)
spt16FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1019 aa)
crzAC2H2 finger domain transcription factor crzA; Transcription factor involved in the regulation of calcium ion homeostasis. Regulates genes encoding calcium transporters, transcription factors and genes that could be directly or indirectly involved in calcium metabolism. Supports especially pmcA, pmcB and pmcC expression encoding for calcium- translocating P-type ATPases. Binds target promoters at motif A[GT][CG]CA[AC][AG]. Plays an essential role germination, radial growth, and asexual development. Plays also a major role in proper chitin and glucan incorporation into the cell wall. Inv [...] (754 aa)
nut2Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (159 aa)
AFUA_1G05740C6 transcription factor, putative. (1004 aa)
amdRAcetamidase regulatory protein; Positively regulates the expression of genes involved in the catabolism of certain amides, omega amino acids, and lactams. (772 aa)
AFUA_1G03800C6 transcription factor, putative. (822 aa)
AFUA_1G03210MYB family conidiophore development protein FlbD, putative. (314 aa)
rvb2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (469 aa)
AFUA_1G01590C6 transcription factor, putative. (838 aa)
AFUA_1G01240C6 transcription factor, putative. (832 aa)
ubc2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (328 aa)
AFUA_6G13130Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (290 aa)
AFUA_6G12160C6 transcription factor, putative. (697 aa)
AFUA_6G12130C6 transcription factor, putative. (704 aa)
AFUA_6G11750C6 transcription factor, putative. (551 aa)
AFUA_6G11640Fungal specific transcription factor, putative. (494 aa)
AFUA_6G11450C6 transcription factor, putative. (686 aa)
AFUA_6G10140C6 transcription factor, putative. (715 aa)
med7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (261 aa)
AFUA_6G10010C6 transcription factor, putative. (649 aa)
AFUA_6G09870C6 transcription factor, putative. (728 aa)
gliZC6 finger domain transcription factor gliZ; Transcription factor that regulates gliotoxin production and contributes to virulence. (489 aa)
AFUA_6G09335SRF-type transcription factor family protein. (130 aa)
AFUA_6G08790C6 transcription factor (PrnA), putative. (803 aa)
AFUA_6G08550C6 transcription factor, putative. (797 aa)
creCProbable catabolite repression protein creC; Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways (By similarity); Belongs to the WD repeat creC family. (566 aa)
AFUA_6G07230C6 transcription factor, putative. (681 aa)
rtt106Histone chaperone rtt106; Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity). (459 aa)
srb5Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (268 aa)
nut1Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (1007 aa)
AFUA_4G07140Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1239 aa)
swc4SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (588 aa)
eaf1Chromatin modification-related protein eaf1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (1467 aa)
med8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (249 aa)
sebAC2H2 finger domain transcription factor sebA; Transcription factor that is involved in the response to heat shock, oxidative stress, and poor nutrient conditions. Controls expression of oxidative stress response genes such as ccp1, cat1, cat2, sod2; as well as of heat shock genes such as hsf1, hsp30 and hsp90. Plays a role in virulence. (618 aa)
nosAC6 finger domain transcription factor nosA; Transcription factor that mediates stress and developmental response. (685 aa)
yaf9Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (252 aa)
AFUA_4G09860C6 transcription factor, putative. (688 aa)
MED20Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (286 aa)
prtTTranscriptional activator of proteases prtT; Transcription factor required for protein utilization and degradation. Regulates transcription of major secreted proteases including a serine alkaline protease (alk1), a metalloprotease (mep), an aspergillopepsin (pep1), a sedolisin (sed2) and two dipeptidyl- peptidases (dppIV and dppV). However, it is not a virulence determinant in leukopenic mice; Belongs to the prtT family. (696 aa)
AFUA_4G10160C6 transcription factor (AmyR), putative. (622 aa)
eaf3Chromatin modification-related protein eaf3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (330 aa)
rvb1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
AFUA_4G12180C6 transcription factor Prf, putative. (851 aa)
MED19Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (460 aa)
AFUA_4G12560C6 transcription factor, putative. (843 aa)
AFUA_4G12570C6 transcription factor, putative. (645 aa)
ccr4Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (696 aa)
AFUA_4G13130Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (769 aa)
wetADevelopmental regulatory protein wetA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Plays an essential role in the completion of conidial maturation and is essential for trehalose biogenesis in conidia. Negatively regulates expression of the melanin biosynthetic gene cluster. Plays also an a role in the early phase of fungal growth including proper hyphal branching. (566 aa)
tpcETrypacidin cluster transcription factor; Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of trypacidin, a metabolite with antiprotozoal activity and a possible role in the infection process. Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)), thus triggering host necrotic cell death. (396 aa)
tpcDTrypacidin cluster transcriptional coactivator tpcD; Transcriptional coactivator; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process. With tpcE, coregulates the production of trypacidin. (437 aa)
AFUA_4G14590C6 transcription factor, putative. (654 aa)
AFUA_1G17640C6 transcription factor RegA. (866 aa)
AFUA_1G17150C6 transcription factor, putative. (633 aa)
swc5SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (359 aa)
brlAC2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (By similarity). Positively regulates expression of the gliotoxin biosynthetic gene cluster in actively growing vegetative cells, and likely bridges morphological and chem [...] (426 aa)
AFUA_1G15470C6 transcription factor (UaY), putative. (1088 aa)
AFUA_1G15370C6 transcription factor, putative. (1045 aa)
laeASecondary metabolism regulator laeA; Methyltransferase that performs auto-methylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression. Positively controls expression of 20% to 40% of major classes of secondary metabolite biosynthesis genes such as nonribosomal peptide synthetases, polyketide synthases, and P450 monooxygenases. Controls the expression of the gliotoxin gene cluster. Controls the expression of the fumit [...] (373 aa)
AFUA_1G14360C6 transcription factor, putative. (738 aa)
hog1Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. (366 aa)
iws1Transcription factor iws1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family. (460 aa)
AFUA_1G11620C6 transcription factor QutA, putative. (905 aa)
AFUA_1G11000C6 transcription factor, putative. (795 aa)
hir1Protein hir1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1043 aa)
AFUA_5G05570Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (177 aa)
set2Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (966 aa)
AFUA_5G06140Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (574 aa)
AFUA_5G06800C6 transcription factor, putative. (606 aa)
AFUA_5G10040C6 transcription factor, putative. (683 aa)
sreAGATA-type transcription factor sreA; GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence element 5'-ATCWGATAA-3' of target promoters. Iron acquisition regulation is critical for survival under both iron- limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity). SreA targets include genes encoding a number of key iron-regulated factors such as those involved in siderophore biosynthesis. (546 aa)
AFUA_5G11460Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (284 aa)
AFUA_5G12060C2H2 transcription factor, putative. (1062 aa)
dot1Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (502 aa)
atfBBasic leucine zipper (bZIP) transcription factor atfB; Transcription factor that acts as a key player in the regulatory circuit that integrates secondary metabolism and cellular response to oxidative stress (By similarity). Regulates the genes involved in development, as well as osmotic, oxidative, and cell wall stresses. Participates in the caspofungin paradoxical effect (CPE), where fungi grow beyond the minimum inhibitory concentration of caspofungin. Plays a role in virulence ; Belongs to the bZIP family. ATF subfamily. (328 aa)
AFUA_5G14290C6 transcription factor, putative. (787 aa)
AFUA_5G14390C6 transcription factor, putative. (606 aa)
AFUA_5G14530C6 transcription factor, putative. (601 aa)
spt6Transcription elongation factor spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1420 aa)
AFUA_3G06050Fungal specific transcription factor, putative. (742 aa)
srb8Mediator of RNA polymerase II transcription subunit 12; Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). (1617 aa)
AFUA_3G06740C6 transcription factor (Gal4), putative. (672 aa)
AFUA_3G08050C6 transcription factor (OTam), putative. (738 aa)
AFUA_3G08520SRF-type transcription factor RlmA. (600 aa)
mbf1Multiprotein-bridging factor 1; Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators. (154 aa)
AFUA_3G09130C6 transcription factor, putative. (777 aa)
MED9Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (167 aa)
dvrAC2H2 finger domain transcription factor dvrA; Transcription factor that seems to function as negative regulators of virulence by affecting the capacity to damage host cells and to stimulate a proinflammatory response. (679 aa)
AFUA_3G10160C6 transcription factor, putative. (874 aa)
asf1Histone chaperone asf1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (282 aa)
AFUA_3G11380ARID/BRIGHT domain protein (SWI1), putative. (981 aa)
nhp6Non-histone chromosomal protein 6; DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity). (104 aa)
pacCpH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes (By similarity). (676 aa)
AFUA_3G11990C6 transcription factor (Mut3), putative. (1062 aa)
AFUA_3G12180C6 transcription factor, putative. (692 aa)
AFUA_3G12780C6 transcription factor, putative. (670 aa)
AFUA_3G12940C6 transcription factor, putative. (754 aa)
AFUA_3G13600C6 transcription factor, putative. (629 aa)
ssn3Serine/threonine-protein kinase ssn3; Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity). (426 aa)
soh1Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (162 aa)
bud32EKC/KEOPS complex subunit bud32; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is r [...] (277 aa)
tfb5General transcription and DNA repair factor IIH subunit tfb5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (72 aa)
AFUA_3G14840C6 transcription factor, putative. (646 aa)
AFUA_2G17860C6 transcription factor, putative. (644 aa)
AFUA_2G16310Fungal specific transcription factor, putative. (755 aa)
ssn8RNA polymerase II holoenzyme cyclin-like subunit; Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By s [...] (302 aa)
AFUA_2G15680Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (111 aa)
xlnRXylanolytic transcriptional activator xlnR; Transcriptional activator of the xylanolytic system. Involved in the regulation of extracellular cellulolytic and xylanolytic genes and in the regulation of the intracellular activities of D-xylose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of D-xylose (By similarity); Belongs to the xlnR/xlr1 family. (954 aa)
sconBProbable E3 ubiquitin ligase complex SCF subunit sconB; Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. (696 aa)
srb7Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (207 aa)
ptaBTranscriptional activator ptaB; Transcriptional regulator that forms a complex with somA to control biofilm formation; Belongs to the MFG1 family. (729 aa)
creAProbable DNA-binding protein creA; Transcription regulator component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Represses the transcription of the alcR, alcA and aldA genes by binding to a GC- rich region in their promoter. Plays also a role in response to carbon starvation and the control of extracellular proteases activity (By similarity); Belongs to the creA/MIG C2H2-type zinc-finger protein family. (424 aa)
AFUA_2G10640Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. (508 aa)
AFUA_2G10400C6 transcription factor, putative. (611 aa)
AFUA_2G08240C6 transcription factor, putative. (726 aa)
stuACell pattern formation-associated protein stuA; Transcription factor that regulates asexual reproduction. Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (By similarity). Controls the expression of 6 secondary metabolite biosynthetic clusters including 2 involved in the synthesis of alkaloids (fumigaclavine and fumitremorgen), 2 clusters of the ETP class (gliotoxin and an unknown ETP-like toxin), a cluster predicted to produce pseurotin A, and the product of the last cluster is unknown. Controls the product [...] (635 aa)
rat15'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (1058 aa)
AFUA_4G03430C6 transcription factor, putative. (641 aa)
AFUA_4G04360RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (479 aa)
kapCPutative transcription factor kapC; Putative transcription factor; Belongs to the bZIP family. (280 aa)
nscRC6 finger domain transcription factor nscR; Transcription factor that specifically regulates the neosartoricin biosynthesis gene cluster. (774 aa)
AFUA_7G01310C6 transcription factor, putative. (737 aa)
AFUA_7G01810C6 transcription factor, putative. (864 aa)
somATranscriptional activator somA; Transcription factor that controls the expression of genes related to the process of conidiation and adherence and regulates biofilm formation. Controls conidiation and adhesion primarily by affecting the expression of the three regulatory genes flbB, stuA and medA. Required for virulence in an egg and a mouse infection model. Belongs to the FLO8 family. (784 aa)
swr1Helicase swr1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1695 aa)
fumRC6 finger transcription factor fumR; Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of pseurotin and fumagillin. (622 aa)
AFUA_8G00750C2H2 transcription factor, putative. (715 aa)
AFUA_8G01140C6 transcription factor, putative. (533 aa)
AFUA_8G01240C6 transcription factor, putative. (563 aa)
AFUA_8G01990C6 transcription factor, putative. (805 aa)
AFUA_8G02640C6 transcription factor, putative. (684 aa)
AFUA_8G02710C6 transcription factor, putative. (887 aa)
AFUA_8G07360C6 transcription factor, putative. (724 aa)
AFUA_8G07180C6 transcription factor, putative. (571 aa)
AFUA_8G07000C6 transcription factor, putative. (755 aa)
AFUA_8G06460C6 transcription factor, putative. (761 aa)
AFUA_8G06010C6 transcription factor, putative. (655 aa)
AFUA_8G04540C6 transcription factor, putative. (875 aa)
AFUA_8G04130C6 transcription factor (Ctf1B), putative. (885 aa)
AFUA_8G03970C6 finger domain protein, putative. (901 aa)
AFUA_6G01840C6 transcription factor, putative. (663 aa)
AFUA_6G02110MADS box transcription factor Mcm1. (219 aa)
egd1Nascent polypeptide-associated complex subunit beta; Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the [...] (186 aa)
AFUA_6G03110C6 transcription factor, putative. (645 aa)
fmpRC6 finger transcription factor fmpR; Transcription factor that regulates the gene cluster that mediates the biosynthesis of fumipyrrole, a brown pigment that is involved in growth and conidiation. (525 aa)
kae1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (352 aa)
epl1Enhancer of polycomb-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity). (582 aa)
med6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (324 aa)
rai1Decapping nuclease rai1; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). Belongs to the DXO/Dom3Z family. (365 aa)
AFUA_5G01550C6 transcription factor, putative. (689 aa)
AFUA_5G01700Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit. (662 aa)
htz1Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (138 aa)
AFUA_5G02270C6 transcription factor, putative. (590 aa)
AFUA_5G03030C6 transcription factor, putative. (971 aa)
hapXbZIP transcription factor hapX; Transcription factor required for repression of genes during iron starvation. Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine ; Belongs to the bZIP family. YAP subfamily. (491 aa)
AFUA_3G04230Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (667 aa)
AFUA_3G02750C6 transcription factor, putative. (779 aa)
AFUA_3G02210C6 transcription factor, putative. (365 aa)
AFUA_3G02160C6 transcription factor, putative. (708 aa)
AFUA_3G01880Fungal specific transcription factor, putative. (659 aa)
AFUA_3G01510C6 transcription factor, putative. (740 aa)
AFUA_3G00690C6 transcription factor, putative. (720 aa)
AFUA_3G00210C6 finger domain protein, putative. (746 aa)
AFUA_7G04340C6 transcription factor, putative. (850 aa)
AFUA_7G04820C6 transcription factor, putative. (553 aa)
AFUA_7G04890C6 transcription factor, putative. (703 aa)
AFUA_7G05080C6 transcription factor, putative. (664 aa)
pob3FACT complex subunit pob3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (573 aa)
AFUA_7G06320C6 transcription factor, putative. (588 aa)
rgr1Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (1093 aa)
arp4Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (466 aa)
jhd1JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. (1418 aa)
acuKTranscription activator of gluconeogenesis acuK; Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). Belongs to the ERT1/acuK family. (682 aa)
esa1Histone acetyltransferase esa1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (483 aa)
AFUA_2G05380C6 transcription factor, putative. (763 aa)
AFUA_2G05310C6 transcription factor, putative. (968 aa)
AFUA_2G04790Mediator of RNA polymerase II transcription subunit 13; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. (1429 aa)
AFUA_2G03810Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (487 aa)
AFUA_2G03460C6 transcription factor (Leu3), putative. (920 aa)
AFUA_2G03430C6 transcription factor, putative. (696 aa)
cgi121EKC/KEOPS complex subunit cgi121; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Cgi121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transc [...] (189 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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