Dihydroorotate reductase PyrE, putative.

Sterol 14-alpha demethylase; Cytochrome P450 monooxygenase involved in the biosynthesis of ergosterol. The existence of several duplicated sterol 14-alpha demethylase genes could be a good strategy to modulate the composition and fluidity of the cell membrane (Probable). Catalyzes C14- demethylation of erburicol to produce 4,4,24-trimethyl cholesta- 8,24(28)-dien-3-beta-ol. As a target of azole drugs, plays a crucial role in azole susceptibility.

Sterol 14-alpha demethylase; Cytochrome P450 monooxygenase involved in the biosynthesis of ergosterol. The existence of several duplicated sterol 14-alpha demethylase genes could be a good strategy to modulate the composition and fluidity of the cell membrane (Probable). Catalyzes C14- demethylation of erburicol to produce 4,4,24-trimethyl cholesta- 8,24(28)-dien-3-beta-ol. As a target of azole drugs, plays a crucial role in azole susceptibility.

Dihydroorotate reductase PyrE, putative.

Sterol 14-alpha demethylase; Cytochrome P450 monooxygenase involved in the biosynthesis of ergosterol. The existence of several duplicated sterol 14-alpha demethylase genes could be a good strategy to modulate the composition and fluidity of the cell membrane (Probable). Catalyzes C14- demethylation of erburicol to produce 4,4,24-trimethyl cholesta- 8,24(28)-dien-3-beta-ol. As a target of azole drugs, plays a crucial role in azole susceptibility.

Sterol 14-alpha demethylase; Cytochrome P450 monooxygenase involved in the biosynthesis of ergosterol. The existence of several duplicated sterol 14-alpha demethylase genes could be a good strategy to modulate the composition and fluidity of the cell membrane (By similarity). Catalyzes C14-demethylation of erburicol to produce 4,4,24-trimethyl cholesta-8,24(28)-dien-3-beta-ol. Shows a slight substrate preference toward eburicol over obtusifoliol. As a target of azole drugs, plays a crucial role in azole susceptibility.

Sterol 14-alpha demethylase; Cytochrome P450 monooxygenase involved in the biosynthesis of ergosterol. The existence of several duplicated sterol 14-alpha demethylase genes could be a good strategy to modulate the composition and fluidity of the cell membrane (Probable). Catalyzes C14- demethylation of erburicol to produce 4,4,24-trimethyl cholesta- 8,24(28)-dien-3-beta-ol. As a target of azole drugs, plays a crucial role in azole susceptibility.

bZIP transcription factor hapX; Transcription factor required for repression of genes during iron starvation. Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine ; Belongs to the bZIP family. YAP subfamily.

Sterol 14-alpha demethylase; Cytochrome P450 monooxygenase involved in the biosynthesis of ergosterol. The existence of several duplicated sterol 14-alpha demethylase genes could be a good strategy to modulate the composition and fluidity of the cell membrane (By similarity). Catalyzes C14-demethylation of erburicol to produce 4,4,24-trimethyl cholesta-8,24(28)-dien-3-beta-ol. Shows a slight substrate preference toward eburicol over obtusifoliol. As a target of azole drugs, plays a crucial role in azole susceptibility.

Sterol 14-alpha demethylase; Cytochrome P450 monooxygenase involved in the biosynthesis of ergosterol. The existence of several duplicated sterol 14-alpha demethylase genes could be a good strategy to modulate the composition and fluidity of the cell membrane (Probable). Catalyzes C14- demethylation of erburicol to produce 4,4,24-trimethyl cholesta- 8,24(28)-dien-3-beta-ol. As a target of azole drugs, plays a crucial role in azole susceptibility.

Iron transport multicopper oxidase fetC; Cell surface ferroxidase; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism. Required to oxidize Fe(2+) and release it from the transporter (By similarity).

High affinity iron permease ftrA; High affinity iron permease; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism ; Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.

Iron transport multicopper oxidase fetC; Cell surface ferroxidase; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism. Required to oxidize Fe(2+) and release it from the transporter (By similarity).

bZIP transcription factor hapX; Transcription factor required for repression of genes during iron starvation. Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine ; Belongs to the bZIP family. YAP subfamily.

Iron transport multicopper oxidase fetC; Cell surface ferroxidase; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism. Required to oxidize Fe(2+) and release it from the transporter (By similarity).

MFS siderochrome iron transporter B; Major facilitator transporter involved in triacetylfusarinine C (TAFC) uptake. Can also transport ferricrocin and coprogen, but not ferrichrysin.

Iron transport multicopper oxidase fetC; Cell surface ferroxidase; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism. Required to oxidize Fe(2+) and release it from the transporter (By similarity).

GATA-type transcription factor sreA; GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence element 5'-ATCWGATAA-3' of target promoters. Iron acquisition regulation is critical for survival under both iron- limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity). SreA targets include genes encoding a number of key iron-regulated factors such as those involved in siderophore biosynthesis.

High affinity iron permease ftrA; High affinity iron permease; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism ; Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.

Iron transport multicopper oxidase fetC; Cell surface ferroxidase; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism. Required to oxidize Fe(2+) and release it from the transporter (By similarity).

High affinity iron permease ftrA; High affinity iron permease; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism ; Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.

bZIP transcription factor hapX; Transcription factor required for repression of genes during iron starvation. Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine ; Belongs to the bZIP family. YAP subfamily.

High affinity iron permease ftrA; High affinity iron permease; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism ; Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.

MFS siderochrome iron transporter B; Major facilitator transporter involved in triacetylfusarinine C (TAFC) uptake. Can also transport ferricrocin and coprogen, but not ferrichrysin.

High affinity iron permease ftrA; High affinity iron permease; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism ; Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.

GATA-type transcription factor sreA; GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence element 5'-ATCWGATAA-3' of target promoters. Iron acquisition regulation is critical for survival under both iron- limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity). SreA targets include genes encoding a number of key iron-regulated factors such as those involved in siderophore biosynthesis.

bZIP transcription factor hapX; Transcription factor required for repression of genes during iron starvation. Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine ; Belongs to the bZIP family. YAP subfamily.

Sterol 14-alpha demethylase; Cytochrome P450 monooxygenase involved in the biosynthesis of ergosterol. The existence of several duplicated sterol 14-alpha demethylase genes could be a good strategy to modulate the composition and fluidity of the cell membrane (Probable). Catalyzes C14- demethylation of erburicol to produce 4,4,24-trimethyl cholesta- 8,24(28)-dien-3-beta-ol. As a target of azole drugs, plays a crucial role in azole susceptibility.

bZIP transcription factor hapX; Transcription factor required for repression of genes during iron starvation. Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine ; Belongs to the bZIP family. YAP subfamily.

Iron transport multicopper oxidase fetC; Cell surface ferroxidase; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism. Required to oxidize Fe(2+) and release it from the transporter (By similarity).

bZIP transcription factor hapX; Transcription factor required for repression of genes during iron starvation. Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine ; Belongs to the bZIP family. YAP subfamily.

High affinity iron permease ftrA; High affinity iron permease; part of the reductive iron assimilatory system (RIA), a siderophore-independent high affinity iron uptake mechanism ; Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.

bZIP transcription factor hapX; Transcription factor required for repression of genes during iron starvation. Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine ; Belongs to the bZIP family. YAP subfamily.

MFS siderochrome iron transporter B; Major facilitator transporter involved in triacetylfusarinine C (TAFC) uptake. Can also transport ferricrocin and coprogen, but not ferrichrysin.

bZIP transcription factor hapX; Transcription factor required for repression of genes during iron starvation. Represses iron-dependent and mitochondrial-localized activities including respiration, TCA cycle, amino acid metabolism, iron-sulfur-cluster and heme biosynthesis. Iron starvation causes a massive remodeling of the amino acid pool and hapX is essential for the coordination of the production of siderophores and their precursor ornithine ; Belongs to the bZIP family. YAP subfamily.

GATA-type transcription factor sreA; GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence element 5'-ATCWGATAA-3' of target promoters. Iron acquisition regulation is critical for survival under both iron- limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity). SreA targets include genes encoding a number of key iron-regulated factors such as those involved in siderophore biosynthesis.

Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pat [...]

Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.

Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pat [...]

Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the recepto [...]