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| | AFUA_1G09220 | SNF7 family protein. (217 aa) |
| | AFUA_1G09950 | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (294 aa) |
| | AFUA_1G11080 | Non-specific serine/threonine protein kinase. (1072 aa) |
| | AFUA_1G11860 | Mitochondrial import receptor subunit tom22. (143 aa) |
| | AFUA_4G13140 | Uncharacterized protein. (209 aa) |
| | AFUA_4G12080 | Ubiquitin conjugating enzyme (MmsB), putative. (139 aa) |
| | AFUA_4G11160 | Cell division control protein Cdc31, putative. (258 aa) |
| | mdm34 | Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (572 aa) |
| | atg1 | Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] (973 aa) |
| | AFUA_4G06180 | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (364 aa) |
| | AFUA_4G06170 | BZIP domain-containing protein. (289 aa) |
| | AFUA_6G06720 | Serine/threonine protein kinase, putative. (890 aa) |
| | AFUA_6G06840 | Uncharacterized protein. (120 aa) |
| | atg5 | Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1- like activating enzyme and atg10 as an E2- [...] (326 aa) |
| | AFUA_4G06085 | Uncharacterized protein. (435 aa) |
| | atg12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity). (174 aa) |
| | atg18 | Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct atg9 trafficking to the pre- autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (436 aa) |
| | AFUA_6G05174 | TOM complex component Tom7, putative. (53 aa) |
| | AFUA_6G11190 | Protein kinase (VPS15), putative. (1637 aa) |
| | AFUA_8G05240 | Peroxisomal targeting signal-1 receptor (PEX5), putaitve. (569 aa) |
| | AFUA_8G05170 | Autophagy protein Apg6, putative. (446 aa) |
| | AFUA_8G04810 | Casein kinase, putative; Belongs to the protein kinase superfamily. (336 aa) |
| | AFUA_6G02420 | Ubiquitin conjugating enzyme (UbcM), putative; Belongs to the ubiquitin-conjugating enzyme family. (149 aa) |
| | AFUA_6G04500 | Snf1 kinase complex beta-subunit Gal83, putative. (463 aa) |
| | AFUA_6G05110 | Mitochondrial import receptor subunit (Tom40), putative. (355 aa) |
| | AFUA_5G01700 | Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit. (662 aa) |
| | xanA | Isonitrile hydratase-like protein xanA; Isonitrile hydratase-like protein; part of the gene cluster that mediates the biosynthesis of the isocyanide xanthocillin and its derivatives. The first step of the pathway consists in the conversion of tyrosine into a vinyl-isonitrile intermediate by the isocyanide synthase xanB. Subsequent oxidative dimerization of this intermediate to form xanthocillin may involve the cytochrome P450 monooxygenase xanG, whose expression is coregulated with that of XanB. Xanthocillin can be further modified by the isonitrile hydratase-like protein xanA which in [...] (236 aa) |
| | AFUA_3G02420 | ThiJ/PfpI family transcriptional regulator, putative. (232 aa) |
| | AFUA_3G02050 | Uncharacterized protein. (171 aa) |
| | AFUA_2G06250 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (723 aa) |
| | atg13 | Autophagy-related protein 13; Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, atg13 is also required for glycogen storage during stationary phase (By similarity). (958 aa) |
| | AFUA_2G01700 | Non-specific serine/threonine protein kinase. (793 aa) |
| | AFUA_2G01660 | Mitochondrial outer membrane translocase receptor (TOM70), putative. (630 aa) |
| | atg8 | Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] (118 aa) |
| | AFUA_1G06660 | CBS domain protein. (879 aa) |
| | AFUA_1G06420 | SNF7 family protein. (241 aa) |
| | AFUA_1G05640 | Protein phosphatase. (739 aa) |
| | AFUA_1G02240 | Uncharacterized protein. (252 aa) |
| | AFUA_6G13100 | Magnesium dependent phosphatase, putative. (209 aa) |
| | atg9 | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] (951 aa) |
| | AFUA_6G11380 | Mitochondrial import receptor subunit (Tom20), putative. (169 aa) |
| | AFUA_6G07930 | Uncharacterized protein. (406 aa) |
| | AFUA_5G08670 | Phosphatidylinositol 3-kinase VPS34. (898 aa) |
| | AFUA_5G06310 | Uncharacterized protein. (216 aa) |
| | AFUA_5G08530 | Phosphatidylinositol 3,5-bisphosphate-binding protein, putative. (258 aa) |
| | AFUA_5G08510 | Dynein family protein. (307 aa) |
| | AFUA_3G11700 | Ubiquitin carboxyl-terminal hydrolase. (649 aa) |
| | atg11 | Autophagy-related protein 11; Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity). (1264 aa) |
| | AFUA_3G11260 | Ubiquitin (UbiC), putative. (154 aa) |
| | AFUA_3G09990 | Uncharacterized protein. (437 aa) |
| | AFUA_3G06720 | ThiJ/PfpI family protein. (350 aa) |
| | AFUA_3G05820 | ZZ type zinc finger domain protein. (838 aa) |
| | AFUA_3G05340 | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. (226 aa) |
| | AFUA_5G14240 | ThiJ/PfpI family protein. (226 aa) |
| | AFUA_5G13890 | SNF7 family protein. (229 aa) |
| | AFUA_5G13620 | Ubiquitin C-terminal hydrolase, putative; Belongs to the peptidase C19 family. (679 aa) |
| | AFUA_5G13410 | SNF7 family protein. (224 aa) |
| | AFUA_5G13320 | UV radiation resistance protein (UVRAG), putative. (619 aa) |
| | tel1 | Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2796 aa) |
| | atg16 | Autophagy protein 16; Stabilizes the atg5-atg12 conjugate which is necessary for autophagy. The atg5-atg12/atg16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also atg3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). (172 aa) |
| | atg3 | Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8. The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of [...] (353 aa) |
| | AFUA_2G16692 | Vacuolar sorting protein SNF7 family protein, putative. (480 aa) |
| | AFUA_5G13392 | Transmembrane GTPase Fzo1, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (932 aa) |
