(120 nodes) M Phase network (Aspergillus fumigatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AFUA_2G13860	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (142 aa)
	AFUA_2G11430	Spindle pole body component. (891 aa)
	AFUA_2G11230	Nuclear pore protein (SEH1), putative; Belongs to the WD repeat SEC13 family. (376 aa)
	AFUA_2G11110	Structural maintenance of chromosomes protein. (1179 aa)
	nde1	Nuclear distribution protein nudE homolog 1; Required for nuclear migration within hyphae during vegetative growth. (621 aa)
	hhfA	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	AFUA_2G16692	Vacuolar sorting protein SNF7 family protein, putative. (480 aa)
	AFUA_3G08265	Uncharacterized protein. (283 aa)
	AFUA_4G06085	Uncharacterized protein. (435 aa)
	AFUA_2G02165	ELYS domain-containing protein. (347 aa)
	AFUA_3G01872	HET domain-containing protein. (796 aa)
	AFUA_5G01245	mRNA stability protein; Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. (105 aa)
	AFUA_1G11410	Ubiquitin conjugating enzyme E2, putative; Belongs to the ubiquitin-conjugating enzyme family. (427 aa)
	AFUA_1G13580	M protein repeat protein. (731 aa)
	AFUA_1G13390	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (455 aa)
	AFUA_4G04740	Ran exchange factor Prp20/Pim1, putative. (544 aa)
	AFUA_4G04720	Nuclear pore protein (Nic96), putative. (1048 aa)
	AFUA_7G00250	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
	AFUA_7G01060	Cysteine-rich secreted protein. (343 aa)
	AFUA_7G01940	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (1139 aa)
	AFUA_8G06510	Uncharacterized protein. (172 aa)
	AFUA_8G05680	Serine/threonine-protein kinase. (1119 aa)
	myoA	Myosin-1; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Plays an important role in polarized growth, spore germination, hyphal morphogenesis, and septal wall formation (By similarity). (1249 aa)
	AFUA_8G04810	Casein kinase, putative; Belongs to the protein kinase superfamily. (336 aa)
	AFUA_8G04660	Noc1p protein, putative. (679 aa)
	AFUA_6G02900	Rad21/Rec8 N terminal domain protein. (741 aa)
	AFUA_6G04100	Mis6 domain protein. (735 aa)
	AFUA_6G04580	NIF domain protein. (625 aa)
	AFUA_6G04650	Uncharacterized protein. (894 aa)
	AFUA_6G04720	Mitochondrial mRNA processing protein PET127, putative. (791 aa)
	AFUA_5G01180	RAN small monomeric GTPase (Ran), putative. (480 aa)
	AFUA_5G01700	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit. (662 aa)
	AFUA_5G01730	MYB DNA-binding domain protein. (2031 aa)
	htz1	Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (138 aa)
	AFUA_5G02170	Nuclear condensin complex subunit 3, putative. (1120 aa)
	AFUA_5G02730	Spindle pole body component. (888 aa)
	AFUA_5G02910	NAP family protein; Belongs to the nucleosome assembly protein (NAP) family. (354 aa)
	AFUA_5G03820	Spindle pole body associated protein SnaD, putative. (832 aa)
	AFUA_5G04320	Secretion related GTPase SrgB/Ypt1. (201 aa)
	AFUA_3G03630	Uncharacterized protein. (380 aa)
	AFUA_3G02880	Alpha-L-rhamnosidase C, putative. (813 aa)
	AFUA_7G03890	Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (880 aa)
	AFUA_7G05400	Uncharacterized protein. (362 aa)
	AFUA_7G06020	Non-repetitive nucleoporin, putative. (1357 aa)
	plyD	Probable pectate lyase D; Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester (By similarity); Belongs to the polysaccharide lyase 3 family. (242 aa)
	AFUA_2G05850	Double-strand-break repair protein rad21. (606 aa)
	AFUA_2G05470	Sister chromatid cohesion protein. (1772 aa)
	AFUA_2G04920	Nuclear pore complex subunit Nup159, putative. (1466 aa)
	AFUA_2G03810	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (487 aa)
	AFUA_2G03150	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1009 aa)
	AFUA_2G02170	Structural maintenance of chromosomes protein. (1441 aa)
	AFUA_1G07590	Cupin domain protein. (634 aa)
	AFUA_1G06420	SNF7 family protein. (241 aa)
	AFUA_1G05720	C-14 sterol reductase. (518 aa)
	AFUA_1G03910	Spo7-like protein. (467 aa)
	AFUA_1G03150	C-14 sterol reductase. (498 aa)
	AFUA_1G02550	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
	AFUA_1G02400	Uncharacterized protein. (873 aa)
	AFUA_6G13300	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (215 aa)
	AFUA_6G13100	Magnesium dependent phosphatase, putative. (209 aa)
	AFUA_6G12980	Spindle pole body component, putative. (911 aa)
	AFUA_6G12560	AAA family ATPase, putative; Belongs to the AAA ATPase family. (802 aa)
	AFUA_6G10730	Nucleoporin NUP49/NSP49, putative. (481 aa)
	AFUA_6G09540	Endoglucanase, putative. (330 aa)
	AFUA_6G08620	Golgi reassembly stacking protein, putative. (370 aa)
	AFUA_6G08530	Sister chromatid separation protein (Src1), putative. (734 aa)
	AFUA_6G07120	Nuclear movement protein NudC. (200 aa)
	jip5	WD repeat-containing protein jip5. (416 aa)
	AFUA_4G05840	Nuclear pore complex subunit Nup133, putative. (1136 aa)
	AFUA_4G06170	BZIP domain-containing protein. (289 aa)
	AFUA_4G06180	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (364 aa)
	AFUA_4G06830	SUMO conjugating enzyme (UbcI), putative; Belongs to the ubiquitin-conjugating enzyme family. (190 aa)
	AFUA_4G07100	Nuclear envelope protein, putative. (652 aa)
	AFUA_4G07620	Uncharacterized protein. (828 aa)
	mdm34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (572 aa)
	AFUA_4G11070	Nucleoporin SONB, putative. (1984 aa)
	AFUA_4G12890	Uncharacterized protein. (477 aa)
	AFUA_1G17550	HET domain protein. (793 aa)
	AFUA_1G15720	Importin beta-1 subunit. (872 aa)
	AFUA_1G14610	Lipin Smp2, putative. (765 aa)
	AFUA_1G13960	DUF292 domian protein. (332 aa)
	AFUA_1G13100	Nucleoporin (Nup184), putative. (1815 aa)
	AFUA_1G12820	Spindle pole body component. (947 aa)
	AFUA_1G12670	Uncharacterized protein. (426 aa)
	AFUA_1G10910	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (466 aa)
	AFUA_1G10860	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (1072 aa)
	AFUA_1G10850	Ubiquitin-like modifier SUMO, putative. (93 aa)
	AFUA_1G10400	Uncharacterized protein. (1313 aa)
	AFUA_1G09950	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (294 aa)
	AFUA_1G09460	NIF domain protein. (518 aa)
	AFUA_1G09300	Uncharacterized protein. (381 aa)
	AFUA_1G09220	SNF7 family protein. (217 aa)
	AFUA_1G08960	mRNA stability protein; Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. (167 aa)
	AFUA_5G08510	Dynein family protein. (307 aa)
	AFUA_5G08620	Ser/Thr protein phosphatase family. (430 aa)
	AFUA_5G09710	Separin, putative. (2120 aa)
	nuf2	Probable kinetochore protein nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (463 aa)
	AFUA_5G12670	Nuclear pore complex subunit Nup192, putative. (1622 aa)
	AFUA_5G13410	SNF7 family protein. (224 aa)
	AFUA_5G13890	SNF7 family protein. (229 aa)
	htb1	Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (140 aa)
	hta1	Histone H2A; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (133 aa)
	AFUA_3G05530	Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1118 aa)
	AFUA_3G07680	Ran GTPase activating protein 1 (RNA1 protein). (422 aa)
	AFUA_3G08260	Structural maintenance of chromosomes protein. (1289 aa)
	AFUA_3G09160	Extracellular proline-rich protein. (191 aa)
	AFUA_3G09360	Vacuolar sorting ATPase Vps4, putative; Belongs to the AAA ATPase family. (435 aa)
	AFUA_3G09370	Spindle-pole body protein (Pcp1), putative. (1271 aa)
	ndc80	Probable kinetochore protein ndc80; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. (736 aa)
	AFUA_3G11260	Ubiquitin (UbiC), putative. (154 aa)
	AFUA_3G11320	Spindle pole body component. (1035 aa)
	AFUA_3G11860	Microtubule associated protein EB1, putative. (278 aa)
	AFUA_2G16850	Sister chromatid cohesion and DNA repair protein (BimD), putative. (1492 aa)
	AFUA_2G16080	Nuclear cohesin complex subunit (Psc3), putative. (1213 aa)
	AFUA_2G15750	Spindle pole body component. (826 aa)
	AFUA_2G15010	Serine threonine protein kinase, putative. (2058 aa)
	AFUA_2G14990	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	AFUA_2G14080	Structural maintenance of chromosomes protein. (1199 aa)
	AFUA_2G14010	Uncharacterized protein. (651 aa)
	AFUA_2G13450	Dynactin, putative. (1378 aa)

Your Current Organism:

Aspergillus fumigatus

NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFUA_1G02400	AFUA_6G12980	Q4WKI0	Q4WLM6	Uncharacterized protein.	Spindle pole body component, putative.	0.441
AFUA_1G02400	AFUA_8G05680	Q4WKI0	Q4WC53	Uncharacterized protein.	Serine/threonine-protein kinase.	0.642
AFUA_1G02550	AFUA_1G06420	Q4WKG5	Q4WJC9	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	SNF7 family protein.	0.584
AFUA_1G02550	AFUA_1G10910	Q4WKG5	Q4WT14	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.988
AFUA_1G02550	AFUA_2G03150	Q4WKG5	Q4WI43	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.680
AFUA_1G02550	AFUA_2G13860	Q4WKG5	Q4X0D4	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.489
AFUA_1G02550	AFUA_2G14990	Q4WKG5	Q4X021	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.901
AFUA_1G02550	AFUA_3G09360	Q4WKG5	Q4WXF8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Vacuolar sorting ATPase Vps4, putative; Belongs to the AAA ATPase family.	0.554
AFUA_1G02550	AFUA_3G11860	Q4WKG5	Q4WY56	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Microtubule associated protein EB1, putative.	0.869
AFUA_1G02550	AFUA_5G08510	Q4WKG5	Q4WUH8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Dynein family protein.	0.901
AFUA_1G02550	AFUA_6G04100	Q4WKG5	Q4WDA9	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Mis6 domain protein.	0.839
AFUA_1G02550	AFUA_6G12560	Q4WKG5	Q4WLR8	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	AAA family ATPase, putative; Belongs to the AAA ATPase family.	0.545
AFUA_1G02550	AFUA_6G12980	Q4WKG5	Q4WLM6	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Spindle pole body component, putative.	0.781
AFUA_1G02550	AFUA_7G00250	Q4WKG5	Q4WA70	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.988
AFUA_1G02550	AFUA_8G04660	Q4WKG5	Q4WCF0	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Noc1p protein, putative.	0.667
AFUA_1G02550	AFUA_8G05680	Q4WKG5	Q4WC53	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Serine/threonine-protein kinase.	0.714
AFUA_1G02550	AFUA_8G06510	Q4WKG5	Q4WBX0	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Uncharacterized protein.	0.886
AFUA_1G02550	hhfA	Q4WKG5	Q7LKT3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.493
AFUA_1G02550	htb1	Q4WKG5	Q4WWC5	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Histone H2B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.447
AFUA_1G03150	AFUA_1G05720	Q4WKA5	Q4WJJ9	C-14 sterol reductase.	C-14 sterol reductase.	0.901