STRINGSTRING
AFUA_2G00660 AFUA_2G00660 AFUA_8G02840 AFUA_8G02840 AFUA_8G05570 AFUA_8G05570 AFUA_8G04810 AFUA_8G04810 mmm1 mmm1 atg8 atg8 AFUA_1G07160 AFUA_1G07160 AFUA_1G05800 AFUA_1G05800 AFUA_4G06180 AFUA_4G06180 atg1 atg1 mdm34 mdm34 AFUA_4G10240 AFUA_4G10240 AFUA_4G11530 AFUA_4G11530 AFUA_4G13670 AFUA_4G13670 AFUA_4G13720 AFUA_4G13720 AFUA_1G15950 AFUA_1G15950 AFUA_1G15800 AFUA_1G15800 mdm12 mdm12 hog1 hog1 AFUA_1G09950 AFUA_1G09950 AFUA_5G07480 AFUA_5G07480 AFUA_5G08390 AFUA_5G08390 mpkC mpkC AFUA_5G11970 AFUA_5G11970 AFUA_5G12640 AFUA_5G12640 mdmB mdmB AFUA_3G06080 AFUA_3G06080 AFUA_3G08230 AFUA_3G08230 AFUA_3G11080 AFUA_3G11080 atg11 atg11 fis1 fis1 AFUA_2G10270 AFUA_2G10270
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_2G00660Sensor histidine kinase/response regulator TcsB/Sln1, putative. (1096 aa)
AFUA_8G02840Dynamin-like GTPase Dnm1, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (800 aa)
AFUA_8G05570Transcription factor (Sin3), putative. (1497 aa)
AFUA_8G04810Casein kinase, putative; Belongs to the protein kinase superfamily. (336 aa)
mmm1Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 su [...] (496 aa)
atg8Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] (118 aa)
AFUA_1G07160Ubiquitin carboxyl-terminal hydrolase. (872 aa)
AFUA_1G05800MAP kinase kinase (Mkk2), putative. (503 aa)
AFUA_4G06180Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (364 aa)
atg1Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] (973 aa)
mdm34Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (572 aa)
AFUA_4G10240Small nuclear ribonucleoprotein Sm D3. (116 aa)
AFUA_4G11530Intermembrane space AAA protease IAP-1. (799 aa)
AFUA_4G13670WSC domain protein, putative. (293 aa)
AFUA_4G13720Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (424 aa)
AFUA_1G15950MAP kinase kinase (Pbs2), putative. (656 aa)
AFUA_1G15800Protein phosphatase 2C, putative. (865 aa)
mdm12Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pat [...] (439 aa)
hog1Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. (366 aa)
AFUA_1G09950Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (294 aa)
AFUA_5G07480Uncharacterized protein. (196 aa)
AFUA_5G08390Response regulator, putative. (850 aa)
mpkCMitogen-activated protein kinase mpkC; Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source. (378 aa)
AFUA_5G11970Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1106 aa)
AFUA_5G12640DNA polymerase gamma. (1135 aa)
mdmBMitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the recepto [...] (471 aa)
AFUA_3G06080Multicopy suppressor of stt4 mutation. (905 aa)
AFUA_3G08230MRS7 family protein. (614 aa)
AFUA_3G11080MAP kinase kinase kinase (Bck1), putative. (1617 aa)
atg11Autophagy-related protein 11; Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity). (1264 aa)
fis1Mitochondrial fission 1 protein; Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). (151 aa)
AFUA_2G10270Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2384 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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