STRINGSTRING
AFUA_2G15312 AFUA_2G15312 AFUA_1G02980 AFUA_1G02980 AFUA_6G03590 AFUA_6G03590 AFUA_1G12800 AFUA_1G12800 AFUA_1G13630 AFUA_1G13630 AFUA_6G11020 AFUA_6G11020 catA catA hxkA hxkA AFUA_4G00290 AFUA_4G00290 pfkA pfkA AFUA_4G04520 AFUA_4G04520 AFUA_4G04410 AFUA_4G04410 AFUA_4G03900 AFUA_4G03900 AFUA_4G03890 AFUA_4G03890 AFUA_4G03760 AFUA_4G03760 AFUA_7G02420 AFUA_7G02420 AFUA_8G01210 AFUA_8G01210 AFUA_8G02300 AFUA_8G02300 AFUA_8G02560 AFUA_8G02560 AFUA_8G05200 AFUA_8G05200 AFUA_8G04000 AFUA_8G04000 AFUA_6G02230 AFUA_6G02230 AFUA_6G02470 AFUA_6G02470 AFUA_6G02490 AFUA_6G02490 AFUA_6G02860 AFUA_6G02860 AFUA_6G03540 AFUA_6G03540 AFUA_6G03980 AFUA_6G03980 AFUA_6G04920 AFUA_6G04920 AFUA_6G04970 AFUA_6G04970 AFUA_6G05210 AFUA_6G05210 AFUA_5G01030 AFUA_5G01030 AFUA_5G01970 AFUA_5G01970 AFUA_5G02180 AFUA_5G02180 AFUA_5G03480 AFUA_5G03480 AFUA_5G04230 AFUA_5G04230 AFUA_5G04250 AFUA_5G04250 AFUA_3G04170 AFUA_3G04170 AFUA_3G02910 AFUA_3G02910 AFUA_3G00790 AFUA_3G00790 AFUA_7G05670 AFUA_7G05670 AFUA_7G05720 AFUA_7G05720 AFUA_7G05740 AFUA_7G05740 AFUA_7G06090 AFUA_7G06090 AFUA_7G06100 AFUA_7G06100 AFUA_2G05910 AFUA_2G05910 AFUA_2G04870 AFUA_2G04870 AFUA_2G04490 AFUA_2G04490 AFUA_2G02100 AFUA_2G02100 AFUA_2G02020 AFUA_2G02020 AFUA_2G01040 AFUA_2G01040 AFUA_2G00450 AFUA_2G00450 AFUA_2G00200 AFUA_2G00200 AFUA_1G06960 AFUA_1G06960 AFUA_1G06150 AFUA_1G06150 AFUA_1G04160 AFUA_1G04160 AFUA_1G00530 AFUA_1G00530 AFUA_6G14200 AFUA_6G14200 acoA acoA AFUA_6G10610 AFUA_6G10610 AFUA_6G08730 AFUA_6G08730 AFUA_6G08050 AFUA_6G08050 AFUA_6G07770 AFUA_6G07770 AFUA_6G07720 AFUA_6G07720 AFUA_6G07430 AFUA_6G07430 AFUA_6G06370 AFUA_6G06370 AFUA_4G07710 AFUA_4G07710 AFUA_4G07810 AFUA_4G07810 AFUA_4G08140 AFUA_4G08140 AFUA_4G10410 AFUA_4G10410 AFUA_4G10790 AFUA_4G10790 AFUA_4G11080 AFUA_4G11080 AFUA_4G11310 AFUA_4G11310 AFUA_4G11650 AFUA_4G11650 AFUA_4G12050 AFUA_4G12050 AFUA_4G12870 AFUA_4G12870 AFUA_1G15590 AFUA_1G15590 AFUA_1G13500 AFUA_1G13500 AFUA_1G12070 AFUA_1G12070 AFUA_1G10830 AFUA_1G10830 AFUA_1G10780 AFUA_1G10780 AFUA_1G10350 AFUA_1G10350 AFUA_1G09470 AFUA_1G09470 AFUA_5G05500 AFUA_5G05500 AFUA_5G06130 AFUA_5G06130 AFUA_5G09230 AFUA_5G09230 AFUA_5G09680 AFUA_5G09680 AFUA_5G09860 AFUA_5G09860 AFUA_5G10290 AFUA_5G10290 AFUA_5G10370 AFUA_5G10370 AFUA_5G12690 AFUA_5G12690 AFUA_5G12790 AFUA_5G12790 AFUA_5G13450 AFUA_5G13450 AFUA_5G14790 AFUA_5G14790 AFUA_3G05370 AFUA_3G05370 AFUA_3G06550 AFUA_3G06550 AFUA_3G07810 AFUA_3G07810 AFUA_3G08470 AFUA_3G08470 AFUA_3G08660 AFUA_3G08660 AFUA_3G09290 AFUA_3G09290 AFUA_3G09320 AFUA_3G09320 AFUA_3G10750 AFUA_3G10750 AFUA_3G11690 AFUA_3G11690 AFUA_3G13380 AFUA_3G13380 AFUA_3G14470 AFUA_3G14470 easC easC AFUA_2G16330 AFUA_2G16330 AFUA_2G15190 AFUA_2G15190 AFUA_2G11300 AFUA_2G11300 AFUA_2G11020 AFUA_2G11020 AFUA_2G10920 AFUA_2G10920 AFUA_2G09790 AFUA_2G09790 AFUA_2G09650 AFUA_2G09650 AFUA_2G08280 AFUA_2G08280 AFUA_2G07810 AFUA_2G07810 icl1 icl1 catB catB enoA enoA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_2G15312Citrate synthase; Belongs to the citrate synthase family. (433 aa)
AFUA_1G029806-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (265 aa)
AFUA_6G03590Citrate synthase; Belongs to the citrate synthase family. (465 aa)
AFUA_1G12800Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (385 aa)
AFUA_1G13630D-isomer specific 2-hydroxyacid dehydrogenase family protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (322 aa)
AFUA_6G110203-hydroxyisobutyrate dehydrogenase. (365 aa)
catACatalase A; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (750 aa)
hxkAHexokinase-1; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. (549 aa)
AFUA_4G00290Succinyl-CoA synthetase beta subunit, putative. (407 aa)
pfkAATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (808 aa)
AFUA_4G04520Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (444 aa)
AFUA_4G044103-hydroxybutyryl-CoA dehydrogenase, putative. (338 aa)
AFUA_4G03900Peroxisomal multifunctional beta-oxidation protein (MFP), putative. (899 aa)
AFUA_4G03890Uncharacterized protein. (294 aa)
AFUA_4G03760Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1060 aa)
AFUA_7G02420Malic enzyme. (576 aa)
AFUA_8G01210Enoyl-CoA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (267 aa)
AFUA_8G02300FMN-dependent dehydrogenase family protein. (374 aa)
AFUA_8G02560Glyceraldehyde-3-phosphate dehydrogenase, putative; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (360 aa)
AFUA_8G05200Cysteine synthase, putative. (401 aa)
AFUA_8G04000Acetyl-CoA acetyltransferase, putative; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
AFUA_6G02230Phosphotransferase. (493 aa)
AFUA_6G02470Fumarate hydratase, putative. (582 aa)
AFUA_6G02490Aspartate aminotransferase. (412 aa)
AFUA_6G02860Isocitrate lyase. (649 aa)
AFUA_6G03540Malate synthase; Belongs to the malate synthase family. (539 aa)
AFUA_6G03980Phosphotransferase. (476 aa)
AFUA_6G04920Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (418 aa)
AFUA_6G04970Phosphoserine aminotransferase. (428 aa)
AFUA_6G05210Malate dehydrogenase, NAD-dependent; Belongs to the LDH/MDH superfamily. (330 aa)
AFUA_5G01030Glyceraldehyde-3-phosphate dehydrogenase. (332 aa)
AFUA_5G01970Glyceraldehyde-3-phosphate dehydrogenase. (338 aa)
AFUA_5G02180Cysteine synthase (O-acetylserine (Thiol)-lyase) (Csase). (371 aa)
AFUA_5G03480Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (689 aa)
AFUA_5G04230Citrate synthase; Belongs to the citrate synthase family. (474 aa)
AFUA_5G04250Homocysteine synthase CysD. (434 aa)
AFUA_3G04170Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (377 aa)
AFUA_3G02910Dihydroxy-acetone synthase, putative. (714 aa)
AFUA_3G00790Methylaspartate ammonia-lyase, putative. (399 aa)
AFUA_7G05670Ribose phosphate diphosphokinase Prs1, putative. (484 aa)
AFUA_7G05720Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (485 aa)
AFUA_7G05740Malate dehydrogenase. (340 aa)
AFUA_7G06090Fatty-acyl coenzyme A oxidase (Pox1), putative. (444 aa)
AFUA_7G06100Acyl-CoA dehydrogenasea family protein. (247 aa)
AFUA_2G05910Phosphotransferase. (490 aa)
AFUA_2G04870Pyruvate dehydrogenase E1 component alpha subunit, putative. (360 aa)
AFUA_2G04490D-3-phosphoglycerate dehydrogenase. (635 aa)
AFUA_2G02100Dihydrolipoyl dehydrogenase. (513 aa)
AFUA_2G02020Formamidase FmdS. (411 aa)
AFUA_2G01040S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (379 aa)
AFUA_2G00450Phosphotransferase. (530 aa)
AFUA_2G00200Catalase, putative. (573 aa)
AFUA_1G06960Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (370 aa)
AFUA_1G06150L-serine dehydratase, putative. (445 aa)
AFUA_1G04160Aspartate aminotransferase, putative. (444 aa)
AFUA_1G00530Gluconokinase; Belongs to the gluconokinase GntK/GntV family. (201 aa)
AFUA_6G14200Acetyl-CoA-acetyltransferase, putative; Belongs to the thiolase-like superfamily. Thiolase family. (433 aa)
acoAAconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate, a step in the citric acid cycle. Also catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. Belongs to the aconitase/IPM isomerase family. (787 aa)
AFUA_6G10610Ribose 5-phosphate isomerase A. (272 aa)
AFUA_6G087306-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (518 aa)
AFUA_6G080506-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (508 aa)
AFUA_6G07770Alanine aminotransferase, putative. (501 aa)
AFUA_6G07720Phosphoenolpyruvate carboxykinase AcuF. (601 aa)
AFUA_6G07430Pyruvate kinase; Belongs to the pyruvate kinase family. (527 aa)
AFUA_6G06370Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (455 aa)
AFUA_4G07710Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1193 aa)
AFUA_4G07810L-serine dehydratase, putative. (460 aa)
AFUA_4G08140Threonine dehydratase. (567 aa)
AFUA_4G10410Aspartate aminotransferase, putative. (437 aa)
AFUA_4G10790Phosphoribosyl diphosphate synthase isoform 4. (320 aa)
AFUA_4G11080Acetyl-coenzyme A synthetase. (670 aa)
AFUA_4G11310Fructose-1,6-bisphosphatase Fbp1, putative; Belongs to the FBPase class 1 family. (353 aa)
AFUA_4G11650Alpha-ketoglutarate dehydrogenase complex subunit Kgd1, putative. (1057 aa)
AFUA_4G12050Gluconokinase; Belongs to the gluconokinase GntK/GntV family. (233 aa)
AFUA_4G12870Methylmalonate-semialdehyde dehydrogenase, putative. (602 aa)
AFUA_1G15590Succinate dehydrogenase [ubiquinone] cytochrome b small subunit. (170 aa)
AFUA_1G13500Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (684 aa)
AFUA_1G12070Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (175 aa)
AFUA_1G10830Succinyl-CoA synthetase subunit alpha, putative. (678 aa)
AFUA_1G10780Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (485 aa)
AFUA_1G10350Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (417 aa)
AFUA_1G09470Aminotransferase, class V, putative. (386 aa)
AFUA_5G05500D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (472 aa)
AFUA_5G06130Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (331 aa)
AFUA_5G09230Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (324 aa)
AFUA_5G09680Succinate dehydrogenase cytochrome b560 subunit. (208 aa)
AFUA_5G09860S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (287 aa)
AFUA_5G10290Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (284 aa)
AFUA_5G10370Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (299 aa)
AFUA_5G12690Dihydroxyacetone kinase (DakA), putative. (604 aa)
AFUA_5G127903-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (588 aa)
AFUA_5G13450Triosephosphate isomerase. (256 aa)
AFUA_5G14790Phosphoenolpyruvate synthase, putative. (806 aa)
AFUA_3G05370Dihydrolipoamide succinyltransferase, putative. (445 aa)
AFUA_3G06550Phosphoserine phosphatase. (469 aa)
AFUA_3G07810Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (647 aa)
AFUA_3G08470Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (502 aa)
AFUA_3G08660Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (501 aa)
AFUA_3G09290Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent. (520 aa)
AFUA_3G09320Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (471 aa)
AFUA_3G10750Probable acetate kinase. (469 aa)
AFUA_3G11690Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (360 aa)
AFUA_3G13380Ribose-phosphate pyrophosphokinase. (436 aa)
AFUA_3G14470Pyridoxal-phosphate dependent enzyme, putative. (385 aa)
easCCatalase easC; Catalase; part of the gene cluster that mediates the biosynthesis of fumiclavanine C, a fungal ergot alkaloid. DmaW catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan. The second step is catalyzed by the methyltransferase easF that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of 4-dimethylallyl-L-abrine (By similarity). The catalase easC and the FAD-dependent oxidoreductase easE then transform 4-dimethyl [...] (520 aa)
AFUA_2G16330Phosphotransferase. (484 aa)
AFUA_2G15190Ribulose-phosphate 3-epimerase. (313 aa)
AFUA_2G11300Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (615 aa)
AFUA_2G11020Triosephosphate isomerase. (287 aa)
AFUA_2G10920Enoyl-CoA hydratase/isomerase family protein; Belongs to the enoyl-CoA hydratase/isomerase family. (294 aa)
AFUA_2G09790Glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
AFUA_2G09650Aspartate transaminase, putative. (469 aa)
AFUA_2G08280Malic enzyme. (661 aa)
AFUA_2G07810Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (537 aa)
icl1Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate. (538 aa)
catBCatalase B; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide; Belongs to the catalase family. (728 aa)
enoAEnolase; Belongs to the enolase family. (438 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
Server load: low (24%) [HD]