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cyp51A cyp51A wetA wetA AFUA_4G13800 AFUA_4G13800 brlA brlA NRPS8 NRPS8 catB catB AFUA_5G15150 AFUA_5G15150 pacC pacC AFUA_3G15395 AFUA_3G15395 AFUA_2G18100 AFUA_2G18100 katG katG AFUA_2G00090 AFUA_2G00090 axeA axeA AFUA_8G07400 AFUA_8G07400 ftmMT ftmMT AFUA_7G00090 AFUA_7G00090 AFUA_4G09580 AFUA_4G09580 abaA abaA gliC gliC gliT gliT AFUA_6G14720 AFUA_6G14720 AFUA_6G14690 AFUA_6G14690
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
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cyp51ASterol 14-alpha demethylase; Cytochrome P450 monooxygenase involved in the biosynthesis of ergosterol. The existence of several duplicated sterol 14-alpha demethylase genes could be a good strategy to modulate the composition and fluidity of the cell membrane (Probable). Catalyzes C14- demethylation of erburicol to produce 4,4,24-trimethyl cholesta- 8,24(28)-dien-3-beta-ol. As a target of azole drugs, plays a crucial role in azole susceptibility. (515 aa)
wetADevelopmental regulatory protein wetA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Plays an essential role in the completion of conidial maturation and is essential for trehalose biogenesis in conidia. Negatively regulates expression of the melanin biosynthetic gene cluster. Plays also an a role in the early phase of fungal growth including proper hyphal branching. (566 aa)
AFUA_4G13800Exo-alpha-sialidase; Sialidase is able to release sialic acid from a wide variety of natural substrates including bovine salivary mucin, colominic acid, bovine fetuin, a serum glycoprotein containing both alpha-2-6 and alpha-2-3-linkages in a ratio of about 3:2, and glycoproteins and glycolipids from thermally denatured human lung epithelial cells. Does not show any trans-sialidase activity since it is able to remove terminal sialic acid residues but is unable to catalyze their transfer to the acceptor substrate. 2-keto-3-deoxynononic acid (KDN) is the preferred substrate and A.fumigat [...] (406 aa)
brlAC2H2 type master regulator of conidiophore development brlA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation. They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Binds promoters of target genes at brlA response elements (BREs) containing the conserved sequence 5'-(C/A)(A/G)AGGG(G/A)-3' (By similarity). Positively regulates expression of the gliotoxin biosynthetic gene cluster in actively growing vegetative cells, and likely bridges morphological and chem [...] (426 aa)
NRPS8Nonribosomal peptide synthetase 8; Nonribosomal peptide synthesis (NRPS) is a key mechanism responsible for the biosynthesis of bioactive metabolites which are potentially contributing to organismal virulence. However, contarary to other nonribosomal peptide synthases, NRPS8 does not encode a secreted peptide, but has more a structural role since it is involved in germ tube formation. (8515 aa)
catBCatalase B; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide; Belongs to the catalase family. (728 aa)
AFUA_5G15150Telomere-associated RecQ helicase, putative. (395 aa)
pacCpH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid- expressed genes (By similarity). (676 aa)
AFUA_3G15395Telomere-associated RecQ helicase, putative. (714 aa)
AFUA_2G18100Telomere-associated RecQ helicase, putative. (850 aa)
katGCatalase-peroxidase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May be involved in protection from the host during host infection. (759 aa)
AFUA_2G00090Telomere-associated RecQ helicase, putative. (460 aa)
axeAProbable acetylxylan esterase A; Acetylxylan esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Degrades acetylated xylans by cleaving acetyl side groups from the hetero-xylan backbone (By similarity); Belongs to the carbohydrate esterase 1 (CE1) family. AxeA subfamily. (371 aa)
AFUA_8G07400Telomere-associated RecQ helicase, putative. (360 aa)
ftmMT6-hydroxytryprostatin B O-methyltransferase; S-adenosyl-L-methionine-dependent O-methyltransferase. Ability to catalyze the conversion of 6-hydroxytryprostatin B to tryprostatin A probably does not occur in vivo. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. (342 aa)
AFUA_7G00090Telomere-associated RecQ helicase, putative. (396 aa)
AFUA_4G09580Major allergen Asp f 2; Belongs to the ZPS1 family. (310 aa)
abaAConidiophore development regulator abaA; BrlA, abaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (By similarity). Essential for differentiation and functionality of phialides as conidiogenous cells. Regulates autolysis and cell death. Positively regulates expression of the gliotoxin biosynt [...] (797 aa)
gliCCytochrome P450 monooxygenase gliC; Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide. The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP. GliP is also able to produce the DKP cyclo-L- tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is suffi [...] (512 aa)
gliTThioredoxin reductase gliT; Thioredoxin reductase; part of the gene cluster that mediates the biosynthesis of gliotoxin, a member of the epipolythiodioxopiperazine (ETP) class of toxins characterized by a disulfide bridged cyclic dipeptide. The first step in gliotoxin biosynthesis is the condensation of serine and phenylalanine to form the cyclo-L-phenylalanyl-L-serine diketopiperazine (DKP) by the NRPS gliP. GliP is also able to produce the DKP cyclo-L- tryptophanyl-L-serine, suggesting that the substrate specificity of the first adenylation (A) domain in gliP is sufficiently relaxed [...] (334 aa)
AFUA_6G14720Telomere-associated RecQ helicase, putative. (1445 aa)
AFUA_6G14690Telomere-associated RecQ helicase, putative. (352 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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