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AFUA_3G03670 AFUA_3G03670 MCM7 MCM7 AFUA_2G10150 AFUA_2G10150 AFUA_2G11170 AFUA_2G11170 pim1 pim1 AFUA_2G12150 AFUA_2G12150 AFUA_2G12220 AFUA_2G12220 AFUA_2G12250 AFUA_2G12250 AFUA_2G12920 AFUA_2G12920 AFUA_2G14020 AFUA_2G14020 AFUA_2G14760 AFUA_2G14760 abcA-2 abcA-2 AFUA_2G17190 AFUA_2G17190 AFUA_3G13000 AFUA_3G13000 AFUA_3G12510 AFUA_3G12510 AFUA_3G12220 AFUA_3G12220 AFUA_3G11390 AFUA_3G11390 AFUA_3G09680 AFUA_3G09680 AFUA_3G09360 AFUA_3G09360 AFUA_3G08300 AFUA_3G08300 AFUA_3G08000 AFUA_3G08000 AFUA_3G07820 AFUA_3G07820 atrI atrI AFUA_5G14820 AFUA_5G14820 PIF1 PIF1 AFUA_5G12720 AFUA_5G12720 AFUA_5G11810 AFUA_5G11810 AFUA_5G11750 AFUA_5G11750 AFUA_5G10550 AFUA_5G10550 AFUA_5G10510 AFUA_5G10510 AFUA_5G09480 AFUA_5G09480 AFUA_5G09460 AFUA_5G09460 AFUA_5G09190 AFUA_5G09190 AFUA_5G08150 AFUA_5G08150 AFUA_5G07970 AFUA_5G07970 AFUA_5G07050 AFUA_5G07050 AFUA_5G07020 AFUA_5G07020 mdr1 mdr1 AFUA_1G09210 AFUA_1G09210 AFUA_1G10310 AFUA_1G10310 abcB abcB AFUA_1G10410 AFUA_1G10410 AFUA_1G10640 AFUA_1G10640 AFUA_1G10720 AFUA_1G10720 AFUA_1G11180 AFUA_1G11180 AFUA_1G12520 AFUA_1G12520 mdr4 mdr4 AFUA_1G15270 AFUA_1G15270 AFUA_1G16440 AFUA_1G16440 AFUA_1G16880 AFUA_1G16880 abcA abcA AFUA_4G14130 AFUA_4G14130 AFUA_4G11530 AFUA_4G11530 AFUA_4G11180 AFUA_4G11180 rvb1 rvb1 mdr2 mdr2 AFUA_4G09150 AFUA_4G09150 AFUA_4G08800 AFUA_4G08800 AFUA_4G06070 AFUA_4G06070 AFUA_6G06780 AFUA_6G06780 AFUA_6G07280 AFUA_6G07280 AFUA_6G08020 AFUA_6G08020 AFUA_6G11360 AFUA_6G11360 AFUA_6G12560 AFUA_6G12560 atm1 atm1 AFUA_1G02060 AFUA_1G02060 AFUA_1G02170 AFUA_1G02170 rvb2 rvb2 AFUA_1G03920 AFUA_1G03920 AFUA_1G04780 AFUA_1G04780 AFUA_1G06170 AFUA_1G06170 AFUA_2G01090 AFUA_2G01090 AFUA_2G01500 AFUA_2G01500 AFUA_2G02680 AFUA_2G02680 AFUA_2G03090 AFUA_2G03090 AFUA_2G05430 AFUA_2G05430 AFUA_7G06680 AFUA_7G06680 AFUA_7G05660 AFUA_7G05660 AFUA_7G05480 AFUA_7G05480 AFUA_7G04310 AFUA_7G04310 AFUA_3G01400 AFUA_3G01400 AFUA_3G02760 AFUA_3G02760 AFUA_3G03430 AFUA_3G03430 AFUA_5G02260 AFUA_5G02260 AFUA_5G01870 AFUA_5G01870 AFUA_5G00790 AFUA_5G00790 AFUA_5G00340 AFUA_5G00340 AFUA_6G05080 AFUA_6G05080 AFUA_6G05040 AFUA_6G05040 atrF atrF AFUA_6G04330 AFUA_6G04330 AFUA_6G03580 AFUA_6G03580 fmpD fmpD AFUA_6G03080 AFUA_6G03080 AFUA_8G04270 AFUA_8G04270 AFUA_8G04740 AFUA_8G04740 AFUA_8G02650 AFUA_8G02650 AFUA_8G00780 AFUA_8G00780 AFUA_7G02200 AFUA_7G02200 abcE abcE AFUA_4G03070 AFUA_4G03070 AFUA_4G03990 AFUA_4G03990 AFUA_4G04660 AFUA_4G04660 AFUA_4G04800 AFUA_4G04800 AFUA_4G01260 AFUA_4G01260 AFUA_4G01050 AFUA_4G01050 abcC abcC AFUA_1G12910 AFUA_1G12910 AFUA_2G17110 AFUA_2G17110 AFUA_1G13060 AFUA_1G13060 AFUA_7G05752 AFUA_7G05752
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_3G03670ABC multidrug transporter, putative. (1314 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (854 aa)
AFUA_2G10150Peroxisome biosynthesis protein (PAS1/Peroxin-1), putative. (1211 aa)
AFUA_2G11170Origin recognition complex subunit Orc4, putative. (704 aa)
pim1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1108 aa)
AFUA_2G12150Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (4925 aa)
AFUA_2G12220Replication factor C subunit 1. (1085 aa)
AFUA_2G12250DNA replication factor C subunit Rfc5, putative. (294 aa)
AFUA_2G12920Mitochondrial AAA ATPase, putative. (952 aa)
AFUA_2G14020ABC transporter, putative. (628 aa)
AFUA_2G14760BCS1-like ATPase, putative; Belongs to the AAA ATPase family. (574 aa)
abcA-2ABC multidrug transporter A-2; Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as itraconazole, posaconazole, and voriconazole. (1499 aa)
AFUA_2G17190AAA domain-containing protein. (1129 aa)
AFUA_3G13000Mitochondrial chaperone BCS1, putative; Belongs to the AAA ATPase family. (499 aa)
AFUA_3G12510Vesicular fusion ATPase, putative. (770 aa)
AFUA_3G12220ABC transporter, putative. (1433 aa)
AFUA_3G11390Proteasome regulatory particle subunit Rpt3, putative; Belongs to the AAA ATPase family. (465 aa)
AFUA_3G09680ABC efflux transporter, putative. (1299 aa)
AFUA_3G09360Vacuolar sorting ATPase Vps4, putative; Belongs to the AAA ATPase family. (435 aa)
AFUA_3G08300DNA replication factor C subunit Rfc2, putative. (394 aa)
AFUA_3G08000Peroxisome biosynthesis protein (PAS8/Peroxin-6), putative. (1442 aa)
AFUA_3G07820Proteasome regulatory particle subunit Rpt1, putative; Belongs to the AAA ATPase family. (439 aa)
atrIABC multidrug transporter atrI; Pleiotropic ABC efflux transporter involved in the basal level of azole susceptibility. Confers resistance to fluconazole, itraconazole and voriconazole. (1472 aa)
AFUA_5G14820Replication factor C subunit. (389 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (788 aa)
AFUA_5G12720ABC multidrug transporter, putative. (1431 aa)
AFUA_5G11810Dynein heavy chain. (4368 aa)
AFUA_5G11750Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. (932 aa)
AFUA_5G10550ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (519 aa)
AFUA_5G10510ABC transporter, putative. (1493 aa)
AFUA_5G09480ABC transporter, putative. (1604 aa)
AFUA_5G09460ABC transporter, putative; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1485 aa)
AFUA_5G09190ABC bile acid transporter, putative. (1875 aa)
AFUA_5G08150ABC bile acid transporter, putative. (1527 aa)
AFUA_5G07970ABC metal ion transporter, putative. (1540 aa)
AFUA_5G07050Proteasome regulatory particle subunit Rpt2, putative; Belongs to the AAA ATPase family. (508 aa)
AFUA_5G07020Ribosome biogenesis ABC transporter Arb1, putative. (622 aa)
mdr1ABC multidrug transporter mdr1; Pleiotropic ABC efflux transporter that may be involved in A.fumigatus adaptation to azoles such as vorizonazole. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1349 aa)
AFUA_1G09210AAA family ATPase/60S ribosome export protein Rix7, putative. (784 aa)
AFUA_1G10310RNase L inhibitor of the ABC superfamily, putative. (703 aa)
abcBABC multidrug transporter B; Pleiotropic ABC efflux transporter that may be involved in A.fumigatus adaptation to azoles such as vorizonazole. (1458 aa)
AFUA_1G10410DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
AFUA_1G10640GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (293 aa)
AFUA_1G10720Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (789 aa)
AFUA_1G11180Heat shock protein/chaperonin HSP78, putative; Belongs to the ClpA/ClpB family. (797 aa)
AFUA_1G12520DNA repair protein (Rad57), putative. (647 aa)
mdr4ABC multidrug transporter mdr4; Pleiotropic ABC efflux transporter that confers resistance to azoles such as itraconazole and voriconazole. (1330 aa)
AFUA_1G15270Heat shock protein Hsp98/Hsp104/ClpA, putative; Belongs to the ClpA/ClpB family. (997 aa)
AFUA_1G16440ABC ATPase, putative. (717 aa)
AFUA_1G16880ABC multidrug transporter, putative. (1600 aa)
abcAABC multidrug transporter A-1; ABC transporter that seems not to be involved in the efflux of toxic substances, at least not the classical compounds such as itraconazole, amphotericin B, voriconazole, posaconazole, ravuconazole, or echinocandins. (1452 aa)
AFUA_4G14130ABC multidrug transporter, putative. (1297 aa)
AFUA_4G11530Intermembrane space AAA protease IAP-1. (799 aa)
AFUA_4G11180AAA family ATPase, putative. (539 aa)
rvb1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (458 aa)
mdr2ABC multidrug transporter mdr2; Pleiotropic ABC efflux transporter that may be involved in A.fumigatus adaptation to azoles. (791 aa)
AFUA_4G09150ABC multidrug transporter, putative. (1397 aa)
AFUA_4G08800ABC a-pheromone efflux pump AtrD. (1347 aa)
AFUA_4G06070Translation initiation regulator (Gcn20), putative. (751 aa)
AFUA_6G06780Proteasome regulatory particle subunit Rpt4, putative; Belongs to the AAA ATPase family. (393 aa)
AFUA_6G07280ABC transporter (Adp1), putative. (1088 aa)
AFUA_6G08020ABC transporter, putative; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1526 aa)
AFUA_6G11360ABC transporter, putative. (757 aa)
AFUA_6G12560AAA family ATPase, putative; Belongs to the AAA ATPase family. (802 aa)
atm1Iron-sulfur clusters transporter atm1, mitochondrial; Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity). (727 aa)
AFUA_1G02060Pachytene checkpoint component Pch2, putative; Belongs to the AAA ATPase family. (455 aa)
AFUA_1G02170ATP-dependent Clp protease, putative. (638 aa)
rvb2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (469 aa)
AFUA_1G03920DNA helicase; Belongs to the MCM family. (892 aa)
AFUA_1G04780Peroxisomal ABC transporter (PXA1), putative. (829 aa)
AFUA_1G06170Proteasome regulatory particle subunit Rpt5, putative; Belongs to the AAA ATPase family. (464 aa)
AFUA_2G01090DNA helicase, putative. (730 aa)
AFUA_2G01500ABC bile acid transporter, putative. (1458 aa)
AFUA_2G02680Mitochondrial inner membrane AAA protease Yta12, putative. (885 aa)
AFUA_2G03090Vacuolar ABC heavy metal transporter (Hmt1), putative. (873 aa)
AFUA_2G05430Uridine kinase; Belongs to the uridine kinase family. (453 aa)
AFUA_7G06680AAA family ATPase, putative. (631 aa)
AFUA_7G05660Translation elongation factor eEF-3, putative. (1065 aa)
AFUA_7G05480Sister chromatid cohesion factor (Chl12), putative. (940 aa)
AFUA_7G04310Cell division control protein; Belongs to the CDC6/cdc18 family. (647 aa)
AFUA_3G01400ABC multidrug transporter, putative; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1424 aa)
AFUA_3G02760ABC multidrug transporter, putative. (1284 aa)
AFUA_3G03430ABC multidrug transporter SitT. (1315 aa)
AFUA_5G02260ABC multidrug transporter, putative; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1469 aa)
AFUA_5G01870DNA replication factor C subunit Rfc3, putative. (396 aa)
AFUA_5G00790ABC multidrug transporter, putative; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1471 aa)
AFUA_5G00340ABC multidrug transporter, putative. (1421 aa)
AFUA_6G05080ABC transporter, putative. (280 aa)
AFUA_6G05040DNA replication factor C subunit Rfc4, putative. (348 aa)
atrFABC multidrug transporter atrF; Pleiotropic ABC efflux transporter involved in the basal level of azole susceptibility. Confers resistance to fluconazole and voriconazole. (1547 aa)
AFUA_6G04330DEAH-box RNA helicase (Dhr1), putative. (1211 aa)
AFUA_6G03580mRNA-nucleus export ATPase (Elf1), putative. (1115 aa)
fmpDABC transporter fmpD; ABC transporter; part of the gene cluster that mediates the biosynthesis of fumipyrrole, a brown pigment that is involved in growth and conidiation. (1285 aa)
AFUA_6G03080ABC multidrug transporter, putative. (1287 aa)
AFUA_8G04270AAA family ATPase, putative. (1654 aa)
AFUA_8G04740Pre-mRNA splicing helicase, putative. (2209 aa)
AFUA_8G02650ABC multidrug transporter, putative; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1453 aa)
AFUA_8G00780Uncharacterized protein. (932 aa)
AFUA_7G02200Meiotic recombination protein (Dmc1), putative; Belongs to the RecA family. (338 aa)
abcEABC multidrug transporter E; Pleiotropic ABC efflux transporter that may be involved in A.fumigatus adaptation to azoles such as vorizonazole. (1274 aa)
AFUA_4G03070DEAD/DEAH box helicase, putative. (2043 aa)
AFUA_4G03990Membrane-spanning ATPase, putative; Belongs to the AAA ATPase family. (419 aa)
AFUA_4G04660Proteasome regulatory particle subunit Rpt6, putative; Belongs to the AAA ATPase family. (389 aa)
AFUA_4G04800AAA family ATPase, putative. (759 aa)
AFUA_4G01260Mitochondrial chaperone ATPase (Bcs1), putative; Belongs to the AAA ATPase family. (520 aa)
AFUA_4G01050ABC multidrug transporter, putative; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1349 aa)
abcCABC multidrug transporter C; Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as itraconazole, posaconazole, and voriconazole (Probable). Also required for normal pathogenesis in a Galleria mellonella (greater wax moth) infection model. Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1497 aa)
AFUA_1G12910ABC fatty acid transporter, putative. (707 aa)
AFUA_2G17110Cell division control protein Cdc48; Belongs to the AAA ATPase family. (819 aa)
AFUA_1G13060Regulator of nonsense transcripts, putative. (1079 aa)
AFUA_7G05752AAA family ATPase, putative. (1009 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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