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AFUA_1G14690 AFUA_1G14690 AFUA_4G04612 AFUA_4G04612 AFUA_2G17110 AFUA_2G17110 AFUA_1G12960 AFUA_1G12960 hsp90 hsp90 AFUA_8G05140 AFUA_8G05140 AFUA_8G04840 AFUA_8G04840 yos9 yos9 AFUA_8G04430 AFUA_8G04430 AFUA_8G03930 AFUA_8G03930 AFUA_6G04210 AFUA_6G04210 AFUA_6G04670 AFUA_6G04670 fes1 fes1 AFUA_5G03500 AFUA_5G03500 AFUA_5G03610 AFUA_5G03610 AFUA_5G04060 AFUA_5G04060 AFUA_7G04110 AFUA_7G04110 AFUA_2G06280 AFUA_2G06280 AFUA_2G06150 AFUA_2G06150 AFUA_2G05790 AFUA_2G05790 AFUA_2G04620 AFUA_2G04620 png1 png1 AFUA_2G02360 AFUA_2G02360 AFUA_1G07440 AFUA_1G07440 AFUA_1G05320 AFUA_1G05320 AFUA_1G05040 AFUA_1G05040 sar1 sar1 AFUA_1G04890 AFUA_1G04890 AFUA_1G03810 AFUA_1G03810 sec23 sec23 npl4 npl4 AFUA_1G02430 AFUA_1G02430 AFUA_1G01720 AFUA_1G01720 AFUA_6G14130 AFUA_6G14130 AFUA_6G13420 AFUA_6G13420 sec24 sec24 AFUA_6G12360 AFUA_6G12360 AFUA_6G06790 AFUA_6G06790 sec13 sec13 AFUA_4G06960 AFUA_4G06960 AFUA_4G07330 AFUA_4G07330 AFUA_4G07340 AFUA_4G07340 AFUA_4G08660 AFUA_4G08660 AFUA_4G10070 AFUA_4G10070 AFUA_1G15050 AFUA_1G15050 AFUA_1G14940 AFUA_1G14940 AFUA_1G14780 AFUA_1G14780 mns1B mns1B AFUA_5G05790 AFUA_5G05790 AFUA_5G06040 AFUA_5G06040 sconC sconC AFUA_5G06750 AFUA_5G06750 AFUA_5G08130 AFUA_5G08130 AFUA_5G08370 AFUA_5G08370 AFUA_5G08970 AFUA_5G08970 AFUA_5G10270 AFUA_5G10270 AFUA_5G12260 AFUA_5G12260 AFUA_3G05400 AFUA_3G05400 AFUA_3G05550 AFUA_3G05550 AFUA_3G06030 AFUA_3G06030 AFUA_3G06901 AFUA_3G06901 AFUA_3G09700 AFUA_3G09700 AFUA_3G13480 AFUA_3G13480 AFUA_2G16800 AFUA_2G16800 AFUA_2G16620 AFUA_2G16620 AFUA_2G16470 AFUA_2G16470 AFUA_2G16290 AFUA_2G16290 sec31 sec31 AFUA_2G12580 AFUA_2G12580 AFUA_2G12180 AFUA_2G12180 AFUA_2G11100 AFUA_2G11100 AFUA_2G11040 AFUA_2G11040 AFUA_2G10590 AFUA_2G10590 AFUA_2G08650 AFUA_2G08650 AFUA_2G08300 AFUA_2G08300 AFUA_4G12850 AFUA_4G12850
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFUA_1G14690Ubiquitin-protein ligase Sel1/Ubx2, putative. (852 aa)
AFUA_4G04612Ubiquitin-conjugating enzyme Ubc6, putative. (307 aa)
AFUA_2G17110Cell division control protein Cdc48; Belongs to the AAA ATPase family. (819 aa)
AFUA_1G12960SCF ubiquitin ligase complex subunit CulA, putative; Belongs to the cullin family. (769 aa)
hsp90Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). (706 aa)
AFUA_8G05140Oxidoreductin. (598 aa)
AFUA_8G04840RING finger protein. (771 aa)
yos9Protein OS-9 homolog; Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity). (520 aa)
AFUA_8G04430Oligosaccharyl transferase subunit (Stt3), putative. (743 aa)
AFUA_8G03930Hsp70 chaperone (HscA), putative; Belongs to the heat shock protein 70 family. (614 aa)
AFUA_6G04210Mannosyl-oligosaccharide glucosidase, putative. (822 aa)
AFUA_6G04670Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (249 aa)
fes1Hsp70 nucleotide exchange factor fes1; Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity). Belongs to the FES1 family. (216 aa)
AFUA_5G03500Alpha glucosidase II, alpha subunit, putative; Belongs to the glycosyl hydrolase 31 family. (967 aa)
AFUA_5G03610Cdc48-dependent protein degradation adaptor protein (Shp1), putative. (394 aa)
AFUA_5G04060Ubiquitin conjugating enzyme (UbcH), putative; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
AFUA_7G04110Protein kinase C substrate, putative. (540 aa)
AFUA_2G06280Oligosaccharyl transferase subunit (Gamma), putative. (325 aa)
AFUA_2G06150Protein disulfide-isomerase. (517 aa)
AFUA_2G05790Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (504 aa)
AFUA_2G04620Hsp70 chaperone BiP/Kar2, putative; Belongs to the heat shock protein 70 family. (672 aa)
png1Protein png1; Belongs to the transglutaminase-like superfamily. PNGase family. (455 aa)
AFUA_2G02360UDP-glucose:glycoprotein glucosyltransferase, putative. (1487 aa)
AFUA_1G07440Molecular chaperone Hsp70; Belongs to the heat shock protein 70 family. (638 aa)
AFUA_1G05320Disulfide isomerase, putative. (478 aa)
AFUA_1G05040Protein mitochondrial targeting protein (Mas1), putative. (413 aa)
sar1Small COPII coat GTPase sar1; Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. Sar1 controls the coat assembly in a stepwise manner. Activated Sar1-GTP binds to membranes first and recruits the sec23/24 complex. These sec23/24-sar1 prebudding intermediates are then collected by the Sec13/31 complex as subunits polymerize to form coated trans [...] (189 aa)
AFUA_1G04890Translocon protein Sec61beta, putative. (131 aa)
AFUA_1G03810Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (189 aa)
sec23Protein transport protein sec23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (780 aa)
npl4Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family. (652 aa)
AFUA_1G02430Ubiquitin fusion degradation protein Ufd1, putative. (384 aa)
AFUA_1G01720Protein kinase and ribonuclease Ire1, putative. (1165 aa)
AFUA_6G14130Ubiquitin conjugating enzyme, putative; Belongs to the ubiquitin-conjugating enzyme family. (168 aa)
AFUA_6G13420Ubiquitin-like protein DskB, putative. (472 aa)
sec24Protein transport protein sec24; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (919 aa)
AFUA_6G12360alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (893 aa)
AFUA_6G06790alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (704 aa)
sec13Protein transport protein sec13; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport facto [...] (306 aa)
AFUA_4G06960UBX domain protein, putative. (306 aa)
AFUA_4G07330ER associated DnaJ chaperone (Hlj1), putative. (376 aa)
AFUA_4G07340Ubiquitin fusion degradation protein UfdB, putative. (1088 aa)
AFUA_4G08660Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (289 aa)
AFUA_4G10070alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
AFUA_1G15050Hsp70 family chaperone Lhs1/Orp150, putative. (997 aa)
AFUA_1G14940Protein translocation complex componenet (Npl1), putative. (697 aa)
AFUA_1G14780BAP31 domain protein, putative. (212 aa)
mns1BProbable mannosyl-oligosaccharide alpha-1,2-mannosidase 1B; Involved in the maturation of Asn-linked oligosaccharides. Progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) (By similarity). (493 aa)
AFUA_5G05790Ubiquitin ligase subunit HrtA, putative. (120 aa)
AFUA_5G06040UV excision repair protein (RadW), putative. (376 aa)
sconCE3 ubiquitin ligase complex SCF subunit sconC; Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor (By similarity). (158 aa)
AFUA_5G06750Protein kinase (Gcn2), putative. (1592 aa)
AFUA_5G08130Protein transport protein Sec61 alpha subunit, putative. (478 aa)
AFUA_5G08370Polyubiquitin binding protein (Doa1/Ufd3), putative. (790 aa)
AFUA_5G08970Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (462 aa)
AFUA_5G10270Heat shock protein Hsp20/Hsp26, putative; Belongs to the small heat shock protein (HSP20) family. (201 aa)
AFUA_5G12260Disulfide isomerase (TigA), putative; Belongs to the protein disulfide isomerase family. (368 aa)
AFUA_3G05400DnaJ and TPR domain protein. (522 aa)
AFUA_3G05550OTU-like cysteine protease, putative. (340 aa)
AFUA_3G06030Ubiquitin conjugating enzyme (UbcD), putative; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
AFUA_3G06901Protein translocation complex subunit Sss1, putative. (88 aa)
AFUA_3G09700Sec23/Sec24 family protein. (1019 aa)
AFUA_3G13480Translation initiation factor 2 alpha subunit, putative. (310 aa)
AFUA_2G16800Lectin family integral membrane protein, putative. (328 aa)
AFUA_2G16620Protein kinase, putative. (768 aa)
AFUA_2G16470Ubiquitin conjugating enzyme (UbcF), putative. (312 aa)
AFUA_2G16290DnaJ domain protein (Mas5), putative. (420 aa)
sec31Protein transport protein sec31; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1263 aa)
AFUA_2G12580Translocation protein Sec62, putative. (401 aa)
AFUA_2G12180Lectin family integral membrane protein, putative. (327 aa)
AFUA_2G11100AMFR protein, putative. (200 aa)
AFUA_2G11040U-box domain protein, putative. (284 aa)
AFUA_2G10590Disulfide isomerase, putative. (737 aa)
AFUA_2G08650RING finger membrane protein. (1617 aa)
AFUA_2G08300DnaJ domain protein, putative. (427 aa)
AFUA_4G12850Calnexin homolog; Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity). Belongs to the calreticulin family. (563 aa)
Your Current Organism:
Aspergillus fumigatus
NCBI taxonomy Id: 330879
Other names: A. fumigatus Af293, Aspergillus fumigatus Af293
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