35 items (Aspergillus fumigatus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AFUA_1G12025	Antibiotic biosynthesis monooxygenase, putative. (107 aa)
	AFUA_4G03830	Uncharacterized protein. (144 aa)
	swr1	Helicase swr1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1695 aa)
	AFUA_8G01090	Thioredoxin, putative. (116 aa)
	esa1	Histone acetyltransferase esa1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (483 aa)
	AFUA_1G05800	MAP kinase kinase (Mkk2), putative. (503 aa)
	AFUA_1G04400	37S ribosomal protein mrp10, mitochondrial; Involved in mitochondrial genome encoded proteins translation. (101 aa)
	AFUA_6G13170	Ubiquitin conjugating enzyme (UbcK), putative; Belongs to the ubiquitin-conjugating enzyme family. (181 aa)
	AFUA_6G12820	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (353 aa)
	AFUA_6G12320	Uncharacterized protein. (484 aa)
	AFUA_6G11410	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa)
	AFUA_6G10300	Thioredoxin, putative. (108 aa)
	AFUA_4G06170	BZIP domain-containing protein. (289 aa)
	AFUA_4G09180	SET domain protein. (367 aa)
	AFUA_4G12680	DNA repair protein Rad50. (1312 aa)
	AFUA_4G13720	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (424 aa)
	AFUA_1G15950	MAP kinase kinase (Pbs2), putative. (656 aa)
	AFUA_1G13820	Uncharacterized protein. (237 aa)
	hir1	Protein hir1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1043 aa)
	AFUA_5G06420	MAP kinase kinase kinase SteC. (973 aa)
	AFUA_5G11320	Thioredoxin; Belongs to the thioredoxin family. (110 aa)
	tel1	Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2796 aa)
	htb1	Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (140 aa)
	AFUA_3G05900	MAP kinase kinase Ste7. (536 aa)
	AFUA_3G05910	HUN domain-containing protein. (835 aa)
	AFUA_3G06200	Anaphase-promoting complex subunit Apc5, putative. (768 aa)
	AFUA_3G07660	Uncharacterized protein. (200 aa)
	asf1	Histone chaperone asf1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (282 aa)
	AFUA_3G11260	Ubiquitin (UbiC), putative. (154 aa)
	AFUA_3G12850	Ubiquitin conjugating enzyme (UbcB), putative. (178 aa)
	AFUA_3G14970	Thioredoxin; Belongs to the thioredoxin family. (109 aa)
	AFUA_2G16100	Telomere-binding alpha subunit central domain protein. (635 aa)
	AFUA_2G12460	Uncharacterized protein. (150 aa)
	AFUA_2G11840	Transcriptional corepressor Cyc8, putative. (867 aa)
	AFUA_1G11410	Ubiquitin conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family. (427 aa)

Your Current Organism:

Aspergillus fumigatus

NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFUA_1G05800	AFUA_3G05900	Q4WJJ0	Q4WWH7	MAP kinase kinase (Mkk2), putative.	MAP kinase kinase Ste7.	0.542
AFUA_1G05800	AFUA_4G13720	Q4WJJ0	Q4WQR3	MAP kinase kinase (Mkk2), putative.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.993
AFUA_1G05800	AFUA_5G06420	Q4WJJ0	Q4WTX3	MAP kinase kinase (Mkk2), putative.	MAP kinase kinase kinase SteC.	0.819
AFUA_1G05800	AFUA_6G12820	Q4WJJ0	Q4WLP2	MAP kinase kinase (Mkk2), putative.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.641
AFUA_1G11410	AFUA_3G06200	A4GZ00	Q4WWK5	Ubiquitin conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family.	Anaphase-promoting complex subunit Apc5, putative.	0.979
AFUA_1G11410	AFUA_3G11260	A4GZ00	Q4WXZ8	Ubiquitin conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin (UbiC), putative.	0.826
AFUA_1G11410	AFUA_3G12850	A4GZ00	Q4WYF5	Ubiquitin conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme (UbcB), putative.	0.421
AFUA_1G11410	AFUA_4G06170	A4GZ00	Q4WNL5	Ubiquitin conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family.	BZIP domain-containing protein.	0.826
AFUA_1G11410	AFUA_4G09180	A4GZ00	Q4WPG5	Ubiquitin conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family.	SET domain protein.	0.607
AFUA_1G11410	AFUA_6G13170	A4GZ00	Q4WLK8	Ubiquitin conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme (UbcK), putative; Belongs to the ubiquitin-conjugating enzyme family.	0.976
AFUA_1G11410	esa1	A4GZ00	Q4WHG1	Ubiquitin conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family.	Histone acetyltransferase esa1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...]	0.422
AFUA_1G15950	AFUA_3G05900	Q4WRK9	Q4WWH7	MAP kinase kinase (Pbs2), putative.	MAP kinase kinase Ste7.	0.686
AFUA_1G15950	AFUA_4G13720	Q4WRK9	Q4WQR3	MAP kinase kinase (Pbs2), putative.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.754
AFUA_1G15950	AFUA_5G06420	Q4WRK9	Q4WTX3	MAP kinase kinase (Pbs2), putative.	MAP kinase kinase kinase SteC.	0.983
AFUA_1G15950	AFUA_6G12820	Q4WRK9	Q4WLP2	MAP kinase kinase (Pbs2), putative.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.796
AFUA_2G11840	AFUA_3G06200	Q4X0Y7	Q4WWK5	Transcriptional corepressor Cyc8, putative.	Anaphase-promoting complex subunit Apc5, putative.	0.416
AFUA_2G11840	htb1	Q4X0Y7	Q4WWC5	Transcriptional corepressor Cyc8, putative.	Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.401
AFUA_2G16100	AFUA_4G12680	Q4WZQ8	Q4WQF8	Telomere-binding alpha subunit central domain protein.	DNA repair protein Rad50.	0.447
AFUA_2G16100	AFUA_6G11410	Q4WZQ8	Q4WM28	Telomere-binding alpha subunit central domain protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.472
AFUA_3G05900	AFUA_1G05800	Q4WWH7	Q4WJJ0	MAP kinase kinase Ste7.	MAP kinase kinase (Mkk2), putative.	0.542