STRINGSTRING
AFUA_7G05890 AFUA_7G05890 AFUA_2G06320 AFUA_2G06320 AFUA_2G05650 AFUA_2G05650 esa1 esa1 AFUA_2G04960 AFUA_2G04960 AFUA_2G03070 AFUA_2G03070 AFUA_2G02660 AFUA_2G02660 AFUA_2G02420 AFUA_2G02420 AFUA_2G01670 AFUA_2G01670 AFUA_2G00090 AFUA_2G00090 AFUA_1G07070 AFUA_1G07070 AFUA_1G05860 AFUA_1G05860 AFUA_1G04750 AFUA_1G04750 AFUA_1G04570 AFUA_1G04570 AFUA_6G14720 AFUA_6G14720 AFUA_6G13160 AFUA_6G13160 AFUA_6G11410 AFUA_6G11410 AFUA_6G10560 AFUA_6G10560 AFUA_4G06170 AFUA_4G06170 AFUA_4G06960 AFUA_4G06960 AFUA_4G06970 AFUA_4G06970 AFUA_4G12310 AFUA_4G12310 AFUA_4G12610 AFUA_4G12610 AFUA_4G12680 AFUA_4G12680 AFUA_4G13460 AFUA_4G13460 AFUA_1G17100 AFUA_1G17100 AFUA_1G12520 AFUA_1G12520 AFUA_1G11950 AFUA_1G11950 AFUA_1G10410 AFUA_1G10410 AFUA_5G05960 AFUA_5G05960 AFUA_5G07320 AFUA_5G07320 AFUA_5G08480 AFUA_5G08480 AFUA_5G11170 AFUA_5G11170 AFUA_5G11370 AFUA_5G11370 AFUA_5G11840 AFUA_5G11840 AFUA_5G12010 AFUA_5G12010 lig4 lig4 tel1 tel1 AFUA_5G13220 AFUA_5G13220 AFUA_5G13380 AFUA_5G13380 AFUA_5G13560 AFUA_5G13560 AFUA_5G13570 AFUA_5G13570 AFUA_5G15150 AFUA_5G15150 htb1 htb1 AFUA_3G08800 AFUA_3G08800 AFUA_3G10040 AFUA_3G10040 AFUA_3G10530 AFUA_3G10530 AFUA_3G10960 AFUA_3G10960 AFUA_3G11260 AFUA_3G11260 mus81 mus81 AFUA_3G13260 AFUA_3G13260 AFUA_3G14460 AFUA_3G14460 AFUA_3G15395 AFUA_3G15395 AFUA_2G18100 AFUA_2G18100 AFUA_2G17230 AFUA_2G17230 AFUA_2G14920 AFUA_2G14920 AFUA_2G13650 AFUA_2G13650 AFUA_2G11070 AFUA_2G11070 AFUA_2G08840 AFUA_2G08840 AFUA_2G07660 AFUA_2G07660 csm3 csm3 AFUA_4G04760 AFUA_4G04760 tof1 tof1 AFUA_7G00090 AFUA_7G00090 AFUA_7G00530 AFUA_7G00530 AFUA_8G00430 AFUA_8G00430 AFUA_8G07400 AFUA_8G07400 AFUA_6G02020 AFUA_6G02020 AFUA_6G04350 AFUA_6G04350 AFUA_5G02430 AFUA_5G02430 slx1 slx1 AFUA_7G03750 AFUA_7G03750 AFUA_7G04270 AFUA_7G04270 AFUA_7G04550 AFUA_7G04550 AFUA_7G04640 AFUA_7G04640
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_7G05890Uncharacterized protein. (252 aa)
AFUA_2G06320Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (529 aa)
AFUA_2G05650Cytoplasmic asparaginyl-tRNA synthetase, putative. (574 aa)
esa1Histone acetyltransferase esa1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (483 aa)
AFUA_2G04960RecQ family helicase MusN. (1563 aa)
AFUA_2G03070Uncharacterized protein. (557 aa)
AFUA_2G02660DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (629 aa)
AFUA_2G02420Cytoplasm to vacuole targeting Vps64, putative. (741 aa)
AFUA_2G01670FHA domain protein. (724 aa)
AFUA_2G00090Telomere-associated RecQ helicase, putative. (460 aa)
AFUA_1G07070Cyclin-dependent protein kinase regulator Pho80. (396 aa)
AFUA_1G05860Uncharacterized protein. (404 aa)
AFUA_1G04750Cyclin (Pcl1), putative. (427 aa)
AFUA_1G04570DNA repair protein, putative. (760 aa)
AFUA_6G14720Telomere-associated RecQ helicase, putative. (1445 aa)
AFUA_6G13160Serine/threonine protein kinase, putative. (514 aa)
AFUA_6G11410Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (784 aa)
AFUA_6G10560DNA polymerase delta subunit 4, putative. (193 aa)
AFUA_4G06170BZIP domain-containing protein. (289 aa)
AFUA_4G06960UBX domain protein, putative. (306 aa)
AFUA_4G06970RAD52 DNA repair protein RADC. (564 aa)
AFUA_4G12310DNA repair protein Rtt107, putative. (856 aa)
AFUA_4G12610Uncharacterized protein. (387 aa)
AFUA_4G12680DNA repair protein Rad50. (1312 aa)
AFUA_4G13460SNF2 family helicase/ATPase, putative. (1111 aa)
AFUA_1G17100Uncharacterized protein. (369 aa)
AFUA_1G12520DNA repair protein (Rad57), putative. (647 aa)
AFUA_1G11950Mucin, putative. (614 aa)
AFUA_1G10410DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
AFUA_5G05960Serine/threonine protein kinase, putative. (544 aa)
AFUA_5G07320Poly [ADP-ribose] polymerase. (688 aa)
AFUA_5G08480Serine/threonine protein kinase, putative. (618 aa)
AFUA_5G11170Nucleosome remodeling complex ATPase subunit (Snf2h), putative. (986 aa)
AFUA_5G11370Serine/threonine-protein phosphatase. (340 aa)
AFUA_5G11840Protein kinase, putative. (825 aa)
AFUA_5G12010Serine/threonine-protein phosphatase. (474 aa)
lig4DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. (979 aa)
tel1Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2796 aa)
AFUA_5G13220ERCC4 domain-containing protein. (649 aa)
AFUA_5G13380BRCT domain protein. (786 aa)
AFUA_5G13560FHA domain protein. (610 aa)
AFUA_5G13570Uncharacterized protein. (292 aa)
AFUA_5G15150Telomere-associated RecQ helicase, putative. (395 aa)
htb1Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (140 aa)
AFUA_3G08800DUF1767 domain-containing protein. (249 aa)
AFUA_3G10040Cyclin-like protein (Clg1), putative. (475 aa)
AFUA_3G10530Protein serine/threonine kinase (Ran1), putative; Belongs to the protein kinase superfamily. (423 aa)
AFUA_3G10960Cell wall protein, putative. (267 aa)
AFUA_3G11260Ubiquitin (UbiC), putative. (154 aa)
mus81Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (596 aa)
AFUA_3G13260Rad2-like endonuclease, putative. (869 aa)
AFUA_3G14460Rad51 family DNA repair protein, putative. (456 aa)
AFUA_3G15395Telomere-associated RecQ helicase, putative. (714 aa)
AFUA_2G18100Telomere-associated RecQ helicase, putative. (850 aa)
AFUA_2G17230NACHT domain protein. (1785 aa)
AFUA_2G14920Protein kinase, putative. (1028 aa)
AFUA_2G13650Endonuclease/exonuclease/phosphatase family protein. (362 aa)
AFUA_2G11070Tyrosyl-DNA phosphodiesterase, putative. (564 aa)
AFUA_2G08840Terminal deoxynucleotidyl transferase, putative. (704 aa)
AFUA_2G07660Cyclin-dependent protein kinase complex component, putative. (254 aa)
csm3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with tof1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (270 aa)
AFUA_4G04760Inositol kinase kinase (UvsB), putative; Belongs to the PI3/PI4-kinase family. (2449 aa)
tof1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with csm3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1176 aa)
AFUA_7G00090Telomere-associated RecQ helicase, putative. (396 aa)
AFUA_7G00530NACHT and Ankyrin domain protein. (1334 aa)
AFUA_8G00430EthD domain-containing protein. (157 aa)
AFUA_8G07400Telomere-associated RecQ helicase, putative. (360 aa)
AFUA_6G02020G1/S-specific cyclin Pcl5, putative. (702 aa)
AFUA_6G04350Uncharacterized protein. (277 aa)
AFUA_5G02430ATP dependent DNA ligase domain protein. (912 aa)
slx1Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (423 aa)
AFUA_7G03750Cell-cycle checkpoint protein kinase, putative; Belongs to the protein kinase superfamily. (409 aa)
AFUA_7G042703'-5' exonuclease/helicase (Wrn), putative. (419 aa)
AFUA_7G04550Serine/threonine protein kinase, putative. (389 aa)
AFUA_7G04640Cyclin-dependent protein kinase complex component, putative. (534 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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