(69 nodes) Factors involved in megakaryocyte development and platelet production network (Aspergillus fumigatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AFUA_4G03350	Exo-beta-1,3-glucanase, putative. (779 aa)
	AFUA_7G01150	LipA and NB-ARC domain protein. (1198 aa)
	AFUA_7G01400	Kinesin family protein (BimC), putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1190 aa)
	AFUA_8G01060	Uncharacterized protein. (455 aa)
	AFUA_8G01500	Pfs domain protein, putative. (381 aa)
	AFUA_6G03870	Tetratricopeptide repeat protein. (781 aa)
	AFUA_6G03880	Uncharacterized protein. (255 aa)
	AFUA_6G04100	Mis6 domain protein. (735 aa)
	AFUA_6G04870	Vacuolar protein sorting-associated protein VpsB; Belongs to the STXBP/unc-18/SEC1 family. (595 aa)
	AFUA_3G02560	Uncharacterized protein. (141 aa)
	AFUA_3G02550	Uncharacterized protein. (601 aa)
	AFUA_3G01710	TPR domain protein. (437 aa)
	AFUA_3G00830	Pfs domain protein. (1731 aa)
	AFUA_7G03710	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (955 aa)
	AFUA_7G05890	Uncharacterized protein. (252 aa)
	AFUA_2G03150	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1009 aa)
	AFUA_1G04340	SH3 and Ded_cyto domain protein, putative; Belongs to the DOCK family. (2079 aa)
	ADK2	GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (247 aa)
	cap2	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (322 aa)
	AFUA_1G01140	Uncharacterized protein. (252 aa)
	AFUA_1G01090	Uncharacterized protein. (307 aa)
	AFUA_1G01080	Uncharacterized protein. (153 aa)
	AFUA_1G01070	Uncharacterized protein. (139 aa)
	AFUA_1G00890	Uncharacterized protein. (898 aa)
	AFUA_1G00780	Uncharacterized protein. (215 aa)
	AFUA_1G00560	Pfs domain protein. (345 aa)
	AFUA_6G14220	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (929 aa)
	AFUA_6G13630	Uncharacterized protein. (500 aa)
	AFUA_6G12840	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (726 aa)
	AFUA_6G12120	BNR/Asp-box repeat domain protein. (380 aa)
	AFUA_6G10150	Uncharacterized protein. (80 aa)
	cap1	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (276 aa)
	AFUA_6G09420	Uncharacterized protein. (151 aa)
	AFUA_6G09300	C2H2 finger domain protein, putative. (782 aa)
	AFUA_4G08180	RRN9 domain-containing protein. (606 aa)
	AFUA_4G09540	Acetyltransferase, GNAT family family. (240 aa)
	AFUA_4G12640	RGS domain protein (Rax1), putative. (356 aa)
	AFUA_4G12690	GATA transcription factor LreB. (391 aa)
	AFUA_4G13000	Lysine-specific histone demethylase Aof2, putative. (1081 aa)
	AFUA_4G13960	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (329 aa)
	AFUA_1G17620	TPR domain protein. (334 aa)
	AFUA_1G16170	Uncharacterized protein. (812 aa)
	abfC	Probable alpha-L-arabinofuranosidase C; Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides (By similarity); Belongs to the glycosyl hydrolase 51 family. (505 aa)
	AFUA_1G09520	Uncharacterized protein. (390 aa)
	AFUA_5G07980	Uncharacterized protein. (544 aa)
	AFUA_5G09420	Clock controled protein (Ccg-8), putative. (510 aa)
	sreA	GATA-type transcription factor sreA; GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence element 5'-ATCWGATAA-3' of target promoters. Iron acquisition regulation is critical for survival under both iron- limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity). SreA targets include genes encoding a number of key iron-regulated factors such as those involved in siderophore biosynthesis. (546 aa)
	AFUA_5G13050	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (777 aa)
	AFUA_5G13190	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1769 aa)
	AFUA_5G14920	Uncharacterized protein. (559 aa)
	AFUA_5G15040	Uncharacterized protein. (776 aa)
	AFUA_3G06300	Rho GTPase Rac, putative. (199 aa)
	AFUA_3G12820	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (849 aa)
	AFUA_3G13770	Vacuolar segregation protein (Pep7), putative. (672 aa)
	AFUA_3G13870	GATA-type sexual development transcription factor NsdD. (493 aa)
	AFUA_3G14650	LipA and NB-ARC domain protein. (661 aa)
	AFUA_2G17420	Pfs and NB-ARC domain protein. (917 aa)
	AFUA_2G15160	Alpha-L-arabinofuranosidase A. (656 aa)
	AFUA_2G14730	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1632 aa)
	AFUA_2G14510	Uncharacterized protein. (1208 aa)
	AFUA_2G14490	Endoglucanase, putative. (506 aa)
	AFUA_2G14280	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (769 aa)
	AFUA_2G12200	cAMP-dependent protein kinase catalytic subunit PkaC1; Belongs to the protein kinase superfamily. (490 aa)
	AFUA_2G09510	Uncharacterized protein. (277 aa)
	pkaR	cAMP-dependent protein kinase regulatory subunit. (413 aa)
	AFUA_5G13392	Transmembrane GTPase Fzo1, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (932 aa)
	AFUA_8G06132	FluG domain protein. (544 aa)
	AFUA_8G00350	Uncharacterized protein. (999 aa)
	AFUA_1G12050	Acetyltransferase, GNAT family family. (293 aa)

Your Current Organism:

Aspergillus fumigatus

NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFUA_1G00560	AFUA_6G14220	Q4WL12	Q4WLA6	Pfs domain protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.471
AFUA_1G00780	AFUA_6G14220	Q4WKZ0	Q4WLA6	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.471
AFUA_1G00890	AFUA_6G14220	Q4WKY1	Q4WLA6	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.471
AFUA_1G01070	AFUA_6G14220	Q4WKW3	Q4WLA6	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.471
AFUA_1G01080	AFUA_6G14220	Q4WKW2	Q4WLA6	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.471
AFUA_1G01090	AFUA_6G14220	Q4WKW1	Q4WLA6	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.471
AFUA_1G01140	AFUA_2G03150	Q4WKV6	Q4WI43	Uncharacterized protein.	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.644
AFUA_1G01140	AFUA_3G12820	Q4WKV6	Q4WYF2	Uncharacterized protein.	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.488
AFUA_1G01140	AFUA_5G13190	Q4WKV6	Q4WVS9	Uncharacterized protein.	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.483
AFUA_1G01140	AFUA_6G04100	Q4WKV6	Q4WDA9	Uncharacterized protein.	Mis6 domain protein.	0.401
AFUA_1G01140	AFUA_6G12840	Q4WKV6	Q4WLP0	Uncharacterized protein.	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.581
AFUA_1G01140	AFUA_6G14220	Q4WKV6	Q4WLA6	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.453
AFUA_1G01140	AFUA_7G01400	Q4WKV6	Q4WAI2	Uncharacterized protein.	Kinesin family protein (BimC), putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.932
AFUA_1G01140	AFUA_7G03710	Q4WKV6	Q4WG42	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.570
AFUA_1G04340	AFUA_3G06300	Q4WJY8	Q4WWL5	SH3 and Ded_cyto domain protein, putative; Belongs to the DOCK family.	Rho GTPase Rac, putative.	0.916
AFUA_1G09520	cap2	Q4WTF1	Q4WKB4	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).	0.957
AFUA_1G12050	AFUA_3G13770	E9QVA9	Q4WYP4	Acetyltransferase, GNAT family family.	Vacuolar segregation protein (Pep7), putative.	0.771
AFUA_1G16170	AFUA_6G14220	Q4WRI6	Q4WLA6	Uncharacterized protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.471
AFUA_1G17620	AFUA_6G14220	Q4WR42	Q4WLA6	TPR domain protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.471
AFUA_2G03150	AFUA_1G01140	Q4WI43	Q4WKV6	Kinesin family protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	Uncharacterized protein.	0.644