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| | atg12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity). (174 aa) |
| | AFUA_5G11230 | RAS small monomeric GTPase RasA. (213 aa) |
| | AFUA_5G08570 | cAMP-dependent protein kinase catalytic subunit, putative; Belongs to the protein kinase superfamily. (396 aa) |
| | AFUA_1G13330 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (388 aa) |
| | AFUA_1G11890 | Serine palmitoyltransferase 2, putative. (680 aa) |
| | AFUA_6G11190 | Protein kinase (VPS15), putative. (1637 aa) |
| | pep2 | Vacuolar protease A; Vacuolar aspartic endopeptidase which is probably also secreted and contributes to virulence. (398 aa) |
| | alp2 | Alkaline protease 2; Alkaline protease that allows assimilation of proteinaceous substrates. Acts as a significant virulence factor in invasive aspergillosis. Required for regular sporulation. (495 aa) |
| | AFUA_6G00300 | Serine palmitoyltransferase 1, putative. (613 aa) |
| | AFUA_8G05170 | Autophagy protein Apg6, putative. (446 aa) |
| | AFUA_6G02020 | G1/S-specific cyclin Pcl5, putative. (702 aa) |
| | AFUA_6G04870 | Vacuolar protein sorting-associated protein VpsB; Belongs to the STXBP/unc-18/SEC1 family. (595 aa) |
| | AFUA_7G05790 | Vacuolar morphogenesis protein AvaB, putative. (1038 aa) |
| | AFUA_2G06250 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (723 aa) |
| | atg22-1 | Autophagy-related protein 22-1; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity); Belongs to the ATG22 family. (609 aa) |
| | atg13 | Autophagy-related protein 13; Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, atg13 is also required for glycogen storage during stationary phase (By similarity). (958 aa) |
| | AFUA_2G02610 | SNARE complex subunit (Vam7), putative. (383 aa) |
| | AFUA_2G02510 | TORC1 growth control complex subunit Kog1, putative. (1435 aa) |
| | AFUA_2G01700 | Non-specific serine/threonine protein kinase. (793 aa) |
| | AFUA_2G00310 | Amino acid transporter, putative. (580 aa) |
| | atg8 | Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] (118 aa) |
| | AFUA_1G06920 | Serine/threonine protein kinase, putative. (1230 aa) |
| | AFUA_1G06400 | Non-specific serine/threonine protein kinase. (875 aa) |
| | AFUA_1G05640 | Protein phosphatase. (739 aa) |
| | AFUA_1G05280 | Golgi complex component (Vps8), putative. (1588 aa) |
| | atg2 | Autophagy-related protein 2; Required for cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes completion and peroxisome degradation. Belongs to the ATG2 family. (2160 aa) |
| | AFUA_6G12390 | Serine palmitoyl CoA transferase subunit LcbA. (504 aa) |
| | atg9 | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] (951 aa) |
| | AFUA_6G10830 | Serine/threonine-protein phosphatase. (329 aa) |
| | AFUA_6G10410 | E3 ubiquitin-protein ligase PEP5. (958 aa) |
| | atg5 | Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1- like activating enzyme and atg10 as an E2- [...] (326 aa) |
| | AFUA_4G07760 | Amino acid transporter, putative. (744 aa) |
| | atg1 | Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] (973 aa) |
| | AFUA_4G09520 | SNARE protein Ykt6, putative; Belongs to the synaptobrevin family. (195 aa) |
| | AFUA_4G10710 | Vesicle transport v-snare protein, putative. (224 aa) |
| | AFUA_4G13720 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (424 aa) |
| | AFUA_1G15250 | Autophagy protein Atg27, putative. (333 aa) |
| | AFUA_1G14260 | TGF beta receptor associated protein 1, putative. (1229 aa) |
| | AFUA_1G09560 | Protein transport protein (LST8), putative. (415 aa) |
| | AFUA_5G06450 | Vacuolar protein sorting protein DigA. (961 aa) |
| | AFUA_5G06750 | Protein kinase (Gcn2), putative. (1592 aa) |
| | atg3 | Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8. The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of [...] (353 aa) |
| | AFUA_5G08670 | Phosphatidylinositol 3-kinase VPS34. (898 aa) |
| | AFUA_5G11450 | Kinase; Belongs to the inositol phosphokinase (IPK) family. (480 aa) |
| | AFUA_5G11560 | Arp2/3 complex subunit (Arp3), putative; Belongs to the actin family. (439 aa) |
| | atg18 | Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct atg9 trafficking to the pre- autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (436 aa) |
| | AFUA_5G11780 | TOR signalling pathway regulator (TapA), putative. (358 aa) |
| | AFUA_5G12130 | Rab small monomeric GTPase Rab7, putative. (171 aa) |
| | AFUA_5G13240 | Kinase; Belongs to the inositol phosphokinase (IPK) family. (1359 aa) |
| | AFUA_5G13600 | Probable vacuolar protein sorting-associated protein 16 homolog; Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. (828 aa) |
| | AFUA_3G05340 | Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. (226 aa) |
| | AFUA_3G11200 | Vacuolar assembly protein, putative. (1298 aa) |
| | atg11 | Autophagy-related protein 11; Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity). (1264 aa) |
| | AFUA_3G12510 | Vesicular fusion ATPase, putative. (770 aa) |
| | AFUA_3G13480 | Translation initiation factor 2 alpha subunit, putative. (310 aa) |
| | atg22-2 | Autophagy-related protein 22-2; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity); Belongs to the ATG22 family. (613 aa) |
| | AFUA_2G15010 | Serine threonine protein kinase, putative. (2058 aa) |
| | atg17 | Autophagy-related protein 17; Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity); Belongs to the ATG17 family. (551 aa) |
| | AFUA_2G13750 | Vacuolar sorting protein, putative; Belongs to the STXBP/unc-18/SEC1 family. (666 aa) |
| | AFUA_2G12870 | Vesicular-fusion protein sec17. (292 aa) |
| | AFUA_2G12200 | cAMP-dependent protein kinase catalytic subunit PkaC1; Belongs to the protein kinase superfamily. (490 aa) |
| | atg15 | Putative lipase atg15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by atg15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (650 aa) |
| | AFUA_2G10270 | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2384 aa) |
| | AFUA_2G07770 | Ras small monomeric GTPase RasB. (239 aa) |
| | AFUA_2G07540 | TOR signalling pathway protein TipA, putative. (266 aa) |
